Nodal promotes the self-renewal of human colon cancer stem cells via an autocrine manner through Smad2/3 signaling pathway

scientific article published on 17 February 2014

Nodal promotes the self-renewal of human colon cancer stem cells via an autocrine manner through Smad2/3 signaling pathway is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1155/2014/364134
P932PMC publication ID3947734
P698PubMed publication ID24696849
P5875ResearchGate publication ID261329314

P50authorYuehua GongQ96242267
P2093author name stringZheng Li
Hao Yang
Yang Liu
Zhenzhen Zhang
Shi Yang
Meng Ma
Ying Guo
Zuping He
Linhong Liu
Yanan Hai
P2860cites workA cell initiating human acute myeloid leukaemia after transplantation into SCID miceQ28131777
Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancerQ28274188
ALK7, a receptor for nodal, is dispensable for embryogenesis and left-right patterning in the mouseQ28511846
Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryoQ28585896
Wnt signalling in stem cells and cancerQ29547862
Cancer stem cells from colorectal cancer-derived cell lines.Q30493732
Gdnf upregulates c-Fos transcription via the Ras/Erk1/2 pathway to promote mouse spermatogonial stem cell proliferation.Q34001722
Gfra1 silencing in mouse spermatogonial stem cells results in their differentiation via the inactivation of RET tyrosine kinaseQ34025027
The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapseQ34171959
Expression of nodal, lefty-a, and lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3.Q34340840
Nodal signaling via an autocrine pathway promotes proliferation of mouse spermatogonial stem/progenitor cells through Smad2/3 and Oct-4 activationQ36238402
Signaling in colon cancer stem cellsQ36359958
Human embryonic stem cell microenvironment suppresses the tumorigenic phenotype of aggressive cancer cellsQ36670245
Cancer stem cell markers CD133 and CD24 correlate with invasiveness and differentiation in colorectal adenocarcinomaQ37192661
Development and cancer: at the crossroads of Nodal and Notch signalingQ37350305
Expression of nodal signalling components in cycling human endometrium and in endometrial cancerQ37414264
Colon cancer stem cells: promise of targeted therapy.Q37737414
Cancer stem cell hypotheses: impact on modern molecular physiology and pharmacology research.Q37960771
Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4.Q39997734
TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cellsQ45259297
Activin-Nodal signaling is involved in propagation of mouse embryonic stem cells.Q51092315
Nodal/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy.Q53279352
CD44 is of Functional Importance for Colorectal Cancer Stem CellsQ58022858
Embryonic Protein Nodal Promotes Breast Cancer VascularizationQ60613826
Expression of CD44 variant proteins in human colorectal cancer is related to tumor progressionQ72097100
Stage II colon cancer prognosis prediction by tumor gene expression profilingQ80244020
Colon cancer stem cellsQ82641642
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectneoplastic stem cellsQ1638475
colon cancerQ18555025
P304page(s)364134
P577publication date2014-02-17
P1433published inBioMed Research InternationalQ17509958
P1476titleNodal promotes the self-renewal of human colon cancer stem cells via an autocrine manner through Smad2/3 signaling pathway
P478volume2014

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cites work (P2860)
Q41006491Aldehyde Dehydragenase 1 and Nodal as Significant Prognostic Markers in Colorectal Cancer
Q26830307Are hematopoietic stem cells involved in hepatocarcinogenesis?
Q42243028EGFR signaling promotes inflammation and cancer stem-like activity in inflammatory breast cancer
Q36492667Expression and significance of Nodal in human cancers: a meta-analysis
Q36260634Inhibition of colorectal cancer stem cell survival and invasive potential by hsa-miR-140-5p mediated suppression of Smad2 and autophagy
Q33648524NOMO-1 gene is deleted in early-onset colorectal cancer.
Q38764247Plasticity underlies tumor progression: role of Nodal signaling
Q57801264Regulatory effects of lncRNAs and miRNAs on autophagy in malignant tumorigenesis

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