| review article | Q7318358 |
| scholarly article | Q13442814 |
| P356 | DOI | 10.1042/CS20140695 |
| P698 | PubMed publication ID | 25881670 |
| P50 | author | Paulo Ivo Homem De Bittencourt | Q70949473 |
| Philip Newsholme | Q37842857 | ||
| Mauricio Krause | Q38642930 | ||
| Hilton Kenji Takahashi | Q42530120 | ||
| P2093 | author name string | Patricia Martins Bock | |
| P2860 | cites work | Interleukin-6 regulates pancreatic alpha-cell mass expansion | Q24336156 |
| Reactive oxygen and nitrogen species generation, antioxidant defenses, and β-cell function: a critical role for amino acids | Q27024554 | ||
| Cutting edge: direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kappa B | Q28118928 | ||
| Toll-like receptors in the induction of the innate immune response | Q28144797 | ||
| Heat shock prevents insulin resistance-induced vascular complications by augmenting angiotensin-(1-7) signaling | Q28569037 | ||
| Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes | Q29615593 | ||
| The heat-shock proteins | Q29617227 | ||
| TLR4 links innate immunity and fatty acid-induced insulin resistance | Q29617577 | ||
| Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance | Q33320681 | ||
| Toll-like receptor-4 inhibits enterocyte proliferation via impaired beta-catenin signaling in necrotizing enterocolitis | Q33618589 | ||
| Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax. | Q33688622 | ||
| Tlr2 is critical for diet-induced metabolic syndrome in a murine model. | Q33694600 | ||
| Inhibition of the JNK/Bim pathway by Hsp70 prevents Bax activation in UV‐induced apoptosis | Q33733752 | ||
| Increased toll-like receptor (TLR) activation and TLR ligands in recently diagnosed type 2 diabetic subjects | Q33751565 | ||
| Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase | Q33886831 | ||
| Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3β independent of JNK activation | Q33889357 | ||
| Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome | Q33912989 | ||
| TLR4 and Insulin Resistance | Q34097407 | ||
| Islet NADPH oxidase activity is modulated unevenly by different secretagogues | Q42849049 | ||
| The chaperone proteins HSP70, HSP40/DnaJ and GRP78/BiP suppress misfolding and formation of β-sheet-containing aggregates by human amylin: a potential role for defective chaperone biology in Type 2 diabetes | Q42927518 | ||
| Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet. | Q43091069 | ||
| Heat treatment improves glucose tolerance and prevents skeletal muscle insulin resistance in rats fed a high-fat diet | Q43177148 | ||
| Exercise and possible molecular mechanisms of protection from vascular disease and diabetes: the central role of ROS and nitric oxide | Q43239564 | ||
| Heat shock restores insulin secretion after injury by nitric oxide by maintaining glucokinase activity in rat islets | Q43618521 | ||
| Interleukin-1 beta depletes insulin messenger ribonucleic acid and increases the heat shock protein hsp70 in mouse pancreatic islets without impairing the glucose metabolism | Q43820163 | ||
| Chronic cardiovascular and renal actions of leptin: role of adrenergic activity | Q43908233 | ||
| Decreased expression of heat shock protein 72 in skeletal muscle of patients with type 2 diabetes correlates with insulin resistance | Q43935456 | ||
| NFkappaB, heat shock proteins, HSF-1, and inflammation | Q43959301 | ||
| Pancreatic beta-cells express phagocyte-like NAD(P)H oxidase | Q44453013 | ||
| Aberrant p38 mitogen-activated protein kinase signalling in skeletal muscle from Type 2 diabetic patients. | Q44561132 | ||
| Thermal treatment attenuates neointimal thickening with enhanced expression of heat-shock protein 72 and suppression of oxidative stress | Q44820286 | ||
| Cytokine gene expression in human skeletal muscle during concentric contraction: evidence that IL-8, like IL-6, is influenced by glycogen availability. | Q44836464 | ||
| Inhibition of NADPH oxidase-1 preserves beta cell function | Q45004022 | ||
| Hsp70 release from peripheral blood mononuclear cells. | Q45098360 | ||
| β-arrestin 2 regulates Toll-like receptor 4-mediated apoptotic signalling through glycogen synthase kinase-3β. | Q45167801 | ||
| Increased Hsp70 expression attenuates cytokine-induced cell death in islets of Langerhans from Shb knockout mice. | Q45926398 | ||
| Adrenergic receptors mediate stress-induced elevations in extracellular Hsp72. | Q46613310 | ||
| Mice with beta cell overexpression of glycogen synthase kinase-3beta have reduced beta cell mass and proliferation | Q46791934 | ||
| Inhibition or deletion of the lipopolysaccharide receptor Toll-like receptor-4 confers partial protection against lipid-induced insulin resistance in rodent skeletal muscle | Q46865480 | ||
| Acute nutrient regulation of the mitochondrial glutathione redox state in pancreatic β-cells | Q46912910 | ||
| Interleukin-6 release from human skeletal muscle during exercise: relation to AMPK activity. | Q47668219 | ||
| Heat shock transcription factor 1 attenuates TNFα-induced cardiomyocyte death through suppression of NFκB pathway. | Q50905576 | ||
| Obesity depresses the anti-inflammatory HSP70 pathway, contributing to NAFLD progression. | Q53013442 | ||
| GRP78 overproduction in pancreatic beta cells protects against high-fat-diet-induced diabetes in mice. | Q53117103 | ||
| Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes. | Q53425060 | ||
| Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. | Q53787751 | ||
| Resident macrophages mediate islet amyloid polypeptide-induced islet IL-1β production and β-cell dysfunction. | Q54614933 | ||
| Alterations of NADPH oxidase activity in rat pancreatic islets induced by a high-fat diet. | Q54622392 | ||
| Effect of exercise, training, and glycogen availability on IL-6 receptor expression in human skeletal muscle | Q56240276 | ||
| Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance | Q56742768 | ||
| Measuring the secretion of heat shock proteins from cells | Q57362586 | ||
| Pancreatic Glucagon Damages Isolated Human Islet Function | Q57504474 | ||
| The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease | Q58466366 | ||
| Exercise induces hepatosplanchnic release of heat shock protein 72 in humans | Q59326285 | ||
| Regulation of cyclooxygenase-2 expression by heat: a novel aspect of heat shock factor 1 function in human cells | Q34162773 | ||
| Heat shock induces resistance in rat pancreatic islet cells against nitric oxide, oxygen radicals and streptozotocin toxicity in vitro | Q34224233 | ||
| Exendin-4 protects oxidative stress-induced β-cell apoptosis through reduced JNK and GSK3β activity | Q34255639 | ||
| Conditional ablation of Gsk-3β in islet beta cells results in expanded mass and resistance to fat feeding-induced diabetes in mice | Q34346739 | ||
| Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. | Q34857481 | ||
| Age related changes in pancreatic beta cells: A putative extra-cerebral site of Alzheimer's pathology | Q34878088 | ||
| Chronic sympathetic activation: consequence and cause of age-associated obesity? | Q35640700 | ||
| Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes | Q35641724 | ||
| SIRT1 protects against α-synuclein aggregation by activating molecular chaperones | Q35686386 | ||
| Inducible Toll-like receptor and NF-kappaB regulatory pathway expression in human adipose tissue | Q35688789 | ||
| Divergence of intracellular and extracellular HSP72 in type 2 diabetes: does fat matter? | Q35854610 | ||
| Loss of defense against stress: diabetes and heat shock proteins | Q36058310 | ||
| Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1 | Q36194366 | ||
| Endogenous extra-cellular heat shock protein 72: releasing signal(s) and function. | Q36210031 | ||
| Determinants of the selective toxicity of alloxan to the pancreatic B cell | Q36280972 | ||
| NADPH oxidase NOX2 defines a new antagonistic role for reactive oxygen species and cAMP/PKA in the regulation of insulin secretion. | Q36339543 | ||
| HSP72 protects against obesity-induced insulin resistance | Q36446531 | ||
| Toll-like receptor 4: link to the anti-inflammatory effects of exercise? | Q36619195 | ||
| Association between promoter polymorphisms of the GRP78 gene and risk of type 2 diabetes in a Chinese Han population | Q36661245 | ||
| Interleukin-6 regulation of AMP-activated protein kinase. Potential role in the systemic response to exercise and prevention of the metabolic syndrome | Q36666161 | ||
| The AMP-activated protein kinase: role in regulation of skeletal muscle metabolism and insulin sensitivity | Q36822808 | ||
| Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity | Q36856230 | ||
| Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects | Q36906306 | ||
| Cell surface receptors for molecular chaperones. | Q36963134 | ||
| Inducible heat shock protein 70 and its role in preconditioning and exercise. | Q37018668 | ||
| Localization and expression of Hsp27 and αB-crystallin in rat primary myocardial cells during heat stress in vitro | Q37028056 | ||
| Contribution of IL-6 to the Hsp72, Hsp25, and alphaB-crystallin [corrected] responses to inflammation and exercise training in mouse skeletal and cardiac muscle | Q37033541 | ||
| Islet amyloid: from fundamental biophysics to mechanisms of cytotoxicity | Q37120813 | ||
| Heat shock proteins and exercise: a primer | Q37299302 | ||
| WHO recognition of the global obesity epidemic | Q37366355 | ||
| Hsp70 regulation on Nox4/p22phox and cytoskeletal integrity as an effect of losartan in vascular smooth muscle cells | Q37378895 | ||
| Innate immunity and heat shock response in islet transplantation | Q37419472 | ||
| Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice | Q37465299 | ||
| Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell | Q37610011 | ||
| A clear and present danger: endogenous ligands of Toll-like receptors | Q37615169 | ||
| Intracellular generation of superoxide by the phagocyte NADPH oxidase: how, where, and what for? | Q37792519 | ||
| Extracellular heat shock proteins, cellular export vesicles, and the Stress Observation System: a form of communication during injury, infection, and cell damage. It is never known how far a controversial finding will go! Dedicated to Ferruccio Rito | Q37801877 | ||
| Toll-like receptor signaling pathways--therapeutic opportunities | Q37803540 | ||
| HSP70 expression: does it a novel fatigue signalling factor from immune system to the brain? | Q37849717 | ||
| Regulation of insulin secretion and reactive oxygen species production by free fatty acids in pancreatic islets | Q37900460 | ||
| Oxidative stress, Nox isoforms and complications of diabetes--potential targets for novel therapies | Q38019841 | ||
| A sympathetic view of human obesity | Q38020317 | ||
| Transcriptional regulation of small HSP-HSF1 and beyond. | Q38023045 | ||
| Heat stress: a risk factor for skin carcinogenesis | Q38113038 | ||
| The fat cell senescence hypothesis: a mechanism responsible for abrogating the resolution of inflammation in chronic disease | Q38216179 | ||
| Endoplasmic reticulum stress, diabetes mellitus, and tissue injury | Q38255372 | ||
| Toll-like receptor 2 deficiency improves insulin sensitivity and hepatic insulin signalling in the mouse | Q38339916 | ||
| SIRT1 knockdown promotes neural differentiation and attenuates the heat shock response. | Q39033591 | ||
| Elevated levels of extracellular heat-shock protein 72 (eHSP72) are positively correlated with insulin resistance in vivo and cause pancreatic β-cell dysfunction and death in vitro | Q39044783 | ||
| Physiological concentrations of interleukin-6 directly promote insulin secretion, signal transduction, nitric oxide release, and redox status in a clonal pancreatic β-cell line and mouse islets. | Q39320250 | ||
| L-arginine is essential for pancreatic β-cell functional integrity, metabolism and defense from inflammatory challenge | Q39501747 | ||
| Suppression of NADPH oxidase 2 substantially restores glucose‐induced dysfunction of pancreatic NIT‐1 cells | Q39632457 | ||
| AMPK-mediated GSK3beta inhibition by isoliquiritigenin contributes to protecting mitochondria against iron-catalyzed oxidative stress | Q39760626 | ||
| Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I. | Q39788894 | ||
| Amylin uncovered: a review on the polypeptide responsible for type II diabetes. | Q39846208 | ||
| Pro-inflammatory cytokines increase glucose, alanine and triacylglycerol utilization but inhibit insulin secretion in a clonal pancreatic beta-cell line | Q40073153 | ||
| Impairment of the ubiquitin-proteasome pathway is a downstream endoplasmic reticulum stress response induced by extracellular human islet amyloid polypeptide and contributes to pancreatic beta-cell apoptosis | Q40120929 | ||
| Inhibition of GSK3 promotes replication and survival of pancreatic beta cells | Q40180167 | ||
| Glucose, palmitate and pro-inflammatory cytokines modulate production and activity of a phagocyte-like NADPH oxidase in rat pancreatic islets and a clonal beta cell line | Q40199579 | ||
| Expression of isoforms of NADPH oxidase components in rat pancreatic islets | Q40231191 | ||
| Heat shock protein 72 protects insulin-secreting beta cells from lipopolysaccharide-induced endoplasmic reticulum stress | Q40371176 | ||
| Exosome-dependent trafficking of HSP70: a novel secretory pathway for cellular stress proteins | Q40436107 | ||
| Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes. | Q40673661 | ||
| A high affinity HSF-1 binding site in the 5'-untranslated region of the murine tumor necrosis factor-alpha gene is a transcriptional repressor | Q40765080 | ||
| Natural resistance of human beta cells toward nitric oxide is mediated by heat shock protein 70. | Q40888704 | ||
| Heat shock protein hsp70 overexpression confers resistance against nitric oxide | Q41176293 | ||
| Glucose autoxidation and protein modification. The potential role of 'autoxidative glycosylation' in diabetes | Q42098319 | ||
| Glycoprotein 130 receptor signaling mediates α-cell dysfunction in a rodent model of type 2 diabetes. | Q42216034 | ||
| Discordant gene expression in skeletal muscle and adipose tissue of patients with type 2 diabetes: effect of interleukin-6 infusion. | Q42492116 | ||
| Acute exercise stimulates macrophage function: possible role of NF-kappaB pathways | Q42499706 | ||
| P433 | issue | 11 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 789-803 | |
| P577 | publication date | 2015-06-01 | |
| P1433 | published in | Clinical Science | Q372419 |
| P1476 | title | The regulatory roles of NADPH oxidase, intra- and extra-cellular HSP70 in pancreatic islet function, dysfunction and diabetes | |
| P478 | volume | 128 |
| Q41985668 | Acute exercise boosts cell proliferation and the heat shock response in lymphocytes: correlation with cytokine production and extracellular-to-intracellular HSP70 ratio. |
| Q90295069 | Amelioration of muscle wasting by glucagon-like peptide-1 receptor agonist in muscle atrophy |
| Q90247545 | Chaperone-Based Therapeutic Target Innovation: Heat Shock Protein 70 (HSP70) for Type 2 Diabetes Mellitus |
| Q97636580 | Coronavirus infection (SARS-CoV-2) in obesity and diabetes comorbidities: is heat shock response determinant for the disease complications? |
| Q55153461 | Effects of High-Intensity Interval and Moderate-Intensity Continuous Exercise on Inflammatory, Leptin, IgA, and Lipid Peroxidation Responses in Obese Males. |
| Q38676417 | Emerging Role of Nitric Oxide and Heat Shock Proteins in Insulin Resistance. |
| Q51018833 | Estrogen deprivation does not affect vascular heat shock response in female rats: a comparison with oxidative stress markers. |
| Q46581242 | Exogenous hydrogen sulphide ameliorates diabetic cardiomyopathy in rats by reversing disordered calcium-handling system in sarcoplasmic reticulum |
| Q51674195 | Fine particulate matter potentiates type 2 diabetes development in high-fat diet-treated mice: stress response and extracellular to intracellular HSP70 ratio analysis. |
| Q55104113 | Heat shock protein 70 promotes lipogenesis in HepG2 cells. |
| Q55447437 | Induction chemotherapy reduces extracellular heat shock protein 72 levels, inflammation, lipoperoxidation and changes insulin sensitivity in children and adolescents newly diagnosed with acute lymphoblastic leukemia. |
| Q36136892 | Knockout of Toll-Like Receptors 2 and 4 Prevents Renal Ischemia-Reperfusion-Induced Cardiac Hypertrophy in Mice. |
| Q40576690 | Modulation of rat monocyte/macrophage innate functions by increasing intensities of swimming exercise is associated with heat shock protein status. |
| Q47807793 | Nitric oxide-heat shock protein axis in menopausal hot flushes: neglected metabolic issues of chronic inflammatory diseases associated with deranged heat shock response. |
| Q53810787 | Oral supplementations with L-glutamine or L-alanyl-L-glutamine do not change metabolic alterations induced by long-term high-fat diet in the B6.129F2/J mouse model of insulin resistance. |
| Q64063455 | Passive heating and glycaemic control in non-diabetic and diabetic individuals: A systematic review and meta-analysis |
| Q41081215 | Polymorphisms in NADPH oxidase CYBA gene modify the risk of ESRD in patients with chronic glomerulonephritis |
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