Homing endonucleases: from basics to therapeutic applications.

scientific article published on March 2010

Homing endonucleases: from basics to therapeutic applications. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1007/S00018-009-0188-Y
P698PubMed publication ID19915993

P50authorFrancisco J. BlancoQ16251242
Inés G. MuñozQ42859143
Maria J MarcaidaQ48547074
P2093author name stringGuillermo Montoya
Jesús Prieto
P2860cites workMutations specific to the xeroderma pigmentosum group E Ddb- phenotypeQ24322600
Differential effects of Rad52p overexpression on gene targeting and extrachromosomal homologous recombination in a human cell lineQ24514763
Intertwined structure of the DNA-binding domain of intron endonuclease I-TevI with its substrate.Q24535579
Zinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cellsQ24535831
Mutations altering the cleavage specificity of a homing endonucleaseQ24537781
X-Linked chronic granulomatous disease: mutations in the CYBB gene encoding the gp91-phox component of respiratory-burst oxidase.Q24538965
Familial porphyria cutanea tarda: characterization of seven novel uroporphyrinogen decarboxylase mutations and frequency of common hemochromatosis allelesQ24539508
Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiaeQ24548535
Behavior of restriction-modification systems as selfish mobile elements and their impact on genome evolutionQ24555229
Characterization of the restriction site of a prokaryotic intron-encoded endonucleaseQ24558625
A general two-metal-ion mechanism for catalytic RNAQ24562157
Computational redesign of endonuclease DNA binding and cleavage specificityQ24569661
Strand-specific contacts and divalent metal ion regulate double-strand break formation by the GIY-YIG homing endonuclease I-BmoIQ64387785
The genetics of the hereditary xeroderma pigmentosum syndromeQ64387883
Selection of a remote cleavage site by I-tevI, the td intron-encoded endonucleaseQ64389592
Epidermal morphogenesis and induction of the 67 kD keratin polypeptide by culture of human keratinocytes at the liquid-air interfaceQ68940208
New approaches to understanding Lesch-Nyhan diseaseQ71073952
Xeroderma pigmentosum. Complementation group C and malignant melanomaQ71268962
New tumor formation on split-thickness skin grafted areas in xeroderma pigmentosumQ73271909
Structural parsimony in endonuclease active sites: should the number of homing endonuclease families be redefined?Q73280737
Resurfacing the dorsum of the hand in a patient with Xeroderma pigmentosumQ73579786
A similar active site for non-specific and specific endonucleasesQ74523726
Relationship of the C242T p22phox gene polymorphism to angiographic coronary artery disease and endothelial functionQ78107902
Chronic granulomatous disease caused by mutations other than the common GT deletion in NCF1, the gene encoding the p47phox component of the phagocyte NADPH oxidaseQ80260413
Autoimmune polyendocrinopathy--candidosis--ectodermal dystrophy (APECED): autosomal recessive inheritanceQ93594572
Homing endonuclease structure and functionQ34473961
Does heterozygous beta-thalassemia confer a protection against coronary artery disease?Q34474608
Gene therapy: X-SCID transgene leukaemogenicityQ34567588
Modeling the therapeutic efficacy of p53 restoration in tumorsQ34593294
New founder germline mutations of CDKN2A in melanoma-prone families and multiple primary melanoma development in a patient receiving levodopa treatment.Q34626994
Evolutionarily conserved and functionally important residues in the I-CeuI homing endonucleaseQ34630818
Engineered I-CreI derivatives cleaving sequences from the human XPC gene can induce highly efficient gene correction in mammalian cellsQ34636305
Statistical modeling and analysis of the LAGLIDADG family of site-specific endonucleases and identification of an intein that encodes a site-specific endonuclease of the HNH familyQ34645548
Double-strand breaks at the target locus stimulate gene targeting in embryonic stem cellsQ34784813
The nicking homing endonuclease I-BasI is encoded by a group I intron in the DNA polymerase gene of the Bacillus thuringiensis phage BastilleQ35109019
Segregation analysis with uncertain ascertainment: application to Fanconi anemiaQ35245762
Identification and characterization of nine RFLPs at the adenosine deaminase (ADA) locusQ35248529
New types of conserved sequence domains in DNA-binding regions of homing endonucleasesQ35296069
N-terminal RAG1 frameshift mutations in Omenn's syndrome: internal methionine usage leads to partial V(D)J recombination activity and reveals a fundamental role in vivo for the N-terminal domains.Q35850311
RAD18 and poly(ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair.Q35856709
Mobile group II intronsQ35965810
Crystallization and preliminary X-ray studies of I-PpoI: a nuclear, intron-encoded homing endonuclease from Physarum polycephalumQ36280256
Uroporphyrinogen 3 cosynthetase in human congenital erythropoietic porphyriaQ36448840
Hematopoietic stem-cell transplantationQ36461248
Analysis of DNA double-strand break repair pathways in miceQ36517406
Differential usage of non-homologous end-joining and homologous recombination in double strand break repairQ36522562
Related homing endonucleases I-BmoI and I-TevI use different strategies to cleave homologous recognition sitesQ36529061
A protein encoded by a group I intron in Aspergillus nidulans directly assists RNA splicing and is a DNA endonucleaseQ36546473
A mobile group I intron from Physarum polycephalum can insert itself and induce point mutations in the nuclear ribosomal DNA of saccharomyces cerevisiaeQ36661174
Co-ordination of DNA single strand break repairQ36661965
Characterization of I-Ppo, an intron-encoded endonuclease that mediates homing of a group I intron in the ribosomal DNA of Physarum polycephalumQ36714793
Meganucleases and DNA double-strand break-induced recombination: perspectives for gene therapyQ36737863
Interaction of the intron-encoded mobility endonuclease I-PpoI with its target siteQ36827630
Expression of protein-coding genes embedded in ribosomal DNA.Q36850001
Structural biology of the tumor suppressor p53.Q37137883
Generation of a nicking enzyme that stimulates site-specific gene conversion from the I-AniI LAGLIDADG homing endonucleaseQ37146915
I-TevI, the endonuclease encoded by the mobile td intron, recognizes binding and cleavage domains on its DNA targetQ37586978
Intron-encoded endonuclease I-TevI binds as a monomer to effect sequential cleavage via conformational changes in the td homing site.Q37625189
The structural basis of damaged DNA recognition and endonucleolytic cleavage for very short patch repair endonucleaseQ33941852
Genetic analysis of the Chlamydomonas reinhardtii I-CreI mobile intron homing system in Escherichia coliQ33971499
Gene conversion tracts from double-strand break repair in mammalian cellsQ33995776
Zinc finger as distance determinant in the flexible linker of intron endonuclease I-TevI.Q34064923
A 76-kb duplicon maps close to the BCR gene on chromosome 22 and the ABL gene on chromosome 9: possible involvement in the genesis of the Philadelphia chromosome translocationQ34076060
Mutations in severe combined immune deficiency (SCID) due to JAK3 deficiency.Q34098712
The phage T4 nrdB intron: a deletion mutant of a version found in the wildQ34114074
A self-splicing group I intron in the DNA polymerase gene of Bacillus subtilis bacteriophage SPO1.Q34157210
A novel engineered meganuclease induces homologous recombination in yeast and mammalian cellsQ34200585
Adenosine deaminase deficiency: Frequency and comparative pathology in autosomally recessive severe combined immunodeficiencyQ34218448
Double-strand-break-induced homologous recombination in mammalian cellsQ34253008
Natural history of paroxysmal nocturnal hemoglobinuriaQ34296074
An intron in the nuclear ribosomal DNA of Didymium iridis codes for a group I ribozyme and a novel ribozyme that cooperate in self-splicingQ34336918
Beyond homing: competition between intron endonucleases confers a selective advantage on flanking genetic markersQ34371890
Group I intron homing in Bacillus phages SPO1 and SP82: a gene conversion event initiated by a nicking homing endonucleaseQ34435844
The DNA polymerase genes of several HMU-bacteriophages have similar group I introns with highly divergent open reading framesQ24606570
Structural and biochemical analyses of DNA and RNA binding by a bifunctional homing endonuclease and group I intron splicing factorQ24630148
Fractured genes: a novel genomic arrangement involving new split inteins and a new homing endonuclease familyQ24649588
Induction of homologous recombination in mammalian chromosomes by using the I-SceI system of Saccharomyces cerevisiaeQ24652685
Efficient targeting of a SCID gene by an engineered single-chain homing endonucleaseQ24654113
High-frequency modification of plant genes using engineered zinc-finger nucleasesQ24654686
A combinatorial approach to create artificial homing endonucleases cleaving chosen sequencesQ24670002
The restriction fold turns to the dark side: a bacterial homing endonuclease with a PD-(D/E)-XK motifQ24673408
Homing endonuclease I-CreI derivatives with novel DNA target specificitiesQ24674606
A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genesQ24684053
The recent transfer of a homing endonuclease geneQ24802877
In vivo selection of engineered homing endonucleases using double-strand break induced homologous recombinationQ24811303
Potentiation of gene targeting in human cells by expression of Saccharomyces cerevisiae Rad52Q24813430
A novel endonuclease mechanism directly visualized for I-PpoIQ27620540
Conformational changes and cleavage by the homing endonuclease I-PpoI: a critical role for a leucine residue in the active siteQ27625320
The homing endonuclease I-CreI uses three metals, one of which is shared between the two active sitesQ27630852
Crystal structure of the intein homing endonuclease PI-SceI bound to its recognition sequenceQ27639613
Catalytic domain structure and hypothesis for function of GIY-YIG intron endonuclease I-TevIQ27639807
Crystal structure of the thermostable archaeal intron-encoded endonuclease I-DmoIQ27639829
Design, activity, and structure of a highly specific artificial endonucleaseQ27639919
Flexible DNA target site recognition by divergent homing endonuclease isoschizomers I-CreI and I-MsoIQ27641297
The crystal structure of the gene targeting homing endonuclease I-SceI reveals the origins of its target site specificityQ27642627
Mutability of an HNH nuclease imidazole general base and exchange of a deprotonation mechanismQ27644841
Crystal structures of I-SceI complexed to nicked DNA substrates: snapshots of intermediates along the DNA cleavage reaction pathwayQ27650402
Crystal structure of I-DmoI in complex with its target DNA provides new insights into meganuclease engineeringQ27652711
Molecular basis of xeroderma pigmentosum group C DNA recognition by engineered meganucleasesQ27652792
Generation of single-chain LAGLIDADG homing endonucleases from native homodimeric precursor proteinsQ27653454
Mg2+ binding to the active site of EcoRV endonuclease: a crystallographic study of complexes with substrate and product DNA at 2 A resolutionQ27730328
The structure of I-Crel, a group I intron-encoded homing endonucleaseQ27739151
DNA binding and cleavage by the nuclear intron-encoded homing endonuclease I-PpoIQ27764571
The role of metals in catalysis by the restriction endonuclease BamHIQ27765729
DNA recognition and cleavage by the LAGLIDADG homing endonuclease I-CreIQ27765995
Directed evolution and substrate specificity profile of homing endonuclease I-SceI.Q27936586
Role of the interdomain linker in distance determination for remote cleavage by homing endonuclease I-TevI.Q38290691
R.KpnI, an HNH superfamily REase, exhibits differential discrimination at non-canonical sequences in the presence of Ca2+ and Mg2+.Q38302770
Intron-encoded homing endonuclease I-TevI also functions as a transcriptional autorepressorQ38336787
Degenerate DNA recognition by I-PpoI endonuclease.Q38340018
Purification, biochemical characterization and protein-DNA interactions of the I-CreI endonuclease produced in Escherichia coliQ38342598
Profile of the DNA recognition site of the archaeal homing endonuclease I-DmoI.Q38346827
Substrate binding and turnover by the highly specific I-PpoI endonuclease.Q38362623
An in vivo selection system for homing endonuclease activityQ39538487
Biochemical characterization of I-CmoeI reveals that this H-N-H homing endonuclease shares functional similarities with H-N-H colicinsQ39600917
Configuration of the catalytic GIY-YIG domain of intron endonuclease I-TevI: coincidence of computational and molecular findingsQ39728000
Mammalian gene targeting with designed zinc finger nucleasesQ40371944
A family of nuclear homing endonucleases.Q40410128
Targeted disruption of pyrin, the FMF protein, causes heightened sensitivity to endotoxin and a defect in macrophage apoptosisQ40562330
Self-splicing group I intron in cyanobacterial initiator methionine tRNA: evidence for lateral transfer of introns in bacteriaQ40793395
Tissue-specific alternative splicing in the human INK4a/ARF cell cycle regulatory locusQ40935835
AG dinucleotide insertion in a patient with chronic granulomatous disease lacking cytosolic 67-kD protein.Q41328402
Activity and specificity of the bacterial PD-(D/E)XK homing endonuclease I-Ssp6803I.Q41425873
Identification of a single HNH active site in type IIS restriction endonuclease Eco31I.Q42009522
Phage T4 SegB protein is a homing endonuclease required for the preferred inheritance of T4 tRNA gene region occurring in co-infection with a related phageQ42028906
Molecular basis for alpha-thalassemia associated with the structural mutant hemoglobin Suan-Dok (alpha 2 109leu----arg)Q42138102
Metal-dependent DNA cleavage mechanism of the I-CreI LAGLIDADG homing endonucleaseQ42168586
Unconventional GIY-YIG homing endonuclease encoded in group I introns in closely related strains of the Bacillus cereus groupQ42183439
Genetic correction of DNA repair-deficient/cancer-prone xeroderma pigmentosum group C keratinocytesQ42444805
Cleavage and recognition pattern of a double-strand-specific endonuclease (I-creI) encoded by the chloroplast 23S rRNA intron of Chlamydomonas reinhardtiiQ42603591
The catalytic group-I introns of the psbA gene of chlamydomonas reinhardtii : core structures, ORFs and evolutionary implicationsQ42607861
SegG endonuclease promotes marker exclusion and mediates co-conversion from a distant cleavage siteQ42612439
Functional characterization of isoschizomeric His-Cys box homing endonucleases from NaegleriaQ42638572
A novel group I intron-encoded endonuclease specific for the anticodon region of tRNA(fMet) genesQ42645053
In vivo mobility of a group I twintron in nuclear ribosomal DNA of the myxomycete Didymium iridisQ42658745
I-NjaI, a nuclear intron-encoded homing endonuclease from Naegleria, generates a pentanucleotide 3' cleavage-overhang within a 19 base-pair partially symmetric DNA recognition siteQ42690366
Thermodynamics of DNA target site recognition by homing endonucleases.Q42920176
HNH family subclassification leads to identification of commonality in the His-Me endonuclease superfamilyQ43104961
Distance determination by GIY-YIG intron endonucleases: discrimination between repression and cleavage functionsQ43257111
Selfish DNA: new abode for homing endonucleasesQ43439091
Engineering of restriction endonucleases: using methylation activity of the bifunctional endonuclease Eco57I to select the mutant with a novel sequence specificityQ44356433
Acute intermittent porphyria--impact of mutations found in the hydroxymethylbilane synthase gene on biochemical and enzymatic protein propertiesQ45775369
Questions linger about unexplained gene-therapy trial deathQ45858907
Genetic correction of sickle cell disease: insights using transgenic mouse modelsQ45864964
Identification of 217 unreported mutations in the F8 gene in a group of 1,410 unselected Italian patients with hemophilia A.Q45874679
Haemophilia B mutations in Sweden: a population-based study of mutational heterogeneityQ45876762
Deterministic regulation of hematopoietic stem cell self-renewal and differentiation.Q46163240
Cancer in xeroderma pigmentosum and related disorders of DNA repairQ46465906
Silent exonic mutations in the low-density lipoprotein receptor gene that cause familial hypercholesterolemia by affecting mRNA splicingQ46654772
RAG proteins shepherd double-strand breaks to a specific pathway, suppressing error-prone repair, but RAG nicking initiates homologous recombinationQ47765927
Detection of RAG mutations and prenatal diagnosis in families presenting with either T-B- severe combined immunodeficiency or Omenn's syndromeQ47940148
Oligomeric structure diversity within the GIY-YIG nuclease familyQ48020673
I-Ssp6803I: the first homing endonuclease from the PD-(D/E)XK superfamily exhibits an unusual mode of DNA recognitionQ48416651
Mutations and polymorphisms in the human ornithine transcarbamylase (OTC) gene.Q48492547
Identification of a new subfamily of HNH nucleases and experimental characterization of a representative member, HphI restriction endonuclease.Q51121910
From monomeric to homodimeric endonucleases and back: engineering novel specificity of LAGLIDADG enzymes.Q51154994
Hin4II, a new prototype restriction endonuclease from Haemophilus influenzae RFL4: discovery, cloning and expression in Escherichia coli.Q51280499
High-frequency homologous recombination in plants mediated by zinc-finger nucleases.Q51327085
Custom zinc-finger nucleases for use in human cells.Q51391970
Chimeras of the homing endonuclease PI-SceI and the homologous Candida tropicalis intein: a study to explore the possibility of exchanging DNA-binding modules to obtain highly specific endonucleases with altered specificity.Q51715930
Three-dimensional modeling of the I-TevI homing endonuclease catalytic domain, a GIY-YIG superfamily member, using NMR restraints and Monte Carlo dynamics.Q52050322
Coincidence of cleavage sites of intron endonuclease I-TevI and critical sequences of the host thymidylate synthase gene.Q54497541
The td intron endonuclease I-TevI makes extensive sequence-tolerant contacts across the minor groove of its DNA target.Q55549287
CD40 Ligand Gene Defects Responsible for X-Linked Hyper-IgM SyndromeQ55670500
Identical mutations in RAG1 or RAG2 genes leading to defective V(D)J recombinase activity can cause either T-B-severe combined immune deficiency or Omenn syndromeQ55670920
The Structure of I-CeuI Homing Endonuclease: Evolving Asymmetric DNA Recognition from a Symmetric Protein ScaffoldQ57240373
Two-domain structure of the td intron-encoded endonuclease I-TevI correlates with the two-domain configuration of the homing siteQ59622199
Molecular background of polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome in a Polish population: novel AIRE mutations and an estimate of disease prevalenceQ59697428
Clinical and immunologic consequences of a somatic reversion in a patient with X-linked severe combined immunodeficiencyQ61701733
The maturase encoded by a group I intron from Aspergillus nidulans stabilizes RNA tertiary structure and promotes rapid splicingQ62696756
Identification of mutations in the uroporphyrinogen III cosynthase gene in German patients with congenital erythropoietic porphyriaQ64046016
A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophyQ28142117
Group II introns: structure and catalytic versatility of large natural ribozymesQ28188097
Enhancing Gene Targeting with Designed Zinc Finger NucleasesQ28202461
Chromosomal stability and the DNA double-stranded break connectionQ28205315
LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1Q28210584
Nucleases and helicases take center stage in homologous recombinationQ28241737
Highly efficient endogenous human gene correction using designed zinc-finger nucleasesQ28243157
Mechanism of homologous recombination: mediators and helicases take on regulatory functionsQ28259452
Gene targeting using zinc finger nucleasesQ28265983
The double-strand-break repair model for recombinationQ28267259
A review of the molecular genetics of the human alpha-globin gene clusterQ28268949
Systematic analysis of molecular defects in the ferrochelatase gene from patients with erythropoietic protoporphyriaQ28270688
Mutations in human CPO gene predict clinical expression of either hepatic hereditary coproporphyria or erythropoietic harderoporphyriaQ28272057
Base damage and single-strand break repair: mechanisms and functional significance of short- and long-patch repair subpathwaysQ28275827
Isolation and characterization of new homing endonuclease specificities at individual target site positionsQ28277286
DNA binding and cleavage by the HNH homing endonuclease I-HmuIQ28277295
Engineering of large numbers of highly specific homing endonucleases that induce recombination on novel DNA targetsQ28283796
Molecular characterization of homozygous variegate porphyriaQ28288554
Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleasesQ28307957
Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cellsQ28511551
Pathways of DNA double-strand break repair during the mammalian cell cycleQ28608969
Homing endonucleases: structural and functional insight into the catalysts of intron/intein mobilityQ28775736
Single-strand break repair and genetic diseaseQ29615347
Chimeric nucleases stimulate gene targeting in human cellsQ29615384
Restoration of p53 function leads to tumour regression in vivoQ29618727
Generation of induced pluripotent stem cells using recombinant proteinsQ29619162
Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissueQ29620725
Semi-rational approaches to engineering enzyme activity: combining the benefits of directed evolution and rational designQ30789079
Stepwise manipulation of DNA specificity in Flp recombinase: progressively adapting Flp to individual and combinatorial mutations in its target siteQ30883432
Assessing the plasticity of DNA target site recognition of the PI-SceI homing endonuclease using a bacterial two-hybrid selection systemQ31029529
Phylogenomic analysis of the GIY-YIG nuclease superfamilyQ33241531
Altered target site specificity variants of the I-PpoI His-Cys box homing endonucleaseQ33295151
Computer design of obligate heterodimer meganucleases allows efficient cutting of custom DNA sequencesQ33319940
Analysis of gene targeting and intrachromosomal homologous recombination stimulated by genomic double-strand breaks in mouse embryonic stem cellsQ33774945
High-frequency gene targeting in Arabidopsis plants expressing the yeast RAD54 geneQ33922824
Peripheral blood stem cells for allogeneic transplantation: a reviewQ33937058
P433issue5
P304page(s)727-748
P577publication date2010-03-01
P1433published inCellular and Molecular Life SciencesQ5058352
P1476titleHoming endonucleases: from basics to therapeutic applications
P478volume67

Reverse relations

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