Role of a major autoepitope in forming the DNA binding site of the p70 (Ku) antigen

scientific article published on June 1, 1992

Role of a major autoepitope in forming the DNA binding site of the p70 (Ku) antigen is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1084/JEM.175.6.1677
P953full work available at URLhttps://europepmc.org/articles/PMC2119251
https://europepmc.org/articles/PMC2119251?pdf=render
P932PMC publication ID2119251
P698PubMed publication ID1375268
P5875ResearchGate publication ID277485502

P2093author name stringJ. Wang
C. H. Chou
W. H. Reeves
M. W. Knuth
P2860cites workProtein-DNA recognitionQ22065421
The autoantigen Ku is indistinguishable from NF IV, a protein forming multimeric protein-DNA complexesQ24682674
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activityQ26778490
A repressor (MAT alpha 2 Product) and its operator control expression of a set of cell type specific genes in yeastQ27935499
The B-cell-specific Oct-2 protein contains POU box- and homeo box-type domainsQ28114875
Cloning and characterization of a cDNA that encodes a 70-kDa novel human thyroid autoantigenQ28116539
The protein Id: a negative regulator of helix-loop-helix DNA binding proteinsQ28237471
Purification and characterization of proximal sequence element-binding protein 1, a transcription activating protein related to Ku and TREF that binds the proximal sequence element of the human U1 promoterQ28253961
The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene productsQ28293090
Empirical Predictions of Protein ConformationQ28300310
Molecular cloning of cDNA encoding the p70 (Ku) lupus autoantigenQ35131599
Human autoantibody-reactive epitopes of SS-B/La are highly conserved in comparison with epitopes recognized by murine monoclonal antibodiesQ36354257
Assembly of the mitochondrial membrane system. CBP6, a yeast nuclear gene necessary for synthesis of cytochrome b.Q36422894
DNA recognition by proteins with the helix-turn-helix motifQ37943261
Nuclear proteins TREF1 and TREF2 bind to the transcriptional control element of the transferrin receptor gene and appear to be associated as a heterodimerQ38343243
Characterization of a high molecular weight acidic nuclear protein recognized by autoantibodies in sera from patients with polymyositis-scleroderma overlapQ40684049
Identification of nuclear factor IV/Ku autoantigen in a human 2D-gel protein database. Modification of the large subunit depends on cellular proliferationQ41687144
Purification and characterization of Ku-2, an octamer-binding protein related to the autoantigen Ku.Q41695337
Characterization of the 70kDa component of the human Ku autoantigen expressed in insect cell nuclei using a recombinant baculovirus vectorQ42073049
Antigenic determinants of the Ku (p70/p80) autoantigen are poorly conserved between speciesQ42830339
Binding of a simian virus 40 T antigen-related protein to DNAQ44167079
I-POU: a POU-domain protein that inhibits neuron-specific gene activationQ44430992
A general method for rapid site-directed mutagenesis using the polymerase chain reaction.Q48247178
The presence of an antigen reactive with a human autoantibody in Trichosia pubescens (Diptera: Sciaridae) and its association with certain transcriptionally active regions of the genome.Q52449901
Purification of an 86-70 kDa nuclear DNA-associated protein complex.Q53864064
The POU domain is a bipartite DNA-binding structureQ58990231
Epitopes of the p70 and p80 (Ku) lupus autoantigensQ67687079
Ku polypeptides synthesized in vitro assemble into complexes which recognize ends of double-stranded DNAQ67728079
Antinuclear antibodies as probes to explore the structural organization of the genomeQ68825266
Mechanism of interaction between Ku protein and DNAQ70144316
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectnuclear antigensQ76742702
DNA helicaseQ106939956
P304page(s)1677-1684
P577publication date1992-06-01
P1433published inJournal of Experimental MedicineQ3186912
P1476titleRole of a major autoepitope in forming the DNA binding site of the p70 (Ku) antigen
P478volume175

Reverse relations

cites work (P2860)
Q64386695Accumulation of Ku70 at DNA double-strand breaks in living epithelial cells
Q40029447Accumulation of Ku80 proteins at DNA double-strand breaks in living cells
Q35134487Advances in B-cell epitope analysis of autoantigens in connective tissue diseases
Q40898008Asymmetric nature of two subunits of RAD18, a RING-type ubiquitin ligase E3, in the human RAD6A-RAD18 ternary complex.
Q22010847Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity
Q36436250Autoantibodies to intracellular autoantigens and their B-cell epitopes: molecular probes to study the autoimmune response.
Q36362953Autoimmunity and apoptosis
Q35092331Autoimmunity to nucleosomes related to viral infection: a focus on hapten-carrier complex formation
Q41191958Characterization of a Ku86 variant protein that results in altered DNA binding and diminished DNA-dependent protein kinase activity
Q34746959Complementation of the ionizing radiation sensitivity, DNA end binding, and V(D)J recombination defects of double-strand break repair mutants by the p86 Ku autoantigen
Q64386670Computational studies on full-length Ku70 with DNA duplexes: base interactions and a helical path
Q36887381Defining the minimal domain of Ku80 for interaction with Ku70.
Q41072582Double-strand break repair by Ku70 requires heterodimerization with Ku80 and DNA binding functions
Q34719669Epstein-Barr virus-induced autoimmune responses. II. Immunoglobulin G autoantibodies to mimicking and nonmimicking epitopes. Presence in autoimmune disease
Q78791290Evidence implicating Ku antigen as a structural factor in RNA polymerase II-mediated transcription
Q73877076Functional properties of the separate subunits of human DNA helicase II/Ku autoantigen
Q73881371Identification of a functional CT-element in the Phytophthora infestans piypt1 gene promoter
Q31942819Identification of estrogen-induced genes downregulated by AhR agonists in MCF-7 breast cancer cells using suppression subtractive hybridization.
Q39265275In vivo association of Ku with mammalian origins of DNA replication
Q40790661Inhibition of Ku heterodimer DNA end binding activity during granulocytic differentiation of human promyelocytic cell lines
Q28608946Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids
Q22009460Isolation of Ku70-binding proteins (KUBs)
Q36380622Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination In vivo
Q34804030Ku80 removal from DNA through double strand break-induced ubiquitylation
Q42127065Ku80-deleted cells are defective at base excision repair
Q24548851Mapping of protein-protein interactions within the DNA-dependent protein kinase complex
Q36560927Modulation of thermal induction of hsp70 expression by Ku autoantigen or its individual subunits
Q41551864Murine monoclonal antibodies specific for conserved and non-conserved antigenic determinants of the human and murine Ku autoantigens
Q40401377Production and characterization of recombinant human Ku antigen
Q36562433Protein-protein and protein-DNA interaction regions within the DNA end-binding protein Ku70-Ku86.
Q36825322Random phage mimotopes recognized by monoclonal antibodies against the pyruvate dehydrogenase complex-E2 (PDC-E2).
Q71785541Relationship between estrogen structure and conformational changes in estrogen receptor/DNA complexes
Q36475735Role of Ku70 and Bax in epigallocatechin-3-gallate-induced apoptosis of A549 cells in vivo
Q72180517Similar DNA binding properties of free P70 (KU) subunit and P70/P80 heterodimer
Q27634006Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
Q41263744The DNA-dependent protein kinase, DNA-PK: 10 years and no ends in sight
Q42599202The role of the SAP motif in promoting Holliday junction binding and resolution by SpCCE1.
Q40372175What to do at an end: DNA double-strand-break repair

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