IL-22-producing CD4+T cells in the treatment response of rheumatoid arthritis to combination therapy with methotrexate and leflunomide

scientific article published on 24 January 2017

IL-22-producing CD4+T cells in the treatment response of rheumatoid arthritis to combination therapy with methotrexate and leflunomide is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/SREP41143
P932PMC publication ID5259708
P698PubMed publication ID28117352

P2093author name stringTao Liu
Ling Zhao
Wei Zhong
Zhenyu Jiang
P2860cites workEULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 updateQ26859134
The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritisQ27860872
Combination treatment with leflunomide and methotrexate for patients with active rheumatoid arthritisQ28308126
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brainQ29614225
Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatmentQ33896725
In early rheumatoid arthritis, patients with a good initial response to methotrexate have excellent 2-year clinical outcomes, but radiological progression is not fully prevented: data from the methotrexate responders population in the SWEFOT trialQ34022672
Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritisQ34315745
2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid ArthritisQ34500921
Amelioration of experimental autoimmune uveitis by leflunomide in Lewis ratsQ34692643
Endogenous IL-22 plays a dual role in arthritis: regulation of established arthritis via IFN-γ responsesQ35133818
Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights.Q35150010
Interleukin-22 is produced by invariant natural killer T lymphocytes during influenza A virus infection: potential role in protection against lung epithelial damagesQ35841871
Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cellsQ37383893
Interleukin-22 Secreted by NKp44+ Natural Killer Cells Promotes Proliferation of Fibroblast-Like Synoviocytes in Rheumatoid ArthritisQ37624160
Recent advances in IL-22 biology.Q37851777
IL-22, not simply a Th17 cytokineQ38081171
Proposal for a new nomenclature of disease-modifying antirheumatic drugsQ38144973
The role of the Th17 cytokines IL-17 and IL-22 in Rheumatoid Arthritis pathogenesis and developments in cytokine immunotherapyQ38281473
Expression of interleukin-22 in rheumatoid arthritis: potential role as a proinflammatory cytokine.Q50485305
High susceptibility to collagen-induced arthritis in mice lacking IFN-gamma receptors.Q52525666
IL-22/IL-22R1 axis and S100A8/A9 alarmins in human osteoarthritic and rheumatoid arthritis synovial fibroblasts.Q52643628
Loss of IL-22 inhibits autoantibody formation in collagen-induced arthritis in mice.Q53148065
Leflunomide suppresses TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal protein kinase, and apoptosisQ73163237
Accelerated collagen-induced arthritis in IFN-gamma receptor-deficient miceQ73370075
Human beta-defensin 2 but not beta-defensin 1 is expressed preferentially in colonic mucosa of inflammatory bowel diseaseQ74593708
IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migrationQ82829186
Remission induction therapy with methotrexate and prednisone in patients with early rheumatoid and undifferentiated arthritis (the IMPROVED study)Q83608994
Effect of methotrexate on serum levels of IL-22 in patients with psoriasisQ84320861
CCL20 and IL22 Messenger RNA Expression After Adalimumab vs Methotrexate Treatment of Psoriasis: A Randomized Clinical TrialQ38411982
Treating rheumatoid arthritis to target: 2014 update of the recommendations of an international task forceQ38476881
Th17 Cell Pathway in Human Immunity: Lessons from Genetics and Therapeutic InterventionsQ38673368
Biological and pathological activities of interleukin-22.Q38753752
Immunoregulation therapy changes the frequency of interleukin (IL)-22+ CD4+ T cells in systemic lupus erythematosus patientsQ41922047
Mechanism of action of leflunomide in rheumatoid arthritis.Q42541034
Methotrexate--how does it really work?Q43144564
Induction of apoptosis and modulation of activation and effector function in T cells by immunosuppressive drugsQ43977140
Restriction of de novo pyrimidine biosynthesis inhibits Th1 cell activation and promotes Th2 cell differentiationQ44129543
Concomitant leflunomide therapy in patients with active rheumatoid arthritis despite stable doses of methotrexate. A randomized, double-blind, placebo-controlled trialQ44205088
Combination of MTX and LEF attenuates inflammatory bone erosion by down-regulation of receptor activator of NF-kB ligand and interleukin-17 in type II collagen-induced arthritis ratsQ45032600
Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells.Q45939390
The SMILE study -- safety of methotrexate in combination with leflunomide in rheumatoid arthritisQ46052545
IL-22+ CD4+ T cells in patients with rheumatoid arthritisQ46431837
Drug-free remission, functioning and radiographic damage after 4 years of response-driven treatment in patients with recent-onset rheumatoid arthritisQ46458365
Th1 but not Th17 cells predominate in the joints of patients with rheumatoid arthritisQ46862865
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectrheumatoid arthritisQ187255
methotrexateQ422232
P304page(s)41143
P577publication date2017-01-24
P1433published inScientific ReportsQ2261792
P1476titleIL-22-producing CD4+T cells in the treatment response of rheumatoid arthritis to combination therapy with methotrexate and leflunomide
P478volume7

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cites work (P2860)
Q42042837A type of human skin dendritic cell marked by CD5 is associated with the development of inflammatory skin disease.
Q58543113Decreased Expression of Sphingosine-1-Phosphate Receptor 1 in the Blood Leukocyte of Rheumatoid Arthritis Patients
Q57166646Immune Mechanisms and Pathways Targeted in Type 1 Diabetes
Q54964170Interleukin-22 (IL-22) Regulates Apoptosis of Paclitaxel-Resistant Non-Small Cell Lung Cancer Cells Through C-Jun N-Terminal Kinase Signaling Pathway.
Q92163993Lower serum interleukin-22 and interleukin-35 levels are associated with disease status in neuromyelitis optica spectrum disorders
Q59352564Safety and Impact of Low-Dose Methotrexate on Endothelial Function and Inflammation in Individuals with Treated Human Immunodeficiency Virus: AIDS Clinical Trials Group Study A5314
Q92131178The protective and pathogenic roles of IL-17 in viral infections: friend or foe?

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