| review article | Q7318358 |
| scholarly article | Q13442814 |
| P50 | author | Thiago Gomes Heck | Q54394831 |
| Paulo Ivo Homem De Bittencourt | Q70949473 | ||
| Rui Curi | Q89797647 | ||
| Philip Newsholme | Q37842857 | ||
| Mauricio Krause | Q38642930 | ||
| P2093 | author name string | Aline Bittencourt | |
| Sofia Pizzato Scomazzon | |||
| P2860 | cites work | β-arrestin 2 regulates Toll-like receptor 4-mediated apoptotic signalling through glycogen synthase kinase-3β. | Q45167801 |
| The repeated bout effect and heat shock proteins: intramuscular HSP27 and HSP70 expression following two bouts of eccentric exercise in humans | Q45711233 | ||
| Adrenergic receptors mediate stress-induced elevations in extracellular Hsp72. | Q46613310 | ||
| Atherosclerosis: a redox-sensitive lipid imbalance suppressible by cyclopentenone prostaglandins. | Q46623802 | ||
| Inhibition or deletion of the lipopolysaccharide receptor Toll-like receptor-4 confers partial protection against lipid-induced insulin resistance in rodent skeletal muscle | Q46865480 | ||
| Ciliary neurotrophic factor prevents acute lipid-induced insulin resistance by attenuating ceramide accumulation and phosphorylation of c-Jun N-terminal kinase in peripheral tissues | Q46882472 | ||
| Inflammatory status as an important determinant of heat shock protein 70 serum concentrations during aging | Q47618312 | ||
| Interleukin-6 release from human skeletal muscle during exercise: relation to AMPK activity. | Q47668219 | ||
| Exercise training modulates heat shock protein response in diabetic rats | Q47788938 | ||
| A possible role of NF-κB and HSP72 in skeletal muscle hypertrophy induced by heat stress in rats | Q48330054 | ||
| 70K heat shock related proteins stimulate protein translocation into microsomes | Q49486847 | ||
| Obesity depresses the anti-inflammatory HSP70 pathway, contributing to NAFLD progression. | Q53013442 | ||
| Exercise-recruited NK cells display exercise-associated eHSP-70. | Q53504966 | ||
| Prolonged reactive oxygen species generation and nuclear factor-kappaB activation after a high-fat, high-carbohydrate meal in the obese. | Q53530472 | ||
| Effect of exercise, training, and glycogen availability on IL-6 receptor expression in human skeletal muscle | Q56240276 | ||
| Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance | Q56742768 | ||
| Exercise induces hepatosplanchnic release of heat shock protein 72 in humans | Q59326285 | ||
| The importance of redox shuttles to pancreatic β-cell energy metabolism and function | Q63248604 | ||
| Infarct limitation of the second window of protection in a conscious rabbit model | Q71415596 | ||
| Hsp70 prevents activation of stress kinases. A novel pathway of cellular thermotolerance | Q73500626 | ||
| HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine | Q73606601 | ||
| HSP72 gene expression progressively increases in human skeletal muscle during prolonged, exhaustive exercise | Q74218049 | ||
| The function of HSP72 in suppression of c-Jun N-terminal kinase activation can be dissociated from its role in prevention of protein damage | Q77985268 | ||
| De-repression of heat shock transcription factor-1 in interleukin-6- treated hepatocytes is mediated by downregulation of glycogen synthase kinase 3beta and MAPK/ERK-1 | Q79712711 | ||
| Toll-like receptor-2 is essential for the development of palmitate-induced insulin resistance in myotubes | Q79785476 | ||
| MRP1/GS-X pump ATPase expression: is this the explanation for the cytoprotection of the heart against oxidative stress-induced redox imbalance in comparison to skeletal muscle cells? | Q79991825 | ||
| Nitric oxide increases GLUT4 expression and regulates AMPK signaling in skeletal muscle | Q80710008 | ||
| Exercise intensity and duration affect blood soluble HSP72 | Q81288511 | ||
| Association between heat-shock protein 70 gene polymorphisms and DNA damage in peripheral blood lymphocytes among coke-oven workers | Q81566471 | ||
| Extracellular heat shock proteins (eHSP70) in exercise: Possible targets outside the immune system and their role for neurodegenerative disorders treatment | Q82428928 | ||
| Skeletal muscle insulin resistance in morbid obesity: the role of interleukin-6 and leptin | Q84660993 | ||
| c-Jun NH2-terminal kinase targeting and phosphorylation of heat shock factor-1 suppress its transcriptional activity | Q23920602 | ||
| NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses | Q27861101 | ||
| Toll-like receptors in the induction of the innate immune response | Q28144797 | ||
| Extracellular Hsp72 concentration relates to a minimum endogenous criteria during acute exercise-heat exposure | Q28299626 | ||
| Exercise increases serum Hsp72 in humans | Q28345140 | ||
| Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways | Q28346530 | ||
| Contraction regulation of Akt in rat skeletal muscle | Q28564227 | ||
| In vivo heat shock protein assembles with septic liver NF-kappaB/I-kappaB complex regulating NF-kappaB activity | Q28565529 | ||
| Anti-inflammatory effects of the 70 kDa heat shock protein in experimental stroke | Q28576568 | ||
| HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice | Q28588529 | ||
| Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases | Q29547555 | ||
| IKK-beta links inflammation to obesity-induced insulin resistance | Q29614285 | ||
| Increased toll-like receptor (TLR) activation and TLR ligands in recently diagnosed type 2 diabetic subjects | Q33751565 | ||
| Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase | Q33886831 | ||
| Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome | Q33912989 | ||
| p27 suppresses arsenite-induced Hsp27/Hsp70 expression through inhibiting JNK2/c-Jun- and HSF-1-dependent pathways | Q34074290 | ||
| TLR4 and Insulin Resistance | Q34097407 | ||
| PDSM, a motif for phosphorylation-dependent SUMO modification | Q34248164 | ||
| Hsp72 functions as a natural inhibitory protein of c-Jun N-terminal kinase | Q34271504 | ||
| Serum HSP70: a novel biomarker for early detection of pancreatic cancer. | Q34322212 | ||
| Heat shock proteins: endogenous modulators of apoptotic cell death | Q34340472 | ||
| Antiproliferative prostaglandins and the MRP/GS-X pump role in cancer immunosuppression and insight into new strategies in cancer gene therapy | Q34360373 | ||
| Increased serum HSP70 levels are associated with the duration of diabetes | Q34505699 | ||
| Extracellular heat shock protein 70 (HSPA1A) and classical vascular risk factors in a general population | Q34505818 | ||
| Oxidative stress in type 2 diabetes: the role of fasting and postprandial glycaemia | Q34569271 | ||
| HSP70 peptidembearing and peptide-negative preparations act as chaperokines | Q35083995 | ||
| Cell stress-associated caspase activation: intrinsically complex? | Q35092336 | ||
| Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates | Q35133872 | ||
| Inducible Toll-like receptor and NF-kappaB regulatory pathway expression in human adipose tissue | Q35688789 | ||
| Plasma heat shock protein 72 as a biomarker of sarcopenia in elderly people | Q35854605 | ||
| Divergence of intracellular and extracellular HSP72 in type 2 diabetes: does fat matter? | Q35854610 | ||
| Heat shock factors: integrators of cell stress, development and lifespan. | Q36109403 | ||
| Release of heat shock proteins (Hsps) and the effects of extracellular Hsps on neural cells and tissues | Q36210025 | ||
| Mechanisms of stress-induced cellular HSP72 release: implications for exercise-induced increases in extracellular HSP72. | Q36356903 | ||
| Releasing signals, secretory pathways, and immune function of endogenous extracellular heat shock protein 72. | Q36357910 | ||
| HSP72 protects against obesity-induced insulin resistance | Q36446531 | ||
| Examining the function and regulation of hsp 70 in cells subjected to metabolic stress | Q36531478 | ||
| Extracellular heat shock proteins in cell signaling | Q36820748 | ||
| Heat shock proteins are important mediators of skeletal muscle insulin sensitivity | Q36896750 | ||
| Beat shock proteins and atrial fibrillation. | Q36905791 | ||
| Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects | Q36906306 | ||
| Cell surface receptors for molecular chaperones. | Q36963134 | ||
| Heat shock protein 72: release and biological significance during exercise. | Q36992110 | ||
| Inducible heat shock protein 70 and its role in preconditioning and exercise. | Q37018668 | ||
| Contribution of IL-6 to the Hsp72, Hsp25, and alphaB-crystallin [corrected] responses to inflammation and exercise training in mouse skeletal and cardiac muscle | Q37033541 | ||
| Skeletal muscle pathways of contraction-enhanced glucose uptake | Q37134203 | ||
| Heat shock proteins and exercise: a primer | Q37299302 | ||
| Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice | Q37465299 | ||
| Stress-induced extracellular Hsp72 is a functionally significant danger signal to the immune system | Q37490925 | ||
| Oxidative stress, diabetes, and diabetic complications | Q37613032 | ||
| Extracellular heat shock proteins, cellular export vesicles, and the Stress Observation System: a form of communication during injury, infection, and cell damage. It is never known how far a controversial finding will go! Dedicated to Ferruccio Rito | Q37801877 | ||
| HSP70 expression: does it a novel fatigue signalling factor from immune system to the brain? | Q37849717 | ||
| Heat shock proteins protect against ischemia and inflammation through multiple mechanisms | Q37871617 | ||
| Over-nutrition, obesity and insulin resistance in the development of β-cell dysfunction | Q37974237 | ||
| The fat cell senescence hypothesis: a mechanism responsible for abrogating the resolution of inflammation in chronic disease | Q38216179 | ||
| S-nitrosation of the insulin receptor, insulin receptor substrate 1, and protein kinase B/Akt: a novel mechanism of insulin resistance. | Q38328824 | ||
| Heat shock protein 70 confers cardiovascular protection during endotoxemia via inhibition of nuclear factor-kappaB activation and inducible nitric oxide synthase expression in the rostral ventrolateral medulla | Q38333999 | ||
| Hsp70 family molecular chaperones and mutant insulin receptor: differential binding specificities of BiP and Hsp70/Hsc70 determines accumulation or degradation of insulin receptor | Q38362717 | ||
| Elevated levels of extracellular heat-shock protein 72 (eHSP72) are positively correlated with insulin resistance in vivo and cause pancreatic β-cell dysfunction and death in vitro | Q39044783 | ||
| Physiological concentrations of interleukin-6 directly promote insulin secretion, signal transduction, nitric oxide release, and redox status in a clonal pancreatic β-cell line and mouse islets. | Q39320250 | ||
| L-arginine is essential for pancreatic β-cell functional integrity, metabolism and defense from inflammatory challenge | Q39501747 | ||
| AMPK-mediated GSK3beta inhibition by isoliquiritigenin contributes to protecting mitochondria against iron-catalyzed oxidative stress | Q39760626 | ||
| Heat shock factor 1 inhibits nuclear factor-kappaB nuclear binding activity during endotoxin tolerance and heat shock | Q39947538 | ||
| Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase | Q40227253 | ||
| LipoCardium: endothelium-directed cyclopentenone prostaglandin-based liposome formulation that completely reverses atherosclerotic lesions | Q40285724 | ||
| Exosome-dependent trafficking of HSP70: a novel secretory pathway for cellular stress proteins | Q40436107 | ||
| Exogenous nitric oxide and endogenous glucose-stimulated beta-cell nitric oxide augment insulin release | Q40687374 | ||
| c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade | Q40692121 | ||
| Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex. | Q40701074 | ||
| Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4. | Q40751982 | ||
| A high affinity HSF-1 binding site in the 5'-untranslated region of the murine tumor necrosis factor-alpha gene is a transcriptional repressor | Q40765080 | ||
| Delayed protection of the ischemic heart--from pathophysiology to therapeutic applications. | Q41197207 | ||
| Hydroxyl radical production and autoxidative glycosylation. Glucose autoxidation as the cause of protein damage in the experimental glycation model of diabetes mellitus and ageing | Q41845928 | ||
| Role of Hsp70 synthesis in the fate of the insulin-receptor complex after heat shock in cultured fetal hepatocytes | Q41930853 | ||
| Dual role of interleukin-6 in regulating insulin sensitivity in murine skeletal muscle | Q42135596 | ||
| The anti-inflammatory mechanisms of Hsp70 | Q42146676 | ||
| The effect of stress-inducible extracellular Hsp72 on human neutrophil chemotaxis: a role during acute intense exercise. | Q42443019 | ||
| Glycogen synthase kinase-3beta facilitates staurosporine- and heat shock-induced apoptosis. Protection by lithium | Q42484847 | ||
| Role of Hsp72 and norepinephrine in the moderate exercise-induced stimulation of neutrophils' microbicide capacity. | Q42499423 | ||
| Heat and exercise acclimation increases intracellular levels of Hsp72 and inhibits exercise-induced increase in intracellular and plasma Hsp72 in humans. | Q42576131 | ||
| Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet. | Q43091069 | ||
| Heat treatment improves glucose tolerance and prevents skeletal muscle insulin resistance in rats fed a high-fat diet | Q43177148 | ||
| Decreased expression of heat shock protein 72 in skeletal muscle of patients with type 2 diabetes correlates with insulin resistance | Q43935456 | ||
| NFkappaB, heat shock proteins, HSF-1, and inflammation | Q43959301 | ||
| Effects of habitual exercise on the eHsp72-induced release of inflammatory cytokines by macrophages from obese Zucker rats | Q43966081 | ||
| Anti-inflammatory activity of 15-deoxy-delta12,14-PGJ2 and 2-cyclopenten-1-one: role of the heat shock response | Q44483407 | ||
| Aberrant p38 mitogen-activated protein kinase signalling in skeletal muscle from Type 2 diabetic patients. | Q44561132 | ||
| Overexpression of rat heat shock protein 70 reduces neuronal injury after transient focal ischemia, transient global ischemia, or kainic acid-induced seizures | Q44633150 | ||
| Insulin action, regional fat, and myocyte lipid: altered relationships with increased adiposity | Q44662133 | ||
| Cytokine gene expression in human skeletal muscle during concentric contraction: evidence that IL-8, like IL-6, is influenced by glycogen availability. | Q44836464 | ||
| Hsp70 release from peripheral blood mononuclear cells. | Q45098360 | ||
| P275 | copyright license | Creative Commons Attribution 3.0 Unported | Q14947546 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | type 2 diabetes | Q3025883 |
| physical exercise | Q219067 | ||
| molecular chaperones | Q422496 | ||
| P5008 | on focus list of Wikimedia project | ScienceSource | Q55439927 |
| P304 | page(s) | 249205 | |
| P577 | publication date | 2015-02-26 | |
| P1433 | published in | Mediators of Inflammation | Q2144494 |
| P1476 | title | The chaperone balance hypothesis: the importance of the extracellular to intracellular HSP70 ratio to inflammation-driven type 2 diabetes, the effect of exercise, and the implications for clinical management | |
| P478 | volume | 2015 |
| Q38991512 | A comparison of two commercially available ELISA methods for the quantification of human plasma heat shock protein 70 during rest and exercise stress |
| Q41985668 | Acute exercise boosts cell proliferation and the heat shock response in lymphocytes: correlation with cytokine production and extracellular-to-intracellular HSP70 ratio. |
| Q89039967 | Balneotherapy, Immune System, and Stress Response: A Hormetic Strategy? |
| Q90247545 | Chaperone-Based Therapeutic Target Innovation: Heat Shock Protein 70 (HSP70) for Type 2 Diabetes Mellitus |
| Q90676845 | Chronic heat treatment positively impacts metabolic profile of ovariectomized rats: association with heat shock response pathways |
| Q97636580 | Coronavirus infection (SARS-CoV-2) in obesity and diabetes comorbidities: is heat shock response determinant for the disease complications? |
| Q91605694 | Detectable levels of eHSP72 in plasma are associated with physical activity and antioxidant enzyme activity levels in hypertensive subjects |
| Q53784434 | Determination of the anti-inflammatory and cytoprotective effects of l-glutamine and l-alanine, or dipeptide, supplementation in rats submitted to resistance exercise. |
| Q61805116 | Effects of High-Fat Diet on eHSP72 and Extra-to-Intracellular HSP70 Levels in Mice Submitted to Exercise under Exposure to Fine Particulate Matter |
| Q38676417 | Emerging Role of Nitric Oxide and Heat Shock Proteins in Insulin Resistance. |
| Q51018833 | Estrogen deprivation does not affect vascular heat shock response in female rats: a comparison with oxidative stress markers. |
| Q53716840 | Exercise, heat shock proteins and insulin resistance. |
| Q35962138 | Expression of Heat Shock Protein 70 Gene and Its Correlation with Inflammatory Markers in Essential Hypertension |
| Q51674195 | Fine particulate matter potentiates type 2 diabetes development in high-fat diet-treated mice: stress response and extracellular to intracellular HSP70 ratio analysis. |
| Q45840687 | Heat and Hypoxic Acclimation Increase Monocyte Heat Shock Protein 72 but Do Not Attenuate Inflammation following Hypoxic Exercise |
| Q91782768 | Heat shock protein 60 (HSP60) modulates adiponectin signaling by stabilizing adiponectin receptor |
| Q89166752 | Heat shock protein 72 regulates hepatic lipid accumulation |
| Q52761284 | Heat shock proteins as modulators and therapeutic targets of chronic disease: an integrated perspective. |
| Q41600602 | Hsp72 and Hsp90α mRNA transcription is characterised by large, sustained changes in core temperature during heat acclimation |
| Q55447437 | Induction chemotherapy reduces extracellular heat shock protein 72 levels, inflammation, lipoperoxidation and changes insulin sensitivity in children and adolescents newly diagnosed with acute lymphoblastic leukemia. |
| Q36070681 | Modulating Molecular Chaperones Improves Mitochondrial Bioenergetics and Decreases the Inflammatory Transcriptome in Diabetic Sensory Neurons |
| Q40576690 | Modulation of rat monocyte/macrophage innate functions by increasing intensities of swimming exercise is associated with heat shock protein status. |
| Q53810787 | Oral supplementations with L-glutamine or L-alanyl-L-glutamine do not change metabolic alterations induced by long-term high-fat diet in the B6.129F2/J mouse model of insulin resistance. |
| Q64063455 | Passive heating and glycaemic control in non-diabetic and diabetic individuals: A systematic review and meta-analysis |
| Q55265913 | Physical Exercise Enhanced Heat Shock Protein 60 Expression and Attenuated Inflammation in the Adipose Tissue of Human Diabetic Obese. |
| Q37057856 | Promoting Neuronal Tolerance of Diabetic Stress: Modulating Molecular Chaperones |
| Q59129313 | Resistance training and L-arginine supplementation are determinant in genomic stability, cardiac contractility and muscle mass development in rats |
| Q46331065 | Role of vitamin A oral supplementation on oxidative stress and inflammatory response in the liver of trained rats. |
| Q37740715 | Serial Changes of Heat Shock Protein 70 and Interleukin-8 in Burn Blister Fluid. |
| Q40112313 | Soluble heat shock protein 70 members in patients undergoing allogeneic hematopoietic cell transplantation |
| Q60934712 | The Biological Role of Klotho Protein in the Development of Cardiovascular Diseases |
| Q47095702 | The Effects of Resistance Training Volume on Skeletal Muscle Proteome |
| Q47750360 | The effect of passive heating on heat shock protein 70 and interleukin-6: A possible treatment tool for metabolic diseases? |
| Q36141465 | Time Course Analysis of Skeletal Muscle Pathology of GDE5 Transgenic Mouse |
| Q93080930 | Unveiling the Interplay between the TLR4/MD2 Complex and HSP70 in the Human Cardiovascular System: A Computational Approach |
| Q33616708 | Vitamin A Oral Supplementation Induces Oxidative Stress and Suppresses IL-10 and HSP70 in Skeletal Muscle of Trained Rats |
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