Endocytosis as a mode to regulate functional expression of two-pore domain potassium (K₂p) channels

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Endocytosis as a mode to regulate functional expression of two-pore domain potassium (K₂p) channels is …
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scholarly articleQ13442814
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P6179Dimensions Publication ID1000437521
P356DOI10.1007/S00424-014-1641-9
P932PMC publication ID4428836
P698PubMed publication ID25413469
P5875ResearchGate publication ID268795391

P2093author name stringIta O'Kelly
P2860cites workCaveolae as plasma membrane sensors, protectors and organizers.Q38076024
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Calcineurin selectively docks with the dynamin Ixb splice variant to regulate activity-dependent bulk endocytosisQ38263859
Acid sensitive background potassium channels K2P3.1 and K2P9.1 undergo rapid dynamin-dependent endocytosisQ38794005
Distinct recycling of active and inactive β1 integrinsQ39417083
ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangementsQ21632356
Separation of membrane trafficking and actin remodeling functions of ARF6 with an effector domain mutantQ22254679
A Novel Two-pore Domain K+ Channel, TRESK, Is Localized in the Spinal CordQ24302058
p11, an annexin II subunit, an auxiliary protein associated with the background K+ channel, TASK-1Q24305279
Forward Transport of K2p3.1: mediation by 14-3-3 and COPI, modulation by p11.Q52582531
SNAREs and trafficQ56850814
Clathrin-associated adaptor protein complexesQ58450863
Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotypeQ60710783
Expression and insights on function of potassium channel TWIK-1 in mouse kidneyQ80386188
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Macropinocytosis inhibitors and Arf6 regulate ErbB3 nuclear localization in prostate cancer cellsQ39570673
ADP-ribosylation factor 6 regulates mu-opioid receptor trafficking and signaling via activation of phospholipase D2.Q39814761
ARF6-GTP recruits Nm23-H1 to facilitate dynamin-mediated endocytosis during adherens junctions disassemblyQ40687876
Mechanisms of signal-mediated protein sorting in the endocytic and secretory pathways.Q41157071
TREK-1, a K+ channel involved in polymodal pain perceptionQ41962937
Palmitoylation of the 5-hydroxytryptamine4a receptor regulates receptor phosphorylation, desensitization, and beta-arrestin-mediated endocytosisQ42042378
Arf6, Rab11 and transferrin receptor define distinct populations of recycling endosomes.Q42904996
N-glycosylation-dependent control of functional expression of background potassium channels K2P3.1 and K2P9.1.Q43118904
Nerve growth factor-induced endocytosis of TWIK-related acid-sensitive K⁺ 1 channels in adrenal medullary cells and PC12 cellsQ43459702
Activation of protein kinase C epsilon inhibits the two-pore domain K+ channel, TASK-1, inducing repolarization abnormalities in cardiac ventricular myocytesQ44927182
Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradationQ46065440
Identification and characterization of a new class of trafficking motifs for controlling clathrin-independent internalization and recyclingQ46152012
ARF6 directs axon transport and traffic of integrins and regulates axon growth in adult DRG neurons.Q47336105
Serotonin inhibits neuronal excitability by activating two-pore domain k+ channels in the entorhinal cortexQ48192116
Mtap2 is a constituent of the protein network that regulates twik-related K+ channel expression and trafficking.Q48478462
Intracellular traffic of the K+ channels TASK-1 and TASK-3: role of N- and C-terminal sorting signals and interaction with 14-3-3 proteinsQ48729332
Does sumoylation control K2P1/TWIK1 background K+ channels?Q48785878
Formation of functional heterodimers between the TASK-1 and TASK-3 two-pore domain potassium channel subunitsQ48873005
Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signalingQ24307989
TASK, a human background K+ channel to sense external pH variations near physiological pHQ24314854
The autosomal recessive hypercholesterolemia (ARH) protein interfaces directly with the clathrin-coat machineryQ24321718
TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structureQ24323355
Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptorQ24534474
Role of adaptor complex AP-3 in targeting wild-type and mutated CD63 to lysosomesQ24548353
Interaction with 14-3-3 proteins promotes functional expression of the potassium channels TASK-1 and TASK-3Q24641890
Inhibition of the human two-pore domain potassium channel, TREK-1, by fluoxetine and its metabolite norfluoxetineQ24670560
ARF6 controls post-endocytic recycling through its downstream exocyst complex effectorQ24672390
ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type IgammaQ24675779
The syntaxinsQ24806291
Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design.Q27324635
Inhalational anesthetics activate two-pore-domain background K+ channelsQ28143765
Potassium leak channels and the KCNK family of two-P-domain subunitsQ28205333
Forward transport. 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signalsQ28215227
Biophysical, pharmacological, and functional characteristics of cloned and native mammalian two-pore domain K+ channelsQ28237667
The two-pore domain K+ channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurinQ28246530
NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptorQ28254985
Kinase-regulated quantal assemblies and kiss-and-run recycling of caveolaeQ28260294
The acid-sensitive, anesthetic-activated potassium leak channel, KCNK3, is regulated by 14-3-3β-dependent, protein kinase C (PKC)-mediated endocytic trafficking.Q28272135
Molecular background of leak K+ currents: two-pore domain potassium channelsQ28279763
Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cellsQ28286215
The neuronal background K2P channels: focus on TREK1Q28294077
TASK-3, a new member of the tandem pore K(+) channel familyQ28374393
The structure, function and distribution of the mouse TWIK-1 K+ channelQ28508997
The retention factor p11 confers an endoplasmic reticulum-localization signal to the potassium channel TASK-1Q28568568
ARF6-dependent interaction of the TWIK1 K+ channel with EFA6, a GDP/GTP exchange factor for ARF6Q28588384
AKAP150, a switch to convert mechano-, pH- and arachidonic acid-sensitive TREK K(+) channels into open leak channelsQ28592333
Regulated portals of entry into the cellQ29547391
Signals for sorting of transmembrane proteins to endosomes and lysosomesQ29547469
Mechanisms of endocytosisQ29547609
Molecular mechanism and physiological functions of clathrin-mediated endocytosisQ29615660
Retrograde transport from endosomes to the trans-Golgi networkQ29617826
Pathways of clathrin-independent endocytosisQ29620660
Palmitoylation of protease-activated receptor-1 regulates adaptor protein complex-2 and -3 interaction with tyrosine-based motifs and endocytic sortingQ36890670
Nonclassical, distinct endocytic signals dictate constitutive and PKC-regulated neurotransmitter transporter internalizationQ37004113
The dopamine transporter constitutively internalizes and recycles in a protein kinase C-regulated manner in stably transfected PC12 cell lines.Q37004117
Two-pore potassium channels in the cardiovascular systemQ37151974
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodelingQ37223988
Endosome protein sorting: motifs and machineryQ37251848
Emerging roles for centromeres in meiosis I chromosome segregationQ37256638
VPS10P-domain receptors - regulators of neuronal viability and function.Q37323348
Sorting of lysosomal proteinsQ37338623
The contribution of TWIK-1 channels to astrocyte K(+) current is limited by retention in intracellular compartmentsQ37377591
The ARH adaptor protein regulates endocytosis of the ROMK potassium secretory channel in mouse kidneyQ37403077
Two-pore domain k(+) channels and their role in chemoreceptionQ37702933
From the background to the spotlight: TASK channels in pathological conditions.Q37763279
Trafficking of neuronal two pore domain potassium channelsQ37848077
Retrograde transport: two (or more) roads diverged in an endosomal tree?Q37861301
Endocytosis and signalingQ37862859
Migraine: Role of the TRESK two-pore potassium channelQ37920204
Membrane trafficking and signaling: two sides of the same coinQ37956473
TRESK: the lone ranger of two-pore domain potassium channelsQ37960749
Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: structures, functions and roles in diseaseQ37968311
A single common portal for clathrin-mediated endocytosis of distinct cargo governed by cargo-selective adaptorsQ30478248
Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomesQ30486673
ARF1 and ARF4 regulate recycling endosomal morphology and retrograde transport from endosomes to the Golgi apparatusQ30542954
Cooperative endocytosis of the endosomal SNARE protein syntaxin-8 and the potassium channel TASK-1.Q30580577
A hydrophobic barrier deep within the inner pore of the TWIK-1 K2P potassium channelQ30584146
TASK-3, a novel tandem pore domain acid-sensitive K+ channel. An extracellular histiding as pH sensorQ31625560
Molecular bases for the recognition of tyrosine-based sorting signalsQ33648614
Caveolae, ion channels and cardiac arrhythmiasQ33720799
Molecular and functional properties of two-pore-domain potassium channels.Q33923164
ARF6 is required for growth factor- and rac-mediated membrane ruffling in macrophages at a stage distal to rac membrane targetingQ33960616
Transport at the recycling endosomeQ34020964
Endocytosis without clathrin coatsQ34092223
Clathrin-independent endocytosis: a cargo-centric viewQ34149489
An effector domain mutant of Arf6 implicates phospholipase D in endosomal membrane recyclingQ34298393
A regulatory role for ARF6 in receptor-mediated endocytosisQ34318574
Cargo recognition in clathrin-mediated endocytosisQ34382206
Sumoylation silences the plasma membrane leak K+ channel K2P1.Q34410181
Phosphatidylinositol-(4,5)-bisphosphate regulates sorting signal recognition by the clathrin-associated adaptor complex AP2.Q34421459
SNAREs and trafficQ34436096
Clathrin-protein interactionsQ34744199
Kv11.1 (ERG1) K+ channels localize in cholesterol and sphingolipid enriched membranes and are modulated by membrane cholesterolQ34809832
Intracellular sorting and transport of proteinsQ35131675
Adaptor protein complex-2 (AP-2) and epsin-1 mediate protease-activated receptor-1 internalization via phosphorylation- and ubiquitination-dependent sorting signals.Q35562523
Molecular regulations governing TREK and TRAAK channel functions.Q35693711
The TREK K2P channels and their role in general anaesthesia and neuroprotectionQ35921675
Sorting nexins--unifying trends and new perspectivesQ36000866
Common principles in clathrin-mediated sorting at the Golgi and the plasma membraneQ36142770
Do GGA adaptors bind internal DXXLL motifs?Q36236508
ADP-ribosylation factor 6 regulates a novel plasma membrane recycling pathwayQ36273935
Dynamics of endocytic vesicle creation.Q36300385
Phosphatidylinositol 4,5-bisphosphate and Arf6-regulated membrane traffic.Q36376901
Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasisQ36391968
Palmitoylation controls recycling in lysosomal sorting and traffickingQ36407241
Clathrin-independent endocytosis: from nonexisting to an extreme degree of complexityQ36471204
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P921main subjectinorganic compoundQ190065
membrane proteinQ423042
potassiumQ703
transport proteinQ2111029
protein transportQ14860325
P304page(s)1133-1142
P577publication date2014-11-22
2015-05-01
P1433published inPfluegers ArchivQ1091689
P1476titleEndocytosis as a mode to regulate functional expression of two-pore domain potassium (K₂p) channels
P478volume467

Reverse relations

cites work (P2860)
Q38384425Much more than a leak: structure and function of K₂p-channels
Q36050237TASK-1 Regulates Apoptosis and Proliferation in a Subset of Non-Small Cell Lung Cancers
Q38307741The role of protein-protein interactions in the intracellular traffic of the potassium channels TASK-1 and TASK-3.

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