Lung cell-specific modulation of LPS-induced TLR4 receptor and adaptor localization

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Lung cell-specific modulation of LPS-induced TLR4 receptor and adaptor localization is …
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scholarly articleQ13442814

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P356DOI10.4161/CIB.29053
P932PMC publication ID4134348
P698PubMed publication ID25136402
P5875ResearchGate publication ID264903160

P2093author name stringCordula Stamme
Vicky Sender
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Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4Q28589222
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CD14 controls the LPS-induced endocytosis of Toll-like receptor 4Q28594101
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Ras-related protein Rab10 facilitates TLR4 signaling by promoting replenishment of TLR4 onto the plasma membraneQ34068630
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Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M.Q34997280
Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis.Q35034255
Surfactant protein D increases fusion of Mycobacterium tuberculosis-containing phagosomes with lysosomes in human macrophagesQ35220382
TLR4-dependent GM-CSF protects against lung injury in Gram-negative bacterial pneumonia.Q35850226
LPS-stimulated cytokine production in type I cells is modulated by the renin-angiotensin systemQ35987136
Immunoregulatory functions of surfactant proteinsQ35998804
Pulmonary surfactant protein A and surfactant lipids upregulate IRAK-M, a negative regulator of TLR-mediated inflammation in human macrophagesQ36312347
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Persistence of LPS-induced lung inflammation in surfactant protein-C-deficient miceQ37596427
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Adenylyl cyclase 6 activation negatively regulates TLR4 signaling through lipid raft-mediated endocytosis.Q39064219
Looped host defense peptide CLP-19 binds to microtubules and inhibits surface expression of TLR4 on mouse macrophagesQ39153023
The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulationQ39378070
Pulmonary collectins protect macrophages against pore-forming activity of Legionella pneumophila and suppress its intracellular growthQ39432028
Pulmonary surfactant protein A enhances endolysosomal trafficking in alveolar macrophages through regulation of Rab7.Q39605567
The antimicrobial peptide cathelicidin enhances activation of lung epithelial cells by LPS.Q39669320
Surfactant lipids regulate LPS-induced interleukin-8 production in A549 lung epithelial cells by inhibiting translocation of TLR4 into lipid raft domainsQ39817903
Tetraspanin CD9 negatively regulates lipopolysaccharide-induced macrophage activation and lung inflammationQ39856948
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Role of Toll-like receptor 4 in gram-positive and gram-negative pneumonia in mice.Q40469729
Response of human pulmonary epithelial cells to lipopolysaccharide involves Toll-like receptor 4 (TLR4)-dependent signaling pathways: evidence for an intracellular compartmentalization of TLR4.Q40619554
Differences in LPS-induced activation of bronchial epithelial cells (BEAS-2B) and type II-like pneumocytes (A-549).Q40709151
Soluble CD14 participates in the response of cells to lipopolysaccharideQ41593480
Macrophage dysfunction and susceptibility to pulmonary Pseudomonas aeruginosa infection in surfactant protein C-deficient miceQ41847916
Mice genetically hyporesponsive to lipopolysaccharide (LPS) exhibit a defect in endocytic uptake of LPS and ceramideQ41976871
The Asp299Gly polymorphism alters TLR4 signaling by interfering with recruitment of MyD88 and TRIF.Q42431559
Pulmonary surfactant protein A regulates TLR expression and activity in human macrophagesQ42436985
Expression of functional toll-like receptor-2 and -4 on alveolar epithelial cells.Q42459176
Severe pneumonia mortality in elderly patients is associated with downregulation of Toll-like receptors 2 and 4 on monocytesQ43842687
Mediators of innate immune recognition of bacteria concentrate in lipid rafts and facilitate lipopolysaccharide-induced cell activationQ44015062
Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injuryQ44231448
Gene expression of Toll-like receptors and associated molecules induced by inflammatory stimuli in the primary alveolar macrophageQ44451024
Toll-like receptor 4 mediates innate immune responses to Haemophilus influenzae infection in mouse lungQ45882366
Pulmonary surfactant: functions and molecular composition.Q46027561
Expression of toll-like receptor 2 and 4 in lipopolysaccharide-induced lung injury in mouseQ46497808
The MyD88-dependent, but not the MyD88-independent, pathway of TLR4 signaling is important in clearing nontypeable haemophilus influenzae from the mouse lungQ47706271
Priming of alveolar macrophages upon instillation of lipopolysaccharide in the human lungQ47783138
Cutting edge: myeloid differentiation factor 88 is essential for pulmonary host defense against Pseudomonas aeruginosa but not Staphylococcus aureus.Q47992063
Lateral diffusion of Toll-like receptors reveals that they are transiently confined within lipid rafts on the plasma membraneQ50097740
Essential role of MD-2 in LPS responsiveness and TLR4 distributionQ50109313
Glia maturation factor-gamma is preferentially expressed in microvascular endothelial and inflammatory cells and modulates actin cytoskeleton reorganization.Q53608532
The inflammatory versus constitutive trafficking of mononuclear phagocytes into the alveolar space of mice is associated with drastic changes in their gene expression profiles.Q53665387
The critical role of hematopoietic cells in lipopolysaccharide-induced airway inflammation.Q53875945
The development of early host response to Pseudomonas aeruginosa lung infection is critically dependent on myeloid differentiation factor 88 in mice.Q54701109
Toll-like receptor mRNA levels in alveolar macrophages after inhalation of endotoxinQ61601195
Potential role of membrane internalization and vesicle fusion in adhesion of neutrophils in response to lipopolysaccharide and TNFQ71860188
CD14-dependent lipopolysaccharide-induced beta-defensin-2 expression in human tracheobronchial epitheliumQ73959879
Innate immune recognition of bacterial lipopolysaccharide: dependence on interactions with membrane lipids and endocytic movementQ74760805
Toll/IL-1R domain-containing adaptor protein (TIRAP) is a critical mediator of antibacterial defense in the lung against Klebsiella pneumoniae but not Pseudomonas aeruginosaQ79755032
A role of Toll-IL-1 receptor domain-containing adaptor-inducing IFN-beta in the host response to Pseudomonas aeruginosa lung infection in miceQ79803397
Impaired phospholipases A₂production by stimulated macrophages from patients with acute respiratory distress syndromeQ84521031
Host defence during Klebsiella pneumonia relies on haematopoietic-expressed Toll-like receptors 4 and 2Q84586444
P921main subjecttoll-like receptorQ408004
P304page(s)e29053
P577publication date2014-05-16
P1433published inCommunicative & integrative biologyQ27722161
P1476titleLung cell-specific modulation of LPS-induced TLR4 receptor and adaptor localization
P478volume7