The reaction mechanism of FokI excludes the possibility of targeting zinc finger nucleases to unique DNA sites.

scientific article published on April 2011

The reaction mechanism of FokI excludes the possibility of targeting zinc finger nucleases to unique DNA sites. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1042/BST0390584
P698PubMed publication ID21428944

P50authorKelly SandersQ42544855
P2093author name stringStephen E Halford
Lucy E Catto
Christian Pernstich
David A Rusling
P2860cites workStructure of the metal-independent restriction enzyme BfiI reveals fusion of a specific DNA-binding domain with a nonspecific nucleaseQ24535057
Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domainQ24567623
REBASE--a database for DNA restriction and modification: enzymes, genes and genomesQ24644735
FokI dimerization is required for DNA cleavageQ24657843
Structure of FokI has implications for DNA cleavageQ24657897
A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genesQ24684053
Protein assembly and DNA looping by the FokI restriction endonucleaseQ25257871
Structural analysis of the heterodimeric type IIS restriction endonuclease R.BspD6I acting as a complex between a monomeric site-specific nickase and a catalytic subunitQ27652407
Structure of the multimodular endonuclease FokI bound to DNAQ27740190
Gene targeting using zinc finger nucleasesQ28265983
Zinc-finger nucleases: the next generation emergesQ28283445
An improved zinc-finger nuclease architecture for highly specific genome editingQ28307951
Rapid mutation of endogenous zebrafish genes using zinc finger nucleases made by Oligomerized Pool ENgineering (OPEN).Q33406501
Zinc finger nucleases as tools to understand and treat human diseasesQ33622931
Requirements for double-strand cleavage by chimeric restriction enzymes with zinc finger DNA-recognition domainsQ33786657
Advances in zinc finger engineering.Q34029160
Many type IIs restriction endonucleases interact with two recognition sites before cleaving DNA.Q34103727
Site-specific DNA-nicking mutants of the heterodimeric restriction endonuclease R.BbvCI.Q34410970
Natural and engineered nicking endonucleases--from cleavage mechanism to engineering of strand-specificityQ34474076
MmeI: a minimal Type II restriction-modification system that only modifies one DNA strand for host protectionQ34598959
Type II restriction endonucleasesQ34996805
Induction and repair of zinc-finger nuclease-targeted double-strand breaks in Caenorhabditis elegans somatic cellsQ35133826
How the Bfi I restriction enzyme uses one active site to cut two DNA strandsQ35143107
Enzyme-mediated DNA loopingQ35771536
Functional domains in Fok I restriction endonuclease.Q37000625
Zinc finger nuclease technology heralds a new era in mammalian transgenesis.Q37656595
Class-IIS restriction enzymes--a reviewQ37765759
DNA binding and recognition by the IIs restriction endonuclease MboII.Q38295631
Mva1269I: a monomeric type IIS restriction endonuclease from Micrococcus varians with two EcoRI- and FokI-like catalytic domainsQ38319941
Crystal structure of restriction endonuclease BglI bound to its interrupted DNA recognition sequenceQ38333398
Engineering Nt.BtsCI and Nb.BtsCI nicking enzymes and applications in generating long overhangs.Q39373513
Quantification of zinc finger nuclease-associated toxicityQ39672301
A novel mechanism for the scission of double-stranded DNA: BfiI cuts both 3'-5' and 5'-3' strands by rotating a single active siteQ39986656
Diversity of type II restriction endonucleases that require two DNA recognition sitesQ40240500
Dynamics and consequences of DNA looping by the FokI restriction endonucleaseQ41967553
DNA looping by two-site restriction endonucleases: heterogeneous probability distributions for loop size and unbinding forceQ42000366
Targeting individual subunits of the FokI restriction endonuclease to specific DNA strandsQ43141069
DNA excision by the Sfi I restriction endonucleaseQ47708855
P433issue2
P304page(s)584-588
P577publication date2011-04-01
P1433published inBiochemical Society TransactionsQ864226
P1476titleThe reaction mechanism of FokI excludes the possibility of targeting zinc finger nucleases to unique DNA sites
P478volume39

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cites work (P2860)
Q41959958A novel zinc-finger nuclease platform with a sequence-specific cleavage module.
Q48114494Chemical Approach to Biological Safety: Molecular-Level Control of an Integrated Zinc Finger Nuclease.
Q35991442Monomeric site-specific nucleases for genome editing
Q50488180Nuclear gene targeting in Chlamydomonas using engineered zinc-finger nucleases.
Q39875872Site- and strand-specific nicking of DNA by fusion proteins derived from MutH and I-SceI or TALE repeats
Q35070354TALE-PvuII fusion proteins--novel tools for gene targeting.
Q38005211Targeted gene therapies: tools, applications, optimization
Q33784986The I-TevI nuclease and linker domains contribute to the specificity of monomeric TALENs
Q33843093Type II restriction endonucleases--a historical perspective and more
Q39888811Zinc-finger recombinase activities in vitro

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