| scholarly article | Q13442814 |
| P2093 | author name string | Chi Wai Eric So | |
| Maria Teresa Esposito | |||
| P2860 | cites work | DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formation | Q21144955 |
| Role of the polycomb repressive complex 2 in acute promyelocytic leukemia | Q24309258 | ||
| Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions | Q24318843 | ||
| The role of FLT3 in haematopoietic malignancies | Q24319174 | ||
| Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro | Q24321787 | ||
| The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway | Q24336089 | ||
| Overexpression of human RAD51 and RAD52 reduces double-strand break-induced homologous recombination in mammalian cells | Q24555124 | ||
| XRCC3 promotes homology-directed repair of DNA damage in mammalian cells | Q24597771 | ||
| The DNA-damage response in human biology and disease | Q24606586 | ||
| FLT3-ITD-TKD dual mutants associated with AML confer resistance to FLT3 PTK inhibitors and cytotoxic agents by overexpression of Bcl-x(L). | Q27824823 | ||
| Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy | Q27860519 | ||
| hDOT1L links histone methylation to leukemogenesis | Q27935809 | ||
| Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase | Q28131711 | ||
| DNA double-strand breaks: signaling, repair and the cancer connection | Q28204231 | ||
| Role of the histone deacetylase complex in acute promyelocytic leukaemia | Q28263534 | ||
| Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis | Q28274000 | ||
| Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells | Q28288970 | ||
| Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile | Q28294205 | ||
| Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age | Q28505636 | ||
| Panobinostat enhances cytarabine and daunorubicin sensitivities in AML cells through suppressing the expression of BRCA1, CHK1, and Rad51 | Q28535006 | ||
| Characterisation of the promoter region of the human DNA-repair gene Rad51 | Q28611391 | ||
| MLL translocations, histone modifications and leukaemia stem-cell development | Q29615368 | ||
| Base-excision repair of oxidative DNA damage | Q29615373 | ||
| FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress | Q29615562 | ||
| DNA repair pathways as targets for cancer therapy | Q29615572 | ||
| Increased risk of acute myeloid leukaemia due to polymorphisms in detoxification and DNA repair enzymes | Q80970138 | ||
| TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome | Q83080803 | ||
| RAD51 and XRCC3 polymorphisms: impact on the risk and treatment outcomes of de novo inv(16) or t(16;16)/CBFβ-MYH11(+) acute myeloid leukemia | Q83375774 | ||
| DNA damage response in adult stem cells: pathways and consequences | Q83389981 | ||
| RAD51 and XRCC3 gene polymorphisms and the risk of developing acute myeloid leukemia | Q84496513 | ||
| SnapShot: Acute myeloid leukemia | Q85444163 | ||
| Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia | Q29615735 | ||
| Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia | Q29616211 | ||
| ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis | Q29617340 | ||
| Functional connection between Rad51 and PML in homology-directed repair | Q31037336 | ||
| Genomic polymorphisms provide prognostic information in intermediate-risk acute myeloblastic leukemia. | Q33235067 | ||
| PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites | Q33306325 | ||
| Retinoic acid and arsenic trioxide for acute promyelocytic leukemia | Q33409020 | ||
| Oncogene-induced reactive oxygen species fuel hyperproliferation and DNA damage response activation | Q33580123 | ||
| Wild-type H- and N-Ras promote mutant K-Ras-driven tumorigenesis by modulating the DNA damage response | Q33778215 | ||
| Microsatellite instability is not a defining genetic feature of acute myeloid leukemogenesis in adults: results of a retrospective study of 132 patients and review of the literature | Q33949925 | ||
| Genomic DNA breakpoints in AML1/RUNX1 and ETO cluster with topoisomerase II DNA cleavage and DNase I hypersensitive sites in t(8;21) leukemia. | Q34016369 | ||
| Bmi1 regulates mitochondrial function and the DNA damage response pathway | Q34017298 | ||
| Acute myeloid leukemia outcome: role of nucleotide excision repair polymorphisms in intermediate risk patients | Q34052352 | ||
| The genotype distribution of the XRCC1 gene indicates a role for base excision repair in the development of therapy-related acute myeloblastic leukemia | Q34155718 | ||
| EZH2 protein: a promising immunomarker for the detection of hepatocellular carcinomas in liver needle biopsies | Q34165364 | ||
| Spontaneous DNA damage, genome instability, and cancer--when DNA replication escapes control. | Q34175345 | ||
| Chromosomal aberrations in Bloom syndrome patients with myeloid malignancies | Q34309000 | ||
| Cells expressing FLT3/ITD mutations exhibit elevated repair errors generated through alternative NHEJ pathways: implications for genomic instability and therapy | Q34450478 | ||
| How nucleotide excision repair protects against cancer | Q34568150 | ||
| MLL-AF9 and MLL-ENL alter the dynamic association of transcriptional regulators with genes critical for leukemia | Q34571591 | ||
| Overexpression of Rad51 protein stimulates homologous recombination and increases resistance of mammalian cells to ionizing radiation | Q34669076 | ||
| DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis | Q35083276 | ||
| shRNA screening identifies JMJD1C as being required for leukemia maintenance | Q35087190 | ||
| An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway | Q35682245 | ||
| The p21Waf1 pathway is involved in blocking leukemogenesis by the t(8;21) fusion protein AML1-ETO. | Q35828623 | ||
| Polycomb repressive complex 2 is required for MLL-AF9 leukemia | Q35882496 | ||
| Werner's syndrome and acute myeloid leukemia | Q35911293 | ||
| Promyelocytic leukemia nuclear bodies support a late step in DNA double-strand break repair by homologous recombination | Q35914635 | ||
| Fanconi anemia and leukemia: tracking the genes | Q35920580 | ||
| Evaluation of checkpoint kinase targeting therapy in acute myeloid leukemia with complex karyotype | Q36009717 | ||
| Model for MLL translocations in therapy-related leukemia involving topoisomerase IIβ-mediated DNA strand breaks and gene proximity | Q36061440 | ||
| Acute myeloid leukemia with a complex aberrant karyotype is a distinct biological entity characterized by genomic imbalances and a specific gene expression profile | Q36104615 | ||
| p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced death | Q36445874 | ||
| A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification | Q36447915 | ||
| The multifaceted mismatch-repair system | Q36448284 | ||
| Multiple mixed lineage leukemia (MLL) fusion proteins suppress p53-mediated response to DNA damage | Q40430768 | ||
| Inhibition of Chk1 by activated PKB/Akt. | Q40563144 | ||
| Variant XRCC3 implicated in cancer is functional in homology-directed repair of double-strand breaks | Q40728591 | ||
| Increased error-prone non homologous DNA end-joining--a proposed mechanism of chromosomal instability in Bloom's syndrome | Q40736242 | ||
| A role for PML and the nuclear body in genomic stability | Q40905918 | ||
| Topoisomerase II inhibitors induce DNA double-strand breaks at a specific site within the AML1 locus | Q41119522 | ||
| Oncogenic transcription factors in the human acute leukemias | Q41628889 | ||
| Oncogenic K-ras cooperates with PML-RAR alpha to induce an acute promyelocytic leukemia-like disease. | Q42082533 | ||
| NHEJ and its backup pathways in chromosomal translocations | Q42714738 | ||
| Acute leukemia in children with Down syndrome | Q42739970 | ||
| Overcoming treatment resistance in acute promyelocytic leukemia and beyond | Q42962705 | ||
| Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials. | Q43102402 | ||
| OGG1 is a novel prognostic indicator in acute myeloid leukaemia | Q43214271 | ||
| Ras-induced reactive oxygen species promote growth factor-independent proliferation in human CD34+ hematopoietic progenitor cells | Q43223170 | ||
| Constitutive activation of the DNA damage signaling pathway in acute myeloid leukemia with complex karyotype: potential importance for checkpoint targeting therapy. | Q43258053 | ||
| Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells | Q43734888 | ||
| Inhibition of Chk1-dependent G2 DNA damage checkpoint radiosensitizes p53 mutant human cells | Q43800235 | ||
| XRCC1 Arg399Gln variation and leukemia susceptibility: evidence from 2,647 cases and 5,518 controls | Q44094234 | ||
| Increased error-prone NHEJ activity in myeloid leukemias is associated with DNA damage at sites that recruit key nonhomologous end-joining proteins | Q44408414 | ||
| Polymorphisms in genes involved in homologous recombination repair interact to increase the risk of developing acute myeloid leukemia | Q44854704 | ||
| Genetic variation in XPD predicts treatment outcome and risk of acute myeloid leukemia following chemotherapy. | Q45038571 | ||
| Direct involvement of the small GTPase Rac in activation of the superoxide-producing NADPH oxidase Nox1. | Q45345920 | ||
| The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells | Q45375299 | ||
| Chromosomal instability syndromes are sensitive to poly ADP-ribose polymerase inhibitors | Q46436813 | ||
| DNA topoisomerase II in therapy-related acute promyelocytic leukemia. | Q46437040 | ||
| Forced homo-oligomerization of RARalpha leads to transformation of primary hematopoietic cells | Q46940626 | ||
| MLL genomic breakpoint distribution within the breakpoint cluster region in de novo leukemia in children | Q47691731 | ||
| Genetic polymorphisms of RAD51 and XRCC3 and acute myeloid leukemia risk: a meta-analysis | Q47698173 | ||
| Homologous pairing promoted by the human Rad52 protein | Q49236959 | ||
| The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia. | Q50335773 | ||
| High risk of leukemia after short-term dose-intensive chemotherapy in young patients with solid tumors. | Q50866450 | ||
| XRCC1 Arg194Trp and Arg399Gln polymorphisms are significantly associated with shorter survival in acute myeloid leukemia. | Q51004249 | ||
| DNA damage response and inflammatory signaling limit the MLL-ENL-induced leukemogenesis in vivo. | Q53173236 | ||
| BRCA2-dependent and independent formation of RAD51 nuclear foci. | Q53939630 | ||
| Combined genetic and transcriptional profiling of acute myeloid leukemia with normal and complex karyotypes | Q58861922 | ||
| Polymorphisms in human homeobox HLX1 and DNA repair RAD51 genes increase the risk of therapy-related acute myeloid leukemia | Q60428769 | ||
| Microsatellite instability occurs in defined subsets of patients with acute myeloblastic leukaemia | Q60428780 | ||
| Recruitment of RXR by Homotetrameric RARα Fusion Proteins Is Essential for Transformation | Q61818562 | ||
| Reactive oxygen species, DNA damage, and error-prone repair: a model for genomic instability with progression in myeloid leukemia? | Q64387821 | ||
| A single nucleotide polymorphism in the 5' untranslated region of RAD51 and risk of cancer among BRCA1/2 mutation carriers | Q74459364 | ||
| Microsatellite instability and p53 mutations are associated with abnormal expression of the MSH2 gene in adult acute leukemia | Q77974873 | ||
| High level of microsatellite instability but not hypermethylation of mismatch repair genes in therapy-related and secondary acute myeloid leukaemia and myelodysplastic syndrome | Q77999595 | ||
| Chemotherapy-related secondary leukemias: A role for DNA repair by error-prone non-homologous end joining in topoisomerase II - Induced chromosomal rearrangements | Q79595709 | ||
| Preferential loss of mismatch repair function in refractory and relapsed acute myeloid leukemia: potential contribution to AML progression | Q80567383 | ||
| Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l | Q36730426 | ||
| PARP1 is required for chromosomal translocations. | Q36873293 | ||
| Myelodysplastic syndrome: an inability to appropriately respond to damaged DNA? | Q37060144 | ||
| Poly(ADP-ribose) polymerase inhibitor ABT-888 potentiates the cytotoxic activity of temozolomide in leukemia cells: influence of mismatch repair status and O6-methylguanine-DNA methyltransferase activity | Q37089235 | ||
| Microsatellite instability induced mutations in DNA repair genes CtIP and MRE11 confer hypersensitivity to poly (ADP-ribose) polymerase inhibitors in myeloid malignancies | Q37144872 | ||
| Mouse models of human AML accurately predict chemotherapy response | Q37152257 | ||
| Genomic instability in myeloid malignancies: increased reactive oxygen species (ROS), DNA double strand breaks (DSBs) and error-prone repair | Q37158105 | ||
| Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: potential for therapy of myeloid leukemia and myelodysplastic syndromes | Q37175571 | ||
| The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation | Q37200691 | ||
| Impairment of p53 acetylation, stability and function by an oncogenic transcription factor | Q37258978 | ||
| PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination. | Q37334922 | ||
| p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage | Q37342444 | ||
| DNA-damage response in tissue-specific and cancer stem cells | Q37826528 | ||
| Do reactive oxygen species play a role in myeloid leukemias? | Q37852492 | ||
| Transcriptional and epigenetic networks in haematological malignancy | Q37863271 | ||
| Mixed lineage leukemia protein in normal and leukemic stem cells | Q38100107 | ||
| End-joining, translocations and cancer | Q38113932 | ||
| Gene-expression profiling identifies distinct subclasses of core binding factor acute myeloid leukemia | Q38301992 | ||
| Identification of a molecular signature for leukemic promyelocytes and their normal counterparts: Focus on DNA repair genes. | Q38309335 | ||
| Acute myeloid leukemia fusion proteins deregulate genes involved in stem cell maintenance and DNA repair | Q38347126 | ||
| From genotype to phenotype: correlating XRCC1 polymorphisms with mutagen sensitivity | Q38351985 | ||
| Methylation of the hMLH1 promoter and its association with microsatellite instability in acute myeloid leukemia. | Q38358667 | ||
| Loss of genetic material is more common than gain in acute myeloid leukemia with complex aberrant karyotype: a detailed analysis of 125 cases using conventional chromosome analysis and fluorescence in situ hybridization including 24-color FISH. | Q38487721 | ||
| Addiction of t(8;21) and inv(16) acute myeloid leukemia to native RUNX1. | Q39093568 | ||
| Pim kinases phosphorylate Chk1 and regulate its functions in acute myeloid leukemia | Q39142229 | ||
| Expression of leukemia-associated fusion proteins increases sensitivity to histone deacetylase inhibitor-induced DNA damage and apoptosis | Q39174421 | ||
| The prognostic impact of 17p (p53) deletion in 2272 adults with acute myeloid leukemia | Q40009452 | ||
| Internal tandem duplication of FLT3 (FLT3/ITD) induces increased ROS production, DNA damage, and misrepair: implications for poor prognosis in AML. | Q40025562 | ||
| Evidence that a mutation in the MLH1 3'-untranslated region confers a mutator phenotype and mismatch repair deficiency in patients with relapsed leukemia | Q40040874 | ||
| Protein arginine-methyltransferase-dependent oncogenesis | Q40077054 | ||
| Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly(ADP-ribose)-dependent pathway in the early response to DNA-damaging agents | Q40146768 | ||
| DNA repair contributes to the drug-resistant phenotype of primary acute myeloid leukaemia cells with FLT3 internal tandem duplications and is reversed by the FLT3 inhibitor PKC412. | Q40215417 | ||
| Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. | Q40252270 | ||
| MLL chimeric protein activation renders cells vulnerable to chromosomal damage: an explanation for the very short latency of infant leukemia | Q40281320 | ||
| Forced retinoic acid receptor alpha homodimers prime mice for APL-like leukemia | Q40317782 | ||
| P433 | issue | 6 | |
| P921 | main subject | leukemia | Q29496 |
| acute myeloid leukemia | Q264118 | ||
| pathogenesis | Q372016 | ||
| DNA damage | Q5205747 | ||
| P304 | page(s) | 545-561 | |
| P577 | publication date | 2014-08-12 | |
| P1433 | published in | Chromosoma | Q15765851 |
| P1476 | title | DNA damage accumulation and repair defects in acute myeloid leukemia: implications for pathogenesis, disease progression, and chemotherapy resistance | |
| P478 | volume | 123 |
| Q39510346 | A Phase 1 Study of the PARP Inhibitor Veliparib in Combination with Temozolomide in Acute Myeloid Leukemia |
| Q52764412 | A Small-Molecule Inhibitor of WEE1, AZD1775, Synergizes with Olaparib by Impairing Homologous Recombination and Enhancing DNA Damage and Apoptosis in Acute Leukemia. |
| Q26995561 | Aberrant nuclear factor-kappa B activity in acute myeloid leukemia: from molecular pathogenesis to therapeutic target |
| Q47132650 | DNA damage in acute myeloid leukemia patients of Northern Mexico |
| Q47808353 | Depletion of SIRT6 enzymatic activity increases acute myeloid leukemia cells' vulnerability to DNA-damaging agents. |
| Q46624842 | Distinct signaling events promote resistance to mitoxantrone and etoposide in pediatric AML: a Children's Oncology Group report |
| Q38785380 | Emerging cell cycle inhibitors for acute myeloid leukemia |
| Q39942266 | Genetic variants involved in oxidative stress, base excision repair, DNA methylation, and folate metabolism pathways influence myeloid neoplasias susceptibility and prognosis |
| Q37170575 | High expression of S100A8 gene is associated with drug resistance to etoposide and poor prognosis in acute myeloid leukemia through influencing the apoptosis pathway |
| Q38736981 | INPP4B-mediated DNA repair pathway confers resistance to chemotherapy in acute myeloid leukemia |
| Q38694866 | Identifying high-risk adult AML patients: epigenetic and genetic risk factors and their implications for therapy. |
| Q91801399 | Inhibition of the mutated c-KIT kinase in AML1-ETO-positive leukemia cells restores sensitivity to PARP inhibitor |
| Q89777211 | MLL-AF9 leukemias are sensitive to PARP1 inhibitors combined with cytotoxic drugs |
| Q36577713 | RECQ helicases are deregulated in hematological malignancies in association with a prognostic value |
| Q38817669 | Synthetic lethal targeting of oncogenic transcription factors in acute leukemia by PARP inhibitors |
| Q33855938 | Taking a Bad Turn: Compromised DNA Damage Response in Leukemia |
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