The many roles of the highly interactive HSV protein ICP27, a key regulator of infection

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The many roles of the highly interactive HSV protein ICP27, a key regulator of infection is …
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P356DOI10.2217/FMB.11.119
P8608Fatcat IDrelease_gt4iy4oz7bgytlthdl27ip7mtm
P698PubMed publication ID22082288

P50authorRozanne M Sandri-GoldinQ58658227
P2860cites workImproved disorder prediction by combination of orthogonal approachesQ21143869
Intrinsically unstructured proteins and their functionsQ22061731
Function and structure of inherently disordered proteinsQ22061740
Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factorQ24291748
NHERF1/EBP50 head-to-tail intramolecular interaction masks association with PDZ domain ligandsQ24294023
TREX is a conserved complex coupling transcription with messenger RNA exportQ24295211
ATP is required for interactions between UAP56 and two conserved mRNA export proteins, Aly and CIP29, to assemble the TREX complexQ24299834
eIF4A3 is a novel component of the exon junction complexQ24305305
Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8Q24306711
Recruitment of the human TREX complex to mRNA during splicingQ24306879
Kaposi's sarcoma-associated herpesvirus ORF57 protein interacts with PYM to enhance translation of viral intronless mRNAsQ24309306
Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replicationQ24310689
Proteomics of herpes simplex virus infected cell protein 27: association with translation initiation factorsQ24317336
HSV-1 ICP27 suppresses NF-kappaB activity by stabilizing IkappaBalphaQ24320024
Human mRNA export machinery recruited to the 5' end of mRNAQ24338302
Herpes simplex virus IE63 (ICP27) protein interacts with spliceosome-associated protein 145 and inhibits splicing prior to the first catalytic stepQ24529096
The 65 and 110 kDa SR-related proteins of the U4/U6.U5 tri-snRNP are essential for the assembly of mature spliceosomesQ24534416
Association of herpes simplex virus type 1 ICP8 and ICP27 proteins with cellular RNA polymerase II holoenzymeQ24537648
ICP27 interacts with the RNA export factor Aly/REF to direct herpes simplex virus type 1 intronless mRNAs to the TAP export pathwayQ24538841
The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substratesQ24539652
Sorting out the complexity of SR protein functionsQ24539813
A molecular link between SR protein dephosphorylation and mRNA exportQ24561984
Splicing enhances translation in mammalian cells: an additional function of the exon junction complexQ24623819
An emerging role for TOR signaling in mammalian tissue and stem cell physiologyQ24629305
RNA-binding of the human cytomegalovirus transactivator protein UL69, mediated by arginine-rich motifs, is not required for nuclear export of unspliced RNA.Q25255330
Arginine methylation of the ICP27 RGG box regulates ICP27 export and is required for efficient herpes simplex virus 1 replicationQ37191893
The tail binds to the head-neck domain, inhibiting ATPase activity of myosin VIIAQ37208900
The cellular RNA export receptor TAP/NXF1 is required for ICP27-mediated export of herpes simplex virus 1 RNA, but the TREX complex adaptor protein Aly/REF appears to be dispensableQ37232829
The Kinesin-1 tail conformationally restricts the nucleotide pocketQ37263164
Structural and biophysical properties of the integrin-associated cytoskeletal protein talinQ37287318
Translation of intronless RNAs is strongly stimulated by the Epstein-Barr virus mRNA export factor EB2.Q37318448
Arginine methylation of the ICP27 RGG box regulates the functional interactions of ICP27 with SRPK1 and Aly/REF during herpes simplex virus 1 infectionQ37333812
Linking folding and bindingQ37373866
Serine/threonine phosphatase 1 modulates the subnuclear distribution of pre-mRNA splicing factorsQ37382850
The scaffold protein PDZK1 undergoes a head-to-tail intramolecular association that negatively regulates its interaction with EBP50.Q37395713
Herpesvirus protein ICP27 switches PML isoform by altering mRNA splicingQ37406026
General and target-specific RNA binding properties of Epstein-Barr virus SM posttranscriptional regulatory protein.Q37410659
Epstein-Barr virus protein EB2 contains an N-terminal transferable nuclear export signal that promotes nucleocytoplasmic export by directly binding TAP/NXF1.Q37452534
UAP56- a key player with surprisingly diverse roles in pre-mRNA splicing and nuclear exportQ37464314
The HSV-1 ICP27 RGG box specifically binds flexible, GC-rich sequences but not G-quartet structuresQ37467403
Viral disorder or disordered viruses: do viral proteins possess unique features?Q37745117
The interface between transcription and mRNP export: from THO to THSC/TREX-2.Q37769964
mTORC1 signaling: what we still don't knowQ37817590
Characterization of the betaherpesviral pUL69 protein family reveals binding of the cellular mRNA export factor UAP56 as a prerequisite for stimulation of nuclear mRNA export and for efficient viral replicationQ38698595
Herpes simplex virus type 1 ICP27-dependent activation of NF-kappaB.Q39290324
Bimolecular fluorescence complementation: visualization of molecular interactions in living cellsQ39304667
Herpes simplex virus type 1 blocks the apoptotic host cell defense mechanisms that target Bcl-2 and manipulates activation of p38 mitogen-activated protein kinase to improve viral replicationQ39610177
Binding of the human cytomegalovirus (HCMV) tegument protein UL69 to UAP56/URH49 is not required for efficient replication of HCMV.Q39683107
Identification of a lytic-cycle Epstein-Barr virus gene product that can regulate PKR activationQ39698299
CK2 protein kinase is stimulated and redistributed by functional herpes simplex virus ICP27 proteinQ39736755
Arginine methylation of REF/ALY promotes efficient handover of mRNA to TAP/NXF1.Q39744182
ICP27 interacts with SRPK1 to mediate HSV splicing inhibition by altering SR protein phosphorylationQ39744901
Specific interactions of distamycin with G-quadruplex DNA.Q39758740
Protein arginine methyltransferase 1 regulates herpes simplex virus replication through ICP27 RGG-box methylationQ39774755
Role for G-quadruplex RNA binding by Epstein-Barr virus nuclear antigen 1 in DNA replication and metaphase chromosome attachmentQ39816429
Human protein arginine methyltransferases in vivo--distinct properties of eight canonical members of the PRMT familyQ39885118
The Epstein-Barr virus (EBV) protein EB is an mRNA export factor essential for virus productionQ39977670
Transactivation of a viral target gene by herpes simplex virus ICP27 is posttranscriptional and does not require the endogenous promoter or polyadenylation siteQ39996395
Mechanism of coupled folding and binding of an intrinsically disordered proteinQ40210194
SR proteins SRp20 and 9G8 contribute to efficient export of herpes simplex virus 1 mRNAsQ40279625
Functional co-operation between the Kaposi's sarcoma-associated herpesvirus ORF57 and ORF50 regulatory proteinsQ40532662
The evolutionarily conserved Kaposi's sarcoma-associated herpesvirus ORF57 protein interacts with REF protein and acts as an RNA export factorQ40553504
A novel nuclear export signal and a REF interaction domain both promote mRNA export by the Epstein-Barr virus EB2 protein.Q40693893
Herpes simplex virus gene products required for viral inhibition of expression of G1-phase functionsQ40746209
Herpes simplex virus 1 ICP27 is required for transcription of two viral late (gamma 2) genes in infected cellsQ40808226
Herpes simplex virus infection blocks events in the G1 phase of the cell cycleQ40901688
The UL69 transactivator protein of human cytomegalovirus interacts with DEXD/H-Box RNA helicase UAP56 to promote cytoplasmic accumulation of unspliced RNA.Q41807684
ATP-dependent recruitment of export factor Aly/REF onto intronless mRNAs by RNA helicase UAP56Q41911142
Role for herpes simplex virus 1 ICP27 in the inhibition of type I interferon signalingQ42114837
Intrinsic disorder in the common N-terminus of human adenovirus 5 E1B-55K and its related E1BN proteins indicated by studies on E1B-93R.Q42613429
Identification of an ICP27-responsive element in the coding region of a herpes simplex virus type 1 late geneQ42644431
Herpes simplex virus-1 infection causes the secretion of a type I interferon-antagonizing protein and inhibits signaling at or before Jak-1 activationQ42695727
mTOR kinase domain phosphorylation promotes mTORC1 signaling, cell growth, and cell cycle progressionQ42793655
The DExH/D box protein HEL/UAP56 is essential for mRNA nuclear export in DrosophilaQ43790549
Structural disorder and modular organization in Paramyxovirinae N and P.Q44067762
SR splicing factors serve as adapter proteins for TAP-dependent mRNA exportQ44384538
Splicing inhibition at the level of spliceosome assembly in the presence of herpes simplex virus protein ICP27.Q45733376
Immediate early protein IE63 of herpes simplex virus type 1 binds RNA directlyQ45768926
A herpesvirus regulatory protein appears to act post-transcriptionally by affecting mRNA processingQ46590676
Binding of ATP to UAP56 is necessary for mRNA exportQ46645611
Protein phosphorylation and the nuclear organization of pre-mRNA splicingQ47895857
Protein intrinsic disorder and human papillomaviruses: increased amount of disorder in E6 and E7 oncoproteins from high risk HPVs.Q51936092
A zyxin head-tail interaction regulates zyxin-VASP complex formation.Q51945202
Disorder and sequence repeats in hub proteins and their implications for network evolution.Q52673882
The gene product encoded by ORF 57 of herpesvirus saimiri regulates the redistribution of the splicing factor SC-35.Q53930982
Insights into Allosteric Control of Vinculin Function from Its Large Scale Conformational DynamicsQ57829294
Structure of the C-terminal FG-nucleoporin binding domain of Tap/NXF1Q27638140
Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoproteinQ27656864
Insight into the molecular mechanism of the multitasking kinesin-8 motorQ27664275
Structural Basis for the Recognition of Cellular mRNA Export Factor REF by Herpes Viral Proteins HSV-1 ICP27 and HVS ORF57Q27666677
Conserved structures and diversity of functions of RNA-binding proteinsQ27861066
The multifunctional herpes simplex virus IE63 protein interacts with heterogeneous ribonucleoprotein K and with casein kinase 2Q28145355
Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNAQ28187189
Regulation of Raf through phosphorylation and N terminus-C terminus interactionQ28187593
Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and AlyQ28202041
SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factorsQ28289413
Mutually exclusive interactions drive handover of mRNA from export adaptors to TAPQ28512678
The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequencesQ28646657
Intrinsically disordered human C/EBP homologous protein regulates biological activity of colon cancer cells during calcium stressQ28910465
The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decayQ29616054
Fragile X mental retardation protein targets G quartet mRNAs important for neuronal functionQ29616372
The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoansQ29620818
Flexible nets. The roles of intrinsic disorder in protein interaction networks.Q30351593
Improving protein structure prediction using multiple sequence-based contact predictionsQ30405821
Nuclear sequestration of cellular chaperone and proteasomal machinery during herpes simplex virus type 1 infectionQ30449490
The kinesin-1 motor protein is regulated by a direct interaction of its head and tailQ30482648
Identification of herpes simplex virus RNAs that interact specifically with regulatory protein ICP27 in vivo.Q30941982
Intrinsic disorder is a common feature of hub proteins from four eukaryotic interactomesQ33252616
Natively unstructured loops differ from other loopsQ33292014
Hsc70 focus formation at the periphery of HSV-1 transcription sites requires ICP27.Q33317262
Bimolecular fluorescence complementation (BiFC) analysis as a probe of protein interactions in living cellsQ33345889
Virus-Induced Chaperone-Enriched (VICE) domains function as nuclear protein quality control centers during HSV-1 infectionQ33509511
Varicella-zoster virus IE4 protein interacts with SR proteins and exports mRNAs through the TAP/NXF1 pathwayQ33516235
Kaposi's sarcoma-associated herpesvirus ORF57 protein binds and protects a nuclear noncoding RNA from cellular RNA decay pathwaysQ33539794
ICP27 phosphorylation site mutants are defective in herpes simplex virus 1 replication and gene expressionQ33648884
ICP27 phosphorylation site mutants display altered functional interactions with cellular export factors Aly/REF and TAP/NXF1 but are able to bind herpes simplex virus 1 RNAQ33648948
Human cytomegalovirus UL69 protein facilitates translation by associating with the mRNA cap-binding complex and excluding 4EBP1Q33664623
ICP27 recruits Aly/REF but not TAP/NXF1 to herpes simplex virus type 1 transcription sites although TAP/NXF1 is required for ICP27 exportQ33707490
Control of VP16 translation by the herpes simplex virus type 1 immediate-early protein ICP27.Q33707539
Herpes simplex virus 1 regulatory protein ICP27 undergoes a head-to-tail intramolecular interactionQ33826787
Accumulation of herpes simplex virus type 1 early and leaky-late proteins correlates with apoptosis prevention in infected human HEp-2 cellsQ33835841
Epstein-Barr virus SM protein interacts with mRNA in vivo and mediates a gene-specific increase in cytoplasmic mRNA.Q33842488
Herpes simplex virus ICP27 activation of stress kinases JNK and p38.Q33843399
The splicing factor SRp20 modifies splicing of its own mRNA and ASF/SF2 antagonizes this regulationQ33887326
An interaction between KSHV ORF57 and UIF provides mRNA-adaptor redundancy in herpesvirus intronless mRNA export.Q33981279
Three arginine residues within the RGG box are crucial for ICP27 binding to herpes simplex virus 1 GC-rich sequences and for efficient viral RNA exportQ33990699
The protein kingdom extended: ordered and intrinsically disordered proteins, their folding, supramolecular complex formation, and aggregation.Q34046537
Herpes simplex virus ICP27 protein provides viral mRNAs with access to the cellular mRNA export pathway.Q34083087
A conserved mRNA export machinery coupled to pre-mRNA splicingQ34120025
Head-to-tail intramolecular interaction of herpes simplex virus type 1 regulatory protein ICP27 is important for its interaction with cellular mRNA export receptor TAP/NXF1Q34285978
Epstein-Barr Virus SM protein utilizes cellular splicing factor SRp20 to mediate alternative splicingQ34295965
Direct stimulation of translation by the multifunctional herpesvirus ICP27 protein.Q34302063
G-quartet-dependent recognition between the FMRP RGG box and RNA.Q34365357
SRprises along a messenger's journeyQ34400219
Kaposi's Sarcoma-Associated Herpesvirus ORF57 Interacts with Cellular RNA Export Cofactors RBM15 and OTT3 To Promote Expression of Viral ORF59Q34529918
ICP27 interacts with the C-terminal domain of RNA polymerase II and facilitates its recruitment to herpes simplex virus 1 transcription sites, where it undergoes proteasomal degradation during infectionQ34545620
Kaposi's sarcoma-associated herpesvirus ORF57 promotes escape of viral and human interleukin-6 from microRNA-mediated suppressionQ34742851
Promyelocytic leukemia protein mediates interferon-based anti-herpes simplex virus 1 effectsQ35020024
The solution structure of REF2-I reveals interdomain interactions and regions involved in binding mRNA export factors and RNA.Q35110861
The histone acetyltransferase CLOCK is an essential component of the herpes simplex virus 1 transcriptome that includes TFIID, ICP4, ICP27, and ICP22.Q35192700
ICP27 mediates HSV RNA export by shuttling through a leucine-rich nuclear export signal and binding viral intronless RNAs through an RGG motifQ35194372
Kaposi's sarcoma-associated herpesvirus ORF57 protein enhances mRNA accumulation independently of effects on nuclear RNA exportQ36098956
Exon junction complexes mediate the enhancing effect of splicing on mRNA expressionQ36160767
Serine phosphorylation of SR proteins is required for their recruitment to sites of transcription in vivoQ36255596
Promoter- and cell-specific transcriptional transactivation by the Kaposi's sarcoma-associated herpesvirus ORF57/Mta proteinQ36315189
Direct interaction between the N- and C-terminal portions of the herpes simplex virus type 1 origin binding protein UL9 implies the formation of a head-to-tail dimer.Q36315207
Kaposi's sarcoma-associated herpesvirus ORF57 functions as a viral splicing factor and promotes expression of intron-containing viral lytic genes in spliceosome-mediated RNA splicingQ36484026
Herpes simplex virus ICP27 increases translation of a subset of viral late mRNAsQ36498119
A herpes simplex virus type 1 immediate-early gene product, IE63, regulates small nuclear ribonucleoprotein distribution.Q36569586
Epstein-Barr virus SM protein functions as an alternative splicing factorQ36747769
PML and PML nuclear bodies: implications in antiviral defenceQ36753891
Splicing is required for rapid and efficient mRNA export in metazoansQ36776804
Herpes simplex virus type 1 ICP27 regulates expression of a variant, secreted form of glycoprotein C by an intron retention mechanismQ36804576
Herpesvirus saimiri ORF57: a post-transcriptional regulatory proteinQ36992582
The human cytomegalovirus regulatory protein UL69 and its effect on mRNA exportQ36992585
Efficient nuclear export of herpes simplex virus 1 transcripts requires both RNA binding by ICP27 and ICP27 interaction with TAP/NXF1Q37051636
Herpes simplex virus type 1 ICP27 induces p38 mitogen-activated protein kinase signaling and apoptosis in HeLa cellsQ37099797
Kaposi's sarcoma-associated herpesvirus ORF57 in viral RNA processingQ37125662
The many roles of the regulatory protein ICP27 during herpes simplex virus infectionQ37175495
P433issue11
P1104number of pages17
P304page(s)1261-1277
P577publication date2011-11-01
P1433published inFuture MicrobiologyQ15759961
P1476titleThe many roles of the highly interactive HSV protein ICP27, a key regulator of infection
P478volume6

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