Chromatin insulator elements: establishing barriers to set heterochromatin boundaries

scientific article published on February 2012

Chromatin insulator elements: establishing barriers to set heterochromatin boundaries is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2217/EPI.11.112
P698PubMed publication ID22332659
P5875ResearchGate publication ID221830822

P50authorAdam WestQ54255719
Gráinne BarkessQ42991178
P2860cites workCorrelation between histone lysine methylation and developmental changes at the chicken beta-globin locusQ43703042
Topological constraints governing the use of the chicken HS4 chromatin insulator in oncoretrovirus vectorsQ43980881
Acetylation of histone H2B mirrors that of H4 and H3 at the chicken beta-globin locus but not at housekeeping genesQ44514687
Recruitment of histone modifications by USF proteins at a vertebrate barrier elementQ45138460
Transcriptional repression mediated by repositioning of genes to the nuclear laminaQ46755262
Large-scale chromatin structural domains within mitotic and interphase chromosomes in vivo and in vitroQ46871282
Both CTCF-dependent and -independent insulators are found between the mouse T cell receptor alpha and Dad1 genesQ47769588
Isolation, characterization, and structure of the folded interphase genome of Drosophila melanogasterQ52433065
Radial loops and helical coils coexist in metaphase chromosomes.Q53703047
A user's guide to the encyclopedia of DNA elements (ENCODE)Q21092716
Architectural roles of multiple chromatin insulators at the human apolipoprotein gene clusterQ24309356
Conserved CTCF insulator elements flank the mouse and human beta-globin lociQ24537420
Mediation of CTCF transcriptional insulation by DEAD-box RNA-binding protein p68 and steroid receptor RNA activator SRAQ24611482
CTCF: master weaver of the genomeQ24621388
Genome-wide maps of chromatin state in pluripotent and lineage-committed cellsQ24632506
Analysis of the vertebrate insulator protein CTCF-binding sites in the human genomeQ24648552
CTCFBSDB: a CTCF-binding site database for characterization of vertebrate genomic insulatorsQ24649669
Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domainsQ24655087
G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesisQ24673923
Systematic discovery of regulatory motifs in conserved regions of the human genome, including thousands of CTCF insulator sitesQ24682593
The replacement histone H2A.Z in a hyperacetylated form is a feature of active genes in the chickenQ24814761
High-resolution profiling of histone methylations in the human genomeQ27860906
Comprehensive mapping of long-range interactions reveals folding principles of the human genomeQ28131819
The protein CTCF is required for the enhancer blocking activity of vertebrate insulatorsQ28142800
Domain organization of human chromosomes revealed by mapping of nuclear lamina interactionsQ28279406
Integrative analysis of the Caenorhabditis elegans genome by the modENCODE projectQ28301622
A TALE nuclease architecture for efficient genome editingQ28301656
Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early developmentQ28304098
Transitions in histone acetylation reveal boundaries of three separately regulated neighboring lociQ28364099
Whole-genome analysis of histone H3 lysine 27 trimethylation in ArabidopsisQ28469184
Histone H3-K9 methyltransferase ESET is essential for early developmentQ28513000
CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locusQ28590210
Genome Engineering With Zinc-Finger NucleasesQ29301748
Integration of external signaling pathways with the core transcriptional network in embryonic stem cellsQ29547179
Genomic maps and comparative analysis of histone modifications in human and mouseQ29614418
Linking DNA methylation and histone modification: patterns and paradigmsQ29617801
Cohesin mediates transcriptional insulation by CCCTC-binding factorQ29618130
Cohesins functionally associate with CTCF on mammalian chromosome armsQ29618753
The NIH Roadmap Epigenomics Mapping ConsortiumQ29619856
Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stabilityQ29620365
The polycomb-group gene Ezh2 is required for early mouse developmentQ29620406
Cohesin is required for higher-order chromatin conformation at the imprinted IGF2-H19 locusQ30946870
Genome-wide identification of in vivo protein-DNA binding sites from ChIP-Seq dataQ31169616
Arabidopsis TFL2/LHP1 specifically associates with genes marked by trimethylation of histone H3 lysine 27.Q33286417
Identification and characterization of cell type-specific and ubiquitous chromatin regulatory structures in the human genomeQ33294656
5'HS5 of the human beta-globin locus control region is dispensable for the formation of the beta-globin active chromatin hub.Q33332161
Genome-wide association of histone H3 lysine nine methylation with CHG DNA methylation in Arabidopsis thalianaQ33367576
Targeted deletion of multiple CTCF-binding elements in the human C-MYC gene reveals a requirement for CTCF in C-MYC expressionQ33476843
VEZF1 elements mediate protection from DNA methylationQ33523011
A comprehensive map of insulator elements for the Drosophila genomeQ33525010
Optimized lentiviral vector design improves titer and transgene expression of vectors containing the chicken beta-globin locus HS4 insulator elementQ33713427
The insulator protein SU(HW) fine-tunes nuclear lamina interactions of the Drosophila genomeQ33760885
A CTCF-independent role for cohesin in tissue-specific transcriptionQ33812535
Distinct epigenomic landscapes of pluripotent and lineage-committed human cells.Q33842527
An insulator element and condensed chromatin region separate the chicken beta-globin locus from an independently regulated erythroid-specific folate receptor geneQ33891173
Methylation of histone H4 by arginine methyltransferase PRMT1 is essential in vivo for many subsequent histone modificationsQ33917698
Histone crosstalk directed by H2B ubiquitination is required for chromatin boundary integrityQ33979550
Sequences downstream of the erythroid promoter are required for high level expression of the human alpha-spectrin geneQ33981947
Position-effect protection and enhancer blocking by the chicken beta-globin insulator are separable activitiesQ34067751
Silencing of transgene transcription precedes methylation of promoter DNA and histone H3 lysine 9.Q34107315
Systematic protein location mapping reveals five principal chromatin types in Drosophila cellsQ34141226
Spatial organization of gene expression: the active chromatin hub.Q34230157
A 5' element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in DrosophilaQ34352447
Mutation of a barrier insulator in the human ankyrin-1 gene is associated with hereditary spherocytosisQ34360145
Insulators: many functions, many mechanisms.Q34515901
Plasticity in patterns of histone modifications and chromosomal proteins in Drosophila heterochromatinQ34548233
Broad chromosomal domains of histone modification patterns in C. elegansQ34548272
The role of Hox genes during vertebrate limb developmentQ34654700
Cohesin: genomic insights into controlling gene transcription and developmentQ34762370
A position-effect assay for boundaries of higher order chromosomal domainsQ34778762
Conserved, developmentally regulated mechanism couples chromosomal looping and heterochromatin barrier activity at the homeobox gene A locusQ34937659
Cohesin mediates chromatin interactions that regulate mammalian β-globin expressionQ34979002
Nonallelic transcriptional roles of CTCF and cohesins at imprinted loci.Q35139414
RNAi-independent role for Argonaute2 in CTCF/CP190 chromatin insulator functionQ35193225
Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulatorsQ35209588
A cis-regulatory map of the Drosophila genome.Q35229726
Genome-wide CTCF distribution in vertebrates defines equivalent sites that aid the identification of disease-associated genes.Q35384578
The barrier function of an insulator couples high histone acetylation levels with specific protection of promoter DNA from methylationQ35778363
The polycomb group protein Suz12 is required for embryonic stem cell differentiationQ35856936
Characterization of the chicken beta-globin insulatorQ35956059
Retrovirus silencer blocking by the cHS4 insulator is CTCF independentQ36079373
Chromatin boundaries and chromatin domains.Q36238580
USF1 recruits histone modification complexes and is critical for maintenance of a chromatin barrierQ36315893
Insulators and promoters: closer than we thinkQ36337521
We gather together: insulators and genome organizationQ36407771
Vezf1 regulates genomic DNA methylation through its effects on expression of DNA methyltransferase Dnmt3bQ36802984
CTCF regulates cell cycle progression of alphabeta T cells in the thymusQ36967236
An insulator with barrier-element activity promotes alpha-spectrin gene expression in erythroid cellsQ37100755
Chromatin insulators: lessons from the fly.Q37343925
Genomic imprinting: employing and avoiding epigenetic processesQ37362832
Inactive X chromosome-specific histone H3 modifications and CpG hypomethylation flank a chromatin boundary between an X-inactivated and an escape geneQ37477610
Silencing chromatin: comparing modes and mechanismsQ37827337
TAL effectors: customizable proteins for DNA targetingQ37940951
The c-myc insulator element and matrix attachment regions define the c-myc chromosomal domainQ38492610
Boundary sequences stabilize transgene expression from subtle position effects in retroviral vectorsQ39820803
Physical properties of a genomic condensed chromatin fragmentQ40564871
Transcriptional repression mediated by polycomb group proteins and other chromatin-associated repressors is selectively blocked by insulatorsQ40908961
Large histone H3 lysine 9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cellsQ41868578
Flanking HS-62.5 and 3' HS1, and regions upstream of the LCR, are not required for beta-globin transcriptionQ41891258
Identification of higher-order functional domains in the human ENCODE regionsQ41981321
H3K27me3 forms BLOCs over silent genes and intergenic regions and specifies a histone banding pattern on a mouse autosomal chromosomeQ42076431
Molecular maps of the reorganization of genome-nuclear lamina interactions during differentiationQ42472280
Extended core sequences from the cHS4 insulator are necessary for protecting retroviral vectors from silencing position effectsQ42829430
Factors binding a non-classical Cis-element prevent heterochromatin effects on locus control region activityQ42831502
Reassessing the abundance of H3K9me2 chromatin domains in embryonic stem cellsQ43206621
A wt1-controlled chromatin switching mechanism underpins tissue-specific wnt4 activation and repressionQ43221537
P433issue1
P304page(s)67-80
P577publication date2012-02-01
P1433published inEpigenomicsQ20737165
P1476titleChromatin insulator elements: establishing barriers to set heterochromatin boundaries
P478volume4

Reverse relations

cites work (P2860)
Q47136573A chimeric HS4 insulator-scaffold attachment region enhances transgene expression in transfected Chinese hamster ovary cells
Q37439219A chimeric HS4-SAR insulator (IS2) that prevents silencing and enhances expression of lentiviral vectors in pluripotent stem cells
Q37657825Altered enhancer transcription underlies Huntington's disease striatal transcriptional signature
Q34061185An enhancer-blocking element regulates the cell-specific expression of alcohol dehydrogenase 7.
Q40607067CTCF binding to the first intron of the major immediate early (MIE) gene of human cytomegalovirus (HCMV) negatively regulates MIE gene expression and HCMV replication
Q33588115CTCF regulates the human p53 gene through direct interaction with its natural antisense transcript, Wrap53.
Q40758954Centromeric barrier disruption leads to mitotic defects in Schizosaccharomyces pombe
Q38210929Chromatin dynamics from S-phase to mitosis: contributions of histone modifications
Q35053078Deletion of an X-inactivation boundary disrupts adjacent gene silencing
Q38981846Distinct and overlapping control of 5-methylcytosine and 5-hydroxymethylcytosine by the TET proteins in human cancer cells
Q34825042Effective blocking of the white enhancer requires cooperation between two main mechanisms suggested for the insulator function
Q39597255Establishment of Reporter Lines for Detecting Fragile X Mental Retardation (FMR1) Gene Reactivation in Human Neural Cells
Q42158675Establishment of expression-state boundaries by Rif1 and Taz1 in fission yeast
Q36109371Functional Requirements for Fab-7 Boundary Activity in the Bithorax Complex
Q38963694Highly conserved ENY2/Sus1 protein binds to Drosophila CTCF and is required for barrier activity
Q42977652Histone deacetylase inhibition activates transgene expression from integration-defective lentiviral vectors in dividing and non-dividing cells.
Q26775263Insulators and domains of gene expression
Q23916604Longitudinal epigenetic variation of DNA methyltransferase genes associated with vulnerability to post-traumatic stress disorder (PTSD)
Q36316644More than insulator: multiple roles of CTCF at the H19-Igf2 imprinted domain.
Q38725574Position-effect variegation revisited: HUSHing up heterochromatin in human cells.
Q37166402Protecting a transgene expression from the HAC-based vector by different chromatin insulators
Q41837903The Putzig partners DREF, TRF2 and KEN are involved in the regulation of the Drosophila telomere retrotransposons, HeT-A and TART.
Q37066312The chicken hypersensitivity site 4 core insulator blocks promoter interference in lentiviral vectors
Q34038690piRNA clusters and open chromatin structure
Q36777890tDNA insulators and the emerging role of TFIIIC in genome organization

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