Mechanisms of mitochondrial fission and fusion

scientific article published on June 2013

Mechanisms of mitochondrial fission and fusion is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1101/CSHPERSPECT.A011072
P932PMC publication ID3660830
P698PubMed publication ID23732471
P5875ResearchGate publication ID237016673

P2093author name stringAlexander M van der Bliek
Qinfang Shen
Sumihiro Kawajiri
P2860cites workPINK1 is selectively stabilized on impaired mitochondria to activate ParkinQ21145802
OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28Q24290356
Control of mitochondrial morphology by a human mitofusinQ24290831
Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cellsQ24291591
Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cellsQ24293452
piRNA-associated germline nuage formation and spermatogenesis require MitoPLD profusogenic mitochondrial-surface lipid signalingQ24296728
MiD49 and MiD51, new components of the mitochondrial fission machineryQ24300113
Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerizationQ24300125
MARCH-V is a novel mitofusin 2- and Drp1-binding protein able to change mitochondrial morphologyQ24300832
A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosisQ24306318
Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fissionQ24307570
Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fissionQ24307740
An actin-dependent step in mitochondrial fission mediated by the ER-associated formin INF2Q24311384
Identification and functional characterization of a novel human protein highly related to the yeast dynamin-like GTPase Vps1pQ24312112
The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cellsQ24312865
Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cellsQ24315625
Identification of a novel protein that regulates mitochondrial fusion by modulating mitofusin (Mfn) protein functionQ24315653
The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial divisionQ24316439
Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondriaQ24320227
Redox imbalance in Parkinson's diseaseQ36899782
Coassembly of Mgm1 isoforms requires cardiolipin and mediates mitochondrial inner membrane fusionQ37365417
Endoplasmic reticulum-mitochondria contacts: function of the junctionQ37417736
Mitochondrial dynamics in mammalian health and diseaseQ37543838
Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein Drp1Q37774674
Fusion and fission: interlinked processes critical for mitochondrial healthQ38039146
Disruption of a dynamin homologue affects endocytosis, organelle morphology, and cytokinesis in Dictyostelium discoideumQ38329730
The ubiquitin ligase Mul1 induces mitophagy in skeletal muscle in response to muscle-wasting stimuliQ39247172
Ablation of the single dynamin of T. brucei blocks mitochondrial fission and endocytosis and leads to a precise cytokinesis arrest.Q40264875
Two Dictyostelium orthologs of the prokaryotic cell division protein FtsZ localize to mitochondria and are required for the maintenance of normal mitochondrial morphologyQ40495226
Structural basis of mitochondrial tethering by mitofusin complexes.Q40527845
Rab32 is an A-kinase anchoring protein and participates in mitochondrial dynamicsQ40709834
Dynamics of mitochondria in living cells: shape changes, dislocations, fusion, and fission of mitochondriaQ40763148
Dynamin subunit interactions revealedQ40875077
Alternative topogenesis of Mgm1 and mitochondrial morphology depend on ATP and a functional import motor.Q41825724
MARF and Opa1 control mitochondrial and cardiac function in DrosophilaQ42136255
The dynamin-related protein Mgm1p assembles into oligomers and hydrolyzes GTP to function in mitochondrial membrane fusionQ42449841
Double labelling of subcellular structures with organelle-targeted GFP mutants in vivoQ42632757
Normal mitochondrial structure and genome maintenance in yeast requires the dynamin-like product of the MGM1 gene.Q42693107
Regulation of mitochondrial morphology by membrane potential, and DRP1-dependent division and FZO1-dependent fusion reaction in mammalian cellsQ44317746
Cells lacking Pcp1p/Ugo2p, a rhomboid-like protease required for Mgm1p processing, lose mtDNA and mitochondrial structure in a Dnm1p-dependent manner, but remain competent for mitochondrial fusionQ44538988
Loss of the intermembrane space protein Mgm1/OPA1 induces swelling and localized constrictions along the lengths of mitochondriaQ44768454
OPA1 deficiency associated with increased autophagy in retinal ganglion cells in a murine model of dominant optic atrophy.Q46113788
Instability of the mitofusin Fzo1 regulates mitochondrial morphology during the mating response of the yeast Saccharomyces cerevisiaeQ46370669
Normal mitochondrial dynamics requires rhomboid-7 and affects Drosophila lifespan and neuronal functionQ47070303
Mitochondrial fusion protein mutated in CMT2A.Q47398556
Diverse eukaryotes have retained mitochondrial homologues of the bacterial division protein FtsZ.Q47603690
Two types of ftsZ genes isolated from the unicellular primitive red alga Galdieria sulphurariaQ47913830
Tagging and tracking individual networks within a complex mitochondrial web with photoactivatable GFP.Q48938808
Release of OPA1 during apoptosis participates in the rapid and complete release of cytochrome c and subsequent mitochondrial fragmentationQ50757649
Mitochondrial function and actin regulate dynamin-related protein 1-dependent mitochondrial fissionQ50769548
A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis.Q51962923
Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology.Q53548157
Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission.Q53571110
Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent mannerQ57245842
OPA1 alternate splicing uncouples an evolutionary conserved function in mitochondrial fusion from a vertebrate restricted function in apoptosisQ79196601
OPA1 cleavage depends on decreased mitochondrial ATP level and bivalent metalsQ81161420
A bacterial dynamin-like protein mediating nucleotide-independent membrane fusionQ83124285
Monitoring of relative mitochondrial membrane potential in living cells by fluorescence microscopyQ36208685
Ganglioside-induced differentiation associated protein 1 is a regulator of the mitochondrial network: new implications for Charcot-Marie-Tooth diseaseQ36320982
The WD repeat protein, Mdv1p, functions as a molecular adaptor by interacting with Dnm1p and Fis1p during mitochondrial fissionQ36325123
Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondriaQ36453541
Stress-induced phosphorylation and proteasomal degradation of mitofusin 2 facilitates mitochondrial fragmentation and apoptosis.Q36477755
Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilizationQ36496658
Role of cardiolipin in cytochrome c release from mitochondriaQ36790564
CaM kinase I alpha-induced phosphorylation of Drp1 regulates mitochondrial morphologyQ36817918
MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fissionQ24320331
Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis inductionQ24320479
Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosisQ24338169
Fission and selective fusion govern mitochondrial segregation and elimination by autophagyQ24652230
A human dynamin-related protein controls the distribution of mitochondriaQ24682958
Mechanisms of mitophagyQ27310261
The C. elegans Opa1 homologue EAT-3 is essential for resistance to free radicalsQ27314280
The molecular mechanisms of OPA1-mediated optic atrophy in Drosophila model and prospects for antioxidant treatmentQ27314564
Mechanism of neuroprotective mitochondrial remodeling by PKA/AKAP1Q27322213
Structure of a Bacterial Dynamin-like Protein Lipid Tube Provides a Mechanism For Assembly and Membrane CurvingQ27658911
Structural basis of oligomerization in the stalk region of dynamin-like MxAQ27660998
G domain dimerization controls dynamin's assembly-stimulated GTPase activityQ27661004
Molecular architecture of a dynamin adaptor: implications for assembly of mitochondrial fission complexesQ27666346
The conserved GTPase Gem1 regulates endoplasmic reticulum-mitochondria connectionsQ27929791
Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Su e/g.Q27929830
Dnm1 forms spirals that are structurally tailored to fit mitochondriaQ27930356
Ugo1p links the Fzo1p and Mgm1p GTPases for mitochondrial fusionQ27930869
The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast.Q27932045
Mdm30 is an F-box protein required for maintenance of fusion-competent mitochondria in yeastQ27932731
Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1pQ27933279
Processing of Mgm1 by the Rhomboid-type Protease Pcp1 Is Required for Maintenance of Mitochondrial Morphology and of Mitochondrial DNAQ27933366
Mitochondrial DNA maintenance in yeast requires a protein containing a region related to the GTP-binding domain of dynaminQ27934616
Fzo1p is a mitochondrial outer membrane protein essential for the biogenesis of functional mitochondria in Saccharomyces cerevisiaeQ27935307
Mitochondrial inner-membrane fusion and crista maintenance requires the dynamin-related GTPase Mgm1.Q27936009
A novel two-step mechanism for removal of a mitochondrial signal sequence involves the mAAA complex and the putative rhomboid protease Pcp1.Q27936823
Nonredundant roles of mitochondria-associated F-box proteins Mfb1 and Mdm30 in maintenance of mitochondrial morphology in yeastQ27936897
The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondriaQ27937583
The dynamin-related GTPase, Mgm1p, is an intermembrane space protein required for maintenance of fusion competent mitochondriaQ27938333
Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1pQ27940327
A novel dynamin-like protein associates with cytoplasmic vesicles and tubules of the endoplasmic reticulum in mammalian cellsQ28117314
Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophyQ28140286
The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane spaceQ28215023
OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusionQ28251846
The dynamin superfamily: universal membrane tubulation and fission molecules?Q28252404
Identification and subcellular localization of a novel mammalian dynamin-related protein homologous to yeast Vps1p and Dnm1pQ28252923
Dymple, a novel dynamin-like high molecular weight GTPase lacking a proline-rich carboxyl-terminal domain in mammalian cellsQ28258371
Late-Neoproterozoic deep-ocean oxygenation and the rise of animal lifeQ28278079
Mitochondrial fusion and fission in cell life and deathQ28299119
The deletion of bacterial dynamin and flotillin genes results in pleiotrophic effects on cell division, cell growth and in cell shape maintenanceQ28489060
Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodelingQ28506506
Role of Bax and Bak in mitochondrial morphogenesisQ28591724
Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1Q28594164
SLP-2 is required for stress-induced mitochondrial hyperfusionQ28594182
Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic developmentQ28594513
Conformational changes in Dnm1 support a contractile mechanism for mitochondrial fissionQ28854266
Mitochondria: in sickness and in healthQ29614825
Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by ParkinQ29615623
Mitochondrial fission, fusion, and stressQ29616536
S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injuryQ29616550
The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosisQ29616568
During autophagy mitochondria elongate, are spared from degradation and sustain cell viability.Q29616569
The machines that divide and fuse mitochondriaQ29617094
Dynasore, a cell-permeable inhibitor of dynaminQ29619881
ER tubules mark sites of mitochondrial divisionQ29619991
C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membraneQ29620388
Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell deathQ29620448
BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosisQ29620466
The WD-repeats of Net2p interact with Dnm1p and Fis1p to regulate division of mitochondriaQ30480605
PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosisQ33868451
S-Nitrosylation of DRP1 does not affect enzymatic activity and is not specific to Alzheimer's diseaseQ33945990
Architecture of active mammalian respiratory chain supercomplexes.Q33994333
Rab32 Modulates Apoptosis Onset and Mitochondria-associated Membrane (MAM) PropertiesQ34181492
Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase.Q34433265
GSK3beta-mediated Drp1 phosphorylation induced elongated mitochondrial morphology against oxidative stressQ34489873
Aberrant mitochondrial fission in neurons induced by protein kinase C{delta} under oxidative stress conditions in vivoQ34489899
Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvationQ35064216
Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cellsQ35754670
Axonal transport of mitochondria requires milton to recruit kinesin heavy chain and is light chain independentQ36117548
OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L.Q36119045
Regulation of the mitochondrial dynamin-like protein Opa1 by proteolytic cleavageQ36119051
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectmitochondrionQ39572
mitochondrial fissionQ6881852
P577publication date2013-06-01
P1433published inCold Spring Harbor Perspectives in BiologyQ3927509
P1476titleMechanisms of mitochondrial fission and fusion
P478volume5

Reverse relations

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