| scholarly article | Q13442814 |
| P2093 | author name string | Scott D Blystone | |
| Burk Jubelt | |||
| George P Christophi | |||
| Paul T Massa | |||
| Ross C Gruber | |||
| Chad A Hudson | |||
| Michael Panos | |||
| Akos T Mersich | |||
| Rebecca L Christophi | |||
| P2860 | cites work | Human recombinant PLD2 can repress p65 activity of guinea pigs of chronic asthma in vivo. | Q46546221 |
| Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1. | Q46661965 | ||
| Lipopolysaccharide-activated SHP-1-deficient motheaten microglia release increased nitric oxide, TNF-alpha, and IL-1beta | Q46787369 | ||
| Changes in the activation level of NF-kappa B in lymphocytes of MS patients during glucocorticoid pulse therapy | Q46986854 | ||
| Expression and regulation of a disintegrin and metalloproteinase (ADAM) 8 in experimental asthma | Q47755798 | ||
| Elevated serum levels of IFN-gamma, IL-4 and TNF-alpha/unelevated serum levels of IL-10 in patients with demyelinating diseases during the acute stage | Q47817750 | ||
| Functional consequences of the SHP-1 defect in motheaten viable mice: role of NF-kappa B. | Q47939238 | ||
| CSF chemokine levels in relapsing neuromyelitis optica and multiple sclerosis | Q47953458 | ||
| Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis | Q22252943 | ||
| Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients | Q24563395 | ||
| Kallikreins are associated with secondary progressive multiple sclerosis and promote neurodegeneration | Q24643613 | ||
| Adrenodoxin reductase-adrenodoxin complex structure suggests electron transfer path in steroid biosynthesis | Q27627708 | ||
| The effect of phosphatases SHP-1 and SHIP-1 on signaling by the ITIM- and ITAM-containing Fcgamma receptors FcgammaRIIB and FcgammaRIIA | Q28207451 | ||
| The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs | Q28215674 | ||
| Expression and modulation of IFN-gamma-inducible chemokines (IP-10, Mig, and I-TAC) in human brain endothelium and astrocytes: possible relevance for the immune invasion of the central nervous system and the pathogenesis of multiple sclerosis | Q28216915 | ||
| Activity of a newly identified serine protease in CNS demyelination | Q28218638 | ||
| Human Protein Tyrosine Phosphatase 1C (PTPN6) Gene Structure: Alternate Promoter Usage and Exon Skipping Generate Multiple Transcripts | Q48074087 | ||
| Multiple sclerosis: cytokine receptors on oligodendrocytes predict innate regulation | Q48101693 | ||
| Microglial/macrophage accumulation during cuprizone-induced demyelination in C57BL/6 mice | Q48300700 | ||
| pSTAT1, pSTAT3, and T-bet expression in peripheral blood mononuclear cells from relapsing-remitting multiple sclerosis patients correlates with disease activity | Q48463355 | ||
| Transcription factor NF-kappaB and inhibitor I kappaBalpha are localized in macrophages in active multiple sclerosis lesions | Q48463773 | ||
| Monocyte/macrophage differentiation in early multiple sclerosis lesions | Q48752790 | ||
| Upregulation of transcription factors controlling MHC expression in multiple sclerosis lesions | Q48777649 | ||
| CXC chemokine receptors on human oligodendrocytes: implications for multiple sclerosis. | Q48962767 | ||
| Multiple sclerosis is associated with an imbalance between tumour necrosis factor-alpha (TNF-alpha)- and IL-10-secreting blood cells that is corrected by interferon-beta (IFN-beta) treatment. | Q53685193 | ||
| The gene encoding hematopoietic cell phosphatase (SHP-1) is structurally and transcriptionally intact in polycythemia vera | Q57901019 | ||
| Macrophages in multiple sclerosis | Q61709749 | ||
| Multiple sclerosis is associated with high levels of circulating dendritic cells secreting pro-inflammatory cytokines | Q62065049 | ||
| Identification of a novel integrin beta subunit expressed on cultured monocytes (macrophages). Evidence that one alpha subunit can associate with multiple beta subunits | Q67653129 | ||
| The adhesion molecules used by monocytes for migration across endothelium include CD11a/CD18, CD11b/CD18, and VLA-4 on monocytes and ICAM-1, VCAM-1, and other ligands on endothelium | Q71686734 | ||
| Increased transforming growth factor-beta, interleukin-4, and interferon-gamma in multiple sclerosis | Q72173669 | ||
| Expression and function of the protein tyrosine phosphatase SHP-1 in oligodendrocytes | Q73396817 | ||
| Increased expression of CD11b/CD18 on phagocytes in ischaemic disease: a bridge between inflammation and coagulation | Q73652772 | ||
| Cytokine secretion profile of myelin basic protein-specific T cells in multiple sclerosis | Q73694671 | ||
| Expression of the interferon-gamma-inducible chemokines IP-10 and Mig and their receptor, CXCR3, in multiple sclerosis lesions | Q73855301 | ||
| Intracellular cytokine profile in T-cell subsets of multiple sclerosis patients: different features in primary progressive disease | Q74275775 | ||
| Eotaxin (CCL11) and eotaxin-2 (CCL24) induce recruitment of eosinophils, basophils, neutrophils, and macrophages as well as features of early- and late-phase allergic reactions following cutaneous injection in human atopic and nonatopic volunteers | Q74650644 | ||
| Increased inducible activation of NF-kappaB and responsive genes in astrocytes deficient in the protein tyrosine phosphatase SHP-1 | Q77124651 | ||
| Caspase-1 regulates the inflammatory process leading to autoimmune demyelination | Q78145110 | ||
| The detection of ADAM8 protein on cells of the human immune system and the demonstration of its expression on peripheral blood B cells, dendritic cells and monocyte subsets | Q79707831 | ||
| Innate immunity in multiple sclerosis: myeloid dendritic cells in secondary progressive multiple sclerosis are activated and drive a proinflammatory immune response | Q80209390 | ||
| Brain microglia and blood-derived macrophages: molecular profiles and functional roles in multiple sclerosis and animal models of autoimmune demyelinating disease | Q81077809 | ||
| Maturation and localization of macrophages and microglia during infection with a neurotropic murine coronavirus | Q81438898 | ||
| Intrathecal activation of the IL-17/IL-8 axis in opticospinal multiple sclerosis | Q81470272 | ||
| Determination of the sequential degradation of myelin proteins by macrophages | Q81480733 | ||
| Macrophages and neurodegeneration | Q81683775 | ||
| Inverse regulation of inducible nitric oxide synthase (iNOS) and arginase I by the protein tyrosine phosphatase SHP-1 in CNS glia | Q82976155 | ||
| Chemokine expression by astrocytes plays a role in microglia/macrophage activation and subsequent neurodegeneration in secondary progressive multiple sclerosis | Q83870435 | ||
| SHP-1 regulates STAT6 phosphorylation and IL-4-mediated function in a cell type-specific manner | Q45197331 | ||
| Reduced expression and promoter methylation of p16 gene in Epstein-Barr virus-associated gastric carcinoma | Q45729967 | ||
| MHC variant peptide-mediated anergy of encephalitogenic T cells requires SHP-1. | Q46266985 | ||
| Regulation of the Leishmania-induced innate inflammatory response by the protein tyrosine phosphatase SHP-1. | Q46498026 | ||
| Homogeneity of active demyelinating lesions in established multiple sclerosis | Q28266507 | ||
| Association of the interferon-dependent tyrosine kinase Tyk-2 with the hematopoietic cell phosphatase | Q28294908 | ||
| Methylation-dependent gene silencing induced by interleukin 1beta via nitric oxide production | Q28577262 | ||
| Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1 | Q28609564 | ||
| Risk alleles for multiple sclerosis identified by a genomewide study | Q29614890 | ||
| Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination | Q29614990 | ||
| Multiple sclerosis | Q29616022 | ||
| Foreign DNA integration. Genome-wide perturbations of methylation and transcription in the recipient genomes | Q30661510 | ||
| The short arm of chromosome 11 is a "hot spot" for hypermethylation in human neoplasia | Q33636876 | ||
| Anti-CCL2 treatment inhibits Theiler's murine encephalomyelitis virus-induced demyelinating disease | Q33693006 | ||
| Infection with human immunodeficiency virus type 1 upregulates DNA methyltransferase, resulting in de novo methylation of the gamma interferon (IFN-gamma) promoter and subsequent downregulation of IFN-gamma production | Q33777676 | ||
| Regulation of macrophage gene expression by pro- and anti-inflammatory cytokines | Q33868159 | ||
| Multiple sclerosis: a polygenic disease involving epistatic interactions, germline rearrangements and environmental effects | Q33874081 | ||
| The multiple sclerosis degradome: enzymatic cascades in development and progression of central nervous system inflammatory disease. | Q33898964 | ||
| SHP-1 deficiency and increased inflammatory gene expression in PBMCs of multiple sclerosis patients. | Q33904273 | ||
| Development of a sensitive multi-well colorimetric assay for active NFkappaB | Q34233830 | ||
| Anti-alpha4 integrin therapy for multiple sclerosis: mechanisms and rationale. | Q34413750 | ||
| Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1. | Q34574880 | ||
| Normal-appearing white matter in multiple sclerosis is in a subtle balance between inflammation and neuroprotection | Q34721399 | ||
| src homology 2 domain-containing tyrosine phosphatase SHP-1 controls the development of allergic airway inflammation | Q34827219 | ||
| Critical role for protein tyrosine phosphatase SHP-1 in controlling infection of central nervous system glia and demyelination by Theiler's murine encephalomyelitis virus | Q35000580 | ||
| Neuropathology of multiple sclerosis-new concepts. | Q35196334 | ||
| Chemokines and chemokine receptors in autoimmune encephalomyelitis as a model for central nervous system inflammatory disease regulation | Q35672765 | ||
| Lack of phosphotyrosine phosphatase SHP-1 expression in malignant T-cell lymphoma cells results from methylation of the SHP-1 promoter | Q35745808 | ||
| Activation of NF-kappaB and c-jun transcription factors in multiple sclerosis lesions. Implications for oligodendrocyte pathology. | Q35788090 | ||
| CCR1+/CCR5+ mononuclear phagocytes accumulate in the central nervous system of patients with multiple sclerosis. | Q35788387 | ||
| Adhesion mechanisms regulating the migration of monocytes | Q35790360 | ||
| Negative regulation of the SH2-homology containing protein-tyrosine phosphatase-1 (SHP-1) P2 promoter by the HTLV-1 Tax oncoprotein | Q35990647 | ||
| Theiler's virus persistence in the central nervous system of mice is associated with continuous viral replication and a difference in outcome of infection of infiltrating macrophages versus oligodendrocytes | Q36127613 | ||
| Multiple sclerosis genetics: leaving no stone unturned | Q36171871 | ||
| Promoter-specific induction of the phosphatase SHP-1 by viral infection and cytokines in CNS glia | Q36174906 | ||
| Granulocyte-macrophage and macrophage colony-stimulating factors differentially regulate alpha v integrin expression on cultured human macrophages | Q36180127 | ||
| The expression and function of chemokines involved in CNS inflammation | Q36323788 | ||
| Transcription factor NF-kappaB: a sensor for smoke and stress signals | Q36357810 | ||
| CD47-signal regulatory protein alpha (SIRPalpha) regulates Fcgamma and complement receptor-mediated phagocytosis | Q36369098 | ||
| Abnormal chemokine-induced responses of immature and mature hematopoietic cells from motheaten mice implicate the protein tyrosine phosphatase SHP-1 in chemokine responses | Q36375270 | ||
| Integrin alpha v beta 3 differentially regulates adhesive and phagocytic functions of the fibronectin receptor alpha 5 beta 1. | Q36382983 | ||
| Regulation of avoidant behaviors and pain by the anti-inflammatory tyrosine phosphatase SHP-1. | Q36426984 | ||
| Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis | Q36571893 | ||
| The HTLV-1 neurological complex | Q36655609 | ||
| Effectors of demyelination and remyelination in the CNS: implications for multiple sclerosis. | Q36771875 | ||
| A specific viral cause of multiple sclerosis: one virus, one disease | Q36800060 | ||
| Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13. | Q36813436 | ||
| Induction of IL-33 expression and activity in central nervous system glia | Q36838536 | ||
| Inflammation-mediated cytosine damage: a mechanistic link between inflammation and the epigenetic alterations in human cancers | Q36851776 | ||
| Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger | Q36937153 | ||
| Modulation of macrophage infiltration and inflammatory activity by the phosphatase SHP-1 in virus-induced demyelinating disease | Q37033330 | ||
| Mechanisms of SHP-1 P2 promoter regulation in hematopoietic cells and its silencing in HTLV-1-transformed T cells | Q37062143 | ||
| Macrophage polarization in bacterial infections | Q37259940 | ||
| Regulation of the DNA methyltransferase by the Ras-AP-1 signaling pathway | Q38299575 | ||
| The role of protein tyrosine phosphatase SHP-1 in the regulation of IFN-gamma signaling in neural cells | Q38351176 | ||
| Presence of simian virus 40 DNA sequences in diffuse large B-cell lymphomas in Tunisia correlates with aberrant promoter hypermethylation of multiple tumor suppressor genes. | Q38872031 | ||
| Increased IL-13 but not IL-5 production by CD4-positive T cells and CD8-positive T cells in multiple sclerosis during relapse phase | Q39316343 | ||
| Neurokinin A engages neurokinin-1 receptor to induce NF-kappaB-dependent gene expression in murine macrophages: implications of ERK1/2 and PI 3-kinase/Akt pathways | Q39966051 | ||
| IL-4 induces expression of TARC/CCL17 via two STAT6 binding sites | Q40261012 | ||
| Leukocyte CD11/CD18 integrins: biological and clinical relevance. | Q40456608 | ||
| Increased expression of caspase-1 and interleukin-18 in peripheral blood mononuclear cells in patients with multiple sclerosis. | Q40477272 | ||
| The role of the Th2 CC chemokine ligand CCL17 in pulmonary fibrosis | Q40512631 | ||
| Receptor Activator of NF-κB Ligand Stimulates Recruitment of SHP-1 to the Complex Containing TNFR-Associated Factor 6 That Regulates Osteoclastogenesis | Q40633180 | ||
| SHP-1 regulates Fcgamma receptor-mediated phagocytosis and the activation of RAC. | Q40710791 | ||
| Molecular mechanisms underlying SHP-1 gene expression | Q40724050 | ||
| Caspase-1 expression in multiple sclerosis plaques and cultured glial cells | Q40733610 | ||
| Reduction of hematopoietic cell-specific tyrosine phosphatase SHP-1 gene expression in natural killer cell lymphoma and various types of lymphomas/leukemias : combination analysis with cDNA expression array and tissue microarray | Q40777171 | ||
| Interleukin-13 upregulates eotaxin expression in airway epithelial cells by a STAT6-dependent mechanism. | Q40797795 | ||
| IL-4-activated STAT-6 inhibits IFN-gamma-induced CD40 gene expression in macrophages/microglia | Q40841314 | ||
| Protein-tyrosine phosphatase Shp-1 is a negative regulator of IL-4- and IL-13-dependent signal transduction. | Q40988710 | ||
| Cytokine profile of myelin basic protein-reactive T cells in multiple sclerosis and healthy individuals. | Q41102106 | ||
| Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis | Q41433234 | ||
| Role of astrocytes and chemokine systems in acute TNFalpha induced demyelinating syndrome: CCR2-dependent signals promote astrocyte activation and survival via NF-kappaB and Akt. | Q41583855 | ||
| The cytokine storm in multiple sclerosis | Q41734496 | ||
| Role of the chemokine receptor CCR4 and its ligand thymus- and activation-regulated chemokine/CCL17 for lymphocyte recruitment in cutaneous lupus erythematosus | Q42479840 | ||
| Role of tumor necrosis factor-alpha in the spontaneous development of pulmonary fibrosis in viable motheaten mutant mice | Q42839706 | ||
| Transcriptional activity of the SHP-1 gene in MCF7 cells is differentially regulated by binding of NF-Y factor to two distinct CCAAT-elements | Q43620029 | ||
| Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism | Q43803694 | ||
| IL-4 pretreatment selectively enhances cytokine and chemokine production in lipopolysaccharide-stimulated mouse peritoneal macrophages | Q43891715 | ||
| Expression of the tyrosine phosphatase SRC homology 2 domain-containing protein tyrosine phosphatase 1 determines T cell activation threshold and severity of experimental autoimmune encephalomyelitis. | Q43968811 | ||
| Low expression of interferon-stimulated genes in active multiple sclerosis is linked to subnormal phosphorylation of STAT1. | Q44088417 | ||
| Regulation of the dephosphorylation of Stat6. Participation of Tyr-713 in the interleukin-4 receptor alpha, the tyrosine phosphatase SHP-1, and the proteasome | Q44234657 | ||
| Arginase and autoimmune inflammation in the central nervous system | Q44563491 | ||
| Regulation of inhibitory protein-kappaB and monocyte chemoattractant protein-1 by angiotensin II type 2 receptor-activated Src homology protein tyrosine phosphatase-1 in fetal vascular smooth muscle cells | Q44699080 | ||
| Dysmyelination and reduced myelin basic protein gene expression by oligodendrocytes of SHP-1-deficient mice | Q44936994 | ||
| Distinct promoters regulate tissue-specific and differential expression of kallikrein 6 in CNS demyelinating disease | Q45177746 | ||
| P433 | issue | 7 | |
| P921 | main subject | inflammation | Q101991 |
| phenotype | Q104053 | ||
| patient | Q181600 | ||
| macrophage | Q184204 | ||
| multiple sclerosis | Q8277 | ||
| P304 | page(s) | 742-759 | |
| P577 | publication date | 2009-04-27 | |
| P1433 | published in | Laboratory Investigation | Q6467260 |
| P1476 | title | Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotype | |
| P478 | volume | 89 |
| Q28395476 | "Of mice and men": arginine metabolism in macrophages |
| Q34805483 | Alteration in the gene encoding protein tyrosine phosphatase nonreceptor type 6 (PTPN6/SHP1) may contribute to neutrophilic dermatoses |
| Q39332621 | Astaxanthin treatment reduced oxidative induced pro-inflammatory cytokines secretion in U937: SHP-1 as a novel biological target. |
| Q33905233 | Central neuroinvasion and demyelination by inflammatory macrophages after peripheral virus infection is controlled by SHP-1. |
| Q42773865 | Classically and alternatively activated bone marrow derived macrophages differ in cytoskeletal functions and migration towards specific CNS cell types |
| Q41818218 | Commentary: IL-4 and IL-13 receptors and signaling |
| Q35802861 | Cx3cr1 deficiency in mice attenuates hepatic granuloma formation during acute schistosomiasis by enhancing the M2-type polarization of macrophages |
| Q90589852 | Ets-2 deletion in myeloid cells attenuates IL-1α-mediated inflammatory disease caused by a Ptpn6 point mutation |
| Q34500740 | Gene Expression Changes in Multiple Sclerosis Relapse Suggest Activation of T and Non-T Cells |
| Q33723775 | Gene expression profiles in granuloma tissue reveal novel diagnostic markers in sarcoidosis |
| Q28727258 | Identification of VHY/Dusp15 as a regulator of oligodendrocyte differentiation through a systematic genomics approach |
| Q36125752 | Immune markers and differential signaling networks in ulcerative colitis and Crohn's disease |
| Q39677902 | Immune receptor expressed on myeloid cells 1 (IREM-1) inhibits B cell activation factor (BAFF)-mediated inflammatory regulation of THP-1 cells through modulation of the activities of extracellular regulated kinase (ERK). |
| Q35085607 | Increased expression of the chemokine CCL23 in eosinophilic chronic rhinosinusitis with nasal polyps |
| Q42000292 | Increased promoter methylation of the immune regulatory gene SHP-1 in leukocytes of multiple sclerosis subjects |
| Q37348839 | Interferon-beta treatment in multiple sclerosis attenuates inflammatory gene expression through inducible activity of the phosphatase SHP-1. |
| Q35785935 | Interleukin-33 upregulation in peripheral leukocytes and CNS of multiple sclerosis patients. |
| Q37665065 | Macrophage polarization and HIV-1 infection. |
| Q38793618 | Macrophage polarization in response to oral commensals and pathogens |
| Q37983759 | Microglial carbohydrate-binding receptors for neural repair. |
| Q51529671 | Phytosterols ameliorate clinical manifestations and inflammation in experimental autoimmune encephalomyelitis. |
| Q38842536 | Protein tyrosine phosphatase SHP-1: resurgence as new drug target for human autoimmune disorders. |
| Q36091339 | Quantitative differences in the immunomodulatory effects of Rebif and Avonex in IFN-β 1a treated multiple sclerosis patients |
| Q34382358 | Real-time imaging and genetic dissection of host-microbe interactions in zebrafish |
| Q38974101 | Role of the JAK/STAT signaling pathway in regulation of innate immunity in neuroinflammatory diseases. |
| Q34580138 | SHP-1 regulation of mast cell function in allergic inflammation and anaphylaxis |
| Q35610619 | Schistosoma mansoni Soluble Egg Antigens Induce Expression of the Negative Regulators SOCS1 and SHP1 in Human Dendritic Cells via Interaction with the Mannose Receptor |
| Q39367824 | Shp1 function in myeloid cells |
| Q39351460 | Synthetic peptides containing ITIM-like domains block expression of inflammatory mediators and migration/invasion of cancer cells through activation of SHP-1 and PI3K. |
| Q39404438 | Synthetic peptides containing ITIM-like sequences of IREM-1 (CD300F) differentially regulate MyD88 and TRIF-mediated TLR signalling through activation of SHP and/or PI3K. |
| Q64266337 | Targeted SHP-1 Silencing Modulates the Macrophage Phenotype, Leading to Metabolic Improvement in Dietary Obese Mice |
| Q64897993 | The Role of Monocytes and Macrophages in Autoimmune Diseases: A Comprehensive Review. |
| Q35946448 | The control of reactive oxygen species production by SHP-1 in oligodendrocytes |
| Q38540498 | The role of the ubiquitin-editing enzyme A20 in diseases of the central nervous system and other pathological processes |
| Q47401912 | Therapeutic potential of curcumin for multiple sclerosis. |
| Q38357504 | Toll-Like Receptor Pathways in Autoimmune Diseases |
| Q58774371 | Tryptophan and arginine catabolic enzymes and regulatory cytokines in clinically isolated syndrome and multiple sclerosis |
| Q37676043 | Tyrosine phosphatase SHP-1 in allergic and anaphylactic inflammation |
| Q47194138 | Update on riboflavin and multiple sclerosis: a systematic review |
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