The posteriorizing gene Gbx2 is a direct target of Wnt signalling and the earliest factor in neural crest induction

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The posteriorizing gene Gbx2 is a direct target of Wnt signalling and the earliest factor in neural crest induction is …
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scholarly articleQ13442814

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P356DOI10.1242/DEV.036954
P932PMC publication ID2808295
P698PubMed publication ID19736322
P5875ResearchGate publication ID26795212

P50authorRoberto MayorQ37838827
P2093author name stringBo Li
Mauricio Moreno
Sei Kuriyama
P2860cites workRegulation of LEF-1/TCF transcription factors by Wnt and other signalsQ28141939
Lrig3 regulates neural crest formation in Xenopus by modulating Fgf and Wnt signaling pathwaysQ28312188
Loss of Gbx2 results in neural crest cell patterning and pharyngeal arch artery defects in the mouse embryoQ28594025
Appendix G: In Situ Hybridization: An Improved Whole-Mount Method for Xenopus EmbryosQ29620084
The Wnt/beta-catenin pathway posteriorizes neural tissue in Xenopus by an indirect mechanism requiring FGF signallingQ32057810
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Regulation of dorsal fate in the neuraxis by Wnt-1 and Wnt-3aQ33721756
Xwnt11 is a target of Xenopus Brachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway.Q33898502
Beta-catenin signaling activity dissected in the early Xenopus embryo: a novel antisense approachQ33908686
Positioning the isthmic organizer where Otx2 and Gbx2meet.Q33927269
Cloning and characterization of three Xenopus slug promoters reveal direct regulation by Lef/beta-catenin signaling.Q33950969
Vertebrate anteroposterior patterning: the Xenopus neurectoderm as a paradigmQ34072813
Otx2, Gbx2 and Fgf8 interact to position and maintain a mid-hindbrain organizerQ34076850
Neural plate patterning: upstream and downstream of the isthmic organizerQ34185965
Regulation of Msx genes by a Bmp gradient is essential for neural crest specificationQ34277895
The structure and expression of the Xenopus Krox-20 gene: conserved and divergent patterns of expression in rhombomeres and neural crest.Q34361106
Induction and development of neural crest in Xenopus laevisQ34361802
Early induction of neural crest cells: lessons learned from frog, fish and chickQ34723602
Epidermal keratin gene expressed in embryos of Xenopus laevisQ35012917
The activity of Pax3 and Zic1 regulates three distinct cell fates at the neural plate borderQ35810702
Molecular mechanisms of neural crest inductionQ35843297
Gene-regulatory interactions in neural crest evolution and developmentQ35885247
Early development of the cranial sensory nervous system: from a common field to individual placodesQ35942303
Tol2: a versatile gene transfer vector in vertebratesQ36187507
Translation of mRNA injected into Xenopus oocytes is specifically inhibited by antisense RNA.Q36212817
Genetic network during neural crest induction: from cell specification to cell survival.Q36220839
Induction and specification of cranial placodesQ36469493
Chromatin immunoprecipitation for studying transcriptional regulation in Xenopus oocytes and tadpolesQ36494460
A gene regulatory network orchestrates neural crest formationQ37181700
The genesis of avian neural crest cells: a classic embryonic inductionQ37349008
Neural crest determination by co-activation of Pax3 and Zic1 genes in Xenopus ectodermQ38327715
Msx1 and Pax3 cooperate to mediate FGF8 and WNT signals during Xenopus neural crest induction.Q38330996
Xenopus Zic-related-1 and Sox-2, two factors induced by chordin, have distinct activities in the initiation of neural inductionQ38338824
Direct regulation of the Xenopus engrailed-2 promoter by the Wnt signaling pathway, and a molecular screen for Wnt-responsive genes, confirm a role for Wnt signaling during neural patterning in Xenopus.Q38527333
A balance of FGF, BMP and WNT signalling positions the future placode territory in the headQ40398079
Neural crest induction by paraxial mesoderm in Xenopus embryos requires FGF signals.Q40584140
Zebrafish zic1 expression in brain and somites is affected by BMP and hedgehog signallingQ40804726
Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivoQ41436510
Xiro, a Xenopus homolog of the Drosophila Iroquois complex genes, controls development at the neural plateQ41976395
Differential requirements of BMP and Wnt signalling during gastrulation and neurulation define two steps in neural crest inductionQ42067316
A developmentally regulated, nervous system-specific gene in Xenopus encodes a putative RNA-binding proteinQ43725689
Posteriorization by FGF, Wnt, and retinoic acid is required for neural crest inductionQ43849682
Ectodermal Wnt function as a neural crest inducer.Q46043546
Neural crest induction in Xenopus: evidence for a two-signal model.Q46365285
Anterior neurectoderm is progressively induced during gastrulation: the role of the Xenopus homeobox gene orthodenticleQ46410468
xDnmt1 regulates transcriptional silencing in pre-MBT Xenopus embryos independently of its catalytic functionQ46729896
Cephalic expression and molecular characterization of Xenopus En-2Q46880356
Ventral and lateral regions of the zebrafish gastrula, including the neural crest progenitors, are established by a bmp2b/swirl pathway of genesQ47073994
Xenopus Six1 gene is expressed in neurogenic cranial placodes and maintained in the differentiating lateral linesQ47834355
The inductive properties of mesoderm suggest that the neural crest cells are specified by a BMP gradientQ47862681
Opl: a zinc finger protein that regulates neural determination and patterning in Xenopus.Q47875764
Xenopus Zic family and its role in neural and neural crest developmentQ48022555
Control of cell behavior during vertebrate development by Slug, a zinc finger geneQ48082697
A role for Gbx2 in repression of Otx2 and positioning the mid/hindbrain organizerQ48110711
Comparative analysis of Otx2, Gbx2, Pax2, Fgf8 and Wnt1 gene expressions during the formation of the chick midbrain/hindbrain domain.Q48208878
The homeoprotein Xiro1 is required for midbrain-hindbrain boundary formation.Q48646454
Tissues and signals involved in the induction of placodal Six1 expression in Xenopus laevisQ48705949
Neuroepithelial co-expression of Gbx2 and Otx2 precedes Fgf8 expression in the isthmic organizerQ48964505
Conserved expression control and shared activity between cognate T-box genes Tbx2 and Tbx3 in connection with Sonic hedgehog signaling during Xenopus eye development.Q50109476
Neural crests are actively precluded from the anterior neural fold by a novel inhibitory mechanism dependent on Dickkopf1 secreted by the prechordal mesoderm.Q51979531
Identification of a BMP inhibitor-responsive promoter module required for expression of the early neural gene zic1.Q52033324
Essential role of non-canonical Wnt signalling in neural crest migration.Q52051294
Neural crest induction by the canonical Wnt pathway can be dissociated from anterior-posterior neural patterning in Xenopus.Q52057839
Six1 promotes a placodal fate within the lateral neurogenic ectoderm by functioning as both a transcriptional activator and repressor.Q52085976
A balance between the anti-apoptotic activity of Slug and the apoptotic activity of msx1 is required for the proper development of the neural crest.Q52086392
Snail precedes slug in the genetic cascade required for the specification and migration of the Xenopus neural crest.Q52111064
Requirement of FoxD3-class signaling for neural crest determination in Xenopus.Q52131385
Establishment and maintenance of the border of the neural plate in the chick: involvement of FGF and BMP activity.Q52176692
Development of neural crest in Xenopus.Q52180357
Xenopus msx1 mediates epidermal induction and neural inhibition by BMP4.Q52193245
Expression of Pax-3 is initiated in the early neural plate by posteriorizing signals produced by the organizer and by posterior non-axial mesoderm.Q52194790
A posteriorising factor, retinoic acid, reveals that anteroposterior patterning controls the timing of neuronal differentiation in Xenopus neuroectoderm.Q52199224
Analysis of Dishevelled signalling pathways during Xenopus development.Q52199252
Neural crest formation in Xenopus laevis: mechanisms of Xslug induction.Q52200484
The Xenopus laevis homeobox gene Xgbx-2 is an early marker of anteroposterior patterning in the ectoderm.Q52202909
Induction of the prospective neural crest of Xenopus.Q52209849
Transcriptional regulation of a Xenopus embryonic epidermal keratin gene.Q52246296
Caudalization of neural fate by tissue recombination and bFGFQ70935497
Requirement of Sox2-mediated signaling for differentiation of early Xenopus neuroectodermQ73386441
Molecular cloning and embryonic expression of Xenopus Six homeobox genesQ73568844
Paraxial-fated mesoderm is required for neural crest induction in Xenopus embryosQ74213802
P433issue19
P407language of work or nameEnglishQ1860
P1104number of pages12
P304page(s)3267-3278
P577publication date2009-10-01
P1433published inDevelopmentQ3025404
P1476titleThe posteriorizing gene Gbx2 is a direct target of Wnt signalling and the earliest factor in neural crest induction
P478volume136

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