Meningococcal interactions with the host

scientific article published on 28 May 2009

Meningococcal interactions with the host is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/J.VACCINE.2009.04.069
P698PubMed publication ID19481311

P50authorXavier NassifQ89819839
P2093author name stringMumtaz Virji
Etienne Carbonnelle
Philippe Morand
Sandrine Bourdoulous
Darryl J Hill
Natalie J Griffiths
Isabel Murillo
P2860cites workType IV pilus structure by cryo-electron microscopy and crystallography: implications for pilus assembly and functionsQ41625721
Highly conserved Neisseria meningitidis surface protein confers protection against experimental infectionQ41966979
Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491Q22122399
An interaction between alpha-actinin and the beta 1 integrin subunit in vitroQ24317203
Crystal structure of the OpcA integral membrane adhesin from Neisseria meningitidisQ24531430
Extracellular bacterial pathogen induces host cell surface reorganization to resist shear stressQ27317860
Cooperative retraction of bundled type IV pili enables nanonewton force generationQ27333547
Crystallographic structure reveals phosphorylated pilin from Neisseria: phosphoserine sites modify type IV pilus surface chemistry and fibre morphologyQ27639839
Crystal Structure of Neisserial Surface Protein A (NspA), a Conserved Outer Membrane Protein with Vaccine PotentialQ27641060
3D structure/function analysis of PilX reveals how minor pilins can modulate the virulence properties of type IV piliQ27648472
Structure of a widely conserved type IV pilus biogenesis factor that affects the stability of secretin multimersQ27650426
Structure of the fibre-forming protein pilin at 2.6 A resolutionQ27729288
Pilus retraction powers bacterial twitching motilityQ28138923
The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissuesQ28141489
Recognition of sialylated meningococcal lipopolysaccharide by siglecs expressed on myeloid cells leads to enhanced bacterial uptakeQ28203722
Structure-function relationship of type-IV prepilin peptidase of Pseudomonas aeruginosa--a reviewQ28243795
Formation of oligomeric rings by XcpQ and PilQ, which are involved in protein transport across the outer membrane of Pseudomonas aeruginosaQ28492505
Amino acid substitutions in PilD, a bifunctional enzyme of Pseudomonas aeruginosa. Effect on leader peptidase and N-methyltransferase activities in vitro and in vivoQ28492721
Syndecan-4 associates with alpha-actininQ28565623
Type IV pili and twitching motilityQ29615262
Initiation of biofilm formation in Pseudomonas fluorescens WCS365 proceeds via multiple, convergent signalling pathways: a genetic analysisQ29616613
ERM proteins and merlin: integrators at the cell cortexQ29619893
Characterization of MspA, an immunogenic autotransporter protein that mediates adhesion to epithelial and endothelial cells in Neisseria meningitidis.Q30159832
Recognition of saccharides by the OpcA, OpaD, and OpaB outer membrane proteins from Neisseria meningitidisQ30160180
Neisseria meningitidis infection of human endothelial cells interferes with leukocyte transmigration by preventing the formation of endothelial docking structuresQ30480402
Genetic characterization of pilin glycosylation and phase variation in Neisseria meningitidisQ30540451
Molecular and biological analysis of eight genetic islands that distinguish Neisseria meningitidis from the closely related pathogen Neisseria gonorrhoeaeQ30847631
Identification of a novel gene involved in pilin glycosylation in Neisseria meningitidisQ32001499
Using laser tweezers to measure twitching motility in NeisseriaQ33216565
Alternative Neisseria spp. type IV pilin glycosylation with a glyceramido acetamido trideoxyhexose residueQ33297467
Cloning and expression in Escherichia coli of opc, the gene for an unusual class 5 outer membrane protein from Neisseria meningitidis (meningococci/surface antigen)Q33311967
The effect of immune selection on the structure of the meningococcal opa protein repertoireQ33325914
CD46-independent binding of neisserial type IV pili and the major pilus adhesin, PilC, to human epithelial cellsQ33768892
Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing.Q33892877
Direct observation of extension and retraction of type IV piliQ33948884
Neisseria gonorrhoeae PilV, a type IV pilus-associated protein essential to human epithelial cell adherenceQ33953123
AAA proteins. Lords of the ringQ33967586
Analysis of the PilQ secretin from Neisseria meningitidis by transmission electron microscopy reveals a dodecameric quaternary structure.Q33996354
Functional activity of anti-Neisserial surface protein A monoclonal antibodies against strains of Neisseria meningitidis serogroup B.Q34007747
Immunization with recombinant Opc outer membrane protein from Neisseria meningitidis: influence of sequence variation and levels of expression on the bactericidal immune response against meningococciQ34007787
Role of pili and the phase-variable PilC protein in natural competence for transformation of Neisseria gonorrhoeaeQ34021865
Interactions of pathogenic neisseriae with epithelial cell membranesQ34059736
Characterization of the pilF-pilD pilus-assembly locus of Neisseria gonorrhoeae.Q34295957
How do extracellular pathogens cross the blood-brain barrier?Q34522621
NadA diversity and carriage in Neisseria meningitidisQ34761302
Three-dimensional structure of the Neisseria meningitidis secretin PilQ determined from negative-stain transmission electron microscopy.Q34892226
Biology and pathogenesis of the evolutionarily successful, obligate human bacterium Neisseria meningitidisQ34983505
Roles of pilin and PilC in adhesion of Neisseria meningitidis to human epithelial and endothelial cellsQ35196315
T-cell responses to outer membrane proteins of Neisseria meningitidis: comparative study of the Opa, Opc, and PorA proteins.Q35464174
Antigenic variation of gonococcal pilus involves assembly of separated silent gene segmentsQ35597748
Alpha-actinin revisited: a fresh look at an old playerQ35745364
Purification and three-dimensional electron microscopy structure of the Neisseria meningitidis type IV pilus biogenesis protein PilG.Q42063250
Discovery of a novel protein modification: alpha-glycerophosphate is a substituent of meningococcal pilinQ42092526
Interactions between the lipoprotein PilP and the secretin PilQ in Neisseria meningitidisQ42412537
Neisserial outer membrane vesicles bind the coinhibitory receptor carcinoembryonic antigen-related cellular adhesion molecule 1 and suppress CD4+ T lymphocyte function.Q42413093
The comP locus of Neisseria gonorrhoeae encodes a type IV prepilin that is dispensable for pilus biogenesis but essential for natural transformation.Q42599192
Genetic characterization of pilin glycosylation in Neisseria meningitidis.Q42625107
PilP, a pilus biogenesis lipoprotein in Neisseria gonorrhoeae, affects expression of PilQ as a high-molecular-mass multimer.Q42656450
Two-partner secretion systems of Neisseria meningitidis associated with invasive clonal complexesQ42664149
Recombinational reassortment among opa genes from ET-37 complex Neisseria meningitidis isolates of diverse geographical originsQ42672607
Identification and characterization of pilG, a highly conserved pilus-assembly gene in pathogenic NeisseriaQ42676806
Mutational analysis of human CEACAM1: the potential of receptor polymorphism in increasing host susceptibility to bacterial infection.Q42836287
Many carried meningococci lack the genes required for capsule synthesis and transportQ43450474
Intranasal immunization of mice with recombinant Streptococcus gordonii expressing NadA of Neisseria meningitidis induces systemic bactericidal antibodies and local IgA.Q43519880
Allelic polymorphism and site-specific recombination in the opc locus of Neisseria meningitidis.Q43625288
Recombinant Opc protein from Neisseria meningitidis reconstituted into liposomes elicits opsonic antibodies following immunizationQ43694080
Neisserial binding to CEACAM1 arrests the activation and proliferation of CD4+ T lymphocytesQ43890850
The cyanobacterial PilT protein responsible for cell motility and transformation hydrolyzes ATP.Q44198770
Fibronectin mediates Opc-dependent internalization of Neisseria meningitidis in human brain microvascular endothelial cellsQ44208778
The role of pili in the interactions of pathogenic Neisseria with cultured human endothelial cellsQ44240746
Mapping the binding domains on meningococcal Opa proteins for CEACAM1 and CEA receptorsQ44655587
The pilus-retraction protein PilT: ultrastructure of the biological assembly.Q44855130
The HrpB-HrpA two-partner secretion system is essential for intracellular survival of Neisseria meningitidisQ44964045
Carcinoembryonic antigens (CD66) on epithelial cells and neutrophils are receptors for Opa proteins of pathogenic neisseriaeQ46981783
Variable expression of the Opc outer membrane protein in Neisseria meningitidis is caused by size variation of a promoter containing poly-cytidineQ47372926
Opc- and pilus-dependent interactions of meningococci with human endothelial cells: molecular mechanisms and modulation by surface polysaccharidesQ47673074
Structure and function of repetitive sequence elements associated with a highly polymorphic domain of the Neisseria meningitidis PilQ proteinQ47694549
Carcinoembryonic antigen-related cell adhesion molecule (CEACAM)-binding recombinant polypeptide confers protection against infection by respiratory and urogenital pathogensQ47846681
Meningococcal pilin: a glycoprotein substituted with digalactosyl 2,4-diacetamido-2,4,6-trideoxyhexoseQ48070795
Characterization of the opa (class 5) gene family of Neisseria meningitidisQ48223983
CD46 in meningococcal diseaseQ48250643
The repertoire of silent pilus genes in Neisseria gonorrhoeae: evidence for gene conversion.Q48369411
The product of the pilQ gene is essential for the biogenesis of type IV pili in Neisseria gonorrhoeaeQ48788182
Functional implications of the expression of PilC proteins in meningococci.Q51039916
Critical determinants of the interactions of capsule-expressing Neisseria meningitidis with host cells: the role of receptor density in increased cellular targeting via the outer membrane Opa proteins.Q51814030
The 5C protein of Neisseria meningitidis is highly immunogenic in humans and induces bactericidal antibodies.Q54282592
Neisseria meningitidis NhhA is a multifunctional trimeric autotransporter adhesin.Q54462447
Membrane cofactor protein (MCP or CD46) is a cellular pilus receptor for pathogenic Neisseria.Q54560552
Meningococcal Opa and Opc proteins: their role in colonization and invasion of human epithelial and endothelial cells.Q55065744
Genetic mechanisms for loss of encapsulation in polysialyltransferase-gene-positive meningococci isolated from healthy carriersQ57706975
Neisseria PilC protein identified as type-4 pilus tip-located adhesinQ59097833
Critical determinants of host receptor targeting by Neisseria meningitidis and Neisseria gonorrhoeae : identification of Opa adhesiotopes on the N-domain of CD66 moleculesQ61374915
A systematic genetic analysis in Neisseria meningitidis defines the Pil proteins required for assembly, functionality, stabilization and export of type IV piliQ63369231
Type IV pilus biogenesis in Neisseria meningitidis: PilW is involved in a step occurring after pilus assembly, essential for fibre stability and functionQ63369237
Down-regulation of pili and capsule of Neisseria meningitidis upon contact with epithelial cells is mediated by CrgA regulatory proteinQ64449501
The adhesive property of the type IV pilus-associated component PilC1 of pathogenic Neisseria is supported by the conformational structure of the N-terminal part of the moleculeQ64449577
Type IV pili of pathogenic Neisseriae elicit cortical plaque formation in epithelial cellsQ64449799
Consequences of the loss of O-linked glycosylation of meningococcal type IV pilin on piliation and pilus-mediated adhesionQ64449937
Investigations into the molecular basis of meningococcal toxicity for human endothelial and epithelial cells: the synergistic effect of LPS and piliQ64450171
Pilus-dependence of four Pseudomonas aeruginosa bacteriophages with non-contractile tailsQ64452328
Capsule phase variation in Neisseria meningitidis serogroup B by slipped-strand mispairing in the polysialyltransferase gene (siaD): correlation with bacterial invasion and the outbreak of meningococcal diseaseQ71538870
Distinct mechanisms of interactions of Opc-expressing meningococci at apical and basolateral surfaces of human endothelial cells; the role of integrins in apical interactionsQ71669928
Underestimation of meningococci in tonsillar tissue by nasopharyngeal swabbingQ73219247
Genetic Basis for NongroupableNeisseria meningitidisQ73332286
Identification and characterisation of a novel conserved outer membrane protein from Neisseria meningitidisQ73985146
Biliary glycoprotein (CD66a), a cell adhesion molecule of the immunoglobulin superfamily, on human lymphocytes: structure, expression and involvement in T cell activationQ77646998
Structure of the Neisseria meningitidis outer membrane PilQ secretin complex at 12 A resolutionQ80341119
An Arg-Gly-Asp-directed receptor on the surface of human melanoma cells exists in an divalent cation-dependent functional complex with the disialoganglioside GD2.Q36217603
Cerebral microcirculation shear stress levels determine Neisseria meningitidis attachment sites along the blood-brain barrierQ36228828
Activation of ErbB2 receptor tyrosine kinase supports invasion of endothelial cells by Neisseria meningitidisQ36293988
A functional two-partner secretion system contributes to adhesion of Neisseria meningitidis to epithelial cellsQ36314792
Purification and characterization of eight class 5 outer membrane protein variants from a clone of Neisseria meningitidis serogroup A.Q36355197
Implications of phase variation of a gene (pgtA) encoding a pilin galactosyl transferase in gonococcal pathogenesisQ36370821
The meningococcal PilT protein is required for induction of intimate attachment to epithelial cells following pilus-mediated adhesion.Q36456158
Targeted vaccination with meningococcal polysaccharide vaccine in one district of the Czech RepublicQ36504440
Unified nomenclature for pathogenic Neisseria speciesQ36634163
Gonococcal and meningococcal pathogenesis as defined by human cell, cell culture, and organ culture assaysQ36634342
Current status of meningococcal group B vaccine candidates: capsular or noncapsular?Q36642138
Identification, localization, and distribution of the PilT protein in Neisseria gonorrhoeaeQ36750654
Unique modifications with phosphocholine and phosphoethanolamine define alternate antigenic forms of Neisseria gonorrhoeae type IV piliQ36987172
A force-dependent switch reverses type IV pilus retractionQ37284932
Mannose-binding lectin binds to two major outer membrane proteins, opacity protein and porin, of Neisseria meningitidis.Q37867614
Invasion of endothelial cells by Neisseria meningitidis requires cortactin recruitment by a phosphoinositide-3-kinase/Rac1 signalling pathway triggered by the lipo-oligosaccharideQ38322667
Interaction with type IV pili induces structural changes in the bacterial outer membrane secretin PilQ.Q38329612
Type IV pilus retraction in pathogenic Neisseria is regulated by the PilC proteins.Q38342126
Analysis of the role of pglI in pilin glycosylation of Neisseria meningitidis.Q38342290
Opacity-associated adhesin repertoire in hyperinvasive Neisseria meningitidisQ38481856
Haplotypic diversity in human CEACAM genes: effects on susceptibility to meningococcal diseaseQ38929396
Carcinoembryonic antigen family receptor specificity of Neisseria meningitidis Opa variants influences adherence to and invasion of proinflammatory cytokine-activated endothelial cells.Q39516473
Aquifex aeolicus PilT, homologue of a surface motility protein, is a thermostable oligomeric NTPaseQ39680720
Neisseria meningitidis Opc invasin binds to the cytoskeletal protein alpha-actininQ39915129
Neisseria meningitidis C114 contains silent, truncated pilin genes that are homologous to Neisseria gonorrhoeae pil sequencesQ39952778
IFN-gamma amplifies NFkappaB-dependent Neisseria meningitidis invasion of epithelial cells via specific upregulation of CEA-related cell adhesion molecule 1.Q40086481
Co-ordinate action of bacterial adhesins and human carcinoembryonic antigen receptors in enhanced cellular invasion by capsulate serum resistant Neisseria meningitidisQ40247357
PilT is required for PI(3,4,5)P3-mediated crosstalk between Neisseria gonorrhoeae and epithelial cells.Q40385895
Components and dynamics of fiber formation define a ubiquitous biogenesis pathway for bacterial piliQ40388345
Neisseria meningitidis NadA is a new invasin which promotes bacterial adhesion to and penetration into human epithelial cells.Q40468661
PilX, a pilus-associated protein essential for bacterial aggregation, is a key to pilus-facilitated attachment of Neisseria meningitidis to human cells.Q40478265
Neisseria meningitidis undergoes PilC phase variation and PilE sequence variation during invasive diseaseQ40595205
Neisseria meningitidis App, a new adhesin with autocatalytic serine protease activityQ40658481
Identification and characterization of App: an immunogenic autotransporter protein of Neisseria meningitidis.Q40688629
A superfamily of proteins involved in different secretion pathways in gram-negative bacteria: modular structure and specificity of the N-terminal domainQ40755737
Inverse relationship between pilus-mediated gonococcal adherence and surface expression of the pilus receptor, CD46.Q40787303
Locally inducible CD66a (CEACAM1) as an amplifier of the human intestinal T cell responseQ40852219
Prepilin-like molecules in type 4 pilus biogenesis: minor subunits, chaperones or mediators of organelle translocation?Q40953462
PilT mutations lead to simultaneous defects in competence for natural transformation and twitching motility in piliated Neisseria gonorrhoeae.Q41017039
Neisseria meningitidis producing the Opc adhesin binds epithelial cell proteoglycan receptorsQ41046627
Modulation of cell surface sialic acid expression in Neisseria meningitidis via a transposable genetic element.Q41063588
Phase variation of gonococcal pili by frameshift mutation in pilC, a novel gene for pilus assemblyQ41079923
The opcA and (psi)opcB regions in Neisseria: genes, pseudogenes, deletions, insertion elements and DNA islandsQ41482254
Two-dimensional structure of the Opc invasin from Neisseria meningitidisQ41489778
Post-translational modifications of meningococcal pili. Identification of common substituents: glycans and alpha-glycerophosphate--a reviewQ41532698
Expression of the Opc protein correlates with invasion of epithelial and endothelial cells by Neisseria meningitidisQ41599981
P407language of work or nameEnglishQ1860
P304page(s)B78-89
P577publication date2009-05-28
P1433published inVaccineQ7907941
P1476titleMeningococcal interactions with the host
P478volume27 Suppl 2

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