Exogenous delivery of heat shock protein 70 increases lifespan in a mouse model of amyotrophic lateral sclerosis. (scientific article published in November 2007)

Behavioural and anatomical effects of systemically administered leukemia inhibitory factor in the SOD1(G93A G1H) mouse model of familial amyotrophic lateral sclerosis

Q48228139

Heat shock-like protein is transferred from glia to axon

Q48385741

Induction of multiple heat shock proteins and neuroprotection in a primary culture model of familial amyotrophic lateral sclerosis

Q48430053

The neuronal stress response: nuclear translocation of heat shock proteins as an indicator of hyperthermic stress.

Q48858849

Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model.

Q51659718

Preparation of PCR-quality mouse genomic DNA with hot sodium hydroxide and tris (HotSHOT).

Q52166624

Superoxide dismutase and neurofilament transgenic models of amyotrophic lateral sclerosis.

Q52531687

Benefit of tianeptine and morphine in a transgenic model of familial amyotrophic lateral sclerosis

Q58282308

Erratum: Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

Q59048476

Exercise induces hepatosplanchnic release of heat shock protein 72 in humans

Q59326285

Functional Role of Caspase-1 and Caspase-3 in an ALS Transgenic Mouse Model

Q60144092

Selective release from cultured mammalian cells of heat-shock (stress) proteins that resemble glia-axon transfer proteins

Q69948836

Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man

Q75310510

The genetic and molecular mechanisms of motor neuron disease

Q77892135

Complete dissociation of motor neuron death from motor dysfunction by Bax deletion in a mouse model of ALS

Q80159256

Background and gender effects on survival in the TgN(SOD1-G93A)1Gur mouse model of ALS

Q80384279

A compensatory subpopulation of motor neurons in a mouse model of amyotrophic lateral sclerosis

Q81011294

Extracellular heat shock protein 70: a critical component for motoneuron survival

Q81375749

Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice

Q28251779

Exercise increases serum Hsp72 in humans

Q28345140

Mechanisms of neurodegeneration in amyotrophic lateral sclerosis

Q28365454

Onset and progression in inherited ALS determined by motor neurons and microglia

Q29619515

Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests

Q33711537

Glucose ingestion attenuates the exercise-induced increase in circulating heat shock protein 72 and heat shock protein 60 in humans

Q33716811

Exercise induces the release of heat shock protein 72 from the human brain in vivo

Q33716849

Amyotrophic lateral sclerosis: a proposed mechanism

Q34066549

A trimeric protein complex functions as a synaptic chaperone machine.

Q34093245

Amyotrophic lateral sclerosis. unfolding the toxicity of the misfolded

Q34175381

The synaptic vesicle protein CSP alpha prevents presynaptic degeneration.

Q34314406

Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis

Q34736976

Inflammatory processes in amyotrophic lateral sclerosis

Q34936474

Formation of high molecular weight complexes of mutant Cu, Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis.

Q35818148

Heat-shock proteins induce T-cell regulation of chronic inflammation

Q36085622

Microglia as potential contributors to motor neuron injury in amyotrophic lateral sclerosis

Q36104618

Release of heat shock proteins (Hsps) and the effects of extracellular Hsps on neural cells and tissues

Q36210025

Cell death of motoneurons in the chick embryo spinal cord. II. A quantitative and qualitative analysis of degeneration in the ventral root, including evidence for axon outgrowth and limb innervation prior to cell death

Q39461898

Neuron death in vertebrate development: in vitro methods

Q40443420

Tissue-specific differences in heat shock protein hsc70 and hsp70 in the control and hyperthermic rabbit

Q40656516

Expression of heat shock genes (hsp70) in the rabbit spinal cord: localization of constitutive and hyperthermia-inducible mRNA species

Q40735254

Up-regulation of protein chaperones preserves viability of cells expressing toxic Cu/Zn-superoxide dismutase mutants associated with amyotrophic lateral sclerosis

Q40975834

Antigen retrieval in cryostat tissue sections and cultured cells by treatment with sodium dodecyl sulfate (SDS).

Q41207174

Animal models of ALS.

Q41341489

Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons

Q41644415

High threshold for induction of the stress response in motor neurons is associated with failure to activate HSF1.

Q42170314

Mutant Cu/Zn-superoxide dismutase proteins have altered solubility and interact with heat shock/stress proteins in models of amyotrophic lateral sclerosis

Q42830531

RPR 119990, a novel alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid antagonist: synthesis, pharmacological properties, and activity in an animal model of amyotrophic lateral sclerosis.

Q43740386

In vitro studies show that Hsp70 can be released by glia and that exogenous Hsp70 can enhance neuronal stress tolerance

Q43751823

Reduced glycogen availability is associated with an elevation in HSP72 in contracting human skeletal muscle

Q43875696

Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice

Q43977943

Habitual physical activity facilitates stress-induced HSP72 induction in brain, peripheral, and immune tissues

Q44193708

Elevation of the Hsp70 chaperone does not effect toxicity in mouse models of familial amyotrophic lateral sclerosis

Q44197126

Efficient three-drug cocktail for disease induced by mutant superoxide dismutase

Q44383435

Vesicular acetylcholine transporter can be a morphological marker for the reinnervation to muscle of regenerating motor axons

Q44904006

Vascular endothelial growth factor prolongs survival in a transgenic mouse model of ALS.

Q45076564

Peroxisome proliferator-activated receptor-gamma agonist extends survival in transgenic mouse model of amyotrophic lateral sclerosis

Q45223163

The cysteine string secretory vesicle protein activates Hsc70 ATPase

Q46053336

Effects of intraperitoneal injection of Rofecoxib in a mouse model of ALS.

Q46416699

The oral antidiabetic pioglitazone protects from neurodegeneration and amyotrophic lateral sclerosis-like symptoms in superoxide dismutase-G93A transgenic mice.

Q46667874

The effect of insulin antibodies on the metabolic action of inhaled and subcutaneous insulin: a prospective randomized pharmacodynamic study

Q46670291

Exogenous Hsc70, but not thermal preconditioning, confers protection to motoneurons subjected to oxidative stress.

Q46964976

Thalidomide and lenalidomide extend survival in a transgenic mouse model of amyotrophic lateral sclerosis.

Q46970968

Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS.

Q47951637

Heat-shock proteins in axoplasm: high constitutive levels and transfer of inducible isoforms from glia

Q47983189

P433

issue

P407

language of work or name

English

Q1860

P921

main subject

amyotrophic lateral sclerosis

Q206901

lifetime

Q22675021

P304

page(s)

13173-13180

P577

publication date

2007-11-01

P1433

published in

Journal of Neuroscience

Q1709864

P1476

title

Exogenous delivery of heat shock protein 70 increases lifespan in a mouse model of amyotrophic lateral sclerosis

P478

volume

Reverse relations

cites work (P2860)

Q49633688	A Metadata Analysis of Oxidative Stress Etiology in Preclinical Amyotrophic Lateral Sclerosis: Benefits of Antioxidant Therapy
Q48435698	A Novel Iron Chelator-Radical Scavenger Ameliorates Motor Dysfunction and Improves Life Span and Mitochondrial Biogenesis in SOD1G93A ALS Mice
Q36861919	A drosophila model for amyotrophic lateral sclerosis reveals motor neuron damage by human SOD1.
Q28307965	Activation of the heat shock response in a primary cellular model of motoneuron neurodegeneration-evidence for neuroprotective and neurotoxic effects
Q36151904	Administration of Recombinant Heat Shock Protein 70 Delays Peripheral Muscle Denervation in the SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis
Q58621641	Amyloid assembly and disassembly
Q38203487	Barcoding heat shock proteins to human diseases: looking beyond the heat shock response
Q33535799	Caloric restriction shortens lifespan through an increase in lipid peroxidation, inflammation and apoptosis in the G93A mouse, an animal model of ALS.
Q41699630	Cellular Chaperones As Therapeutic Targets in ALS to Restore Protein Homeostasis and Improve Cellular Function
Q37407284	Characterization of early pathogenesis in the SOD1(G93A) mouse model of ALS: part I, background and methods.
Q37407302	Characterization of early pathogenesis in the SOD1(G93A) mouse model of ALS: part II, results and discussion
Q24302479	Characterization of the Properties of a Novel Mutation in VAPB in Familial Amyotrophic Lateral Sclerosis
Q36300695	Compartmentalization of superoxide dismutase 1 (SOD1G93A) aggregates determines their toxicity
Q39036105	Could Sirtuin Activities Modify ALS Onset and Progression?
Q48215421	Cuprizone-induced demyelination in CNP::GFP transgenic mice.
Q27312600	Destabilizing protein polymorphisms in the genetic background direct phenotypic expression of mutant SOD1 toxicity
Q36428139	Dynamics of endogenous Hsp70 synthesis in the brain of olfactory bulbectomized mice
Q34835102	Dysfunction of endocytic kinase AAK1 in ALS
Q35058419	Early gene expression changes in spinal cord from SOD1(G93A) Amyotrophic Lateral Sclerosis animal model
Q51022924	Effects of diet on adenosine monophosphate-activated protein kinase activity and disease progression in an amyotrophic lateral sclerosis model.
Q37004619	Effects of heated hydrotherapy on muscle HSP70 and glucose metabolism in old and young vervet monkeys
Q36896295	Engineering therapeutic protein disaggregases.
Q35188379	Focused cerebellar laser light induced hyperthermia improves symptoms and pathology of polyglutamine disease SCA1 in a mouse model
Q33832895	Functional muscle analysis of the Tcap knockout mouse.
Q53441459	Glycoprotein nonmetastatic melanoma protein B ameliorates skeletal muscle lesions in a SOD1G93A mouse model of amyotrophic lateral sclerosis.
Q48188782	Heat shock factor-1 influences pathological lesion distribution of polyglutamine-induced neurodegeneration
Q34539778	Heat shock protein-based therapy as a potential candidate for treating the sphingolipidoses.
Q38815318	Heat shock proteins as potential targets for protective strategies in neurodegeneration
Q26864311	Heat shock proteins at the crossroads between cancer and Alzheimer's disease
Q34170760	Hsp70 and its molecular role in nervous system diseases
Q38813520	Hypothermia improves disease manifestations in SMA mice via SMN augmentation.
Q35784862	Inducing Muscle Heat Shock Protein 70 Improves Insulin Sensitivity and Muscular Performance in Aged Mice
Q38765994	Induction of heat shock proteins in differentiated human neuronal cells following co-application of celastrol and arimoclomol.
Q30413856	Inner ear supporting cells protect hair cells by secreting HSP70.
Q48227312	Interplay between recombinant Hsp70 and proteasomes: proteasome activity modulation and ubiquitin-independent cleavage of Hsp70.
Q26865220	Longitudinal measures of proteostasis in live neurons: features that determine fate in models of neurodegenerative disease
Q35123965	Melittin restores proteasome function in an animal model of ALS
Q38651368	Molecular Mechanisms Underlying Neuroprotective Effect of Intranasal Administration of Human Hsp70 in Mouse Model of Alzheimer's Disease.
Q36749025	Molecular chaperones protect against JNK- and Nmnat-regulated axon degeneration in Drosophila
Q34998292	Nicotinamide mononucleotide adenylyltransferase is a stress response protein regulated by the heat shock factor/hypoxia-inducible factor 1alpha pathway
Q34607796	Nicotinamide/nicotinic acid mononucleotide adenylyltransferase, new insights into an ancient enzyme
Q33936763	One universal common endpoint in mouse models of amyotrophic lateral sclerosis
Q38755364	Possible Function of Molecular Chaperones in Diseases Caused by Propagating Amyloid Aggregates
Q37057856	Promoting Neuronal Tolerance of Diabetic Stress: Modulating Molecular Chaperones
Q92346195	Prospects of HSP70 as a genetic marker for thermo-tolerance and immuno-modulation in animals under climate change scenario
Q39178504	Protein-Remodeling Factors As Potential Therapeutics for Neurodegenerative Disease.
Q92553022	Regional differences in the inflammatory and heat shock response in glia: implications for ALS
Q34979395	Restoring HSP70 deficiencies improves glucose tolerance in diabetic monkeys
Q30425519	SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system
Q34344053	Schwann cell autophagy induced by SAHA, 17-AAG, or clonazepam can reduce bortezomib-induced peripheral neuropathy
Q42736731	Sustained expression of TDP-43 and FUS in motor neurons in rodent's lifetime.
Q38701055	The Role of Skeletal Muscle in Amyotrophic Lateral Sclerosis
Q41716408	The heat shock response in neurons and astroglia and its role in neurodegenerative diseases.
Q36636450	The small heat shock proteins αB-crystallin and Hsp27 suppress SOD1 aggregation in vitro
Q28572236	Valproic acid induces functional heat-shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of Sp1 acetylation
Q37090072	Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration
Q39853994	Vitamin D and/or calcium deficient diets may differentially affect muscle fiber neuromuscular junction innervation
Q37307491	αCAR IGF-1 vector targeting of motor neurons ameliorates disease progression in ALS mice

P356	DOI	10.1523/JNEUROSCI.4057-07.2007
P932	PMC publication ID	6673412
P698	PubMed publication ID	18045911