Sirtuin activators and inhibitors

scientific article published on 25 June 2012

Sirtuin activators and inhibitors is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/BIOF.1032
P932PMC publication ID3467333
P698PubMed publication ID22730114
P5875ResearchGate publication ID228064029

P2093author name stringJosé M Villalba
Francisco J Alcaín
P2860cites workStage-specific antileishmanial activity of an inhibitor of SIR2 histone deacetylase.Q46462678
Sirtuin inhibition protects from the polyalanine muscular dystrophy protein PABPN1.Q46656918
Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cellsQ46709814
Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitorsQ46815953
Structure-activity studies on suramin analogues as inhibitors of NAD+-dependent histone deacetylases (sirtuins)Q58844844
Modified resveratrol Longevinex improves endothelial function in adults with metabolic syndrome receiving standard treatmentQ82686511
Synthesis and biological characterisation of sirtuin inhibitors based on the tenovinsQ83391665
Nicotinamide blocks proliferation and induces apoptosis of chronic lymphocytic leukemia cells through activation of the p53/miR-34a/SIRT1 tumor suppressor networkQ84086369
What is new for an old molecule? Systematic review and recommendations on the use of resveratrolQ21089966
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylaseQ24291829
SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activityQ24294017
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylaseQ24296836
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylaseQ24297207
Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycleQ24299947
Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosisQ24338619
Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcriptionQ24546024
Sir2 mediates longevity in the fly through a pathway related to calorie restrictionQ24560016
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activityQ24595845
Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterasesQ24608197
SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cellsQ24626021
SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activatorQ24626329
SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1Q24633063
Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcriptionQ24633178
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetesQ24645537
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life spanQ24649811
SIRT1 regulates HIV transcription via Tat deacetylationQ24797263
Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suraminQ27644043
Resveratrol improves health and survival of mice on a high-calorie dietQ27860950
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiaeQ27933365
The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylasesQ27934108
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegansQ28131824
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespanQ28203572
Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 geneQ28205723
Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screeningQ28210511
SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}Q28235481
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1Q28237795
Mechanism of human SIRT1 activation by resveratrolQ28238262
Sirtuin activatorsQ28244893
Resveratrol is not a direct activator of SIRT1 enzyme activityQ28261917
SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesisQ28279273
Substrate-specific activation of sirtuins by resveratrolQ28305166
Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's diseaseQ28307422
Identification of a small molecule inhibitor of Sir2pQ28344005
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6Q28509079
SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesityQ28512048
Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1Q28512371
Sirtuin 2, a mammalian homolog of yeast silent information regulator-2 longevity regulator, is an oligodendroglial protein that decelerates cell differentiation through deacetylating alpha-tubulinQ28572741
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosisQ28583941
Sirtuin activators mimic caloric restriction and delay ageing in metazoansQ29547766
Sirtuins in mammals: insights into their biological functionQ29615248
Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese HumansQ32774312
Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivoQ33417863
SIRT6 promotes DNA repair under stress by activating PARP1Q33803766
SRT1720 induces mitochondrial biogenesis and rescues mitochondrial function after oxidant injury in renal proximal tubule cellsQ33861978
Sirtinol treatment reduces inflammation in human dermal microvascular endothelial cellsQ34023370
Sirtuin regulation of mitochondria: energy production, apoptosis, and signalingQ34024056
High absorption but very low bioavailability of oral resveratrol in humansQ34343815
A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages.Q34388936
Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restrictionQ34534198
Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure.Q34622062
Absence of effects of Sir2 overexpression on lifespan in C. elegans and DrosophilaQ34632518
Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in miceQ34743879
Silencing of SIRT2 induces cell death and a decrease in the intracellular ATP level of PC12 cells.Q34747946
Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer.Q35050748
Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases--safety, pharmacokinetics, and pharmacodynamicsQ35215147
Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cellsQ35337908
Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesisQ35802231
Sirtuin modulatorsQ36165220
New agents in intravesical chemotherapy of superficial bladder cancerQ36194981
SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndromeQ36491908
Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscleQ36739504
Brain SIRT1: anatomical distribution and regulation by energy availabilityQ36962837
The Sirtuin family: therapeutic targets to treat diseases of agingQ37087540
Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant miceQ37097951
Association of sirtuin 1 (SIRT1) gene SNPs and transcript expression levels with severe obesityQ37139750
SirT1 is an inhibitor of proliferation and tumor formation in colon cancerQ37258577
Salermide up-regulates death receptor 5 expression through the ATF4-ATF3-CHOP axis and leads to apoptosis in human cancer cellsQ37295559
Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator.Q37343700
Sirtuin inhibitors.Q37481259
Function and regulation of the mitochondrial sirtuin isoform Sirt5 in MammaliaQ37600341
Role of Sirtuin 1 in metabolic regulationQ37771695
Medicinal chemistry of sirtuin inhibitorsQ37868632
Fine tuning our cellular factories: sirtuins in mitochondrial biologyQ37884948
Regulation and protection of mitochondrial physiology by sirtuins.Q37905267
Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activatorsQ38356805
SIRT2 activity is required for the survival of C6 glioma cellsQ39429048
SIRT1-independent mechanisms of the putative sirtuin enzyme activators SRT1720 and SRT2183.Q39572061
SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2.Q39718199
Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice.Q39805050
Study of 1,4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitorsQ39815436
Novel cambinol analogs as sirtuin inhibitors: synthesis, biological evaluation, and rationalization of activity.Q39856102
Sirt7-dependent inhibition of cell growth and proliferation might be instrumental to mediate tissue integrity during aging.Q39875452
Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect.Q39908136
A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cellsQ39969180
Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding modeQ40013998
SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agentsQ40209315
Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymesQ40291559
The effect of combined treatment with cisplatin and histone deacetylase inhibitors on HeLa cellsQ41916312
Mechanistic studies on the effects of nicotinamide on megakaryocytic polyploidization and the roles of NAD+ levels and SIRT inhibitionQ42008823
Chromosomal organization and fluorescence in situ hybridization of the human Sirtuin 6 gene.Q42677167
Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol analoguesQ43205019
Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevityQ43506305
Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistryQ44537505
Discovery of oxazolo[4,5-b]pyridines and related heterocyclic analogs as novel SIRT1 activatorsQ46080032
Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidationQ46220928
Short-term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heartQ46460770
P433issue5
P304page(s)349-359
P577publication date2012-06-25
P1433published inBioFactorsQ15767404
P1476titleSirtuin activators and inhibitors
P478volume38

Reverse relations

cites work (P2860)
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