What to do at an end: DNA double-strand-break repair

scientific article published on October 1995

What to do at an end: DNA double-strand-break repair is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/S0168-9525(00)89121-0
P698PubMed publication ID7482764

P2093author name stringWeaver DT
P2860cites workHuman DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigenQ24336453
Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombinationQ28115740
DNA-dependent kinase (p350) as a candidate gene for the murine SCID defectQ28307262
Bcl-2 expression promotes B- but not T-lymphoid development in scid miceQ28508352
Immunolocalization of Ku-proteins (p80/p70): localization of p70 to nucleoli and periphery of both interphase nuclei and metaphase chromosomesQ28574093
The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigenQ28608938
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumoursQ29547697
Tumor spectrum analysis in p53-mutant miceQ29617436
Cell cycle control and cancerQ29617536
p53 is required for radiation-induced apoptosis in mouse thymocytesQ29620281
Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation.Q34320792
Unexpected effects of the severe combined immunodeficiency mutation on murine lymphomagenesisQ36231592
A DNA end-binding factor involved in double-strand break repair and V(D)J recombinationQ36657203
Studies on mammalian mutants defective in rejoining double-strand breaks in DNA.Q37939692
Role of a major autoepitope in forming the DNA binding site of the p70 (Ku) antigenQ38328506
Functional complementation in mouse-human radiation hybrids assigns the putative murine scid gene to the pericentric region of human chromosome 8.Q38512437
Production and characterization of recombinant human Ku antigenQ40401377
The ionizing radiation-induced replication protein A phosphorylation response differs between ataxia telangiectasia and normal human cellsQ40656810
DNA damage and the DNA-activated protein kinaseQ40806071
Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell lineQ41368190
Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA.Q41435866
Chromosomal location and expression of the genes coding for Ku p70 and p80 in human cell lines and normal tissues.Q41497770
V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repairQ41549015
Impairment of V(D)J recombination in double-strand break repair mutantsQ41560292
Cell-cycle-regulated phosphorylation of DNA replication factor A from human and yeast cellsQ46342912
Isolation of mammalian cell mutants that are X-ray sensitive, impaired in DNA double-strand break repair and defective for V(D)J recombination.Q53464353
Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency.Q53534567
DNA-dependent protein kinase: a potent inhibitor of transcription by RNA polymerase IQ63362934
Complementation of V(D)J recombination defect and X-ray sensitivity of scid mouse cells by human chromosome 8Q64389670
Rescue of T cell-specific V(D)J recombination in SCID mice by DNA-damaging agentsQ64389676
Murine scid cells complement ataxia-telangiectasia cells and show a normal post-irradiation response of DNA synthesisQ72223254
P433issue10
P304page(s)388-392
P577publication date1995-10-01
P1433published inTrends in GeneticsQ2451468
P1476titleWhat to do at an end: DNA double-strand-break repair
P478volume11

Reverse relations

cites work (P2860)
Q36570198A basic motif in the N-terminal region of RAG1 enhances V(D)J recombination activity
Q34325538A comprehensive continuous-time model for the appearance of CGH signal due to chromosomal missegregations during mitosis
Q36711125A coumarin derivative (RKS262) inhibits cell-cycle progression, causes pro-apoptotic signaling and cytotoxicity in ovarian cancer cells.
Q77398644A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination
Q28249903Binding of Ku and c-Abl at the kinase homology region of DNA-dependent protein kinase catalytic subunit
Q44437998Bromate induces loss of heterozygosity in the Thymidine kinase gene of L5178Y/Tk+/−-3.7.2C mouse lymphoma cells
Q64389175Cell cycle-dependent protein expression of mammalian homologs of yeast DNA double-strand break repair genes Rad51 and Rad52
Q64389110Cell proliferation and ku protein expression in ageing humans
Q58985288Cell-free V(D)J recombination
Q41191958Characterization of a Ku86 variant protein that results in altered DNA binding and diminished DNA-dependent protein kinase activity
Q57114846Chromosomes in the Rocky Mountains. Yeast chromosome structure, replication and segregation, Snowmass, CO, USA, 8-13 August 1998
Q73669916Coding joint formation in a cell-free V(D)J recombination system
Q41101441Complementation of V(D)J recombination deficiency in RAG-1(-/-) B cells reveals a requirement for novel elements in the N-terminus of RAG-1.
Q33181759Computational analysis of retrovirus-induced scid cell death.
Q28513366Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells
Q27652436Crystal Structure of MutS2 Endonuclease Domain and the Mechanism of Homologous Recombination Suppression
Q33975168DNA damage-dependent nuclear dynamics of the Mre11 complex
Q52224278DNA double-strand break repair, DNA-PK, and DNA ligases in two human squamous carcinoma cell lines with different radiosensitivity.
Q40815312DNA double-strand breaks trigger apoptosis in p53-deficient fibroblasts
Q35965069DNA double-strand-break sensitivity, DNA replication, and cell cycle arrest phenotypes of Ku-deficient Saccharomyces cerevisiae
Q41321016DNA lesions and repair.
Q74477340Detection of DNA damages and repair in human culture cells with simulated space radiation
Q39880940Direct repeats of the herpes simplex virus a sequence promote nonconservative homologous recombination that is not dependent on XPF/ERCC4
Q38317561Disruption of ATM in p53-null cells causes multiple functional abnormalities in cellular response to ionizing radiation
Q52996354Dose response and adaptive response of non-homologous end joining repair genes and proteins in resting human peripheral blood mononuclear cells exposed to γ radiation.
Q47996057Double-strand break repair mediated by DNA end-joining
Q73105762Effect of age on DNA binding of the ku protein in irradiated human peripheral blood mononuclear cells (PBMC)
Q44248610Efficacy of a glutathione S-transferase pi-activated prodrug in platinum-resistant ovarian cancer cells
Q35206945Enhancer control of V(D)J recombination at the TCRbeta locus: differential effects on DNA cleavage and joining
Q36570214Enhancer control of local accessibility to V(D)J recombinase
Q64387979Expression and DNA binding activity of the Ku heterodimer in bladder carcinoma
Q24554477Fanconi anemia proteins FANCA, FANCC, and FANCG/XRCC9 interact in a functional nuclear complex
Q28590355Functional interaction between DNA-PK and c-Abl in response to DNA damage
Q34631159Germline transformants spreading out to many insect species
Q39716405Hdf1, a yeast Ku-protein homologue, is involved in illegitimate recombination, but not in homologous recombination
Q38550804Homologous recombination and DNA-end joining reactions in zygotes and early embryos of zebrafish (Danio rerio) and Drosophila melanogaster
Q29617437Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells
Q34979828Homologous recombination: ends as the means.
Q24316169Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair
Q33713030Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: the effects of ionizing radiation on growth, survival, and development
Q41103002Immunodeficiencies caused by genetic defects in protein kinases
Q33743064In vitro repair of gaps in bacteriophage T7 DNA.
Q33781560Inactivation of DNA-dependent protein kinase by protein kinase Cdelta: implications for apoptosis
Q38334993Increased expression of DNA-dependent protein kinase confers resistance to adriamycin
Q40673244Involvement of DNA-dependent protein kinase in down-regulation of cell cycle progression
Q38762742Knockdown of NFBD1/MDC1 enhances chemosensitivity to cisplatin or 5-fluorouracil in nasopharyngeal carcinoma CNE1 cells
Q33888149Ku protein stimulates DNA end joining by mammalian DNA ligases: a direct role for Ku in repair of DNA double-strand breaks
Q36380622Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination In vivo
Q28243620Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination
Q36617413Ku70/80 gene expression and DNA-dependent protein kinase (DNA-PK) activity do not correlate with double-strand break (dsb) repair capacity and cellular radiosensitivity in normal human fibroblasts.
Q38354165Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates
Q61714693Lack of detectable defect in DNA double-strand break repair and DNA-dependent protein kinase activity in radiosensitive human severe combined immunodeficiency fibroblasts
Q38864825Low-dose radiation may be a novel approach to enhance the effectiveness of cancer therapeutics
Q34454221MDC1 interacts with Rad51 and facilitates homologous recombination
Q41049010Mechanism of V(D)J recombination
Q33947315Mitotic recombination in yeast: elements controlling its incidence
Q64388259Modulation of X-ray-induced damage recognition and repair in ageing human peripheral blood mononuclear cells by an interleukin-6-type cytokine
Q33835041Molecular mechanisms of IgE regulation
Q41608183Molecular processes and radiosensitivity
Q27932896Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae
Q28594411No requirement for V(D)J recombination in p53-deficient thymic lymphoma
Q39721716Non-homologous DNA end joining in plant cells is associated with deletions and filler DNA insertions
Q38327349OBA/Ku86: DNA binding specificity and involvement in mammalian DNA replication
Q41063544Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints
Q55314232Oxidative stress-induced chromosome breaks within the ABL gene: a model for chromosome rearrangement in nasopharyngeal carcinoma.
Q71118453Phosphorylation of the N-terminal domain of Xenopus TATA-box binding protein by DNA-dependent protein kinase depends on the C-terminal core domain
Q28307236RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination
Q38484258Radiation-Induced Chromosome Aberrations in Ataxia Telangiectasia Cells: High Frequency of Deletions and Misrejoining Detected by FluorescenceIn SituHybridization
Q41430421Recent advances in understanding V(D)J recombination.
Q52303361Recombination and chiasmata: few but intriguing discrepancies.
Q33886585Recombinational repair in yeast: functional interactions between Rad51 and Rad54 proteins.
Q41115358Reduced X-ray resistance and homologous recombination frequencies in a RAD54-/- mutant of the chicken DT40 cell line
Q39718904Regulation of DNA metabolic enzymes upon induction of preB cell development and V(D)J recombination: up-regulation of DNA polymerase delta
Q30176052Regulation of DNA-dependent protein kinase by the Lyn tyrosine kinase
Q33885019Replication and recombination intersect
Q38354221Requirement for Ku80 in growth and immunoglobulin V(D)J recombination
Q38495751Requirement of wild-type p53 protein for maintenance of chromosomal integrity
Q61794192Response to radiotherapy of human uterine cervix carcinoma is not correlated with rearrangements of the HA-ras-1 and/or c-myc genes
Q41239118S-phase and DNA-damage checkpoints: a tale of two yeasts
Q29614221Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage
Q33958829Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells
Q74186454Somatic and germinal mobility of the RescueMu transposon in transgenic maize
Q39575932Specific mismatch recognition in heteroduplex intermediates by p53 suggests a role in fidelity control of homologous recombination
Q64387956The DNA repair protein ku is involved in gp130-mediated signal transduction events in PBMC from young but not from elderly subjects
Q36573229The Drosophila melanogaster RAD54 homolog, DmRAD54, is involved in the repair of radiation damage and recombination
Q73824829The Krüppel-associated box (KRAB)-zinc finger protein Kid-1 and the Wilms' tumor protein WT1, two transcriptional repressor proteins, bind to heteroduplex DNA
Q28513184The PCAF acetylase complex as a potential tumor suppressor
Q40386992The controlling role of ATM in homologous recombinational repair of DNA damage
Q41583649The implications of telomerase biochemistry for human disease
Q34616111Topoisomerase poisons activate the transcription factor NF-kappaB in ACH-2 and CEM cells
Q33888644Transposase makes critical contacts with, and is stimulated by, single-stranded DNA at the P element termini in vitro
Q41011364Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system
Q28209405Up‐regulation of DNA‐dependent protein kinase correlates with radiation resistance in oral squamous cell carcinoma
Q41096246Use of a postlabelling assay to examine the removal of radiation-induced DNA lesions by purified enzymes and human cell extracts
Q36573432V(D)J recombination: in vitro coding joint formation
Q33993510Visualization of repair of double-strand breaks in the bacteriophage T7 genome without normal DNA replication
Q24644470hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks
Q38307731p53 C-terminal interaction with DNA ends and gaps has opposing effect on specific DNA binding by the core

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