Regulation of estrogen receptor signaling in breast carcinogenesis and breast cancer therapy

scientific article published on April 2014

Regulation of estrogen receptor signaling in breast carcinogenesis and breast cancer therapy is …
instance of (P31):
scholarly articleQ13442814
retracted paperQ45182324

External links are
P356DOI10.1007/S00018-013-1376-3
P932PMC publication ID3962223
P698PubMed publication ID25031550
P5875ResearchGate publication ID237056878

P2093author name stringYi Huang
George Wu
Yong Wan
Nancy E Davidson
Zhuan Zhou
Amit Shetty
Joe X Qiao
P2860cites workCytotoxic bistetrahydrofuran annonaceous acetogenins from the seeds of Annona squamosaQ82096722
Two new cytotoxic acetogenins from Annona squamosaQ83756582
Extranuclear expression of hormone receptors in primary breast cancerQ83946426
Global cancer statisticsQ22241238
Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylasesQ24292875
Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formationQ24302554
Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1)Q24306057
Regulation of p53 activity through lysine methylationQ24311514
BRCA1 and BRCA2 mRNA levels are coordinately elevated in human breast cancer cells in response to estrogenQ24316813
Molecular cloning of a phosphotyrosine-independent ligand of the p56lck SH2 domainQ24316893
Regulation of estrogen rapid signaling through arginine methylation by PRMT1Q24317316
Ski co-repressor complexes maintain the basal repressed state of the TGF-beta target gene, SMAD7, via HDAC3 and PRMT5Q24317645
Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300Q24324556
Gene-specific modulation of TAF10 function by SET9-mediated methylationQ24337399
c-Ski inhibits the TGF-beta signaling pathway through stabilization of inactive Smad complexes on Smad-binding elementsQ24337860
Natural substances (acetogenins) from the family Annonaceae are powerful inhibitors of mitochondrial NADH dehydrogenase (Complex I)Q24528261
Differential oestrogen receptor binding is associated with clinical outcome in breast cancerQ24595511
Hormone action in the mammary glandQ24604954
Pioneer transcription factors: establishing competence for gene expressionQ24625373
The epithelial-mesenchymal transition generates cells with properties of stem cellsQ24650786
ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcomeQ24657877
Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formationQ24672514
Prospective identification of tumorigenic breast cancer cellsQ24683474
The estrogen receptor-alpha A908G (K303R) mutation occurs at a low frequency in invasive breast tumors: results from a population-based studyQ25257794
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assaysQ25939005
Structural insights into the mode of action of a pure antiestrogenQ27630646
Regulation of Estrogen Receptor α by the SET7 Lysine MethyltransferaseQ27650581
The architecture of respiratory complex IQ27661963
Molecular basis of agonism and antagonism in the oestrogen receptorQ27746278
The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifenQ27766417
The language of covalent histone modificationsQ27860931
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factorsQ27860937
Estrogen receptor null mice: what have we learned and where will they lead us?Q28137633
Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressorQ28142019
The role of integrin-linked kinase (ILK) in cancer progressionQ28190174
Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor alphaQ28210188
Molecular determinants for the tissue specificity of SERMsQ28211516
A naturally occurring MTA1 variant sequesters oestrogen receptor-alpha in the cytoplasmQ28217197
The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ SignalingQ28243202
AIB1, a steroid receptor coactivator amplified in breast and ovarian cancerQ28245902
Extranuclear coactivator signaling confers insensitivity to tamoxifenQ28246263
The prognostic significance of PELP1 expression in invasive breast cancer with emphasis on the ER-positive luminal-like subtypeQ28247404
The cell fate determination factor DACH1 is expressed in estrogen receptor-alpha-positive breast cancer and represses estrogen receptor-alpha signalingQ28252084
Sumoylation of the estrogen receptor alpha hinge region regulates its transcriptional activityQ28257118
Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1Q28260929
Differential PIAS3 expression in human malignancyQ28261248
Molecular mechanisms of mammalian DNA repair and the DNA damage checkpointsQ28266170
Functional implications of altered subcellular localization of PELP1 in breast cancer cellsQ28270490
The regulation of E2F by pRB-family proteinsQ28278789
Extranuclear functions of ER impact invasive migration and metastasis by breast cancer cellsQ28282169
Molecular definition of breast tumor heterogeneityQ28292256
Estrogen carcinogenesis in breast cancerQ28292500
Regulation of GREB1 transcription by estrogen receptor alpha through a multipartite enhancer spread over 20 kb of upstream flanking sequencesQ28299630
SET domain proteins modulate chromatin domains in eu- and heterochromatin.Q34458687
The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogeneQ34462232
Steering estrogen signals from the plasma membrane to the nucleus: two sides of the coinQ34465352
KLF4, p21 and context-dependent opposing forces in cancerQ34478868
Paracrine signaling through the epithelial estrogen receptor alpha is required for proliferation and morphogenesis in the mammary glandQ34479251
The Actin-binding Protein, Actinin Alpha 4 (ACTN4), Is a Nuclear Receptor Coactivator that Promotes Proliferation of MCF-7 Breast Cancer CellsQ34503108
Breast cancer-amplified sequence 3, a target of metastasis-associated protein 1, contributes to tamoxifen resistance in premenopausal patients with breast cancerQ34549350
Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1.Q34557743
Historical perspective on hormonal therapy of advanced breast cancerQ34575679
Ciz1, a Novel DNA-binding coactivator of the estrogen receptor alpha, confers hypersensitivity to estrogen actionQ34581963
Regulation of Krüppel-like factor 4 by the anaphase promoting complex pathway is involved in TGF-beta signalingQ34606049
The IGF pathway regulates ERα through a S6K1-dependent mechanism in breast cancer cellsQ34609956
Ligand-dependent transcription of estrogen receptor alpha is mediated by the ubiquitin ligase EFP.Q34617201
Nuclear receptor coregulators and human diseaseQ34645711
Regulation of progesterone receptor signaling by BRCA1 in mammary cancerQ34652156
Selective estrogen-receptor modulators and antihormonal resistance in breast cancerQ34692670
MDM2 regulates estrogen receptor α and estrogen responsiveness in breast cancer cellsQ34754561
Breast cancer stem cells revealedQ34913482
Transforming growth factor-beta regulator SnoN modulates mammary gland branching morphogenesis, postlactational involution, and mammary tumorigenesisQ34992779
KLF4-mediated negative regulation of IFITM3 expression plays a critical role in colon cancer pathogenesisQ35023925
Nongenomic actions of steroid hormonesQ35038285
A cell-type-specific transcriptional network required for estrogen regulation of cyclin D1 and cell cycle progression in breast cancerQ35052559
The NuRD complex: linking histone modification to nucleosome remodeling.Q35070017
Proliferation of estrogen receptor-alpha-positive mammary epithelial cells is restrained by transforming growth factor-beta1 in adult miceQ35085031
Cyclin D1, EMS1 and 11q13 amplification in breast cancerQ35130688
Biological evaluation of new mimetics of annonaceous acetogenins: alteration of right scaffold by click linkage with aromatic functionalities.Q35135905
Aromatase inhibitors in breast cancerQ35152297
Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trialsQ35186747
Reciprocal roles of DBC1 and SIRT1 in regulating estrogen receptor α activity and co-activator synergyQ35198394
Repressor of estrogen receptor activity (REA) is essential for mammary gland morphogenesis and functional activities: studies in conditional knockout miceQ35417300
Histone lysine methylation: a signature for chromatin functionQ35571556
Steroid receptors and proliferation in the human breast.Q35605004
Estrogen receptor corepressors -- a role in human breast cancer?Q35624506
Dual role of SnoN in mammalian tumorigenesisQ35641680
Acetogenins from Annonaceae: recent progress in isolation, synthesis and mechanisms of actionQ33986168
Mammary gland development and tumorigenesis in estrogen receptor knockout miceQ33997388
Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) familyQ34013708
The steroid receptor coactivator-1 regulates twist expression and promotes breast cancer metastasisQ34024643
Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase.Q34108153
The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon.Q34128767
Rapid actions of plasma membrane estrogen receptorsQ34214352
Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasiaQ34338550
Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic miceQ34342812
Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signalingQ34411645
Antitumor activity of annonaceous acetogenins in HepS and S180 xenografts bearing miceQ39374473
ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4.Q39401307
Elevated expression of CUEDC2 protein confers endocrine resistance in breast cancer.Q39542346
Estrogen receptor α-mediated transcription induces cell cycle-dependent DNA double-strand breaksQ39626579
Effects of estrogen on the proportion of stem cells in the breast.Q39652970
Negative feedback loop of BRCA1-BARD1 ubiquitin ligase on estrogen receptor alpha stability and activity antagonized by cancer-associated isoform of BARD1.Q39754043
Estrogen receptor beta exerts growth-inhibitory effects on human mammary epithelial cellsQ39852846
Mammosphere-derived gene set predicts outcome in patients with ER-positive breast cancerQ39862906
CK1delta modulates the transcriptional activity of ERalpha via AIB1 in an estrogen-dependent manner and regulates ERalpha-AIB1 interactions.Q39865315
Association of estrogen receptor alpha and histone deacetylase 6 causes rapid deacetylation of tubulin in breast cancer cellsQ39868655
S6 kinase 1 regulates estrogen receptor alpha in control of breast cancer cell proliferationQ39900962
Regulation of estrogen receptor-mediated long range transcription via evolutionarily conserved distal response elementsQ39947046
Cyclin D1b is aberrantly regulated in response to therapeutic challenge and promotes resistance to estrogen antagonistsQ39960786
Estrogens and genomic instability in human breast cancer cells--involvement of Src/Raf/Erk signaling in micronucleus formation by estrogenic chemicalsQ39973430
Repression of transcriptional activity of estrogen receptor alpha by a Cullin3/SPOP ubiquitin E3 ligase complexQ39991661
DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expressionQ40026501
Reversal of the estrogen receptor negative phenotype in breast cancer and restoration of antiestrogen response.Q40041160
Epigenetic modulation of estrogen receptor-alpha by pRb family proteins: a novel mechanism in breast cancerQ40093802
Potentiation of ICI182,780 (Fulvestrant)-induced estrogen receptor-alpha degradation by the estrogen receptor-related receptor-alpha inverse agonist XCT790.Q40107103
Differential regulation of estrogen receptor alpha turnover and transactivation by Mdm2 and stress-inducing agentsQ40124566
An inherent role of integrin-linked kinase-estrogen receptor alpha interaction in cell migration.Q40207973
Estrogen receptor positive breast cancer metastasis: altered hormonal sensitivity and tumor aggressiveness in lymphatic vessels and lymph nodes.Q40230408
Restoration of tamoxifen sensitivity in estrogen receptor-negative breast cancer cells: tamoxifen-bound reactivated ER recruits distinctive corepressor complexesQ40266897
MUC1 oncoprotein stabilizes and activates estrogen receptor alphaQ40326798
E6AP and calmodulin reciprocally regulate estrogen receptor stability.Q40346484
Smad4 inhibits tumor growth by inducing apoptosis in estrogen receptor-alpha-positive breast cancer cellsQ40424228
Estrogen-induced mitochondrial reactive oxygen species as signal-transducing messengers.Q40428340
Detection of DNA strand breaks and oxidized DNA bases at the single-cell level resulting from exposure to estradiol and hydroxylated metabolites.Q40468127
Ligand-dependent switching of ubiquitin-proteasome pathways for estrogen receptorQ40493369
Nine new cytotoxic monotetrahydrofuranic Annonaceous acetogenins from Annona montana.Q40503068
Binding of MCF-7 cell mitochondrial proteins and recombinant human estrogen receptors alpha and beta to human mitochondrial DNA estrogen response elementsQ40515616
Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancerQ40544950
Distinct effects of the antiestrogen Faslodex on the stability of estrogen receptors-alpha and -beta in the breast cancer cell line MCF-7.Q40550400
Repression of endogenous Smad7 by Ski.Q40558828
Nuclear localization of KLF4 is associated with an aggressive phenotype in early-stage breast cancerQ40564116
Cell cycle control by steroid hormonesQ40588075
Recruitment of distinct chromatin-modifying complexes by tamoxifen-complexed estrogen receptor at natural target gene promoters in vivoQ40599656
The anaphase-promoting complex mediates TGF-beta signaling by targeting SnoN for destructionQ40763954
Estrogen receptor beta acts as a dominant regulator of estrogen signalingQ40847288
Structure-activity relationships of diverse Annonaceous acetogenins against multidrug resistant human mammary adenocarcinoma (MCF-7/Adr) cells.Q41104168
Estrogen-induced activation of Cdk4 and Cdk2 during G1-S phase progression is accompanied by increased cyclin D1 expression and decreased cyclin-dependent kinase inhibitor association with cyclin E-Cdk2.Q41115396
Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifenQ41222398
Think globally, act locally: the making of a mouse mammary gland.Q41705141
Overexpressions of c-fos/jun mRNA and their oncoproteins (Fos/Jun) in the mouse uterus treated with three natural estrogensQ42274796
Insulin receptor substrate 1 is a target for the pure antiestrogen ICI 182,780 in breast cancer cellsQ42470095
CHIP (carboxyl terminus of Hsc70-interacting protein) promotes basal and geldanamycin-induced degradation of estrogen receptor-alphaQ42481557
Steroid hormone receptor status of mouse mammary stem cellsQ42498451
Estradiol and antiestrogens regulate a growth inhibitory insulin-like growth factor binding protein 3 autocrine loop in human breast cancer cellsQ42513860
Estrogen-dependent, tamoxifen-resistant tumorigenic growth of MCF-7 cells transfected with HER2/neuQ42807740
Control of mammary stem cell function by steroid hormone signalling.Q43103606
Effect of estradiol, diethylstilbestrol, and resveratrol on F0F1-ATPase activity from mitochondrial preparations of rat heart, liver, and brainQ43807134
Specific binding sites for oestrogen at the outer surfaces of isolated endometrial cellsQ44033734
Smad4 as a transcription corepressor for estrogen receptor alphaQ44308474
Expression analysis of estrogen receptor alpha coregulators in breast carcinoma: evidence that NCOR1 expression is predictive of the response to tamoxifenQ44396175
Metastasis-associated protein 1 deregulation causes inappropriate mammary gland development and tumorigenesisQ44958626
Estrogen induction of the cyclin D1 promoter: involvement of a cAMP response-like elementQ35644045
Non-nuclear actions of estrogen: new targets for prevention and treatment of cardiovascular diseaseQ35679460
Estrogen receptor alpha is a putative substrate for the BRCA1 ubiquitin ligaseQ35749504
A mammary stem cell population identified and characterized in late embryogenesis reveals similarities to human breast cancerQ35750639
Estrogen receptor-positive proliferating cells in the normal and precancerous breast.Q35787982
Association between the estrogen receptor alpha A908G mutation and outcomes in invasive breast cancerQ35794355
Estrogens and their receptors in breast cancer progression: a dual role in cancer proliferation and invasionQ35810732
Breast cancer, stem/progenitor cells and the estrogen receptorQ35820494
Transcriptional activation by nuclear receptorsQ35830313
Post-translational modifications of nuclear receptors and human diseaseQ35842790
Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylationQ35849279
Estradiol abrogates apoptosis in breast cancer cells through inactivation of BAD: Ras-dependent nongenomic pathways requiring signaling through ERK and AktQ35918889
Human breast cell proliferation and its relationship to steroid receptor expression.Q35924753
Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexesQ35974510
Estrogen receptor-alpha expression in the mammary epithelium is required for ductal and alveolar morphogenesis in miceQ35990241
Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genesQ36032594
Crosstalk between estrogen receptor and growth factor receptor pathways as a cause for endocrine therapy resistance in breast cancerQ36035275
Ligand control of coregulator recruitment to nuclear receptorsQ36041022
PES1 promotes breast cancer by differentially regulating ERα and ERβ.Q36129096
Downstream targets of growth factor and oestrogen signalling and endocrine resistance: the potential roles of c-Myc, cyclin D1 and cyclin E.Q36236632
Role of SUMOylation in full antiestrogenicityQ36277244
A repressive role for prohibitin in estrogen signaling.Q36447412
Reversible inhibition of mammary gland growth by transforming growth factor-betaQ36459241
The expanding cosmos of nuclear receptor coactivatorsQ36469825
Phosphorylation at serines 104 and 106 by Erk1/2 MAPK is important for estrogen receptor-alpha activityQ36514584
Atypical protein kinase C regulates dual pathways for degradation of the oncogenic coactivator SRC-3/AIB1.Q36540639
Estrogen receptor pathway: resistance to endocrine therapy and new therapeutic approachesQ36568023
Estrogen-dependent cyclin E-cdk2 activation through p21 redistributionQ36569390
The role of the IGF system in cancer growth and metastasis: overview and recent insightsQ36576678
Derailed estrogen signaling and breast cancer: an authentic couple.Q36589361
Epigenetics and the estrogen receptorQ36721730
SnoN oncoprotein enhances estrogen receptor-α transcriptional activityQ36730663
SUMO and estrogen receptors in breast cancerQ36766502
Oncogenic potential of the nuclear receptor coregulator proline-, glutamic acid-, leucine-rich protein 1/modulator of the nongenomic actions of the estrogen receptorQ28304891
Comparative analyses of mechanistic differences among antiestrogensQ28377133
Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypesQ28504877
Induction of mammary gland development in estrogen receptor-alpha knockout miceQ28589902
Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?Q29030220
An oestrogen-receptor-α-bound human chromatin interactomeQ29541719
Generation of a functional mammary gland from a single stem cellQ29616496
Purification and unique properties of mammary epithelial stem cellsQ29616497
Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinaseQ29617567
Tamoxifen for early breast cancer: an overview of the randomised trials. Early Breast Cancer Trialists' Collaborative GroupQ29619251
Cells of origin in cancerQ29619557
Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell propertiesQ29636244
Estrogen Stimulation of Cell Migration Involves Multiple Signaling Pathway InteractionsQ30429931
The role of Shc and insulin-like growth factor 1 receptor in mediating the translocation of estrogen receptor alpha to the plasma membraneQ30432909
Decreased BRCA1 confers tamoxifen resistance in breast cancer cells by altering estrogen receptor-coregulator interactions.Q30439093
Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinaseQ30439814
Oncogene expression cloning by retroviral transduction of adenovirus E1A-immortalized rat kidney RK3E cells: transformation of a host with epithelial features by c-MYC and the zinc finger protein GKLF.Q30727226
A putative human breast stem cell population is enriched for steroid receptor-positive cellsQ33210333
Destabilization of Krüppel-like factor 4 protein in response to serum stimulation involves the ubiquitin-proteasome pathwayQ33227192
Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transitionQ33411645
Steroid hormone receptors in breast cancer managementQ33539154
Palmitoylation-dependent estrogen receptor alpha membrane localization: regulation by 17beta-estradiolQ33564705
BRCA1 regulates acetylation and ubiquitination of estrogen receptor-alphaQ33576505
Rapid estradiol/ERalpha signaling enhances aromatase enzymatic activity in breast cancer cells.Q33642075
Regulation of aromatase induction by nuclear receptor coregulator PELP1Q33678686
HEXIM1 regulates 17beta-estradiol/estrogen receptor-alpha-mediated expression of cyclin D1 in mammary cells via modulation of P-TEFbQ33702169
The Molecular Pharmacology of SERMsQ33730355
Inhibition of estrogen receptor-DNA binding by the "pure" antiestrogen ICI 164,384 appears to be mediated by impaired receptor dimerizationQ33777797
Involvement of estrogen receptor variant ER-alpha36, not GPR30, in nongenomic estrogen signalingQ33780210
Estrogen inhibits transforming growth factor beta signaling by promoting Smad2/3 degradationQ33825125
The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptorsQ33881484
Increase of GKLF messenger RNA and protein expression during progression of breast cancerQ33927101
Human breast developmentQ33930666
Direct acetylation of the estrogen receptor alpha hinge region by p300 regulates transactivation and hormone sensitivityQ33940612
Regulation of the functional interaction between cyclin D1 and the estrogen receptorQ33966444
17β-Estradiol enhances breast cancer cell motility and invasion via extra-nuclear activation of actin-binding protein ezrin.Q33983217
The AIB1 oncogene promotes breast cancer metastasis by activation of PEA3-mediated matrix metalloproteinase 2 (MMP2) and MMP9 expressionQ36898979
Role of estrogens and their receptors in adhesion and invasiveness of breast cancer cellsQ36935732
Minireview: nuclear receptors and breast cancerQ36971797
Estrogen signaling through the transmembrane G protein-coupled receptor GPR30.Q37083658
Estrogen receptors ER alpha and ER beta in proliferation in the rodent mammary glandQ37094546
Trastuzumab reverses letrozole resistance and amplifies the sensitivity of breast cancer cells to estrogenQ37101433
Estrogen receptors alpha and beta in the rodent mammary glandQ37152373
Targeting Src in breast cancerQ37167029
Estrogen inhibits ATR signaling to cell cycle checkpoints and DNA repairQ37262148
Estrogen regulation of apoptosis: how can one hormone stimulate and inhibit?Q37277121
Regulating the stability of TGFbeta receptors and SmadsQ37333694
Proliferation of breast cancer cells: regulation, mediators, targets for therapyQ37347045
Ski and SnoN, potent negative regulators of TGF-beta signalingQ37359949
Resistance to endocrine therapy: are breast cancer stem cells the culprits?Q37404590
Coactivator AIB1 links estrogen receptor transcriptional activity and stabilityQ37415295
The DEAD-box protein p72 regulates ERalpha-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ERalpha-positive breast cancerQ37428211
Dual effects of TGF-beta on ERalpha-mediated estrogenic transcriptional activity in breast cancerQ37454936
The silent estrogen receptor--can we make it speak?Q37468213
Membrane oestrogen receptor alpha signalling to cell functionsQ37581224
Genomic analyses of hormone signaling and gene regulationQ37690710
Regulation of KLF4 turnover reveals an unexpected tissue-specific role of pVHL in tumorigenesisQ37695618
Biochemical analyses of nuclear receptor-dependent transcription with chromatin templatesQ37726327
Estrogen-induced reactive oxygen species-mediated signalings contribute to breast cancerQ37805183
Clinical significance of estrogen receptor phosphorylationQ37819658
Emerging significance of estrogen cancer coregulator signaling in breast cancer.Q37983997
Emerging roles of the ubiquitin-proteasome system in the steroid receptor signalingQ38000121
Cyclic, proteasome-mediated turnover of unliganded and liganded ERalpha on responsive promoters is an integral feature of estrogen signalingQ38356127
Metastatic behavior of breast cancer subtypesQ38416421
Expression of DBC1 and SIRT1 is associated with poor prognosis for breast carcinomaQ38479914
Six cytotoxic annonaceous acetogenins from Annona squamosa seedsQ38942593
Turning off estrogen receptor beta-mediated transcription requires estrogen-dependent receptor proteolysis.Q39125264
Structure-activity relationships of hybrid annonaceous acetogenins: powerful growth inhibitory effects of their connecting groups between heterocycle and hydrophobic carbon chain bearing THF ring on human cancer cell linesQ39166175
Proteomic identification of E6AP as a molecular target of tamoxifen in MCF7 cells.Q39347752
Novel cytotoxic annonaceous acetogenins from Annona muricataQ74266928
Essential structural factors of annonaceous acetogenins as potent inhibitors of mitochondrial complex IQ77120344
Endocrine control of mammarygland development and function in the C3H/ He Crgl mouseQ78480627
Cyclins and breast cancerQ79922062
Estrogen receptors inhibit Smad3 transcriptional activity through Ap-1 transcription factorsQ80695171
Estrogen receptor activation function 1 works by binding p160 coactivator proteinsQ46064993
Low SAFB levels are associated with worse outcome in breast cancer patientsQ46167250
The history and mechanism of action of fulvestrantQ46467888
Estrogen- and progesterone-receptor status in ECOG 2197: comparison of immunohistochemistry by local and central laboratories and quantitative reverse transcription polymerase chain reaction by central laboratoryQ46589624
Scaffold attachment factor SAFB1 suppresses estrogen receptor alpha-mediated transcription in part via interaction with nuclear receptor corepressorQ46728761
The DNA damage signalling kinase ATM is aberrantly reduced or lost in BRCA1/BRCA2-deficient and ER/PR/ERBB2-triple-negative breast cancerQ46914764
Fulvestrant (ICI 182,780)-dependent interacting proteins mediate immobilization and degradation of estrogen receptor-alphaQ46928900
A potent specific pure antiestrogen with clinical potentialQ46965638
Activin and estrogen crosstalk regulates transcription in human breast cancer cellsQ46968617
Alternate splicing produces a novel cyclin D1 transcriptQ48070740
Oestrogen-receptor-mediated transcription and the influence of co-factors and chromatin stateQ50668328
Two separate mechanisms for ligand-independent activation of the estrogen receptor.Q52194366
Dissociation between steroid receptor expression and cell proliferation in the human breast.Q52528046
Definition of crucial structural factors of acetogenins, potent inhibitors of mitochondrial complex I.Q52584475
Transforming growth factor-beta suppresses the ability of Ski to inhibit tumor metastasis by inducing its degradation.Q53321709
Decreased expression of estrogen receptor beta protein in proliferative preinvasive mammary tumors.Q53399983
Coactivators PGC-1beta and SRC-1 interact functionally to promote the agonist activity of the selective estrogen receptor modulator tamoxifen.Q53540759
Expression of a repressor of estrogen receptor activity in human breast tumors: relationship to some known prognostic markers.Q54298193
Stability of estrogen receptor status in breast carcinoma: a comparison between primary and metastatic tumors with regard to disease course and intervening systemic therapy.Q54400297
Turning Off Estrogen Receptor β-Mediated Transcription Requires Estrogen-Dependent Receptor Proteolysis.Q55614784
High CCND1 amplification identifies a group of poor prognosis women with estrogen receptor positive breast cancerQ58423623
Distinct stem cells contribute to mammary gland development and maintenanceQ59067141
Enhancement of Insulin-Like Growth Factor Signaling in Human Breast Cancer: Estrogen Regulation of Insulin Receptor Substrate-1 Expressionin Vitroandin VivoQ62267728
Expression of insulin-like growth factor binding proteins in human breast cancer correlates with estrogen receptor statusQ62267748
Aromatization of androgens by muscle and adipose tissue in vivoQ67451927
Study on the estrogen production in parenchymatous cells of epithelial ovarian tumorQ68049255
Mechanisms of 4-hydroxytamoxifen anti-growth factor activity in breast cancer cells: alterations of growth factor receptor binding sites and tyrosine kinase activityQ68644618
Novel steroidal pure antiestrogensQ69798290
Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cellsQ72386166
Processing of insulin-like growth factor-II (IGF-II) by human breast cancer cellsQ72524963
Inducible regulatory elements in the human cyclin D1 promoterQ72530064
Deregulation of cyclin E and D1 in breast cancer is associated with inactivation of the retinoblastoma proteinQ73034011
Additional bioactive annonaceous acetogenins from Asimina triloba (Annonaceae)Q73253742
Various phosphorylation pathways, depending on agonist and antagonist binding to endogenous estrogen receptor alpha (ERalpha), differentially affect ERalpha extractability, proteasome-mediated stability, and transcriptional activity in human breastQ73653641
Insulin-like growth factor binding protein-3 induces apoptosis in MCF7 breast cancer cellsQ73702915
Ski-related novel protein N (SnoN), a negative controller of transforming growth factor-beta signaling, is a prognostic marker in estrogen receptor-positive breast carcinomasQ73865005
Estrogen receptor expression in benign breast epithelium and breast cancer riskQ74038716
A hypersensitive estrogen receptor-alpha mutation in premalignant breast lesionsQ74181062
Rapid uptake and binding of estradiol-17beta-6-(O-carboxymethyl)oxime:125I-labeled BSA by female rat liverQ74220615
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectestrogenQ277954
carcinogenesisQ1637543
P304page(s)1549
P577publication date2014-04-01
P1433published inCellular and Molecular Life SciencesQ5058352
P1476titleRegulation of estrogen receptor signaling in breast carcinogenesis and breast cancer therapy
P478volume71

Reverse relations

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