The next step in gene delivery: Molecular engineering of adeno-associated virus serotypes

scientific article published on October 26, 2010

The next step in gene delivery: Molecular engineering of adeno-associated virus serotypes is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.YJMCC.2010.10.017
P953full work available at URLhttps://api.elsevier.com/content/article/PII:S0022282810003962?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0022282810003962?httpAccept=text/plain
P698PubMed publication ID21029739

P2093author name stringJinhui Wang
Joseph E. Rabinowitz
Susan M. Faust
P2860cites workMutational analysis of the adeno-associated virus type 2 (AAV2) capsid gene and construction of AAV2 vectors with altered tropismQ24515072
Adeno-associated virus type 2-mediated gene transfer: role of cellular FKBP52 protein in transgene expressionQ24529167
Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virionsQ24531466
Packaging capacity of adeno-associated virus serotypes: impact of larger genomes on infectivity and postentry stepsQ24533013
The atomic structure of adeno-associated virus (AAV-2), a vector for human gene therapy.Q24533492
Cell-type-specific characteristics modulate the transduction efficiency of adeno-associated virus type 2 and restrain infection of endothelial cellsQ24538924
Adeno-associated virus (AAV) Rep proteins mediate complex formation between AAV DNA and its integration site in human DNAQ24562760
Safety and efficacy of gene transfer for Leber's congenital amaurosisQ24634724
Human RPE65 gene therapy for Leber congenital amaurosis: persistence of early visual improvements and safety at 1 yearQ24634801
Structure of Adeno-Associated Virus Serotype 8, a Gene Therapy VectorQ27647639
ADENOVIRUS-ASSOCIATED DEFECTIVE VIRUS PARTICLESQ28202390
Rapid evolution of a protein in vitro by DNA shufflingQ28245873
A hybrid vector system expands adeno-associated viral vector packaging capacity in a transgene-independent mannerQ28256353
Effect of gene therapy on visual function in Leber's congenital amaurosisQ28277981
Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune responseQ29619095
A muscle-targeting peptide displayed on AAV2 improves muscle tropism on systemic deliveryQ30483589
Steps toward mapping the human vasculature by phage display.Q30804451
Inverting enantioselectivity by directed evolution of hydantoinase for improved production of L-methionineQ30843376
Peptides targeting caspase inhibitorsQ30882598
Molecular breeding of virusesQ30898162
Random peptide libraries displayed on adeno-associated virus to select for targeted gene therapy vectorsQ30975099
Targeted gene delivery to vascular tissue in vivo by tropism-modified adeno-associated virus vectorsQ31036743
In vivo phage display and vascular heterogeneity: implications for targeted medicineQ31060394
In vitro selection of viral vectors with modified tropism: the adeno-associated virus displayQ33187644
Vascular bed-targeted in vivo gene delivery using tropism-modified adeno-associated virusesQ33230629
Directed evolution of adeno-associated virus yields enhanced gene delivery vectorsQ33232270
The epitope recognized by rituximabQ33243656
Structure determination of adeno-associated virus 2: three complete virus particles per asymmetric unitQ45723313
Scalable purification of adeno-associated virus type 2, 4, or 5 using ion-exchange chromatographyQ45731650
Genetic capsid modifications allow efficient re-targeting of adeno-associated virus type 2.Q45745995
A novel adenovirus-adeno-associated virus hybrid vector that displays efficient rescue and delivery of the AAV genomeQ45766163
A dual role of EGFR protein tyrosine kinase signaling in ubiquitination of AAV2 capsids and viral second-strand DNA synthesisQ45867380
Clinical gene transfer studies for hemophilia B.Q45875059
Genetic modification of adeno-associated viral vector type 2 capsid enhances gene transfer efficiency in polarized human airway epithelial cells.Q45880182
Immune responses to AAV in a phase I study for Canavan diseaseQ48620414
Engineering and Selection of Shuffled AAV Genomes: A New Strategy for Producing Targeted Biological NanoparticlesQ56897778
Percutaneous Transendocardial Delivery of Self-complementary Adeno-associated Virus 6 Achieves Global Cardiac Gene Transfer in CaninesQ64375839
Characterization of a nuclear localization signal of canine parvovirus capsid proteinsQ74038314
Modulation of the immune response by systemic targeting of antigens to lymph nodesQ77220667
Gene therapy for haemophiliaQ80702723
Engineering adeno-associated virus serotype 2-based targeting vectors using a new insertion site-position 453-and single point mutationsQ84583870
Isolation of targeted AAV2 vectors from novel virus display librariesQ33256517
Vectors selected from adeno-associated viral display peptide libraries for leukemia cell-targeted cytotoxic gene therapyQ33301839
In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated virusesQ33327474
Engineering and selection of shuffled AAV genomes: a new strategy for producing targeted biological nanoparticlesQ33337378
Chapter 4. Screening phage-display Peptide libraries for vascular targeted peptidesQ33385870
Chimeric AAV Cap sequences alter gene transductionQ33411107
A myocardium tropic adeno-associated virus (AAV) evolved by DNA shuffling and in vivo selectionQ33411254
Successful expansion but not complete restriction of tropism of adeno-associated virus by in vivo biopanning of random virus display peptide librariesQ33428576
Directed evolution of adeno-associated virus for glioma cell transductionQ33484220
Tolerance induction to cytoplasmic beta-galactosidase by hepatic AAV gene transfer: implications for antigen presentation and immunotoxicityQ33490137
Directed evolution of a novel adeno-associated virus (AAV) vector that crosses the seizure-compromised blood-brain barrier (BBB).Q33521174
Systemic Trans-splicing adeno-associated viral delivery efficiently transduces the heart of adult mdx mouse, a model for duchenne muscular dystrophyQ33691883
Adeno-associated virus type 2-mediated gene transfer: role of epidermal growth factor receptor protein tyrosine kinase in transgene expressionQ33786039
Nonrandom transduction of recombinant adeno-associated virus vectors in mouse hepatocytes in vivo: cell cycling does not influence hepatocyte transductionQ33802664
Dynamin is required for recombinant adeno-associated virus type 2 infectionQ33825510
Immune responses to adenovirus and adeno-associated virus in humans.Q33874473
Insertional mutagenesis of AAV2 capsid and the production of recombinant virusQ33883772
AAV vectors avoid inflammatory signals necessary to render transduced hepatocyte targets for destructive T cellsQ33931609
DNA helicase-mediated packaging of adeno-associated virus type 2 genomes into preformed capsidsQ33951407
Adeno-associated virus type 2-mediated gene transfer: correlation of tyrosine phosphorylation of the cellular single-stranded D sequence-binding protein with transgene expression in human cells in vitro and murine tissues in vivoQ34070164
Efficient and selective AAV2-mediated gene transfer directed to human vascular endothelial cellsQ34090326
A viral phospholipase A2 is required for parvovirus infectivityQ34101246
The VP1 capsid protein of adeno-associated virus type 2 is carrying a phospholipase A2 domain required for virus infectivityQ34124491
Ligand-directed targeting of genes to the site of diseaseQ34168868
RGD inclusion in VP3 provides adeno-associated virus type 2 (AAV2)-based vectors with a heparan sulfate-independent cell entry mechanismQ34194223
Novel caprine adeno-associated virus (AAV) capsid (AAV-Go.1) is closely related to the primate AAV-5 and has unique tropism and neutralization propertiesQ34228552
Identification of PDGFR as a receptor for AAV-5 transductionQ34264144
The VP1 N-terminal sequence of canine parvovirus affects nuclear transport of capsids and efficient cell infectionQ34331386
Endosomal processing limits gene transfer to polarized airway epithelia by adeno-associated virus.Q34433170
Adeno-associated virus type 2-mediated gene transfer: role of cellular T-cell protein tyrosine phosphatase in transgene expression in established cell lines in vitro and transgenic mice in vivoQ34472029
AlphaVbeta5 integrin: a co-receptor for adeno-associated virus type 2 infectionQ34486863
Sequence and symmetry requirements within the internal palindromic sequences of the adeno-associated virus terminal repeatQ34556048
Self-complementary AAV vectors; advances and applicationsQ34804660
Robust systemic transduction with AAV9 vectors in mice: efficient global cardiac gene transfer superior to that of AAV8.Q35025591
Endocytosis of adeno-associated virus type 5 leads to accumulation of virus particles in the Golgi compartmentQ39748126
Strategies for improving the transduction efficiency of single-stranded adeno-associated virus vectors in vitro and in vivoQ39979752
Single-polarity recombinant adeno-associated virus 2 vector-mediated transgene expression in vitro and in vivo: mechanism of transductionQ40034184
Differential internalization and nuclear uncoating of self-complementary adeno-associated virus pseudotype vectors as determinants of cardiac cell transductionQ40111373
Identification of their epitope reveals the structural basis for the mechanism of action of the immunosuppressive antibodies basiliximab and daclizumabQ40144650
Impact of capsid conformation and Rep-capsid interactions on adeno-associated virus type 2 genome packagingQ40335965
Self-complementary adeno-associated virus 2 (AAV)-T cell protein tyrosine phosphatase vectors as helper viruses to improve transduction efficiency of conventional single-stranded AAV vectors in vitro and in vivoQ40499221
AAV serotype 2 vectors preferentially integrate into active genes in miceQ40643545
Hepatocyte growth factor receptor is a coreceptor for adeno-associated virus type 2 infection.Q40726384
Inverted terminal repeat sequences are important for intermolecular recombination and circularization of adeno-associated virus genomesQ40726705
Development of novel cell surface CD34-targeted recombinant adenoassociated virus vectors for gene therapyQ41008247
Hepatic AAV gene transfer and the immune system: friends or foes?Q41277780
Mapping and direct visualization of a region-specific viral DNA integration site on chromosome 19q13-qterQ41678112
Induction and role of regulatory CD4+CD25+ T cells in tolerance to the transgene product following hepatic in vivo gene transferQ41920883
Hepatic regulatory T cells and Kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver.Q41972673
Impact of preexisting vector immunity on the efficacy of adeno-associated virus-based HIV-1 Gag vaccines.Q42024301
Adeno-associated virus type 2 contains an integrin alpha5beta1 binding domain essential for viral cell entryQ42051675
Mutations on the external surfaces of adeno-associated virus type 2 capsids that affect transduction and neutralizationQ42203239
Enhancement of adeno-associated virus infection by mobilizing capsids into and out of the nucleolusQ43173416
Insertional mutagenesis of the adeno-associated virus type 2 (AAV2) capsid gene and generation of AAV2 vectors targeted to alternative cell-surface receptorsQ43740107
Real-time single-molecule imaging of the infection pathway of an adeno-associated virusQ43812869
Human immunoglobulin inhibits liver transduction by AAV vectors at low AAV2 neutralizing titers in SCID miceQ43847196
Epidemiology of adenovirus-associated virus infection in a nursery populationQ44631695
Release of canine parvovirus from endocytic vesiclesQ44673556
Evasion of immune responses to introduced human acid alpha-glucosidase by liver-restricted expression in glycogen storage disease type II.Q45259698
Adeno-associated virus type 5 exploits two different entry pathways in human embryo fibroblastsQ45387382
CD8(+) T-cell responses to adeno-associated virus capsid in humansQ45406111
Recombinant adeno-associated virus serotype 9 leads to preferential cardiac transduction in vivoQ45413958
Combinatorial engineering of a gene therapy vector: directed evolution of adeno-associated virusQ45422552
One year transgene expression with adeno-associated virus cardiac gene transferQ45479985
Adeno-associated virus serotype 8 efficiently delivers genes to muscle and heartQ45507049
Genetic modifications of the adeno-associated virus type 2 capsid reduce the affinity and the neutralizing effects of human serum antibodiesQ45709087
Efficient and long-term intracardiac gene transfer in delta-sarcoglycan-deficiency hamster by adeno-associated virus-2 vectorsQ45721911
Adeno-associated virus (AAV) vectors achieve prolonged transgene expression in mouse myocardium and arteries in vivo: a comparative study with adenovirus vectorsQ45721934
Targeting recombinant adeno-associated virus vectors to enhance gene transfer to pancreatic islets and liverQ45722297
Adeno-associated virus type 2 capsids with externalized VP1/VP2 trafficking domains are generated prior to passage through the cytoplasm and are maintained until uncoating occurs in the nucleusQ39306165
Detection of intact rAAV particles up to 6 years after successful gene transfer in the retina of dogs and primatesQ39504342
Infectious entry pathway of adeno-associated virus and adeno-associated virus vectorsQ39589898
Intracellular trafficking of adeno-associated virus vectors: routing to the late endosomal compartment and proteasome degradationQ39602167
Targeting pancreatic islets with phage display assisted by laser pressure catapult microdissectionQ35083665
The 37/67-kilodalton laminin receptor is a receptor for adeno-associated virus serotypes 8, 2, 3, and 9Q35101411
Structurally mapping the diverse phenotype of adeno-associated virus serotype 4.Q35140088
Receptor targeting of adeno-associated virus vectorsQ35165723
Use of Adeno-Associated Virus as a General Transduction Vector for Mammalian CellsQ35228018
Can genes transduced by adeno-associated virus vectors elicit or evade an immune response?Q35613147
Percutaneous transendocardial delivery of self-complementary adeno-associated virus 6 achieves global cardiac gene transfer in canines.Q35621815
Notch1 augments intracellular trafficking of adeno-associated virus type 2.Q35635454
Immune implications of gene therapy for hemophiliaQ35760790
Trans-splicing vectors expand the utility of adeno-associated virus for gene therapyQ35799349
Immune responses to gene therapy vectors: influence on vector function and effector mechanismsQ35904408
Preclinical and clinical gene therapy for haemophiliaQ35915704
Targeted integration of adeno-associated virus (AAV) into human chromosome 19Q35936149
Recombinant adeno-associated virus vectors induce functionally impaired transgene product-specific CD8+ T cells in miceQ36144935
New recombinant serotypes of AAV vectors.Q36172991
Hybrid adeno-associated virus bearing nonhomologous inverted terminal repeats enhances dual-vector reconstruction of minigenes in vivo.Q36238762
Tolerance induction by viral in vivo gene transferQ36320026
Studies of small DNA viruses found in various adenovirus preparations: physical, biological, and immunological characteristicsQ36460379
Rapid uncoating of vector genomes is the key to efficient liver transduction with pseudotyped adeno-associated virus vectorsQ36509889
New approaches in the therapy of cardiomyopathy in muscular dystrophyQ36705183
Organ targeting in vivo using phage display peptide librariesQ36795550
Yeast surface display for screening combinatorial polypeptide librariesQ36865126
Adeno-associated virus general transduction vectors: analysis of proviral structuresQ36868692
Genetics of adeno-associated virus: isolation and preliminary characterization of adeno-associated virus type 2 mutantsQ36893013
Genetic analysis of adeno-associated virus: properties of deletion mutants constructed in vitro and evidence for an adeno-associated virus replication functionQ36918727
Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kineticsQ36937189
Immunity to adeno-associated virus vectors in animals and humans: a continued challengeQ37127246
Clinical gene therapy using recombinant adeno-associated virus vectorsQ37140649
Tailoring the AAV vector capsid for gene therapy.Q37340302
Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID Trial), a first-in-human phase 1/2 clinical trial.Q37364786
Gene therapy for hemophilia: clinical trials and technical tribulationsQ37421639
Incorporation of tumor-targeting peptides into recombinant adeno-associated virus capsidsQ38299901
Capsid modifications overcome low heterogeneous expression of heparan sulfate proteoglycan that limits AAV2-mediated gene transfer and therapeutic efficacy in human ovarian carcinomaQ38436809
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)793-802
P577publication date2010-10-26
P1433published inJournal of Molecular and Cellular CardiologyQ2061932
P1476titleThe next step in gene delivery: molecular engineering of adeno-associated virus serotypes
The next step in gene delivery: Molecular engineering of adeno-associated virus serotypes
P478volume50

Reverse relations

cites work (P2860)
Q26849375A short perspective on gene therapy: Clinical experience on gene therapy of gliomablastoma multiforme
Q37272261Adeno-associated virus-mediated gene therapy for metabolic myopathy
Q40525635Assembly, Engineering and Applications of Virus-Based Protein Nanoparticles
Q36321364Assessment of hazard risk associated with the intravenous use of viral vectors in rodents.
Q34464281Beyond the hammer and the scalpel: selective circuit control for the epilepsies
Q37965045Cardiac gene therapy: from concept to reality
Q42438941Cardiovascular science: opportunities for translating research into improved care
Q35005408Characterization of naturally-occurring humoral immunity to AAV in sheep
Q30525258Cytoplasmic trafficking, endosomal escape, and perinuclear accumulation of adeno-associated virus type 2 particles are facilitated by microtubule network
Q36825693Disruption of Microtubules Post-Virus Entry Enhances Adeno-Associated Virus Vector Transduction.
Q39031877Effect and mechanism of Mitomycin C combined with recombinant adeno-associated virus type II against glioma
Q30420426Efficient single-cell poration by microsecond laser pulses
Q53104041Evaluation of Multiple Biological Therapies for Ischemic Cardiac Disease.
Q40559074Expression mediated by three partial sequences of the human tyrosine hydroxylase promoter in vivo
Q40804917Flexible, AAV-equipped Genetic Modules for Inducible Control of Gene Expression in Mammalian Brain
Q51846343Gene Therapy Used in Cancer Treatment.
Q37994717Gene therapy approaches for lysosomal storage disorders, a good model for the treatment of mendelian diseases
Q26799437Gene therapy for cardiovascular disease: advances in vector development, targeting, and delivery for clinical translation
Q83556143Gene therapy for heart failure
Q38073152Gene therapy for heart failure: where do we stand?
Q35340196Gene therapy for the nervous system: challenges and new strategies
Q39348354Guiding plant virus particles to integrin-displaying cells
Q39834994Inducible and combinatorial gene manipulation in mouse brain
Q40705086Inexpensive, serotype-independent protocol for native and bioengineered recombinant adeno-associated virus purification
Q30412532Laser-induced microbubble poration of localized single cells
Q36037919MicroRNA therapeutics in cardiovascular medicine
Q43139168Overexpression of parkin in the rat nigrostriatal dopamine system protects against methamphetamine neurotoxicity
Q35078590Recombinant AAV-directed gene therapy for type I glycogen storage diseases
Q34297263Significance and applications of nanoparticles in siRNA delivery for cancer therapy
Q92489485Targeting microglia with lentivirus and AAV: Recent advances and remaining challenges
Q37393827The role of apoptosis in immune hyporesponsiveness following AAV8 liver gene transfer
Q37019105Tools, methods, and applications for optophysiology in neuroscience
Q30538923Viral transduction of the neonatal brain delivers controllable genetic mosaicism for visualising and manipulating neuronal circuits in vivo
Q38655270Virus-Derived Peptides for Clinical Applications

Search more.