Hypertonic stress in the kidney: a necessary evil

scientific article published on June 2009

Hypertonic stress in the kidney: a necessary evil is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1152/PHYSIOL.00005.2009
P698PubMed publication ID19509128
P5875ResearchGate publication ID26278704

P2093author name stringMin Seong Kwon
H Moo Kwon
Sun Woo Lim
P2860cites workTonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicityQ22008847
Bridging the NFAT and NF-kappaB families: NFAT5 dimerization regulates cytokine gene transcription in response to osmotic stressQ24291525
Activity of the TonEBP/OREBP transactivation domain varies directly with extracellular NaCl concentrationQ24530428
Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expressionQ24622498
Neuropathy target esterase catalyzes osmoprotective renal synthesis of glycerophosphocholine in response to high NaClQ24679482
The NFAT-related protein NFATL1 (TonEBP/NFAT5) is induced upon T cell activation in a calcineurin-dependent mannerQ28142037
The role of NFAT transcription factors in integrin-mediated carcinoma invasionQ28206477
Impaired renal NaCl absorption in mice lacking the ROMK potassium channel, a model for type II Bartter's syndromeQ28507563
c-Jun is regulated by combination of enhanced expression and phosphorylation in acute-overloaded rat heartQ28565103
Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channelsQ28585485
Mouse TonEBP-NFAT5: expression in early development and alternative splicingQ28588125
Impaired solute accumulation in inner medulla of Clcnk1-/- mice kidneyQ28589823
Living with water stress: evolution of osmolyte systemsQ29615240
Uncompensated polyuria in a mouse model of Bartter's syndromeQ30454291
NFAT5 regulates HIV-1 in primary monocytes via a highly conserved long terminal repeat siteQ33266806
Urinary concentrating defect in mice with selective deletion of phloretin-sensitive urea transporters in the renal collecting ductQ33906016
Aquaporins in the kidney: from molecules to medicineQ34107691
Adaptation of the distal convoluted tubule of the rat. Structural and functional effects of dietary salt intake and chronic diuretic infusionQ34563840
Genome-wide RNAi screening identifies protein damage as a regulator of osmoprotective gene expressionQ35033224
Evolutionary relationships among Rel domains indicate functional diversification by recombinationQ35893955
Influence of macromolecular crowding upon the stability and state of association of proteins: predictions and observationsQ36178505
Novel nuclear localization signal regulated by ambient tonicity in vertebratesQ36825529
Nucleoporin 88 (Nup88) is regulated by hypertonic stress in kidney cells to retain the transcription factor tonicity enhancer-binding protein (TonEBP) in the nucleusQ36861522
NFAT5/TonEBP mutant mice define osmotic stress as a critical feature of the lymphoid microenvironmentQ36986637
Genome-wide RNAi screen and in vivo protein aggregation reporters identify degradation of damaged proteins as an essential hypertonic stress responseQ37016726
Transcription factor tonicity-responsive enhancer-binding protein (TonEBP) which transactivates osmoprotective genes is expressed and upregulated following acute systemic hypertonicity in neurons in brainQ38344848
TonEBP/NFAT5 stimulates transcription of HSP70 in response to hypertonicityQ39675201
Hypertonic-induced lamin A/C synthesis and distribution to nucleoplasmic speckles is mediated by TonEBP/NFAT5 transcriptional activatorQ40047315
Elevated expression of Cyr61 enhances peritoneal dissemination of gastric cancer cells through integrin alpha2beta1.Q40074224
Discovery of osmosensitive transcriptional regulation of human cytochrome P450 3As by the tonicity-responsive enhancer binding protein (nuclear factor of activated T cells 5).Q40113833
Downregulation of renal TonEBP in hypokalemic rats.Q40149475
Tonicity-responsive enhancer binding protein is an essential regulator of aquaporin-2 expression in renal collecting duct principal cellsQ40287311
TonEBP is inhibited by RNA helicase A via interaction involving the E'F loop.Q40371037
Dual effects of hypertonicity on aquaporin-2 expression in cultured renal collecting duct principal cellsQ40432739
Expression of taurine transporter is regulated through the TonE (tonicity-responsive element)/TonEBP (TonE-binding protein) pathway and contributes to cytoprotection in HepG2 cellsQ40556250
Regulation of expression of the stress response gene, Osp94: identification of the tonicity response element and intracellular signalling pathwaysQ40579024
The TonE/TonEBP pathway mediates tonicity-responsive regulation of UT-A urea transporter expressionQ40854151
Bidirectional regulation of tonicity-responsive enhancer binding protein in response to changes in tonicityQ40876238
Enhanced in situ expression of aldose reductase in peripheral nerve and renal glomeruli in diabetic patientsQ43703717
Osmolality and solute composition are strong regulators of AQP2 expression in renal principal cellsQ44185774
Multiple domains of TonEBP cooperate to stimulate transcription in response to hypertonicity.Q44582547
Adaptation of the nematode Caenorhabditis elegans to extreme osmotic stressQ44673762
Urea may regulate urea transporter protein abundance during osmotic diuresisQ44976707
Osmotic response element-binding protein (OREBP) is an essential regulator of the urine concentrating mechanism.Q45044196
Altered expression profile of transporters in the inner medullary collecting duct of aquaporin-1 knockout miceQ45267524
The osmoprotective function of the NFAT5 transcription factor in T cell development and activationQ46040663
Interstitial tonicity controls TonEBP expression in the renal medulla.Q46217199
High NaCl increases TonEBP/OREBP mRNA and protein by stabilizing its mRNA.Q46495861
P304page(s)186-191
P577publication date2009-06-01
P1433published inPhysiologyQ1091804
P1476titleHypertonic stress in the kidney: a necessary evil
P478volume24

Reverse relations

cites work (P2860)
Q58919899A Single Amino Acid Substitution in the Renal Betaine/GABA Transporter Prevents Trafficking to the Plasma Membrane
Q46150276A primary culture system of mouse thick ascending limb cells with preserved function and uromodulin processing.
Q38736926Am I Drinking Enough? Yes, No, and Maybe
Q47315412Cleavage of osmosensitive transcriptional factor NFAT5 by Coxsackieviral protease 2A promotes viral replication
Q36362817Diabetic Myopathy and Mechanisms of Disease
Q34718038Distinct cellular pathways for resistance to urea stress and hypertonic stress
Q36464964Elevated extracellular glucose and uncontrolled type 1 diabetes enhance NFAT5 signaling and disrupt the transverse tubular network in mouse skeletal muscle
Q39220541Environmental hyperosmolality regulates phospholipid biosynthesis in the renal epithelial cell line MDCK.
Q36466647Genome-wide identification and quantitative analysis of cleaved tRNA fragments induced by cellular stress
Q37533285Genome-wide transcriptional profiling and enrichment mapping reveal divergent and conserved roles of Sko1 in the Candida albicans osmotic stress response
Q28073545L-form bacteria, chronic diseases and the origins of life
Q38994841Mutation of a single threonine in the cytoplasmic NH2 terminus disrupts trafficking of renal betaine-GABA transporter 1 during hypertonic stress
Q34883750NF-AT5 is a critical regulator of inflammatory arthritis
Q27026371New insights into the pathogenesis of renal calculi
Q30496797Osmoprotective transcription factor NFAT5/TonEBP modulates nuclear factor-kappaB activity
Q43088122Randall plaque versus renal stone?
Q63353231Salt stress in the renal tubules is linked to TAL-specific expression of uromodulin and an upregulation of heat shock genes
Q60939411Sequential and synchronized hypertonicity-induced activation of Rel-family transcription factors is required for osmoprotection in renal cells
Q37735049The betaine/GABA transporter and betaine: roles in brain, kidney, and liver
Q90208774The evolving role of TonEBP as an immunometabolic stress protein
Q28302484TonEBP stimulates multiple cellular pathways for adaptation to hypertonic stress: organic osmolyte-dependent and -independent pathways

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