c-Myc induction of programmed cell death may contribute to carcinogenesis: a perspective inspired by several concepts of chemical carcinogenesis

scientific article published on April 2011

c-Myc induction of programmed cell death may contribute to carcinogenesis: a perspective inspired by several concepts of chemical carcinogenesis is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.4161/CBT.11.7.14688
P932PMC publication ID3084967
P698PubMed publication ID21278493
P5875ResearchGate publication ID49795832

P50authorMichael P. LisantiQ77913186
P2093author name stringChenguang Wang
D Joshua Liao
Yanhong Tai
P2860cites workc-Myc suppresses the tumorigenicity of lung cancer cells and down-regulates vascular endothelial growth factor expressionQ73383736
Cell cycle basis for the onset and progression of c-Myc-induced, TGFalpha-enhanced mouse mammary gland carcinogenesisQ73540242
Myc/p53 interactions in transgenic mouse mammary development, tumorigenesis and chromosomal instabilityQ74752133
A matter of life and cell deathQ77164675
Bcl-2 expression delays hepatocyte cell cycle progression during liver regenerationQ77769534
Cell Death in MMTV-c-myc Transgenic Mouse Mammary Tumors May Not Be Typical ApoptosisQ79176341
The scavenger cell hypothesis of apoptosis: apoptosis redefined as a process by which a cell in living tissue is destroyed by phagocytosisQ81746515
Mist1-KrasG12D knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma and hepatocellular carcinomaQ82193149
Runx2 and MYC collaborate in lymphoma development by suppressing apoptotic and growth arrest pathways in vivoQ82606388
Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblastsQ24290150
A role for candidate tumor-suppressor gene TCEAL7 in the regulation of c-Myc activity, cyclin D1 levels and cellular transformationQ24314746
Alternative Cyclin D1 Splice Forms Differentially Regulate the DNA Damage ResponseQ24616966
c-Myc Augments Gamma Irradiation-Induced Apoptosis by Suppressing Bcl-XLQ24653312
Developmental context determines latency of MYC-induced tumorigenesisQ24794847
CytoregR inhibits growth and proliferation of human adenocarcinoma cells via induction of apoptosisQ25255979
MYC is a metastasis gene for non-small-cell lung cancerQ27347283
Proliferation, cell cycle and apoptosis in cancerQ28189476
c-MYC: more than just a matter of life and deathQ28205057
Repression of p15INK4b expression by Myc through association with Miz-1Q28210023
Elevated protein expression of cyclin D1 and Fra-1 but decreased expression of c-Myc in human colorectal adenocarcinomas overexpressing beta-cateninQ28220621
The c-Myc oncogene directly induces the H19 noncoding RNA by allele-specific binding to potentiate tumorigenesisQ28240820
The great MYC escape in tumorigenesisQ28272812
Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cellsQ28294137
Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic diseaseQ28570541
Myc deletion rescues Apc deficiency in the small intestineQ28591197
Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesisQ28593886
Cancer. Addiction to oncogenes--the Achilles heal of cancerQ29614243
Disruption of cyclin D1 nuclear export and proteolysis accelerates mammary carcinogenesisQ30417762
c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutationsQ31929763
Hepatotoxin-induced changes in the adult murine liver promote MYC-induced tumorigenesisQ33344462
Cell cycle re-entry and mitochondrial defects in myc-mediated hypertrophic cardiomyopathy and heart failureQ33506647
Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformationQ33591386
E2F2 suppresses Myc-induced proliferation and tumorigenesis.Q33618472
Myc suppression of Nfkb2 accelerates lymphomagenesisQ33624136
MYC oncogenes and human neoplastic diseaseQ33667340
Perspectives on c-Myc, Cyclin D1, and their interaction in cancer formation, progression, and response to chemotherapyQ37058068
Promotion of hepatocarcinogenesis in humans and animal modelsQ37060367
Liver repopulation and carcinogenesis: two sides of the same coin?Q37102829
Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomasQ37118264
The neuronal expression of MYC causes a neurodegenerative phenotype in a novel transgenic mouseQ37150786
Oncogene addictionQ37152445
The microenvironments of multistage carcinogenesisQ37154505
Anti-invasive and antimetastatic activities of ribosomal protein S6 kinase 4 in breast cancer cellsQ37167261
C-Myc is a critical mediator of the phenotypes of Apc loss in the intestineQ37204555
Comparative aspects of animal regenerationQ37206211
Cell competition and its possible relation to cancerQ37218503
Apoptosis-induced compensatory proliferation. The Cell is dead. Long live the Cell!Q37251077
c-Myc: linking transformation and genomic instabilityQ37264779
Tumor dormancy and oncogene addictionQ37286246
Apoptotic signaling by c-MYC.Q37310199
The role of HER2 in early breast cancer metastasis and the origins of resistance to HER2-targeted therapiesQ37326072
Reflecting on 25 years with MYC.Q37333643
Super competition as a possible mechanism to pioneer precancerous fieldsQ37363575
Genetic heterogeneity of Myc-induced mammary tumors reflecting diverse phenotypes including metastatic potentialQ37364112
Mutations affecting conserved cysteine residues within the extracellular domain of Neu promote receptor dimerization and activationQ37375814
Facilitating replication under stress: an oncogenic function of MYC?Q37492244
Apoptosis and cancer: the genesis of a research fieldQ37529250
Myc--what we have learned from flies.Q37550621
Deregulation of cell death (apoptosis): implications for tumor development.Q37605266
ERK and cell death: mechanisms of ERK-induced cell death--apoptosis, autophagy and senescenceQ37618297
Drosophila Myc.Q37621011
Myc's secret life without Max.Q37627095
Cyclin D1 transgene impedes lymphocyte maturation and collaborates in lymphomagenesis with the myc geneQ37631754
The ups and downs of Myc biologyQ37644952
Bim is a suppressor of Myc-induced mouse B cell leukemiaQ37647369
Cellular adaptation in the origin and development of cancerQ37717278
Cdk2: a key regulator of the senescence control function of Myc.Q37743042
Tipping the balance: Cdk2 enables Myc to suppress senescenceQ37780375
Nfkb 1 is dispensable for Myc-induced lymphomagenesisQ38325314
Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-MycQ39126564
Low-level shRNA cytotoxicity can contribute to MYC-induced hepatocellular carcinoma in adult miceQ39639180
Bcl-2 expression delays mammary tumor development in dimethylbenz(a)anthracene-treated transgenic mice.Q54004293
Myc heterozygosity attenuates the phenotypes of APC deficiency in the small intestine.Q54390813
Myc and a Cdk2 senescence switch.Q54702401
Myc, Cdk2 and cellular senescence: Old players, new gameQ58883584
New principle for the analysis of chemical carcinogenesisQ59089097
PIM1 and MYC: a changing relationship?Q63407027
Acquired radioresistance of human tumor cells by DNA-PK/AKT/GSK3beta-mediated cyclin D1 overexpressionQ64387135
Role for Bcl-xL in the regulation of apoptosis by EGF and TGF beta 1 in c-myc overexpressing mammary epithelial cellsQ71657386
Cell proliferation as a major risk factor for cancer: a concept of doubtful validityQ71974064
Paradoxical inhibition of c-myc-induced carcinogenesis by Bcl-2 in transgenic miceQ73078503
Differential regulation of cell cycle characteristics and apoptosis in MMTV-myc and MMTV-ras mouse mammary tumorsQ73099094
Point Mutations in c-Myc Uncouple Neoplastic Transformation from Multiple Other Phenotypes in Rat FibroblastsQ33742040
More than one way to die: apoptosis, necrosis and reactive oxygen damageQ33807850
Cdk2 deficiency decreases ras/CDK4-dependent malignant progression, but not myc-induced tumorigenesisQ33810358
Action of Myc in vivo - proliferation and apoptosisQ33840451
Apoptosis in cancerQ33846227
The association of CCND1 overexpression and cisplatin resistance in testicular germ cell tumors and other cancersQ33882357
Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancerQ33890758
c-Myc is required for the formation of intestinal crypts but dispensable for homeostasis of the adult intestinal epitheliumQ33925138
c-Myc regulates cyclin D-Cdk4 and -Cdk6 activity but affects cell cycle progression at multiple independent pointsQ33958488
The c-Myc transactivation domain is a direct modulator of apoptotic versus proliferative signalsQ33963949
c-Myc in breast cancerQ34055118
Specific protection against breast cancers by cyclin D1 ablationQ34082446
Human c-Myc isoforms differentially regulate cell growth and apoptosis in Drosophila melanogasterQ34124162
You Don't Muck with MYCQ34157211
MYC Inactivation Elicits Oncogene Addiction through Both Tumor Cell-Intrinsic and Host-Dependent MechanismsQ34248882
Myc Function in DrosophilaQ34291633
Genomic and proteomic analysis reveals a threshold level of MYC required for tumor maintenanceQ34314752
Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic miceQ34342812
Apoptosis, Stem Cells, and Tissue RegenerationQ34346968
Novel targeted deregulation of c-Myc cooperates with Bcl-X(L) to cause plasma cell neoplasms in miceQ34380431
Translocations involving c-myc and c-myc functionQ34405431
The resistance phenotype in the development and treatment of cancerQ34571823
Mice bearing the E mu-myc and E mu-pim-1 transgenes develop pre-B-cell leukemia prenatallyQ34613693
Cyclin D1 promotes anchorage-independent cell survival by inhibiting FOXO-mediated anoikisQ34764094
Distinct thresholds govern Myc's biological output in vivoQ34897529
Paradoxical role of apoptosis in tumor progressionQ35014280
Characterization of pancreatic lesions from MT-tgf alpha, Ela-myc and MT-tgf alpha/Ela-myc single and double transgenic miceQ35016285
Identification of CDK4 as a target of c-MYC.Q35051802
Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesionQ35107957
Isoform-specific ras activation and oncogene dependence during MYC- and Wnt-induced mammary tumorigenesisQ35131418
Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switch.Q35133764
Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesisQ35208288
c-myc null cells misregulate cad and gadd45 but not other proposed c-Myc targetsQ35212190
c-myc as a mediator of accelerated apoptosis and involution in mammary glands lacking Socs3.Q35222270
Roles of cyclin D1 and related genes in growth inhibition, senescence and apoptosisQ35591569
Functional link between Myc and the Werner gene in tumorigenesis.Q35601075
Programmed cell death and its protective role with particular reference to apoptosisQ35623794
Multiple cell death pathways as regulators of tumour initiation and progression.Q35743092
Bcl-2 expression inhibits liver carcinogenesis and delays the development of proliferating fociQ35748053
Cancer cell biology: Myc wins the competitionQ35795366
Endogenous bcl-2 is not required for the development of Emu-myc-induced B-cell lymphomaQ35828796
Bcl-2 protein expression and long-term survival in breast cancerQ35834034
MYC levels govern hematopoietic tumor type and latency in transgenic miceQ35848951
Apoptosis in the development and treatment of cancerQ35890843
Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivationQ35928960
Intrinsic tumour suppressionQ35953133
The wild-type Ras: road aheadQ36022672
Specific tumor suppressor function for E2F2 in Myc-induced T cell lymphomagenesisQ36024052
Evasion of the p53 tumour surveillance network by tumour-derived MYC mutantsQ36142180
Myc, cell competition, and compensatory proliferationQ36215291
Differential modulation of cyclin gene expression by MYCQ36258572
Soluble factors mediate competitive and cooperative interactions between cells expressing different levels of Drosophila Myc.Q36276873
Antimalarial therapy prevents Myc-induced lymphomaQ36287308
Tumor cell-selective regulation of NOXA by c-MYC in response to proteasome inhibition.Q36288668
c-myc expression: keep the noise down!Q36305373
C-myc-induced apoptosis in polycystic kidney disease is Bcl-2 and p53 independentQ36380929
A growth-constrained environment drives tumor progression invivoQ36524341
Mechanisms of disease: Oncogene addiction--a rationale for molecular targeting in cancer therapyQ36559283
Tumor dormancy: death and resurrection of cancer as seen through transgenic mouse modelsQ36575307
Conditional transgenic models define how MYC initiates and maintains tumorigenesisQ36578360
Repression of cyclin D1: a novel function of MYCQ36654990
Novel activating mutations in the neu proto-oncogene involved in induction of mammary tumorsQ36668724
Myc-mediated apoptosis is blocked by ectopic expression of Bcl-2Q36678903
c-myc reverses neu-induced transformed morphology by transcriptional repressionQ36680741
Bax regulates c-Myc-induced mammary tumour apoptosis but not proliferation in MMTV-c-myc transgenic miceQ36695757
Histological complexities of pancreatic lesions from transgenic mouse models are consistent with biological and morphological heterogeneity of human pancreatic cancerQ36759171
Targeting the death machinery in mammary epithelial cells: Implications for breast cancer from transgenic and tissue culture experiments.Q36866713
Drosophila SPARC is a self-protective signal expressed by loser cells during cell competition.Q39643477
Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissuesQ39757012
Cdk2 suppresses cellular senescence induced by the c-myc oncogene.Q39763259
Enhanced mRNA cap methylation increases cyclin D1 expression and promotes cell transformationQ39774238
The IKK2/NF-{kappa}B pathway suppresses MYC-induced lymphomagenesis.Q39821427
Myc down-regulation affects cyclin D1/cdk4 activity and induces apoptosis via Smac/Diablo pathway in an astrocytoma cell lineQ39895392
Switch from Mnt-Max to Myc-Max induces p53 and cyclin D1 expression and apoptosis during cholestasis in mouse and human hepatocytesQ39904679
Identification of the cyclin D1b mRNA variant in mouseQ39986947
Cyclin D1 mediates resistance to apoptosis through upregulation of molecular chaperones and consequent redistribution of cell death regulatorsQ39988132
Cyclin D1 is transcriptionally down-regulated by ZO-2 via an E box and the transcription factor c-Myc.Q40078195
c-Myc-induced chemosensitization is mediated by suppression of cyclin D1 expression and nuclear factor-kappa B activity in pancreatic cancer cellsQ40138478
C-myc activation impairs the NF-kappaB and the interferon response: implications for the pathogenesis of Burkitt's lymphomaQ40185161
CDK2 is required by MYC to induce apoptosisQ40270196
Overexpression of cyclin D1 promotes tumor cell growth and confers resistance to cisplatin-mediated apoptosis in an elastase-myc transgene-expressing pancreatic tumor cell lineQ40382268
Transforming growth factor-alpha inhibits the intrinsic pathway of c-Myc-induced apoptosis through activation of nuclear factor-kappaB in murine hepatocellular carcinomasQ40392805
Bcl-2 and c-Myc co-operate in the Epstein-Barr virus-immortalized human B-cell line GM607 but do not confer tumorigenicityQ40397713
The activities of cyclin D1 that drive tumorigenesisQ40571080
c-myc induces autophagy in rat 3Y1 fibroblast cells.Q40638488
Cell proliferation and apoptosis in normal liver and preneoplastic fociQ40662457
BCL-x(L) and BCL2 delay Myc-induced cell cycle entry through elevation of p27 and inhibition of G1 cyclin-dependent kinasesQ40691704
Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression.Q40731052
Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1.Q40769247
Identification of c-myc responsive genes using rat cDNA microarray.Q40841505
Inhibition of Myc-dependent apoptosis by eukaryotic translation initiation factor 4E requires cyclin D1.Q40893166
X-gene product of hepatitis B virus induces apoptosis in liver cellsQ41067693
Liver regeneration versus direct hyperplasia.Q41073460
Mediation of c-Myc-induced apoptosis by p53.Q41441186
Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.Q41714456
Absence of caspase-3 protects pancreatic {beta}-cells from c-Myc-induced apoptosis without leading to tumor formation.Q42006448
Ratcheting Myc.Q42279416
Loss of Rb and Myc activation co-operate to suppress cyclin D1 and contribute to transformationQ42513679
The hepatitis B virus X gene potentiates c-myc-induced liver oncogenesis in transgenic miceQ42651224
Downregulation of c-MYC protein levels contributes to cancer cell survival under dual deficiency of oxygen and glucoseQ42845702
Myc lacks E2F1's ability to suppress skin carcinogenesisQ43728206
Can loss of apoptosis protect against cancer?Q46161155
Bcl-xL gain of function and p19 ARF loss of function cooperate oncogenically with Myc in vivo by distinct mechanismsQ46918938
Drosophila myc regulates organ size by inducing cell competitionQ47071644
dMyc transforms cells into super-competitorsQ47072112
Induction of apoptosis by Drosophila Myc.Q47072146
Early work on the function of Bcl-2, an interview with David VauxQ47670135
The functional basis of c-myc and bcl-2 complementation during multistep lymphomagenesis in vivoQ48074944
Hepatocellular carcinoma results from chronic cyclin D1 overexpression in transgenic miceQ49230994
Persistent sex differences in growth control of early rat liver lesions are programmed during promotion in the resistant hepatocyte model.Q51028514
Frequent amplifications and deletions of G1/S-phase transition genes, CCND1 and MYC in early breast cancers: a potential role in G1/S escape.Q51800297
Insights from Bcl-2 and Myc: malignancy involves abrogation of apoptosis as well as sustained proliferation.Q52177994
The MMTV/c-myc transgene and p53 null alleles collaborate to induce T-cell lymphomas, but not mammary carcinomas in transgenic mice.Q52207180
Interactions between MYC and transforming growth factor alpha alter the growth and tumorigenicity of liver progenitor cells.Q52581219
Is cell competition relevant to cancer?Q52687651
Myc, Cdk2 and cellular senescence: Old players, new game.Q53302314
Oncogenes and the DNA damage response: Myc and E2F1 engage the ATM signaling pathway to activate p53 and induce apoptosis.Q53347808
Bcl-2 delays and alters hepatic carcinogenesis induced by transforming growth factor alpha.Q53401440
Overexpression of Bcl-2 inhibits alveolar cell apoptosis during involution and accelerates c-myc-induced tumorigenesis of the mammary gland in transgenic mice.Q53439560
Constitutive expression of mature transforming growth factor beta1 in the liver accelerates hepatocarcinogenesis in transgenic mice.Q53442937
Lymphomagenesis in E mu-myc transgenic mice can involve ras mutations.Q53515470
Conditional deletion of c-myc does not impair liver regeneration.Q53620103
P433issue7
P921main subjectcarcinogenesisQ1637543
cell deathQ2383867
P304page(s)615-626
P577publication date2011-04-01
P1433published inCancer Biology and TherapyQ2544651
P1476titlec-Myc induction of programmed cell death may contribute to carcinogenesis: a perspective inspired by several concepts of chemical carcinogenesis
P478volume11

Reverse relations

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