Pivotal roles of T-helper 17-related cytokines, IL-17, IL-22, and IL-23, in inflammatory diseases

scientific article published on 14 July 2013

Pivotal roles of T-helper 17-related cytokines, IL-17, IL-22, and IL-23, in inflammatory diseases is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1155/2013/968549
P932PMC publication ID3728507
P698PubMed publication ID23956763
P5875ResearchGate publication ID255976965

P50authorTakayuki YoshimotoQ55477598
P2093author name stringKazunori Watanabe
Yutaka Kawakami
Izuru Mizoguchi
Junichiro Mizuguchi
Ning Qu
Mingli Xu
Masahiro Itoh
Kotaro Kaneko
Jun-ichi Furusawa
P2860cites workInterleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activationQ40560155
Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosionQ40590532
Signals and signs for lymphocyte responsesQ40620206
IL-17 expression in human herpetic stromal keratitis: modulatory effects on chemokine production by corneal fibroblasts.Q40691425
Testicular leukocytes: what are they doing?Q40910109
Interleukin-17 activates human renal epithelial cells in vitro and is expressed during renal allograft rejection.Q41018056
IL-23 signaling enhances Th2 polarization and regulates allergic airway inflammationQ42134014
Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthmaQ42423633
Interleukin-17-producing CD4(+) T cells increase with severity of liver damage in patients with chronic hepatitis B.Q43258398
Overexpression of IL-17 in the knee joint of collagen type II immunized mice promotes collagen arthritis and aggravates joint destructionQ43945860
Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cellsQ43991749
Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responsesQ44158655
Characterization of a suppressor cell line which downgrades experimental autoimmune uveoretinitis in the rat.Q44196802
Experimental autoimmune anti-glomerular basement membrane glomerulonephritis: a protective role for IFN-gamma.Q44948959
Immunodeviation towards a Th17 immune response associated with testicular damage in azoospermic men.Q45035748
Increased serum interleukin 17 in patients with systemic lupus erythematosus.Q45327106
Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells.Q45939390
Disruption of CD40/CD40-ligand interactions in a retinal autoimmunity model results in protection without toleranceQ46561871
Expression of interleukin-22 in rheumatoid arthritis: potential role as a proinflammatory cytokine.Q50485305
Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice.Q51037509
Expression of IL-17 homologs and their receptors in the synovial cells of rheumatoid arthritis patients.Q51474756
Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptidesQ24303817
The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivoQ24600773
A look at autoimmunity and inflammation in the eyeQ24623065
Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodelingQ24647357
Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation responseQ24648465
Interleukin-23 drives innate and T cell-mediated intestinal inflammationQ24677051
APC-derived cytokines and T cell polarization in autoimmune inflammationQ24679426
Th17 and regulatory T cells in mediating and restraining inflammationQ27687428
IL-17 and Th17 CellsQ27860566
Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature deathQ28199430
Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17Q28213628
Aryl hydrocarbon receptor-induced signals up-regulate IL-22 production and inhibit inflammation in the gastrointestinal tractQ28238242
The testis in immune privilegeQ28263610
Translational mini-review series on Th17 cells: are T helper 17 cells really pathogenic in autoimmunity?Q37632475
The Th17 immune response in renal inflammationQ37726972
Regulation of antitumor immune responses by the IL-12 family cytokines, IL-12, IL-23, and IL-27.Q37795583
T(H)17 cells in asthma and inflammationQ37840493
Critical role of the interleukin-23/T-helper 17 cell axis in the pathogenesis of psoriasisQ37986832
IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytesQ38329713
Involvement of corneal epithelial cells in the Th17 response in an in vitro bacterial inflammation model.Q39200064
Cyclosporin A inhibits the production of IL-17 by memory Th17 cells from healthy individuals and patients with rheumatoid arthritisQ39625191
Innate and adaptive interleukin-22 protects mice from inflammatory bowel diseaseQ39902875
The ups and downs of T cell costimulationQ40398747
The polymorphisms of interleukin 17A (IL17A) gene and its association with pediatric asthma in Taiwanese population.Q51827151
Up-regulation of IL-23p19 expression in rheumatoid arthritis synovial fibroblasts by IL-17 through PI3-kinase-, NF-kappaB- and p38 MAPK-dependent signalling pathways.Q52571431
Th22, but not Th17 might be a good index to predict the tissue involvement of systemic lupus erythematosus.Q53119004
The clinical role of IL-23p19 in patients with rheumatoid arthritis.Q53563550
Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease.Q53597450
Bimodal role of endogenous interleukin-6 in concanavalin A-induced hepatitis in mice.Q54064637
Regulation of the development of acute hepatitis by IL-23 through IL-22 and IL-17 production.Q54346247
An anti-IL-12p40 antibody down-regulates type 1 cytokines, chemokines, and IL-12/IL-23 in psoriasis.Q54580427
Interleukin-17 receptor deficiency results in impaired synovial expression of interleukin-1 and matrix metalloproteinases 3, 9, and 13 and prevents cartilage destruction during chronic reactivated streptococcal cell wall-induced arthritis.Q54638927
Differential roles for IFN- and IL-17 in experimental autoimmune uveoretinitisQ62735703
IL-23 and Th17 Cells Enhance Th2-Cell–mediated Eosinophilic Airway Inflammation in MiceQ62735710
Bacterial infection of the testis leading to autoaggressive immunity triggers apparently opposed responses of alpha beta and gamma delta T cellsQ71961225
The role of costimulatory molecules B7-1 and B7-2 in mice with experimental autoimmune uveoretinitisQ73133090
High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanismQ73458527
Regulation of Sertoli cell IL-1 and IL-6 production in vitroQ74027972
Amelioration of experimental autoimmune uveoretinitis by pretreatment with a pathogenic peptide in liposome and anti-CD40 ligand monoclonal antibodyQ74279718
Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synoviumQ77738643
IL-17-producing alveolar macrophages mediate allergic lung inflammation related to asthmaQ79675199
IL-17 plays an important role in the development of experimental autoimmune encephalomyelitisQ79755041
IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitisQ80139461
Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblastsQ81163296
Human immunodeficiency: connecting STAT3, Th17 and human mucosal immunityQ81681390
Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitisQ82136598
Requirement of IL-17RA in Con A induced hepatitis and negative regulation of IL-17 production in mouse T cellsQ82651499
Interleukin-22 is a negative regulator of the allergic responseQ83087817
IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasisQ83163682
Intratesticular expression of mRNAs of both interferon γ and tumor necrosis factor α is significantly increased in experimental autoimmune orchitis in miceQ83273220
Interleukin-17 acts independently of TNF-alpha under arthritic conditionsQ83276448
Differential changes in CD4+ and CD8+ effector and regulatory T lymphocyte subsets in the testis of rats undergoing autoimmune orchitisQ84058720
Blockade of interleukin-6 signaling suppresses experimental autoimmune uveoretinitis by the inhibition of inflammatory Th17 responsesQ84113692
Interleukin-22 promotes human hepatocellular carcinoma by activation of STAT3Q84365414
Critical role of interleukin-17/interleukin-17 receptor axis in mediating Con A-induced hepatitisQ84403800
The gene expression of type 17 T-helper cell-related cytokines in the urinary sediment of patients with systemic lupus erythematosusQ84579960
IL-17 in liver injury: an inflammatory issue?Q84984433
A genome-wide association study identifies IL23R as an inflammatory bowel disease geneQ28270603
TH17 cells in development: an updated view of their molecular identity and genetic programmingQ28276449
Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesions in a mouse modelQ28305960
Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicansQ28508646
IL-23 drives a pathogenic T cell population that induces autoimmune inflammationQ29547525
Unravelling the pathogenesis of inflammatory bowel diseaseQ29547551
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17Q29547855
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineagesQ29547871
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brainQ29614225
How regulatory T cells workQ29614262
IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cellsQ29616148
Development, cytokine profile and function of human interleukin 17-producing helper T cellsQ29617131
Functional diversity of helper T lymphocytesQ29619415
The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxinsQ29620097
Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitisQ29620481
Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosisQ29620506
IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injuryQ30437432
IL-17A inhibits the expansion of IL-17A-producing T cells in mice through "short-loop" inhibition via IL-17 receptorQ30439191
Notch signaling drives IL-22 secretion in CD4+ T cells by stimulating the aryl hydrocarbon receptor.Q33778205
Relevance of male accessory gland infection for subsequent fertility with special focus on prostatitisQ33785441
Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosisQ33862720
High in vivo expression of interleukin-17 receptor in synovial endothelial cells and chondrocytes from arthritis patients.Q33948104
Lineage commitment in the immune system: the T helper lymphocyte grows up.Q33970744
Controlling viral immuno-inflammatory lesions by modulating aryl hydrocarbon receptor signalingQ34102743
Dendritic cells facilitate accumulation of IL-17 T cells in the kidney following acute renal obstructionQ34170356
Immunologically privileged sitesQ34179710
Characterization of dermal dendritic cells in psoriasis. Autostimulation of T lymphocytes and induction of Th1 type cytokinesQ34234920
Increase in TNF-alpha and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a)Q34245272
Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cellsQ34299001
Incidence and prevalence of uveitis in Northern California; the Northern California Epidemiology of Uveitis StudyQ34305621
Characterization of lymphocytes in the adult rat testis by flow cytometry: effects of activin and transforming growth factor beta on lymphocyte subsets in vitroQ34464486
Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes.Q34474419
IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6Q34521302
Pseudomonas aeruginosa invades corneal epithelial cells during experimental infectionQ34534516
IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis.Q34572769
Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitisQ34575334
IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesisQ34577866
TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1.Q34579440
Serum levels of TNF-alpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severityQ34945351
Th17 and natural Treg cell population dynamics in systemic lupus erythematosusQ34978528
Bench to bedside: new approaches to the immunotherapy of uveitic diseaseQ34993229
Role of IL-17 and Th17 cells in herpes simplex virus-induced corneal immunopathology.Q35147745
IL-22-induced regulatory CD11b+ APCs suppress experimental autoimmune uveitisQ35399287
A proinflammatory role for interleukin-22 in the immune response to hepatitis B virusQ35420938
The role of Notch in tumorigenesis: oncogene or tumour suppressor?Q35564593
A T cell-dependent experimental liver injury in mice inducible by concanavalin AQ35603939
Anti-inflammatory role of IL-17 in experimental autoimmune uveitisQ35744691
Th17 cells in human disease.Q35820734
Interleukin-17 is a negative regulator of established allergic asthmaQ36228146
Tissue microcircumstances for leukocytic infiltration into the testis and epididymis in miceQ36235791
Immune privilege and inflammation of the testisQ36243991
Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammationQ36291657
Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responsesQ36294340
Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector categoryQ36537915
Regulation of inflammatory responses by IL-17FQ36639980
IL-17 disrupts corneal barrier following desiccating stress.Q36676135
Notch signalling during peripheral T-cell activation and differentiationQ36684906
Characterization of IL-17+ interphotoreceptor retinoid-binding protein-specific T cells in experimental autoimmune uveitisQ36938567
Minimally activated CD8 autoreactive T cells specific for IRBP express a high level of Foxp3 and are functionally suppressiveQ36959551
New perspectives on effector mechanisms in uveitisQ37101329
Chronic orchitis: a neglected cause of male infertility?Q37108723
Chronic epididymitis: impact on semen parameters and therapeutic optionsQ37108728
The IL-23/Th17 axis contributes to renal injury in experimental glomerulonephritisQ37181960
IL-23, not IL-12, directs autoimmunity to the Goodpasture antigenQ37181998
CD4+ T-regulatory cells: toward therapy for human diseases.Q37211300
Cutting edge: IL-23 receptor gfp reporter mice reveal distinct populations of IL-17-producing cellsQ37242180
A protective function for interleukin 17A in T cell-mediated intestinal inflammationQ37260173
Induction of Th17 differentiation by corneal epithelial-derived cytokinesQ37462911
Myeloid STAT3 inhibits T cell-mediated hepatitis by regulating T helper 1 cytokine and interleukin-17 productionQ37463756
Molecular dissection of psoriasis: integrating genetics and biologyQ37610764
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P921main subjectcellQ7868
inflammationQ101991
peptideQ172847
cytokineQ212354
lymphocyte subsetsQ66004891
hemic and immune systemsQ70202933
P304page(s)968549
P577publication date2013-07-14
P1433published inClinical and Developmental ImmunologyQ15754140
P1476titlePivotal roles of T-helper 17-related cytokines, IL-17, IL-22, and IL-23, in inflammatory diseases
P478volume2013

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