| scholarly article | Q13442814 |
| P50 | author | Marc Vidal | Q81911349 |
| P2093 | author name string | Michael E Cusick | |
| Song Yi | |||
| Benoit Charloteaux | |||
| Quan Zhong | |||
| Nidhi Sahni | |||
| Noor Jailkhani | |||
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| Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion | Q24337116 | ||
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| Splitting p63 | Q24632741 | ||
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| The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain | Q24673655 | ||
| A novel high-throughput (HTP) cloning strategy for site-directed designed chimeragenesis and mutation using the Gateway cloning system | Q24816500 | ||
| Protein-protein interactions and networks: forward and reverse edgetics. | Q54352505 | ||
| Mutation detection by a two-hybrid assay | Q59843183 | ||
| Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review | Q27008867 | ||
| ENU-induced mutation in the DNA-binding domain of KLF3 reveals important roles for KLF3 in cardiovascular development and function in mice | Q27321425 | ||
| A transforming mutation in the pleckstrin homology domain of AKT1 in cancer | Q27646556 | ||
| Mammalian Ras interacts directly with the serine/threonine kinase Raf | Q27860833 | ||
| Network biology: understanding the cell's functional organization | Q27861027 | ||
| Defining protein interactions with yeast actin in vivo | Q27934111 | ||
| A high resolution protein interaction map of the yeast Mediator complex | Q27936324 | ||
| Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins | Q28117120 | ||
| The two-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interest | Q28131694 | ||
| A protein interaction map of Drosophila melanogaster | Q28131783 | ||
| Assembly of Cell Regulatory Systems Through Protein Interaction Domains | Q28155799 | ||
| AnotherTWIST on Baller-Gerold syndrome | Q28213315 | ||
| Network modeling links breast cancer susceptibility and centrosome dysfunction | Q28252491 | ||
| Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1 | Q28272543 | ||
| Involvement of lipid rafts in nephrin phosphorylation and organization of the glomerular slit diaphragm | Q28350870 | ||
| Missense mutation in the second RNA binding domain reveals a role for Prkra (PACT/RAX) during skull development | Q28478412 | ||
| Three-dimensional reconstruction of protein networks provides insight into human genetic disease | Q28530021 | ||
| An ARF-Independent c-MYC-Activated Tumor Suppression Pathway Mediated by Ribosomal Protein-Mdm2 Interaction | Q28590794 | ||
| A map of the interactome network of the metazoan C. elegans | Q29547482 | ||
| Interactome networks and human disease | Q29615773 | ||
| Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease | Q29619085 | ||
| Characterization of disease-associated single amino acid polymorphisms in terms of sequence and structure properties. | Q30329486 | ||
| Loss of protein structure stability as a major causative factor in monogenic disease. | Q30351402 | ||
| Genotype-phenotype correlations in von Hippel-Lindau disease. | Q30357251 | ||
| Protein interactions in human genetic diseases. | Q30367185 | ||
| Cutaneous papillomavirus E6 oncoproteins associate with MAML1 to repress transactivation and NOTCH signaling | Q30419809 | ||
| Mass spectrometry supported determination of protein complex structure | Q30428635 | ||
| Automated yeast two-hybrid screening for nuclear receptor-interacting proteins | Q33209988 | ||
| Mutations that disrupt PHOXB interaction with the neuronal calcium sensor HPCAL1 impede cellular differentiation in neuroblastoma | Q33693337 | ||
| Variability in gene expression underlies incomplete penetrance | Q33717980 | ||
| 'Edgetic' perturbation of a C. elegans BCL2 ortholog | Q33832092 | ||
| Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer | Q34081324 | ||
| Genetic analysis of von Hippel-Lindau disease. | Q34098432 | ||
| Phenotype-genotype relationships in monogenic disease: lessons from the thalassaemias. | Q34205528 | ||
| An experimentally derived confidence score for binary protein-protein interactions | Q34292333 | ||
| Beyond hairballs: The use of quantitative mass spectrometry data to understand protein-protein interactions | Q34308163 | ||
| Viral perturbations of host networks reflect disease etiology | Q34325431 | ||
| Distilling pathophysiology from complex disease genetics | Q34574912 | ||
| High-throughput cloning and expression library creation for functional proteomics | Q34606151 | ||
| Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network | Q34676654 | ||
| Dynamic modularity in protein interaction networks predicts breast cancer outcome | Q34934057 | ||
| Prevalence of incompletely penetrant Huntington's disease alleles among individuals with major depressive disorder | Q35043972 | ||
| Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis | Q35168290 | ||
| Protein interactome reveals converging molecular pathways among autism disorders | Q35203610 | ||
| Structural basis of protein-protein interactions | Q35738224 | ||
| Human and mouse TPIT gene mutations cause early onset pituitary ACTH deficiency | Q35964450 | ||
| Cutaneous β-human papillomavirus E6 proteins bind Mastermind-like coactivators and repress Notch signaling. | Q36061599 | ||
| Comprehensive Analysis of Host Cellular Interactions with Human Papillomavirus E6 Proteins Identifies New E6 Binding Partners and Reflects Viral Diversity | Q36414593 | ||
| Proteomic approaches to the study of papillomavirus-host interactions. | Q36468283 | ||
| Domains, motifs, and scaffolds: the role of modular interactions in the evolution and wiring of cell signaling circuits. | Q36498348 | ||
| FAM111A mutations result in hypoparathyroidism and impaired skeletal development | Q36909275 | ||
| Missense substitutions in the GAS1 protein present in holoprosencephaly patients reduce the affinity for its ligand, SHH | Q36963707 | ||
| Dissecting disease inheritance modes in a three-dimensional protein network challenges the "guilt-by-association" principle | Q37010382 | ||
| Protein networks in disease | Q37125547 | ||
| Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways | Q37184407 | ||
| Literature-curated protein interaction datasets. | Q37196237 | ||
| Multimodal assessment of protein functional deficiency supports pathogenicity of BRCA1 p.V1688del | Q37356517 | ||
| How the Rb tumor suppressor structure and function was revealed by the study of Adenovirus and SV40. | Q37371276 | ||
| A model of developmental evolution: selection, pleiotropy and compensation. | Q37990117 | ||
| Interactome mapping for analysis of complex phenotypes: Insights from benchmarking binary interaction assays | Q38010411 | ||
| Human diseases through the lens of network biology | Q38065572 | ||
| Genotype to phenotype: lessons from model organisms for human genetics | Q38077445 | ||
| Altered RNA binding activity underlies abnormal thyroid hormone metabolism linked to a mutation in selenocysteine insertion sequence-binding protein 2. | Q38297793 | ||
| Evidence for Network Evolution in an Arabidopsis Interactome Map | Q38367823 | ||
| Predisposition to relapsing nephrotic syndrome by a nephrin mutation that interferes with assembly of functioning microdomains | Q39851276 | ||
| Edgetic perturbation models of human inherited disorders | Q42124353 | ||
| Phenotypes of patients with "simple" Mendelian disorders are complex traits: thresholds, modifiers, and systems dynamics | Q42576797 | ||
| High-quality binary interactome mapping | Q42858941 | ||
| The folding and evolution of multidomain proteins | Q47599342 | ||
| Exome and whole-genome sequencing for gene discovery: The future is now! | Q51620246 | ||
| A functional assay for heterozygous mutations in the GTPase activating protein related domain of the neurofibromatosis type 1 gene. | Q52511818 | ||
| P433 | issue | 6 | |
| P921 | main subject | phenotype | Q104053 |
| P304 | page(s) | 649-657 | |
| P577 | publication date | 2013-11-26 | |
| P1433 | published in | Current Opinion in Genetics & Development | Q13505684 |
| P1476 | title | Edgotype: a fundamental link between genotype and phenotype | |
| P478 | volume | 23 |
| Q28550391 | A Pan-Cancer Catalogue of Cancer Driver Protein Interaction Interfaces |
| Q30390381 | A Split-Ubiquitin Based Strategy Selecting for Protein Complex-Interfering Mutations |
| Q64102377 | A network-centric approach to drugging TNF-induced NF-κB signaling |
| Q47205509 | A systematic atlas of chaperome deregulation topologies across the human cancer landscape |
| Q28542982 | Analysis of individual protein regions provides novel insights on cancer pharmacogenomics |
| Q38899318 | Annexin A2 is SUMOylated on its N-terminal domain: regulation by insulin |
| Q28083558 | Applications of comparative evolution to human disease genetics |
| Q34117231 | Assemblages: functional units formed by cellular phase separation |
| Q47693396 | Base-resolution stratification of cancer mutations using functional variomics. |
| Q35789759 | Big-data-based edge biomarkers: study on dynamical drug sensitivity and resistance in individuals. |
| Q60922225 | Capturing variation impact on molecular interactions in the IMEx Consortium mutations data set |
| Q27305647 | Community structure analysis of transcriptional networks reveals distinct molecular pathways for early- and late-onset temporal lobe epilepsy with childhood febrile seizures |
| Q45943371 | Computer-aided biomarker discovery for precision medicine: data resources, models and applications. |
| Q64240621 | Convergent perturbation of the human domain-resolved interactome by viruses and mutations inducing similar disease phenotypes |
| Q41007754 | Diagnosing phenotypes of single-sample individuals by edge biomarkers |
| Q92643628 | Domain-mediated interactions for protein subfamily identification |
| Q104567478 | Dynamic 3D proteomes reveal protein functional alterations at high resolution in situ |
| Q92034887 | Estimating dispensable content in the human interactome |
| Q47285564 | Extended linkers improve the detection of PPIs by DHFR PCA in living cells |
| Q26773100 | Forward Individualized Medicine from Personal Genomes to Interactomes |
| Q39201399 | Functional variomics and network perturbation: connecting genotype to phenotype in cancer. |
| Q26774978 | Fundamentals of protein interaction network mapping |
| Q89238692 | Gene Regulatory Network Perturbation by Genetic and Epigenetic Variation |
| Q35549685 | Genetic perturbations that impair functional trait interactions lead to reduced bone strength and increased fragility in mice |
| Q38797075 | Genetics of Combined Pituitary Hormone Deficiency: Roadmap into the Genome Era. |
| Q35951692 | Genome and network visualization facilitates the analyses of the effects of drugs and mutations on protein-protein and drug-protein networks |
| Q28607523 | Hand/foot splitting and the 're-evolution' of mesopodial skeletal elements during the evolution and radiation of chameleons |
| Q50017200 | Identification of novel diagnostic biomarkers for thyroid carcinoma |
| Q31038202 | Identifying network-based biomarkers of complex diseases from high-throughput data |
| Q102220241 | Inferring the molecular and phenotypic impact of amino acid variants with MutPred2 |
| Q90478903 | Integrating molecular networks with genetic variant interpretation for precision medicine |
| Q38887068 | MSX1 mutations and associated disease phenotypes: genotype-phenotype relations |
| Q36946554 | Modular transcriptional repertoire and MicroRNA target analyses characterize genomic dysregulation in the thymus of Down syndrome infants |
| Q36214423 | PCAN: phenotype consensus analysis to support disease-gene association |
| Q40384986 | PPIXpress: construction of condition-specific protein interaction networks based on transcript expression |
| Q64986488 | Pathway-specific protein domains are predictive for human diseases. |
| Q35203134 | Protein domain-level landscape of cancer-type-specific somatic mutations |
| Q64967550 | Protein ensembles link genotype to phenotype. |
| Q35824701 | Protein-protein interactions as drug targets |
| Q35941833 | Quantitative interactome analysis reveals a chemoresistant edgotype |
| Q64077530 | RMut: R package for a Boolean sensitivity analysis against various types of mutations |
| Q90426893 | RNA Polymerase II CTD phosphatase Rtr1 fine-tunes transcription termination |
| Q42781142 | Reasoning over genetic variance information in cause-and-effect models of neurodegenerative diseases |
| Q87863250 | Regulome networks and mutational landscape in liver cancer: An informative path to precision medicine |
| Q103002632 | Single-cell network biology for resolving cellular heterogeneity in human diseases |
| Q52658141 | Systematic Functional Annotation of Somatic Mutations in Cancer. |
| Q61450671 | Systematic domain-based aggregation of protein structures highlights DNA-, RNA- and other ligand-binding positions |
| Q30584192 | Systematic exploration of ubiquitin sequence, E1 activation efficiency, and experimental fitness in yeast |
| Q33976813 | Systems biology and the analysis of genetic variation |
| Q37712293 | The cancer cell map initiative: defining the hallmark networks of cancer |
| Q28573050 | The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network |
| Q35684524 | Tumor characterization and stratification by integrated molecular profiles reveals essential pan-cancer features |
| Q35743304 | Unravelling personalized dysfunctional gene network of complex diseases based on differential network model |
| Q30367833 | Viewing protein fitness landscapes through a next-gen lens. |
| Q28771729 | Widespread macromolecular interaction perturbations in human genetic disorders |
| Q48221341 | dSysMap: exploring the edgetic role of disease mutations |
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