Toll-Like Receptor Pathways in Autoimmune Diseases

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Toll-Like Receptor Pathways in Autoimmune Diseases is …
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review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1026368519
P356DOI10.1007/S12016-015-8473-Z
P698PubMed publication ID25687121

P50authorPeter SzodorayQ42574350
P2093author name stringMargit Zeher
Ji-Qing Chen
P2860cites workMicroRNAs: novel regulators involved in the pathogenesis of psoriasis?Q21144444
MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4Q22009943
Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria”Q22252938
TAK1 is a ubiquitin-dependent kinase of MKK and IKKQ24291454
The expression of toll-like receptors 3 and 7 in rheumatoid arthritis synovium is increased and costimulation of toll-like receptors 3, 4, and 7/8 results in synergistic cytokine production by dendritic cellsQ80955813
Expression of toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gammaQ81129108
The effect of disease activity on leptin, leptin receptor and suppressor of cytokine signalling-3 expression in relapsing-remitting multiple sclerosisQ81372115
Type I interferons might form the link between Toll-like receptor (TLR) 3/7 and TLR4-mediated synovial inflammation in rheumatoid arthritis (RA)Q81918697
Multiplex screening of 22 single-nucleotide polymorphisms in 7 Toll-like receptors: an association study in rheumatoid arthritisQ83089891
Expression of Toll-like receptors and their signaling pathways in rheumatoid synovitisQ83419942
Activation of JAK-STAT1 signal transduction pathway in lesional skin and monocytes from patients with systemic lupus erythematosusQ83516720
Association study of TLR-9 polymorphisms and systemic lupus erythematosus in northern Chinese Han populationQ85635209
Expression, subcellular localization and cytokinic modulation of Toll-like receptors (TLRs) in normal human keratinocytes: TLR2 up-regulation in psoriatic skinQ24298330
A family of cytokine-inducible inhibitors of signallingQ24313168
A new protein containing an SH2 domain that inhibits JAK kinasesQ24313242
The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activationQ24318742
IRAK: a kinase associated with the interleukin-1 receptorQ24322162
The evolution of vertebrate Toll-like receptorsQ24530086
Selective regulatory function of Socs3 in the formation of IL-17-secreting T cellsQ24547568
Toll-like receptor signallingQ24570126
Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction programQ24673216
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptorsQ27860900
Pathogen recognition and innate immunityQ27861084
Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient miceQ28140546
Tumor necrosis factor receptor-associated factors (TRAFs)Q28199382
Impaired IFN-gamma-dependent inflammatory responses in human keratinocytes overexpressing the suppressor of cytokine signaling 1Q28206163
Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupusQ28212039
Toll-like receptors in innate immunityQ28297257
Integral role of IRF-5 in the gene induction programme activated by Toll-like receptorsQ28303818
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-betaQ28506630
The adaptor molecule TIRAP provides signalling specificity for Toll-like receptorsQ28511605
Structure and function of a new STAT-induced STAT inhibitorQ28584775
Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathwayQ28592087
TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40Q28610812
Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signalingQ28646137
Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasisQ28943518
Toll-like receptors and their crosstalk with other innate receptors in infection and immunityQ29547722
IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursorsQ29618425
Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistryQ29618605
Role of infectious agents in systemic rheumatic diseases.Q33380043
Expression of microRNA-146 suppresses NF-kappaB activity with reduction of metastatic potential in breast cancer cellsQ33609716
SOCS1 and SOCS3 in the control of CNS immunityQ33717795
Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9.Q33731760
Genetic variants in toll-like receptors are not associated with rheumatoid arthritis susceptibility or anti-tumour necrosis factor treatment outcomeQ33778661
The interleukin-1 receptor/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial productsQ33894375
Initial immunopathogenesis of multiple sclerosis: innate immune response.Q38156767
TLR2 and TLR4 in autoimmune diseases: a comprehensive reviewQ38172423
Emerging role of endosomal toll-like receptors in rheumatoid arthritisQ38182971
U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells through TLR7.Q38317464
Identification of SOCS-3 as a potential mediator of central leptin resistanceQ38335615
Epstein-Barr virus infection induces aberrant TLR activation pathway and fibroblast-myofibroblast conversion in sclerodermaQ38380369
Expression of TNF-alpha and related signaling molecules in the peripheral blood mononuclear cells of rheumatoid arthritis patients.Q38402453
MicroRNA-mediated mechanism of vitamin D regulation of innate immune responseQ38626414
Clinical aspects and treatment of systemic lupus erythematosusQ38789734
Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolinesQ39577031
Tumor necrosis factor α induces sustained signaling and a prolonged and unremitting inflammatory response in rheumatoid arthritis synovial fibroblastsQ39648944
Hemagglutinin protein of wild-type measles virus activates toll-like receptor 2 signalingQ39686635
CpG-induced tyrosine phosphorylation occurs via a TLR9-independent mechanism and is required for cytokine secretionQ39726296
Deficient SOCS3 and SHP-1 expression in psoriatic T cellsQ39744026
Antimalarials in rheumatology: efficacy and safetyQ39759674
Toll-like receptor in salivary glands from patients with Sjögren's syndrome: functional analysis by human salivary gland cell lineQ40149890
Expression of functional Toll-like receptors by salivary gland epithelial cells: increased mRNA expression in cells derived from patients with primary Sjögren's syndromeQ40170759
Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradationQ40328896
Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon inductionQ40437839
Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activationQ40497000
Suppressor of cytokine signaling 1 inhibits cytokine induction of CD40 expression in macrophagesQ40708938
The role of anti-malarials in rheumatoid arthritis--the American experience.Q41109179
Systemic sclerosis (scleroderma): an integrated challenge in rehabilitationQ41536190
A role of IL-1R1 signaling in the differentiation of Th17 cells and the development of autoimmune diseasesQ41787535
Anti-apoptotic effects of suppressor of cytokine signaling 3 and 1 in psoriasisQ41788599
Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane culturesQ41939782
IFN-β therapy modulates B-cell and monocyte crosstalk via TLR7 in multiple sclerosis patients.Q42264579
Torque teno virus (TTV) in multiple sclerosis patients with different patterns of disease.Q42275574
Innate immune-related receptors in normal and psoriatic skinQ42436530
Normal keratinocytes express Toll-like receptors (TLRs) 1, 2 and 5: modulation of TLR expression in chronic plaque psoriasisQ42441343
The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritisQ42853439
Toll-like receptor-mediated, enhanced production of profibrotic TIMP-1 in monocytes from patients with systemic sclerosis: role of serum factors.Q43091811
Pimecrolimus identifies a common genomic anti-inflammatory profile, is clinically highly effective in psoriasis and is well toleratedQ44198173
A cytokine gene screen uncovers SOCS1 as genetic risk factor for multiple sclerosisQ44596853
TGF-alpha regulates TLR expression and function on epidermal keratinocytesQ44714065
Monomethylfumarate affects polarization of monocyte-derived dendritic cells resulting in down-regulated Th1 lymphocyte responses.Q44759324
Quantitative analysis of the suppressors of cytokine signaling 1 and 3 in peripheral blood leukocytes of patients with multiple sclerosisQ44999655
Polymorphisms within Toll-like receptors are associated with systemic lupus erythematosus in a cohort of Danish femalesQ45093751
Increased expression of Toll-like receptors (TLRs) 7 and 9 and other cytokines in systemic lupus erythematosus (SLE) patients: ethnic differences and potential new targets for therapeutic drugs.Q45152333
Altered natural killer cells' response to herpes virus infection in multiple sclerosis involves KIR2DL2 expression.Q45355670
Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virusQ45739890
Therapeutic hope for psoriasis offered by SOCS (suppressor of cytokine signaling) mimetic peptideQ45780399
Association of TLR9 gene polymorphisms with lupus nephritis in a Chinese Han population.Q46557429
Immunological alterations in newly diagnosed primary Sjögren's syndrome characterized by skewed peripheral T-cell subsets and inflammatory cytokinesQ46605746
Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes.Q46614190
RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via Toll-like receptor 3.Q46687345
TLR-3 enhances osteoclastogenesis through upregulation of RANKL expression from fibroblast-like synoviocytes in patients with rheumatoid arthritisQ47789840
Tissue inhibitor of metalloproteinase-1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosisQ48062721
Transcription factor NF-kappaB and inhibitor I kappaBalpha are localized in macrophages in active multiple sclerosis lesionsQ48463773
Extracellular GC-rich DNA activates TLR9- and NF-kB-dependent signaling pathways in human adipose-derived mesenchymal stem cells (haMSCs).Q49178540
Enhanced interleukin-10 production by dendritic cells upon stimulation with Toll-like receptor 4 agonists in systemic sclerosis that is possibly implicated in CCL18 secretion.Q51781016
Decreased IL-10 production mediated by Toll-like receptor 9 in B cells in multiple sclerosis.Q51886529
The analysis of CIS, SOCS1, SOSC2 and SOCS3 transcript levels in peripheral blood mononuclear cells of systemic lupus erythematosus and rheumatoid arthritis patients.Q53451202
Comparison of expression of heat-shock protein 60, Toll-like receptors 2 and 4, and T-cell receptor gammadelta in plaque and guttate psoriasis.Q53557801
Regulation of TNF-alpha-mediated hyperplasia through TNF receptors, TRAFs, and NF-kappaB in synoviocytes obtained from patients with rheumatoid arthritis.Q53668963
Increased microRNA-146a/b, TRAF6 gene and decreased IRAK1 gene expressions in the peripheral mononuclear cells of patients with Sjögren's syndrome.Q53709699
The investigation of toll-like receptor 3, 9 and 10 gene polymorphisms in Turkish rheumatoid arthritis patients.Q54430820
Expression of Toll-like receptors 7, 8, and 9 in primary Sjögren's syndrome.Q54432033
Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: toll-like receptor expression in early and longstanding arthritis.Q54505721
Antifibroblast antibodies in systemic sclerosis induce fibroblasts to produce profibrotic chemokines, with partial exploitation of toll-like receptor 4.Q54505727
TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus.Q54536891
Decreased expressions of the TNF-alpha signaling adapters in peripheral blood mononuclear cells (PBMCs) are correlated with disease activity in patients with systemic lupus erythematosus.Q54561488
Overview of epidemiology, pathophysiology, and diagnosis of rheumatoid arthritis.Q55056965
Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodiesQ56774177
A rare polymorphism in the gene for Toll-like receptor 2 is associated with systemic sclerosis phenotype and increases the production of inflammatory mediatorsQ57213592
Association study of IRAK-M and SIGIRR genes with SLE in a large European-descent populationQ57461647
Clinical, serologic, and genetic profiles of patients with associated Sjögren's syndrome and systemic lupus erythematosusQ64388181
Serum tissue inhibitor of metalloproteinases in patients with systemic sclerosisQ71565785
Decreased MMP-9 activity in the serum of patients with diffuse cutaneous systemic sclerosisQ74517333
Chemokine secretion of rheumatoid arthritis synovial fibroblasts stimulated by Toll-like receptor 2 ligandsQ75224600
A macrophage marker, Siglec-1, is increased on circulating monocytes in patients with systemic sclerosis and induced by type I interferons and toll-like receptor agonistsQ79844593
Relationship between matrix metalloproteinases/tissue inhibitors of matrix metalloproteinases systems and autoantibody patterns in systemic sclerosisQ80309322
The expression of SOCS is altered in rheumatoid arthritisQ80860169
Leptin increase in multiple sclerosis associates with reduced number of CD4(+)CD25+ regulatory T cellsQ33935880
Hyaluronan blocks oligodendrocyte progenitor maturation and remyelination through TLR2Q33953332
TRAF6, a molecular bridge spanning adaptive immunity, innate immunity and osteoimmunology.Q34272380
Psoriasis--epidemiology and clinical spectrumQ34291358
Toll-like receptors modulate adult hippocampal neurogenesisQ34664161
Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2.Q34858442
Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family membersQ35079256
Proteomic analysis of plasma identifies the Toll-like receptor agonists S100A8/A9 as a novel possible marker for systemic sclerosis phenotypeQ35144377
Expression and regulation of Toll-like receptor 2 in rheumatoid arthritis synoviumQ35749232
Reading the viral signature by Toll-like receptors and other pattern recognition receptorsQ36001067
Investigation of association between the TRAF family genes and RA susceptibilityQ36013813
Toll-like receptor and antiphospholipid mediated thrombosis: in vivo studiesQ36013878
Toll-like receptor 4 signaling in T cells promotes autoimmune inflammationQ36167500
TLR2 ligation induces the production of IL-23/IL-17 via IL-6, STAT3 and NF-kB pathway in patients with primary Sjogren's syndromeQ36245745
Identification of low-frequency TRAF3IP2 coding variants in psoriatic arthritis patients and functional characterizationQ36245841
Modulation of life and death by the tumor necrosis factor receptor-associated factors (TRAFs).Q36296922
Innate and adaptive immunity and the pathophysiology of psoriasisQ36400854
Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosusQ36403653
Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8.Q36403992
Toll-like receptors: applications to dermatologic diseaseQ36483506
Molecular basis for the unique specificity of TRAF6.Q36882608
TNF signaling: early events and phosphorylation.Q37026589
Statins and demyelination.Q37065090
Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cellsQ37139993
Matrix metalloproteinases and their inhibitors in connective tissue remodelingQ37174661
No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritisQ37207052
Reciprocal regulation of IL-23 and IL-12 following co-activation of Dectin-1 and TLR signaling pathwaysQ37287064
Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotypeQ37301528
Genetic variations in Toll-like receptors (TLRs 3/7/8) are associated with systemic lupus erythematosus in a Taiwanese populationQ37497741
Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer.Q37497786
Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signalingQ37585525
Interferon-beta inhibits Th17 cell differentiation in patients with multiple sclerosisQ37729213
Regulation of remyelination in multiple sclerosis.Q37858668
Toll-like receptors in rheumatic diseases: are we paying a high price for our defense against bugs?Q37868069
P433issue1
P921main subjecttoll-like receptorQ408004
P304page(s)1-17
P577publication date2015-02-17
P1433published inClinical Reviews in Allergy & ImmunologyQ1932354
P1476titleToll-Like Receptor Pathways in Autoimmune Diseases
P478volume50

Reverse relations

cites work (P2860)
Q37099590A Bioinformatics Approach to Prioritize Single Nucleotide Polymorphisms in TLRs Signaling Pathway Genes
Q38376039Association of XRCC1 Arg399Gln and Arg194Trp polymorphisms with susceptibility to multiple autoimmune diseases: a meta-analysis
Q52331790B lymphocytes confer immune tolerance via cell surface GARP-TGF-β complex.
Q52615452Baseline antibody profiles predict toxicity in melanoma patients treated with immune checkpoint inhibitors.
Q38506851Beyond adjuvants: Antagonizing inflammation to enhance vaccine immunity
Q58692935Boosting mTOR-dependent autophagy via upstream TLR4-MyD88-MAPK signalling and downstream NF-κB pathway quenches intestinal inflammation and oxidative stress injury
Q45984203Different IL-17-secreting TLR(+) T cell subsets are associated with disease activity in multiple sclerosis.
Q47548140Distinctive expression of T cell guiding molecules in human autoimmune lymph node stromal cells upon TLR3 triggering
Q95276510Dysregulation of TLR2 Serves as a Prognostic Biomarker in Breast Cancer and Predicts Resistance to Endocrine Therapy in the Luminal B Subtype
Q47826010Epidermal barrier reaction to an in vitro psoriatic microenvironment.
Q54241736Evaluation of the TLR negative regulatory network in CVID patients.
Q47933664Expression of Toll-Like Receptors in Chronic Histiocytic Intervillositis of the Placenta
Q40491107Human Endogenous Retroviral Genetic Element With Immunosuppressive Activity in Both Human Autoimmune Diseases and Experimental Arthritis.
Q41958567IL-10 Modulates Th17 Pathogenicity during Autoimmune Diseases
Q64967770MiR-21 binding site SNP within ITGAM associated with psoriasis susceptibility in women.
Q37604349MicroRNA-181b negatively regulates the proliferation of human epidermal keratinocytes in psoriasis through targeting TLR4.
Q37635819Overexpression of suppressor of cytokine signaling 3 in dorsal root ganglion attenuates cancer-induced pain in rats
Q94601228Ozone Therapy Attenuates NF-κB-Mediated Local Inflammatory Response and Activation of Th17 Cells in Treatment for Psoriasis
Q92408958Pathogenesis of Important Virulence Factors of Porphyromonas gingivalis via Toll-Like Receptors
Q42068012Polyene Phosphatidylcholine inhibited the inflammatory response in LPS-stimulated macrophages and ameliorated the adjuvant-induced rat arthritis
Q36356021Regulation of migration and invasion by Toll-like receptor-9 signaling network in prostate cancer
Q38840238Review on Toll-Like Receptor Activation in Myasthenia Gravis: Application to the Development of New Experimental Models
Q38695565Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling.
Q65001289Sjogren's Syndrome and TAM Receptors: A Possible Contribution to Disease Onset.
Q64921582Sjögren's Syndrome: Animal Models, Etiology, Pathogenesis, Clinical Subtypes, and Diagnosis.
Q91714381The Role of Immune Modulation in Pathogenesis of IgA Nephropathy
Q50158327The molecular basis of immune regulation in autoimmunity.
Q41979349The significance of Toll-like receptor (TLR) 2 and 9 gene polymorphisms in psoriasis
Q39529337Toll-like receptor 7 involves the injury in acute kidney ischemia/reperfusion of STZ-induced diabetic rats
Q90899123Toll-like receptor 9 signaling promotes autophagy and apoptosis via divergent functions of the p38/JNK pathway in human salivary gland cells
Q38925152Toll-like receptors: promising therapeutic targets for inflammatory diseases
Q99577395Trichinella spiralis: inflammation modulator
Q38800476What can Sjögren's syndrome-like disease in mice contribute to human Sjögren's syndrome?
Q37089938Whole-genome transcription and DNA methylation analysis of peripheral blood mononuclear cells identified aberrant gene regulation pathways in systemic lupus erythematosus

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