Cutaneous RANK-RANKL Signaling Upregulates CD8-Mediated Antiviral Immunity during Herpes simplex Virus Infection by Preventing Virus-Induced Langerhans Cell Apoptosis

scientific article published on 15 June 2015

Cutaneous RANK-RANKL Signaling Upregulates CD8-Mediated Antiviral Immunity during Herpes simplex Virus Infection by Preventing Virus-Induced Langerhans Cell Apoptosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/JID.2015.225
P698PubMed publication ID26076314
P5875ResearchGate publication ID278330265

P50authorKarin LoserQ88870845
P2093author name stringBjörn E Clausen
Eva U Lorentzen
Joachim E Kühn
Wali Hafezi
Stefan Beissert
Thomas A Luger
Karin Loser
Lars Klenner
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Regulation of wound healing by growth factors and cytokinesQ29615242
Cancer-associated epithelial cell adhesion molecule (EpCAM; CD326) enables epidermal Langerhans cell motility and migration in vivoQ30513354
Herpes simplex virus type 1 (HSV-1)-induced apoptosis in human dendritic cells as a result of downregulation of cellular FLICE-inhibitory protein and reduced expression of HSV-1 antiapoptotic latency-associated transcript sequencesQ33558390
Epidermal viral immunity induced by CD8alpha+ dendritic cells but not by Langerhans cellsQ34265522
CD4+CD25+ regulatory T cells control Leishmania major persistence and immunityQ34529549
Coordination of early protective immunity to viral infection by regulatory T cellsQ34591024
Immune surveillance by CD8αα+ skin-resident T cells in human herpes virus infectionQ34711496
Engagement of TLR2 reverses the suppressor function of conjunctiva CD4+CD25+ regulatory T cells and promotes herpes simplex virus epitope-specific CD4+CD25- effector T cell responsesQ35027578
Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivityQ36321301
TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activationQ36368029
Tumor necrosis factor/tumor necrosis factor receptor family members that positively regulate immunityQ36380499
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Regulation of cutaneous immunity by the environment: an important role for UV irradiation and vitamin D.Q37524839
Viruses and Langerhans cellsQ37743180
The many roles of the highly interactive HSV protein ICP27, a key regulator of infectionQ37955947
Regulatory T cells: banned cells for decadesQ37967097
Early events in herpes simplex virus lifecycle with implications for an infection of lifetimeQ37980142
An inquiry into the molecular basis of HSV latency and reactivationQ38136266
Langerhans cell antigen capture through tight junctions confers preemptive immunity in experimental staphylococcal scalded skin syndrome.Q39678964
Natural killer cells as novel helpers in anti-herpes simplex virus immune responseQ39948866
Cutting edge: a potent adjuvant effect of ligand to receptor activator of NF-kappa B gene for inducing antigen-specific CD8+ T cell response by DNA and viral vector vaccinationQ40609374
Enhanced Effector and Memory CTL Responses Generated by Incorporation of Receptor Activator of NF-κB (RANK)/RANK Ligand Costimulatory Molecules into Dendritic Cell Immunogens Expressing a Human Tumor-Specific AntigenQ40628569
Entry mechanisms of herpes simplex virus 1 into murine epidermis: involvement of nectin-1 and herpesvirus entry mediator as cellular receptorsQ41699066
Compensatory role of Langerhans cells and langerin-positive dermal dendritic cells in the sensitization phase of murine contact hypersensitivityQ43131210
Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cellsQ43647446
Gr-1+ cells, but not neutrophils, limit virus replication and lesion development following flank infection of mice with herpes simplex virus type-1.Q44401345
Cutting edge: priming of CD8 T cell immunity to herpes simplex virus type 1 requires cognate TLR3 expression in vivoQ45123319
Herpes simplex virus infects skin gamma delta T cells before Langerhans cells and impedes migration of infected Langerhans cells by inducing apoptosis and blocking E-cadherin downregulationQ45375576
Herpes simplex virus infection of human dendritic cells induces apoptosis and allows cross-presentation via uninfected dendritic cellsQ45514140
Herpes simplex virus-specific CD8+ T cells can clear established lytic infections from skin and nerves and can partially limit the early spread of virus after cutaneous inoculationQ45703157
Reciprocal transmission of herpes simplex virus type 1 (HSV-1) between corneal epithelium and trigeminal neurites in an embryonic chick organ cultureQ45732805
Skin Langerhans cells play an essential role in the defense against HSV-1 infection.Q54438163
Long-lived immature dendritic cells mediated by TRANCE-RANK interactionQ56966224
Differential Migration of Epidermal and Dermal Dendritic Cells during Skin InfectionQ57133346
Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cellsQ57184743
Migratory Dendritic Cells Transfer Antigen to a Lymph Node-Resident Dendritic Cell Population for Efficient CTL PrimingQ57227729
Cooperation of TNF family members CD40 ligand, receptor activator of NF-kappa B ligand, and TNF-alpha in the activation of dendritic cells and the expansion of viral specific CD8+ T cell memory responses in HIV-1-infected and HIV-1-uninfected indiviQ78946141
TRANCE counteracts FasL-mediated apoptosis of murine bone marrow-derived dendritic cellsQ81789743
Activation of dendritic cells via TLR7 reduces Foxp3 expression and suppressive function in induced TregsQ83790498
Overexpression of Toll-like receptor 2/4 on monocytes modulates the activities of CD4(+)CD25(+) regulatory T cells in chronic hepatitis B virus infectionQ84961071
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)2676-2687
P577publication date2015-06-15
P1433published inJournal of Investigative DermatologyQ3186921
P1476titleCutaneous RANK-RANKL Signaling Upregulates CD8-Mediated Antiviral Immunity during Herpes simplex Virus Infection by Preventing Virus-Induced Langerhans Cell Apoptosis
P478volume135

Reverse relations

cites work (P2860)
Q40918241Down-RANKing the Threat of HSV-1: RANKL Upregulates MHC-Class-I-Restricted Anti-Viral Immunity in Herpes Simplex Virus Infection
Q90452562Eimeria challenge adversely affected long bone attributes linked to increased resorption in 14-day-old broiler chickens
Q47109271Langerhans Cells-Programmed by the Epidermis.

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