Constitutive activity in the angiotensin II type 1 receptor: discovery and applications

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Constitutive activity in the angiotensin II type 1 receptor: discovery and applications is …
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scholarly articleQ13442814

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P356DOI10.1016/B978-0-12-417197-8.00006-7
P932PMC publication ID7500102
P698PubMed publication ID24931196

P2093author name stringHamiyet Unal
Sadashiva S Karnik
P2860cites workMechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II.Q44898088
Angiotensin II type 1-receptor activating antibodies in renal-allograft rejectionQ45259438
Angiotensin II type-1 receptor activation in the adult heart causes blood pressure-independent hypertrophy and cardiac dysfunctionQ47399226
Mutation of Asn111 in the third transmembrane domain of the AT1A angiotensin II receptor induces its constitutive activation.Q52523512
Angiotensin II partly mediates mechanical stress-induced cardiac hypertrophyQ71888300
The active state of the AT1 angiotensin receptor is generated by angiotensin II inductionQ71955400
Somatic mutations of the angiotensin II (AT1) receptor gene are not present in aldosterone-producing adenomaQ73047836
AT(1) receptor agonistic antibodies from preeclamptic patients cause vascular cells to express tissue factorQ73815485
The constitutively active N111G-AT1 receptor for angiotensin II maintains a high affinity conformation despite being uncoupled from its cognate G protein Gq/11alphaQ73910130
Role of aromaticity of agonist switches of angiotensin II in the activation of the AT1 receptorQ74583639
Manifold active-state conformations in GPCRs: agonist-activated constitutively active mutant AT1 receptor preferentially couples to Gq compared to the wild-type AT1 receptorQ80324798
Angiotensin II AT1 receptor constitutive activation: from molecular mechanisms to pathophysiologyQ82863752
Mechanism of GPCR-directed autoantibodies in diseasesQ84371824
Differential bonding interactions of inverse agonists of angiotensin II type 1 receptor in stabilizing the inactive stateQ24652998
International union of pharmacology. XXIII. The angiotensin II receptorsQ28138041
The two-state model of receptor activationQ28288075
The angiotensin II AT1 receptor structure-activity correlations in the light of rhodopsin structureQ28297667
TM2-TM7 interaction in coupling movement of transmembrane helices to activation of the angiotensin II type-1 receptorQ28569124
Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitroQ28570955
The structure and function of G-protein-coupled receptorsQ29616792
Systematic identification of mutations that constitutively activate the angiotensin II type 1A receptor by screening a randomly mutated cDNA library with an original pharmacological bioassayQ30878932
Analysis of transmembrane domains 1 and 4 of the human angiotensin II AT1 receptor by cysteine-scanning mutagenesisQ33593826
Ligand-specific conformation of extracellular loop-2 in the angiotensin II type 1 receptorQ33855316
Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteinsQ34306079
G protein-coupled receptors sense fluid shear stress in endothelial cellsQ35108277
Renal proximal tubule angiotensin AT1A receptors regulate blood pressureQ35395110
Angiotensinergic stimulation of vascular endothelium in mice causes hypotension, bradycardia, and attenuated angiotensin response.Q35539793
Potential roles of angiotensin receptor-activating autoantibody in the pathophysiology of preeclampsiaQ35681821
Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant miceQ35701236
Gain-of-function mutant of angiotensin II receptor, type 1A, causes hypertension and cardiovascular fibrosis in miceQ35839992
Pleiotropic AT1 receptor signaling pathways mediating physiological and pathogenic actions of angiotensin II.Q36248631
Historical review: Negative efficacy and the constitutive activity of G-protein-coupled receptors.Q36301820
A novel mechanism of mechanical stress-induced angiotensin II type 1-receptor activation without the involvement of angiotensin II.Q37018675
Progression of cardiovascular damage: the role of renin-angiotensin system blockadeQ37681732
The treatment of cardiovascular disease continuum: focus on prevention and RAS blockadeQ37692452
Cardiovascular rhythms and cardiac baroreflex sensitivity in AT(1A) receptor gain-of-function mutant mice.Q39894702
Expression of constitutively active angiotensin receptors in the rostral ventrolateral medulla increases blood pressureQ40291500
Down-regulation of inositol 1,4,5-trisphosphate receptor in cells stably expressing the constitutively active angiotensin II N111G-AT(1) receptorQ40521821
Constitutive internalization of constitutively active agiotensin II AT(1A) receptor mutants is blocked by inverse agonistsQ40765666
The conformational change responsible for AT1 receptor activation is dependent upon two juxtaposed asparagine residues on transmembrane helices III and VII.Q41127850
Peptide and nonpeptide antagonist interaction with constitutively active human AT1 receptorsQ42439737
Mechanism of constitutive activation of the AT1 receptor: influence of the size of the agonist switch binding residue Asn(111).Q42464925
Assessment of homologous internalization of constitutively active N111G mutant of AT(1) receptorQ42479133
Agonist-induced phosphorylation of the angiotensin II (AT(1A)) receptor requires generation of a conformation that is distinct from the inositol phosphate-signaling stateQ42482690
Molecular mechanisms of constitutive activity: mutations at position 111 of the angiotensin AT1 receptorQ42485190
Agonist-independent constitutive activity of angiotensin II receptor promotes cardiac remodeling in miceQ42501397
The fifth transmembrane domain of angiotensin II Type 1 receptor participates in the formation of the ligand-binding pocket and undergoes a counterclockwise rotation upon receptor activationQ42948753
Constitutive activation of angiotensin II type 1 receptor alters the orientation of transmembrane Helix-2.Q43976244
AT1 receptor agonistic antibodies from preeclamptic patients stimulate NADPH oxidaseQ44385661
P304page(s)155-174
P577publication date2014-01-01
P1433published inAdvances in PharmacologyQ15753809
P1476titleConstitutive activity in the angiotensin II type 1 receptor: discovery and applications
P478volume70

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cites work (P2860)
Q26779600Angiotensin Receptors: Structure, Function, Signaling and Clinical Applications
Q90599535Autoantibodies against AT1 Receptor Contribute to Vascular Aging and Endothelial Cell Senescence
Q89394623Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog
Q48044912Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury
Q33653375Influence of antihypertensive drugs on aortic and coronary effects of Ang-(1-7) in pressure-overloaded rats.
Q36241932International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin Receptors: Interpreters of Pathophysiological Angiotensinergic Stimuli [corrected].
Q64227997Mechanism of Hormone Peptide Activation of a GPCR: Angiotensin II Activated State of ATR Initiated by van der Waals Attraction
Q92568655Severe food restriction activates the central renin angiotensin system
Q36443983Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin Receptor
Q36335687Structural basis for selectivity and diversity in angiotensin II receptors
Q35592165Structure of the Angiotensin receptor revealed by serial femtosecond crystallography.
Q35999775Structure-Function Basis of Attenuated Inverse Agonism of Angiotensin II Type 1 Receptor Blockers for Active-State Angiotensin II Type 1 Receptor
Q47233799The CARMA3-Bcl10-MALT1 Signalosome Drives NF-κB Activation and Promotes Aggressiveness in Angiotensin II Receptor-positive Breast Cancer

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