RNA binding proteins: a common denominator of neuronal function and dysfunction

scientific article published on 24 June 2014

RNA binding proteins: a common denominator of neuronal function and dysfunction is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S12264-014-1443-7
P932PMC publication ID5562623
P698PubMed publication ID24962082
P5875ResearchGate publication ID263395218

P50authorEpaminondas DoxakisQ90778883
P2093author name stringEpaminondas Doxakis
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Stress granule assembly is mediated by prion-like aggregation of TIA-1Q24559953
Neuronal Elav-like (Hu) proteins regulate RNA splicing and abundance to control glutamate levels and neuronal excitabilityQ24601827
RNA-binding protein HuR autoregulates its expression by promoting alternative polyadenylation site usageQ24609537
Patterns of variant polyadenylation signal usage in human genesQ24624061
Eukaryotic stress granules are cleared by autophagy and Cdc48/VCP functionQ24629019
Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brainQ24629850
ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear importQ24630100
FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autismQ24631425
The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicingQ24631683
Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALSQ24633692
A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTDQ24634583
A direct role for FMRP in activity-dependent dendritic mRNA transport links filopodial-spine morphogenesis to fragile X syndrome.Q24644826
HITS-CLIP yields genome-wide insights into brain alternative RNA processingQ24648963
Proliferating cells express mRNAs with shortened 3' untranslated regions and fewer microRNA target sitesQ24653978
Dynamic integration of splicing within gene regulatory pathwaysQ26852632
Functional interplay between RNA-binding protein HuR and microRNAsQ26865793
TDP-43-mediated neuron loss in vivo requires RNA-binding activityQ27321280
Alternative isoform regulation in human tissue transcriptomesQ27861118
Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomesQ28114892
The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding proteinQ28117885
Local functions for FMRP in axon growth cone motility and activity-dependent regulation of filopodia and spine synapsesQ28118799
Tissue specific expression of FMR-1 provides evidence for a functional role in fragile X syndromeQ48351859
Reduced extinction of hippocampal-dependent memories in CPEB knockout miceQ48665716
Activity-dependent expression of RNA binding protein HuD and its association with mRNAs in neuronsQ48939998
A hierarchy of Hu RNA binding proteins in developing and adult neuronsQ52195067
Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal deathQ52537887
Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR.Q52894285
Hu proteins regulate polyadenylation by blocking sites containing U-rich sequencesQ53586436
An activity-dependent switch to cap-independent translation triggered by eIF4E dephosphorylationQ57042159
Immunological and pathological study of anti-Ri-associated encephalopathyQ57256469
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Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosisQ28131672
The spliceosome: design principles of a dynamic RNP machineQ28131809
Identification of an RNA binding specificity for the potential splicing factor TLSQ28138875
Protein misfolding, evolution and diseaseQ28143452
Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9Q28208568
Proto-oncoprotein TLS/FUS is associated to the nuclear matrix and complexed with splicing factors PTB, SRm160, and SR proteinsQ28208722
Protein folding and misfoldingQ28235199
Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosisQ28236796
Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6Q28236805
TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factorQ28261458
Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skippingQ28269954
Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndromeQ28273791
Domain architectures and characterization of an RNA-binding protein, TLSQ28276007
Survival motor neuron protein facilitates assembly of stress granulesQ28276466
Fragile X mental retardation protein: nucleocytoplasmic shuttling and association with somatodendritic ribosomesQ28303541
Involvement of Hu and heterogeneous nuclear ribonucleoprotein K in neuronal differentiation through p21 mRNA post-transcriptional regulationQ28304276
Dendrites of mammalian neurons contain specialized P-body-like structures that respond to neuronal activationQ28304355
Tar DNA Binding Protein-43 (TDP-43) Associates with Stress Granules: Analysis of Cultured Cells and Pathological Brain TissueQ28475724
CPEB3 and CPEB4 in neurons: analysis of RNA-binding specificity and translational control of AMPA receptor GluR2 mRNAQ28507871
A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicingQ28512596
Selective modulation of some forms of schaffer collateral-CA1 synaptic plasticity in mice with a disruption of the CPEB-1 geneQ28513435
The neuronal RNA-binding protein Nova-2 is implicated as the autoantigen targeted in POMA patients with dementiaQ28513858
Dendritic localization of the RNA-binding protein HuD in hippocampal neurons: association with polysomes and upregulation during contextual learningQ28564874
Cytoplasmic polyadenylation element-like sequences are involved in dendritic targeting of BDNF mRNA in hippocampal neuronsQ28564937
CPEB-mediated cytoplasmic polyadenylation and the regulation of experience-dependent translation of alpha-CaMKII mRNA at synapsesQ28574713
Protein kinase C stimulates HuD‐mediated mRNA stability and protein expression of neurotrophic factors and enhances dendritic maturation of hippocampal neurons in cultureQ28575286
Increase of the RNA-binding protein HuD and posttranscriptional up-regulation of the GAP-43 gene during spatial memoryQ28578336
Activity-dependent expression of ELAV/Hu RBPs and neuronal mRNAs in seizure and cocaine brainQ28583125
Nova-1 regulates neuron-specific alternative splicing and is essential for neuronal viabilityQ28586051
The FXG: a presynaptic fragile X granule expressed in a subset of developing brain circuitsQ28588310
Dendritic localization of the translational repressor Pumilio 2 and its contribution to dendritic stress granulesQ28590022
mRNA turnover rate limits siRNA and microRNA efficacyQ28914778
Signatures of RNA binding proteins globally coupled to effective microRNA target sitesQ28914779
NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure.Q29347260
Internal initiation of translation of five dendritically localized neuronal mRNAsQ34492771
HuD Promotes BDNF Expression in Brain Neurons via Selective Stabilization of the BDNF Long 3′UTR mRNAQ34576914
Anti-Ri: an antibody associated with paraneoplastic opsoclonus and breast cancer.Q34619192
Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43.Q34982074
TDP-43 is recruited to stress granules in conditions of oxidative insult.Q35003958
Gene structure prediction and alternative splicing analysis using genomically aligned ESTsQ35032875
Reversible Inhibition of PSD-95 mRNA Translation by miR-125a, FMRP Phosphorylation, and mGluR SignalingQ35047447
Compromised paraspeckle formation as a pathogenic factor in FUSopathiesQ35066217
Hu proteins regulate alternative splicing by inducing localized histone hyperacetylation in an RNA-dependent mannerQ35202794
Two previously undescribed members of the mouse CPEB family of genes and their inducible expression in the principal cell layers of the hippocampusQ35234990
Expression of 24,426 human alternative splicing events and predicted cis regulation in 48 tissues and cell linesQ35399488
Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stabilityQ35562869
The tetranucleotide UCAY directs the specific recognition of RNA by the Nova K-homology 3 domainQ35746259
A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neuronsQ35855671
Neuron-specific ELAV/Hu proteins suppress HuR mRNA during neuronal differentiation by alternative polyadenylationQ35860663
Dendritically targeted Bdnf mRNA is essential for energy balance and response to leptinQ35891912
Function of RNA-binding protein Musashi-1 in stem cellsQ36144910
ELAV mediates 3' UTR extension in the Drosophila nervous systemQ36331360
Mammalian ELAV-like neuronal RNA-binding proteins HuB and HuC promote neuronal development in both the central and the peripheral nervous systemsQ36438588
An alternative mode of microRNA target recognitionQ36522819
The RNA-binding protein HuD: a regulator of neuronal differentiation, maintenance and plasticityQ36574657
Neuronal RNA granules: movers and makersQ36597037
RNA-binding ability of FUS regulates neurodegeneration, cytoplasmic mislocalization and incorporation into stress granules associated with FUS carrying ALS-linked mutationsQ36626888
Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAsQ36650975
Circumstances and mechanisms of inhibition of translation by secondary structure in eucaryotic mRNAsQ36796132
MicroRNA-125a represses cell growth by targeting HuR in breast cancerQ36819807
Distinct role of long 3' UTR BDNF mRNA in spine morphology and synaptic plasticity in hippocampal neuronsQ36856173
Defining a neuron: neuronal ELAV proteinsQ36967781
miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levelsQ37068662
Rescuing Z+ agrin splicing in Nova null mice restores synapse formation and unmasks a physiologic defect in motor neuron firingQ37096623
Principles of miRNA-target regulation in metazoan modelsQ37139161
Synaptic vesicle protein trafficking at the glutamate synapse.Q37160079
Progressive lengthening of 3' untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development.Q37160188
Diverse molecular functions of Hu proteinsQ37200596
Pre-mRNA splicing: awash in a sea of proteinsQ29547272
Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencingQ29547470
Alzheimer's disease is a synaptic failureQ29547670
Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogelsQ29614781
RINGO/cdk1 and CPEB mediate poly(A) tail stabilization and translational regulation by ePAB.Q30442890
FUS binds the CTD of RNA polymerase II and regulates its phosphorylation at Ser2.Q30456334
A mouse model of the human Fragile X syndrome I304N mutationQ30484632
Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6Q30492839
Overexpression of human wild-type FUS causes progressive motor neuron degeneration in an age- and dose-dependent fashionQ30532680
Differential repression of alternative transcripts: a screen for miRNA targetsQ30815465
Reprogramming of 3' untranslated regions of mRNAs by alternative polyadenylation in generation of pluripotent stem cells from different cell typesQ33520920
TDP-43 is a developmentally regulated protein essential for early embryonic developmentQ33673895
The Neuronal Splicing Factor Nova Co-Localizes with Target RNAs in the DendriteQ33797879
Splicing factor and exon profiling across human tissuesQ33871191
Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLSQ33889532
Age-related decline in chaperone-mediated autophagyQ33901509
Organization of the human gene encoding heterogeneous nuclear ribonucleoprotein type I (hnRNP I) and characterization of hnRNP I related pseudogene.Q33920730
The RNA-binding protein HuD regulates neuronal cell identity and maturation.Q33934348
Posttranscriptional regulation of gene expression in learning by the neuronal ELAV-like mRNA-stabilizing proteins.Q33944818
CPEB: a life in translationQ34003974
Alternative cleavage and polyadenylation: extent, regulation and functionQ34037217
Interaction with polyglutamine aggregates reveals a Q/N-rich domain in TDP-43.Q34074385
N-methyl-D-aspartate receptor signaling results in Aurora kinase-catalyzed CPEB phosphorylation and alpha CaMKII mRNA polyadenylation at synapsesQ34078959
Distinct 3'UTRs differentially regulate activity-dependent translation of brain-derived neurotrophic factor (BDNF).Q34115778
TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy.Q34131994
Trapping of messenger RNA by Fragile X Mental Retardation protein into cytoplasmic granules induces translation repressionQ34157806
Paraneoplastic syndromes associated with anti-Hu antibodiesQ34246190
Nova2 regulates neuronal migration through an RNA switch in disabled-1 signalingQ34250045
The neurobiology of the opsoclonus-myoclonus syndromeQ34253108
Contrasting pathology of the stress granule proteins TIA-1 and G3BP in tauopathiesQ34281671
Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granulesQ34308339
A conserved family of elav-like genes in vertebratesQ34344417
G-quartet-dependent recognition between the FMRP RGG box and RNA.Q34365357
Symplekin and xGLD-2 are required for CPEB-mediated cytoplasmic polyadenylationQ34369092
miRNA regulons associated with synaptic functionQ34446986
Alternative polyadenylation variants of the RNA binding protein, HuR: abundance, role of AU-rich elements and auto-RegulationQ37235358
A physical and functional link between splicing factors promotes pre-mRNA 3' end processingQ37298592
TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicityQ37339064
A molecular circuit composed of CPEB-1 and c-Jun controls growth hormone-mediated synaptic plasticity in the mouse hippocampusQ37352402
Defects in synapse structure and function precede motor neuron degeneration in Drosophila models of FUS-related ALS.Q37381821
Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAsQ37491595
Biochemical evidence for the association of fragile X mental retardation protein with brain polyribosomal ribonucleoparticlesQ37513552
Prion neurodegeneration: starts and stops at the synapseQ37627087
Alternative pre-mRNA splicing in neurons: growing up and extending its reachQ37649232
Spatially restricting gene expression by local translation at synapsesQ37715121
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease.Q37811131
The complex world of post-transcriptional mechanisms: is their deregulation a common link for diseases? Focus on ELAV-like RNA-binding proteinsQ37930474
RNA dysregulation in diseases of motor neurons.Q37950454
Regulated protein aggregation: stress granules and neurodegenerationQ38060891
TARDBP and FUS mutations associated with amyotrophic lateral sclerosis: summary and updateQ38096349
Emerging complexity of the HuD/ELAVl4 gene; implications for neuronal development, function, and dysfunctionQ38122142
Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB.Q38341668
Mislocalised FUS mutants stall spliceosomal snRNPs in the cytoplasmQ39176818
ALS-associated ataxin 2 polyQ expansions enhance stress-induced caspase 3 activation and increase TDP-43 pathological modificationsQ39319522
Specificity of RNA Binding by CPEB: Requirement for RNA Recognition Motifs and a Novel Zinc FingerQ39574182
Characterizing the RNA targets and position-dependent splicing regulation by TDP-43.Q39584699
S6K1 phosphorylates and regulates fragile X mental retardation protein (FMRP) with the neuronal protein synthesis-dependent mammalian target of rapamycin (mTOR) signaling cascadeQ39627495
A functional human Poly(A) site requires only a potent DSE and an A-rich upstream sequence.Q39722557
Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.Q39761567
Identification and analysis of the human neural polypyrimidine tract binding protein (nPTB) gene promoter region.Q40400706
Fragile X mental retardation protein is associated with translating polyribosomes in neuronal cells.Q40524276
The mRNA stability factor HuR inhibits microRNA-16 targeting of COX-2.Q40531440
Polypyrimidine tract binding protein modulates efficiency of polyadenylation.Q40815645
A point mutation in the FMR-1 gene associated with fragile X mental retardationQ41579799
Absence of expression of the FMR-1 gene in fragile X syndromeQ41669091
Widespread binding of FUS along nascent RNA regulates alternative splicing in the brainQ41955381
FUS regulates genes coding for RNA-binding proteins in neurons by binding to their highly conserved intronsQ42146718
Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptionsQ42246467
Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complexQ42255765
Cytoplasmic polyadenylation element binding protein-dependent protein synthesis is regulated by calcium/calmodulin-dependent protein kinase II.Q42462537
Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS).Q46226347
The RNA binding protein TLS is translocated to dendritic spines by mGluR5 activation and regulates spine morphology.Q46409672
Human, Drosophila, and C.elegans TDP43: nucleic acid binding properties and splicing regulatory functionQ46434717
Bidirectional regulation of cytoplasmic polyadenylation element-binding protein phosphorylation by Ca2+/calmodulin-dependent protein kinase II and protein phosphatase 1 during hippocampal long-term potentiation.Q46535544
Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behaviorQ47071494
Cytoplasmic polyadenylation element binding protein 1-mediated mRNA translation in Purkinje neurons is required for cerebellar long-term depression and motor coordinationQ48136862
Associative and spatial learning and memory deficits in transgenic mice overexpressing the RNA-binding protein HuD.Q48329865
Abnormal TDP-43 expression is identified in the neocortex in cases of dementia pugilistica, but is mainly confined to the limbic system when identified in high and moderate stages of Alzheimer's diseaseQ48332804
P433issue4
P304page(s)610-626
P577publication date2014-06-24
P1433published inNeuroscience BulletinQ15764540
P1476titleRNA binding proteins: a common denominator of neuronal function and dysfunction
P478volume30

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