The HIV-1 passage from cytoplasm to nucleus: the process involving a complex exchange between the components of HIV-1 and cellular machinery to access nucleus and successful integration.

scientific article published on 25 February 2012

The HIV-1 passage from cytoplasm to nucleus: the process involving a complex exchange between the components of HIV-1 and cellular machinery to access nucleus and successful integration. is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID3325773
P698PubMed publication ID22509482

P50authorXiaojian YaoQ92113143
Zhujun AoQ115643007
Kallesh Danappa JayappaQ55299632
P2093author name stringKallesh Danappa Jayappa
P2860cites worktRNAs promote nuclear import of HIV-1 intracellular reverse transcription complexesQ21146036
Transportin-SR, a nuclear import receptor for SR proteinsQ22009980
HIV-1 genome nuclear import is mediated by a central DNA flapQ73726795
Two nuclear localization signals in the HIV-1 matrix protein regulate nuclear import of the HIV-1 pre-integration complexQ73910247
Arginine residues in the C-terminus of HIV-1 Vpr are important for nuclear localization and cell cycle arrestQ74353246
Identification of host proteins required for HIV infection through a functional genomic screenQ24306298
Importin alpha3 interacts with HIV-1 integrase and contributes to HIV-1 nuclear import and replicationQ24322708
Interaction of the human immunodeficiency virus type 1 Vpr protein with the nuclear pore complex.Q24523667
Viral protein R regulates nuclear import of the HIV-1 pre-integration complexQ24533072
Evidence for distinct substrate specificities of importin alpha family members in nuclear protein importQ24554392
Active nuclear import of human immunodeficiency virus type 1 preintegration complexesQ24564507
The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cellsQ24564509
The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytesQ24564711
HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infectionQ24608690
HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathwayQ24642513
Establishment of a functional human immunodeficiency virus type 1 (HIV-1) reverse transcription complex involves the cytoskeletonQ24647043
Human immunodeficiency virus vpr product is a virion-associated regulatory proteinQ24649600
Nuclear pore complexes form immobile networks and have a very low turnover in live mammalian cellsQ24654097
HIV-1 nuclear import: matrix protein is back on center stage, this time together with VprQ24654217
Human immunodeficiency virus type 1 preintegration complexes: studies of organization and compositionQ24673418
Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage infectionQ24673913
Nuclear import of HIV-1 intracellular reverse transcription complexes is mediated by importin 7Q24681578
Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear importQ24684268
Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 VprQ24684633
Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activityQ24685633
Contribution of the C-terminal tri-lysine regions of human immunodeficiency virus type 1 integrase for efficient reverse transcription and viral DNA nuclear importQ24814060
NMR structure of the HIV-1 regulatory protein VPRQ27640614
A human importin-beta family protein, transportin-SR2, interacts with the phosphorylated RS domain of SR proteinsQ28138319
Npap60/Nup50 is a tri-stable switch that stimulates importin-alpha:beta-mediated nuclear protein importQ28217732
A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cellsQ28249434
Genome-wide localization of the nuclear transport machinery couples transcriptional status and nuclear organizationQ28261156
Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNAQ28272788
HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structureQ28283258
HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integraseQ28291170
Phosphorylation of residue 131 of HIV-1 matrix is not required for macrophage infectionQ28302074
Nuclear import defect of human immunodeficiency virus type 1 DNA flap mutants is not dependent on the viral strain or target cell typeQ38761998
The cargo-binding domain of transportin 3 is required for lentivirus nuclear importQ39462609
Transportin 3 and importin α are required for effective nuclear import of HIV-1 integrase in virus-infected cellsQ39590976
Identification of critical amino acid residues in human immunodeficiency virus type 1 IN required for efficient proviral DNA formation at steps prior to integration in dividing and nondividing cells.Q39591194
The karyophilic properties of human immunodeficiency virus type 1 integrase are not required for nuclear import of proviral DNA.Q39592447
Analysis of the viral elements required in the nuclear import of HIV-1 DNA.Q39778927
Conserved sequences in the carboxyl terminus of integrase that are essential for human immunodeficiency virus type 1 replicationQ39873244
HIV-1 exploits importin 7 to maximize nuclear import of its DNA genomeQ39887537
Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virusQ40037960
Cellular functions are required for the synthesis and integration of avian sarcoma virus-specific DNAQ40089752
Triggering neural differentiation of ES cells by subtype switching of importin-alphaQ40198151
Evaluation of the functional involvement of human immunodeficiency virus type 1 integrase in nuclear import of viral cDNA during acute infectionQ40214545
The central DNA flap of the human immunodeficiency virus type 1 is important for viral replicationQ40233853
Class II integrase mutants with changes in putative nuclear localization signals are primarily blocked at a postnuclear entry step of human immunodeficiency virus type 1 replicationQ40275247
HIV-1 integrase is capable of targeting DNA to the nucleus via an importin alpha/beta-dependent mechanism.Q40276999
Vaccinia virus infection disrupts microtubule organization and centrosome function.Q40392464
Human immunodeficiency virus type 1 KK26-27 matrix mutants display impaired infectivity, circularization and integration but not nuclear importQ40408087
Role of Nup98 in nuclear entry of human immunodeficiency virus type 1 cDNA.Q40543314
Assessment of the role of the central DNA flap in human immunodeficiency virus type 1 replication by using a single-cycle replication systemQ40624947
Differential expression of classical nuclear transport factors during cellular proliferation and differentiationQ40689019
The macrophage and HIV-1.Q40785796
Nuclear localization of human immunodeficiency virus type 1 integrase expressed as a fusion protein with green fluorescent protein.Q40948502
Human immunodeficiency virus infection of cells arrested in the cell cycleQ41531689
Unwelcomed guests with master keys: how HIV uses chemokine receptors for cellular entryQ41583314
HIV-1 in blood monocytes: frequency of detection of proviral DNA using PCR and comparison with the total CD4 countQ41642433
HIV-1 DNA Flap formation promotes uncoating of the pre-integration complex at the nuclear poreQ41914326
Productive human immunodeficiency virus type 1 (HIV-1) infection of nonproliferating human monocytesQ41994305
Phosphorylation of HIV-1 gag proteins by protein kinase C.Q42511148
Contribution of host nucleoporin 62 in HIV-1 integrase chromatin association and viral DNA integrationQ42551766
Importin-alpha promotes passage through the nuclear pore complex of human immunodeficiency virus type 1 Vpr.Q42716697
Mapping the dynamic organization of the nuclear pore complex inside single living cells.Q42801001
Characterization of the nuclear import pathway for HIV-1 integrase.Q43559471
HIV-1 infection requires a functional integrase NLS.Q44134677
Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequencesQ44491759
Cytokines alter production of HIV-1 from primary mononuclear phagocytesQ44548244
Dendritic cell infection, depletion and dysfunction in HIV-infected individuals.Q44643651
Interaction of human immunodeficiency virus type 1 integrase with cellular nuclear import receptor importin 7 and its impact on viral replicationQ45406234
Intracellular transport of human immunodeficiency virus type 1 integraseQ45721245
A human immunodeficiency virus type 1 pol gene-derived sequence (cPPT/CTS) increases the efficiency of transduction of human nondividing monocytes and T lymphocytes by lentiviral vectorsQ45730347
Human immunodeficiency virus type 1 Vpr localization: nuclear transport of a viral protein modulated by a putative amphipathic helical structure and its relevance to biological activityQ45756358
Susceptibility of human peripheral blood dendritic cells to infection by human immunodeficiency virusQ45830188
In vitro infection of human monocytes with human T lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV).Q45836762
Transportin-SR2 imports HIV into the nucleusQ45879860
A nucleoprotein complex mediates the integration of retroviral DNA.Q46128219
Long-term cultures of HTLV-III--infected T cells: a model of cytopathology of T-cell depletion in AIDS.Q46175297
Nup-PI: the nucleopore-promoter interaction of genes in yeastQ46925405
A peptide derived from the N-terminal region of HIV-1 Vpr promotes nuclear import in permeabilized cells: elucidation of the NLS region of the Vpr.Q47851803
The HIV-1 DNA flap stimulates HIV vector-mediated cell transduction in the brainQ48895271
Identification of critical motifs within HIV-1 integrase required for importin α3 interaction and viral cDNA nuclear import.Q53232627
Cellular tropism of the human retrovirus HTLV-III/LAV. I. Role of T cell activation and expression of the T4 antigen.Q55244766
Cellular Distribution and Karyophilic Properties of Matrix, Integrase, and Vpr Proteins from the Human and Simian Immunodeficiency VirusesQ56838035
HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulatorQ28307391
Low levels of deoxynucleotides in peripheral blood lymphocytes: a strategy to inhibit human immunodeficiency virus type 1 replicationQ28368051
A second origin of DNA plus-strand synthesis is required for optimal human immunodeficiency virus replicationQ28646734
Association of integrase, matrix, and reverse transcriptase antigens of human immunodeficiency virus type 1 with viral nucleic acids following acute infectionQ28646834
Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infectionQ29547852
Viral dynamics in human immunodeficiency virus type 1 infectionQ29547908
Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replicationQ29616375
The role of mononuclear phagocytes in HTLV-III/LAV infectionQ29618676
Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytesQ29619514
Function of dynein and dynactin in herpes simplex virus capsid transportQ30453354
Nup98 is a mobile nucleoporin with transcription-dependent dynamicsQ30475776
The functionally conserved nucleoporins Nup124p from fission yeast and the human Nup153 mediate nuclear import and activity of the Tf1 retrotransposon and HIV-1 Vpr.Q30475812
Size-dependent DNA mobility in cytoplasm and nucleusQ30832984
Correlation between shiftide activity and HIV-1 integrase inhibition by a peptide selected from a combinatorial libraryQ33315196
The requirement for cellular transportin 3 (TNPO3 or TRN-SR2) during infection maps to human immunodeficiency virus type 1 capsid and not integraseQ33558588
Visualization and characterization of the intracellular movement of vaccinia virus intracellular mature virionsQ33724230
Flexible use of nuclear import pathways by HIV-1.Q33739260
Cytoarchitecture and physical properties of cytoplasm: volume, viscosity, diffusion, intracellular surface areaQ33769782
Characterization of intracellular reverse transcription complexes of Moloney murine leukemia virus.Q33822095
Characterization of intracellular reverse transcription complexes of human immunodeficiency virus type 1.Q33851147
HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2Q33851502
Modulation of HIV-1 infectivity by MAPK, a virion-associated kinaseQ33888794
Efficient HIV-1 replication can occur in the absence of the viral matrix proteinQ33888825
Importin 7 may be dispensable for human immunodeficiency virus type 1 and simian immunodeficiency virus infection of primary macrophagesQ33930505
Integration of murine leukemia virus DNA depends on mitosisQ34051046
Nucleoporins directly stimulate expression of developmental and cell-cycle genes inside the nucleoplasmQ34097834
Dynamic disruptions in nuclear envelope architecture and integrity induced by HIV-1 Vpr.Q34100288
Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1.Q34149318
Capsid is a dominant determinant of retrovirus infectivity in nondividing cellsQ34152408
Establishment of HIV-1 latency in resting CD4+ T cells depends on chemokine-induced changes in the actin cytoskeleton.Q34165677
Human immunodeficiency virus type 1 DNA nuclear import and integration are mitosis independent in cycling cellsQ34227319
Nuclear localization of human immunodeficiency virus type 1 preintegration complexes (PICs): V165A and R166A are pleiotropic integrase mutants primarily defective for integration, not PIC nuclear importQ34350236
Reassessment of the roles of integrase and the central DNA flap in human immunodeficiency virus type 1 nuclear importQ34359748
Evidence for a functional link between uncoating of the human immunodeficiency virus type 1 core and nuclear import of the viral preintegration complexQ34546004
Classical nuclear localization signals: definition, function, and interaction with importin alphaQ34591163
Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapyQ34714816
Effects of microtubule modulators on HIV-1 infection of transformed and resting CD4 T cellsQ34742816
Impact of the central polypurine tract on the kinetics of human immunodeficiency virus type 1 vector transductionQ34859768
Determinants for lentiviral infection of non-dividing cellsQ35016627
The requirement for nucleoporin NUP153 during human immunodeficiency virus type 1 infection is determined by the viral capsid.Q35140243
Structural analyses of purified human immunodeficiency virus type 1 intracellular reverse transcription complexesQ35155063
Rous sarcoma virus infection of synchronized cells establishes provirus integration during S-phase DNA synthesis prior to cellular divisionQ35355310
Residual HIV-1 DNA Flap-independent nuclear import of cPPT/CTS double mutant viruses does not support spreading infectionQ35582736
Rapid actin-dependent viral motility in live cellsQ35815781
Mutagenic analysis of human immunodeficiency virus type 1 Vpr: role of a predicted N-terminal alpha-helical structure in Vpr nuclear localization and virion incorporation.Q35850945
Novel nuclear import of Vpr promoted by importin alpha is crucial for human immunodeficiency virus type 1 replication in macrophages.Q35857586
Subcellular localization of avian sarcoma virus and human immunodeficiency virus type 1 integrasesQ35876147
Importin α: a multipurpose nuclear-transport receptorQ35879618
Association of ERK2 mitogen-activated protein kinase with human immunodeficiency virus particlesQ35887391
Zinc folds the N-terminal domain of HIV-1 integrase, promotes multimerization, and enhances catalytic activityQ35922636
Microtubule-dependent plus- and minus end-directed motilities are competing processes for nuclear targeting of adenovirusQ36255836
Characterization of HIV-1 vpr nuclear import: analysis of signals and pathwaysQ36255858
Visualization of the intracellular behavior of HIV in living cellsQ36323740
Localization of HIV-1 Vpr to the nuclear envelope: impact on Vpr functions and virus replication in macrophagesQ36398981
Exploitation of microtubule cytoskeleton and dynein during parvoviral traffic toward the nucleusQ36525057
Human immunodeficiency virus type 1 viral protein R localization in infected cells and virionsQ36654319
The human immunodeficiency virus type 1 (HIV-1) CD4 receptor and its central role in promotion of HIV-1 infection.Q36669879
A single-stranded gap in human immunodeficiency virus unintegrated linear DNA defined by a central copy of the polypurine tract.Q36688827
Incompletely reverse-transcribed human immunodeficiency virus type 1 genomes in quiescent cells can function as intermediates in the retroviral life cycleQ36693174
Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infectionQ36720691
Human immunodeficiency virus bearing a disrupted central DNA flap is pathogenic in vivoQ36773289
Infection efficiency of T lymphocytes with amphotropic retroviral vectors is cell cycle dependentQ36830482
Distinct functional domains within nucleoporins Nup153 and Nup98 mediate transcription-dependent mobility.Q37221202
Integrase interacts with nucleoporin NUP153 to mediate the nuclear import of human immunodeficiency virus type 1Q37232867
Role of mononuclear phagocytes in the pathogenesis of human immunodeficiency virus infectionQ37925515
P433issue1
P921main subjectcytoplasmQ79899
P304page(s)70-85
P577publication date2012-02-25
P1433published inInternational journal of biochemistry and molecular biologyQ27723022
P1476titleThe HIV-1 passage from cytoplasm to nucleus: the process involving a complex exchange between the components of HIV-1 and cellular machinery to access nucleus and successful integration
P478volume3

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