NOD2 Polymorphisms and Their Impact on Haematopoietic Stem Cell Transplant Outcome

scientific article published on 18 October 2012

NOD2 Polymorphisms and Their Impact on Haematopoietic Stem Cell Transplant Outcome is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1155/2012/180391
P932PMC publication ID3483648
P698PubMed publication ID23119165
P5875ResearchGate publication ID232766951

P50authorSteven G. E. MarshQ7615026
Neema P MayorQ60366069
Bronwen E ShawQ89210680
P2093author name stringJ Alejandro Madrigal
P2860cites workThe contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel diseaseQ22250943
A frameshift mutation in NOD2 associated with susceptibility to Crohn's diseaseQ22251291
Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaBQ24290546
Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detectionQ24292675
Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognitionQ24306842
The Ensembl genome database projectQ24548408
Activation of innate immune antiviral responses by Nod2Q24646833
Function of Nod-like receptors in microbial recognition and host defenseQ24647448
Crohn's disease-associated Nod2 mutants reduce IL10 transcriptionQ47975511
The NOD2 3020insC mutation and the risk of colorectal cancerQ48010156
NOD2 polymorphisms predict severe acute graft-versus-host and treatment-related mortality in T-cell-depleted haematopoietic stem cell transplantation.Q51819756
TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells.Q52550005
Differential effects of NOD2 variants on Crohn's disease risk and phenotype in diverse populations: a metaanalysis.Q52970473
Interleukin 12 is associated with reduced relapse without increased incidence of graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.Q53644897
Influence of intestinal bacterial decontamination using metronidazole and ciprofloxacin or ciprofloxacin alone on the development of acute graft-versus-host disease after marrow transplantation in patients with hematologic malignancies: final resultQ53932647
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's diseaseQ27860821
Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's diseaseQ28201834
Structural principles of leucine-rich repeat (LRR) proteinsQ28241151
Removal of T cells from bone marrow for transplantation: a monoclonal antilymphocyte antibody that fixes human complementQ28266531
Mapping of a susceptibility locus for Crohn's disease on chromosome 16Q28275042
Signalling pathways and molecular interactions of NOD1 and NOD2Q28298636
NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responsesQ28588300
NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentationQ29615617
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entryQ29615618
Mutation, selection, and evolution of the Crohn disease susceptibility gene CARD15.Q30351790
GeneCards: a novel functional genomics compendium with automated data mining and query reformulation supportQ31991500
Crohn's disease and the NOD2 gene: a role for paneth cellsQ33187690
T cell-intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondiiQ33577143
Insufficient evidence for association of NOD2/CARD15 or other inflammatory bowel disease-associated markers on GVHD incidence or other adverse outcomes in T-replete, unrelated donor transplantationQ33839876
The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantationQ33898254
CARD15: a pleiotropic autoimmune gene that confers susceptibility to psoriatic arthritisQ33906401
A Crohn's disease-associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1.Q34084039
NODs: intracellular proteins involved in inflammation and apoptosisQ34199862
The NOD: a signaling module that regulates apoptosis and host defense against pathogensQ34405567
Improving the outcome of unrelated donor stem cell transplantation by molecular matchingQ34494952
CARD15 mutations in Blau syndromeQ34517310
Nods: a family of cytosolic proteins that regulate the host response to pathogensQ34521834
Prevalence of CARD15/NOD2 mutations in Caucasian healthy peopleQ34576207
High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantationQ34582448
Mechanisms of action of antithymocyte globulin: T-cell depletion and beyondQ34616147
Gene-environment interaction modulated by allelic heterogeneity in inflammatory diseases.Q34870666
Distinct roles for Nod2 protein and autocrine interleukin-1beta in muramyl dipeptide-induced mitogen-activated protein kinase activation and cytokine secretion in human macrophagesQ35128167
Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitisQ35596103
Genetic basis for increased intestinal permeability in families with Crohn's disease: role of CARD15 3020insC mutation?Q35760212
LPS antagonism reduces graft-versus-host disease and preserves graft-versus-leukemia activity after experimental bone marrow transplantationQ36028584
T cell-mediated graft-versus-leukemia reactions after allogeneic stem cell transplantationQ36123756
Chronic stimulation of Nod2 mediates tolerance to bacterial productsQ36288640
Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis.Q36330867
Differential tumor surveillance by natural killer (NK) and NKT cells.Q36375962
Hematopoietic stem-cell transplantationQ36461248
NOD2/CARD15 disease associations other than Crohn's diseaseQ36700677
Risk assessment in haematopoietic stem cell transplantation: histocompatibilityQ36797744
Risk assessment in haematopoietic stem cell transplantation: GvHD prevention and treatmentQ36797778
NLR proteins: integral members of innate immunity and mediators of inflammatory diseasesQ36944426
NOD2, an intracellular innate immune sensor involved in host defense and Crohn's diseaseQ37172148
Polymorphisms of cytokine and innate immunity genes and GVHD.Q37173452
CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel diseaseQ37216685
Effect of T-cell-epitope matching at HLA-DPB1 in recipients of unrelated-donor haemopoietic-cell transplantation: a retrospective studyQ37268004
HLA-A disparities illustrate challenges for ranking the impact of HLA mismatches on bone marrow transplant outcomes in the United StatesQ37354960
NOD2 regulates hematopoietic cell function during graft-versus-host diseaseQ37377427
Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognitionQ37544531
Graft-versus-host disease: regulation by microbe-associated molecules and innate immune receptorsQ37665086
Activation of human NK cells by the bacterial pathogen-associated molecular pattern muramyl dipeptide.Q40005450
Use of natural killer cells as immunotherapy for leukaemia.Q40047650
The NOD2-RICK complex signals from the plasma membrane.Q40159855
The frameshift mutation in Nod2 results in unresponsiveness not only to Nod2- but also Nod1-activating peptidoglycan agonistsQ40382410
Synergistic effect of Nod1 and Nod2 agonists with toll-like receptor agonists on human dendritic cells to generate interleukin-12 and T helper type 1 cellsQ40382473
Comparative phenotypic and CARD15 mutational analysis among African American, Hispanic, and White children with Crohn's diseaseQ40411745
Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantationQ40516766
Infevers: an evolving mutation database for auto-inflammatory syndromesQ40528366
Crohn's disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycanQ40679561
Cytokine dysregulation as a mechanism of graft versus host diseaseQ40780265
Graft-versus-leukemia reactions after bone marrow transplantationQ41198977
NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expressionQ41917631
NOD2/CARD15 genotype influences MDP-induced cytokine release and basal IL-12p40 levels in primary isolated peripheral blood monocytesQ42526336
Eight novel CARD15 variants detected by DNA sequence analysis of the CARD15 gene in 111 patients with inflammatory bowel diseaseQ43437819
Polymorphisms in innate immunity genes and risk of non-Hodgkin lymphomaQ43897803
NOD2/CARD15 polymorphisms in allogeneic stem-cell transplantation from unrelated donors: T depletion mattersQ44625050
Single nucleotide polymorphisms in the NOD2/CARD15 gene are associated with an increased risk of relapse and death for patients with acute leukemia after hematopoietic stem-cell transplantation with unrelated donors.Q44848328
Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processingQ45251378
NOD2/CARD15 on bone marrow CD34+ hematopoietic cells mediates induction of cytokines and cell differentiationQ46108727
Expression of toll-like receptor 2, NOD2 and dectin-1 and stimulatory effects of their ligands and histamine in normal human keratinocytesQ46240206
Polymorphism of interleukin-23 receptor gene but not of NOD2/CARD15 is associated with graft-versus-host disease after hematopoietic stem cell transplantation in childrenQ46297998
Nucleotide-binding oligomerization domain-2 modulates specific TLR pathways for the induction of cytokine releaseQ46477488
Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's diseaseQ46504948
NOD2/CARD15 variants are not a risk factor for clinical outcome after nonmyeloablative allogeneic stem cell transplantationQ46588677
Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonistsQ46602287
The effect of NOD2 activation on TLR2-mediated cytokine responses is dependent on activation dose and NOD2 genotypeQ46702416
Impaired dendritic cell function in Crohn's disease patients with NOD2 3020insC mutationQ46930661
Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcomeQ47359749
Host dendritic cells alone are sufficient to initiate acute graft-versus-host diseaseQ47371499
Diverging effects of HLA-DPB1 matching status on outcome following unrelated donor transplantation depending on disease stage and the degree of matching for other HLA alleles.Q47587797
NOD2/CARD15 gene polymorphisms in Crohn's disease: a genotype- phenotype analysisQ47737388
CARD15 and HLA DRB1 alleles influence susceptibility and disease localization in Crohn's diseaseQ47876286
NOD2/CARD15 polymorphisms impair innate immunity and increase susceptibility to gastric cancer in an Italian population.Q47931892
Association between NOD2/CARD15 polymorphisms and coronary artery disease: a case-control study.Q54373423
Elimination of graft-versus-host disease by in-vitro depletion of alloreactive lymphocytes with a monoclonal rat anti-human lymphocyte antibody (CAMPATH-1).Q54469837
Common NOD2 mutations are absent in patients with Crohn's disease in India.Q54501277
Mutations in innate immune system NOD2/CARD 15 and TLR-4 (Thr399Ile) genes influence the risk for severe acute graft-versus-host disease in patients who underwent an allogeneic transplantation.Q54620738
The prevalence of genetic and serologic markers in an unselected European population-based cohort of IBD patientsQ57265428
Role ofNOD2 variants in spondylarthritisQ57667873
High-risk HLA allele mismatch combinations responsible for severe acute graft-versus-host disease and implication for its molecular mechanismQ57918712
Induction of Nod2 in Myelomonocytic and Intestinal Epithelial Cells via Nuclear Factor-κB ActivationQ59383486
Impact on T-cell depletion and CD34+ cell recovery using humanised CD52 monoclonal antibody (CAMPATH-1H) in BM and PSBC collections; comparison with CAMPATH-1M and CAMPATH-1GQ61651674
Prevalence of the NOD2 3020insC mutation in aggregations of breast and lung cancerQ61946726
Effect of NOD2/CARD15 variants in T-cell depleted allogeneic stem cell transplantationQ62658651
Prevention of infection and graft-versus-host disease by suppression of intestinal microflora in children treated with allogeneic bone marrow transplantationQ67271055
Hematopoietic stem cell transplantation: contrasting the outcome of transplantations from HLA-identical siblings, partially HLA-mismatched related donors, and HLA-matched unrelated donorsQ73256350
Is there a graft-versus-leukaemia effect in the absence of graft-versus-host disease in patients undergoing bone marrow transplantation for acute leukaemia?Q73416370
Evidence that continued remission in patients treated for acute leukaemia is dependent upon autologous natural killer cellsQ74284510
The role of cytokines in acute graft-versus-host diseaseQ77309371
Role of interleukin-12 in the development of acute graft-versus-host disease in bone marrow transplant patientsQ78094062
The role of genetic variants of NOD2/CARD15, a receptor of the innate immune system, in GvHD and complications following related and unrelated donor haematopoietic stem cell transplantationQ79768217
Clinical importance of HLA-DPB1 in haematopoietic cell transplantationQ80184175
T-cell depletion prevents from bronchiolitis obliterans and bronchiolitis obliterans with organizing pneumonia after allogeneic hematopoietic stem cell transplantation with related donorsQ80292500
Impact of NOD2/CARD15 haplotypes on the outcome after kidney transplantationQ80323241
Limits of HLA mismatching in unrelated hematopoietic cell transplantationQ80337240
Recipient NOD2/CARD15 variants: a novel independent risk factor for the development of bronchiolitis obliterans after allogeneic stem cell transplantationQ80408010
HLA Association with hematopoietic stem cell transplantation outcome: the number of mismatches at HLA-A, -B, -C, -DRB1, or -DQB1 is strongly associated with overall survivalQ80640486
Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor-kappaB activation: common genetic etiology with Blau syndromeQ80809518
No impact of NOD2/CARD15 on outcome after SCTQ80813551
The importance of HLA-DPB1 in unrelated donor hematopoietic cell transplantationQ80860433
HLA-DPB1 matching status has significant implications for recipients of unrelated donor stem cell transplantsQ81370374
CARD15 mutations are rare in Swedish pediatric Crohn diseaseQ81585225
No impact of NOD2/CARD15 on outcome after SCT: a replyQ81770552
The role of Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and CARD15/NOD2 mutations in the susceptibility and phenotype of Crohn's diseaseQ81880908
Prognostic significance of NOD2/CARD15 variants in HLA-identical sibling hematopoietic stem cell transplantation: effect on long-term outcome is confirmed in 2 independent cohorts and may be modulated by the type of gastrointestinal decontaminationQ82312167
Impact of high-resolution matching in allogeneic unrelated donor stem cell transplantation in SwitzerlandQ82975022
Genetic variations of interleukin-23R (1143A>G) and BPI (A645G), but not of NOD2, are associated with acute graft-versus-host disease after allogeneic transplantationQ84390923
Toll-like receptor 9, NOD2 and IL23R gene polymorphisms influenced outcome in AML patients transplanted from HLA-identical sibling donorsQ84561203
NOD2/CARD15 gene polymorphisms affect outcome in pediatric allogeneic stem cell transplantationQ84615437
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P304page(s)180391
P577publication date2012-10-18
P1433published inBone Marrow ResearchQ26842195
P1476titleNOD2 Polymorphisms and Their Impact on Haematopoietic Stem Cell Transplant Outcome
P478volume2012

Reverse relations

cites work (P2860)
Q42376157Associations of interactions between NLRP3 SNPs and HLA mismatch with acute and extensive chronic graft-versus-host diseases
Q86653462Can determination of gene polymorphism be of practical value in tailoring the treatment of HSCT patients?
Q28080914Identification and utilization of donor and recipient genetic variants to predict survival after HCT: are we ready for primetime?
Q38502469Non-HLA genomics: does it have a role in predicting haematopoietic stem cell transplantation outcome?

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