Exercise induces hepatosplanchnic release of heat shock protein 72 in humans

article by Mark A Febbraio et al published 1 November 2002 in Journal of Physiology

Exercise induces hepatosplanchnic release of heat shock protein 72 in humans is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1113/JPHYSIOL.2002.025148
P932PMC publication ID2290618
P698PubMed publication ID12411538

P50authorBente Klarlund PedersenQ12303219
Adam SteensbergQ56477409
Peter KrustrupQ56486825
P2093author name stringNiels H Secher
Mark A Febbraio
Peter Ott
Charlotte Keller
Henning Bay Nielsen
P2860cites workMaximal perfusion of skeletal muscle in man.Q54444608
A stress-inducible 72-kDa heat-shock protein (HSP72) is expressed on the surface of human tumor cells, but not on normal cellsQ61893867
Differential effects of exercise and heat stress on liver HSP70 accumulation with agingQ71802455
HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokineQ73606601
Heat production in human skeletal muscle at the onset of intense dynamic exerciseQ73680820
HSP72 gene expression progressively increases in human skeletal muscle during prolonged, exhaustive exerciseQ74218049
Exercise increases serum Hsp72 in humansQ28345140
Invited Review: contractile activity-induced mitochondrial biogenesis in skeletal muscleQ31959665
Heat-shock protein protection.Q33591934
Liver protein synthesis in physiology and in disease statesQ34493677
Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4.Q40751982
Heat shock protein 70 kDa: molecular biology, biochemistry, and physiologyQ40833247
In vitro studies show that Hsp70 can be released by glia and that exogenous Hsp70 can enhance neuronal stress toleranceQ43751823
Reduced glycogen availability is associated with an elevation in HSP72 in contracting human skeletal muscleQ43875696
Attenuated hepatosplanchnic uptake of lactate during intense exercise in humansQ43918714
HSP70 and other possible heat shock or oxidative stress proteins are induced in skeletal muscle, heart, and liver during exercise.Q46043779
Serum levels of Hsp 72 measured early after trauma correlate with survivalQ46479365
Hepatic elimination of indocyanine green with special reference to distribution kinetics and the influence of plasma protein bindingQ47722814
Heat shock-like protein is transferred from glia to axonQ48385741
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)957-62
P577publication date2002-11-01
P1433published inJournal of PhysiologyQ7743612
P1476titleExercise induces hepatosplanchnic release of heat shock protein 72 in humans
P478volume544

Reverse relations

cites work (P2860)
Q41985668Acute exercise boosts cell proliferation and the heat shock response in lymphocytes: correlation with cytokine production and extracellular-to-intracellular HSP70 ratio.
Q46613310Adrenergic receptors mediate stress-induced elevations in extracellular Hsp72.
Q35611634Chaperokine-induced signal transduction pathways.
Q33838958Circulating heat shock protein 70 (HSPA1A) in normal and pathological pregnancies.
Q34510413Commensal bacteria and MAMPs are necessary for stress-induced increases in IL-1β and IL-18 but not IL-6, IL-10 or MCP-1.
Q36093644Distinct Skeletal Muscle Gene Regulation from Active Contraction, Passive Vibration, and Whole Body Heat Stress in Humans.
Q42473483Downhill running and exercise in hot environments increase leukocyte Hsp72 (HSPA1A) and Hsp90α (HSPC1) gene transcripts
Q40245107Effect of blood handling on extracellular Hsp72 concentration after high-intensity exercise in humans.
Q79774615Effect of caffeine supplementation on the extracellular heat shock protein 72 response to exercise
Q42515379Effect of heat acclimation on heat shock protein 72 and interleukin-10 in humans
Q38264651Effects of physical activity upon the liver.
Q51709364Elevation of body temperature is an essential factor for exercise-increased extracellular heat shock protein 72 level in rat plasma.
Q36210031Endogenous extra-cellular heat shock protein 72: releasing signal(s) and function.
Q40380318Enhanced expression of heat shock proteins in gradually dying cells and their release from necrotically dead cells
Q26773005Exercise Modulates Oxidative Stress and Inflammation in Aging and Cardiovascular Diseases
Q33716849Exercise induces the release of heat shock protein 72 from the human brain in vivo
Q90128342Exercise plasma metabolomics and xenometabolomics in obese, sedentary, insulin-resistant women: impact of a fitness and weight loss intervention
Q37144219Exercise training-induced changes in inflammatory mediators and heat shock proteins in young tennis players
Q53716840Exercise, heat shock proteins and insulin resistance.
Q36628536Exercising in environmental extremes : a greater threat to immune function?
Q46876544Exogenous delivery of heat shock protein 70 increases lifespan in a mouse model of amyotrophic lateral sclerosis.
Q41001027Exosomes: A Rising Star in Falling Hearts
Q28299626Extracellular Hsp72 concentration relates to a minimum endogenous criteria during acute exercise-heat exposure
Q40235882Extracellular and cellular Hsp72 differ as biomarkers in acute exercise/environmental stress and recovery
Q81375749Extracellular heat shock protein 70: a critical component for motoneuron survival
Q35153907Extracellular heat shock proteins: a new location, a new function
Q24656984Glucose ingestion attenuates interleukin-6 release from contracting skeletal muscle in humans
Q33716811Glucose ingestion attenuates the exercise-induced increase in circulating heat shock protein 72 and heat shock protein 60 in humans
Q37849717HSP70 expression: does it a novel fatigue signalling factor from immune system to the brain?
Q57364783Heat Shock Protein Release and Naturally Occurring Exogenous Heat Shock Proteins
Q42576131Heat and exercise acclimation increases intracellular levels of Hsp72 and inhibits exercise-induced increase in intracellular and plasma Hsp72 in humans.
Q40213339Heat induced release of Hsp70 from prostate carcinoma cells involves both active secretion and passive release from necrotic cells
Q89166752Heat shock protein 72 regulates hepatic lipid accumulation
Q37246996Heat shock protein 72 response to exercise in humans
Q36889463Heat shock protein expression in brain: a protective role spanning intrinsic thermal resistance and defense against neurotropic viruses
Q38672562Heat shock proteins and exercise adaptations. Our knowledge thus far and the road still ahead
Q37299302Heat shock proteins and exercise: a primer
Q36889472Heat shock proteins and the heat shock response during hyperthermia and its modulation by altered physiological conditions
Q35623259Heat shock response and acute lung injury
Q36161251Heat stress and cardiovascular, hormonal, and heat shock proteins in humans.
Q34421765Heat‐shock protein 70 modulates toxic extracellular α‐synuclein oligomers and rescues trans‐synaptic toxicity
Q58601101Hepatokines-a novel group of exercise factors
Q41604794Human resting extracellular heat shock protein 72 concentration decreases during the initial adaptation to exercise in a hot, humid environment
Q48035343Impacts of stocking density on development and puberty attainment of replacement beef heifers
Q34505699Increased serum HSP70 levels are associated with the duration of diabetes
Q37308072Increased serum heat-shock protein 70 levels reflect systemic inflammation, oxidative stress and hepatocellular injury in preeclampsia
Q36927306Induction of the 72 kDa heat shock protein by glucose ingestion in black pregnant women
Q44750437Induction, modification and accumulation of HSP70s in the rat liver after acute exercise: early and late responses.
Q44610001Insulin stimulates interleukin-6 and tumor necrosis factor-alpha gene expression in human subcutaneous adipose tissue
Q37170872Interaction of serum 70-kDa heat shock protein levels and HspA1B (+1267) gene polymorphism with disease severity in patients with chronic heart failure
Q35179777Interactions of aging, overload, and creatine supplementation in rat plantaris muscle
Q42144271Isolated hearts treated with skeletal muscle homogenates exhibit altered function.
Q98196848Metabolic communication during exercise
Q41222071Moderate- and high-intensity exhaustive exercise in the heat induce a similar increase in monocyte Hsp72.
Q91875478Muscle-Liver Substrate Fluxes in Exercising Humans and Potential Effects on Hepatic Metabolism
Q35104956Muscle-derived interleukin-6: lipolytic, anti-inflammatory and immune regulatory effects
Q47807793Nitric oxide-heat shock protein axis in menopausal hot flushes: neglected metabolic issues of chronic inflammatory diseases associated with deranged heat shock response.
Q41833314No endogenous circadian rhythm in resting plasma Hsp72 concentration in humans.
Q41770070Plasma Hsp72 (HSPA1A) and Hsp27 (HSPB1) expression under heat stress: influence of exercise intensity
Q79787757Plasma Hsp72 is higher in runners with more serious symptoms of exertional heat illness
Q46112200Plasma levels of heat shock protein 72 (HSP72) and beta-endorphin as indicators of stress, pain and prognosis in horses with colic
Q35945620Psychoneuroimmunology: then and now.
Q34979395Restoring HSP70 deficiencies improves glucose tolerance in diabetic monkeys
Q30473241Salivary Hsp72 does not track exercise stress and caffeine-stimulated plasma Hsp72 responses in humans
Q36674101Salivary extracellular heat shock protein 70 (eHSP70) levels increase after 59 min of intense exercise and correlate with resting salivary secretory immunoglobulin A (SIgA) levels at rest
Q37733648Selecting exercise regimens and strains to modify obesity and diabetes in rodents: an overview
Q34797199Serum level of soluble Hsp70 is associated with vascular calcification
Q87510032Short-term but not long-term hypoglycaemia enhances plasma levels and hepatic expression of HSP72 in insulin-treated rats: an effect associated with increased IL-6 levels but not with IL-10 or TNF-α
Q37490925Stress-induced extracellular Hsp72 is a functionally significant danger signal to the immune system
Q34569544The Anti-Inflammatory Actions of Exercise Training
Q35169987The chaperone balance hypothesis: the importance of the extracellular to intracellular HSP70 ratio to inflammation-driven type 2 diabetes, the effect of exercise, and the implications for clinical management
Q42276954The effect of 15 consecutive days of heat-exercise acclimation on heat shock protein 70.
Q36036435The effect of dehydration on muscle metabolism and time trial performance during prolonged cycling in males
Q81786265The effect of the rate of heat storage on serum heat shock protein 72 in humans
Q34266323The impact of submaximal exercise during heat and/or hypoxia on the cardiovascular and monocyte HSP72 responses to subsequent (post 24 h) exercise in hypoxia
Q58617447The increased expression of the inducible Hsp70 (HSP70A1A) in serum of patients with heart failure and its protective effect against the cardiotoxic agent doxorubicin
Q38424338The regulatory roles of NADPH oxidase, intra- and extra-cellular HSP70 in pancreatic islet function, dysfunction and diabetes.
Q44495370Toll-like receptor 4 and CD14 mRNA expression are lower in resistive exercise-trained elderly women
Q34956130Toll-like receptors 2 and 4: initiators of non-septic inflammation in critical care medicine?
Q39281019Unconventional Secretion of Heat Shock Proteins in Cancer
Q38548904eHSP70/iHSP70 and divergent functions on the challenge: effect of exercise and tissue specificity in response to stress