Development of a novel AIDS vaccine: the HIV-1 transactivator of transcription protein vaccine

scientific article published on 22 June 2015

Development of a novel AIDS vaccine: the HIV-1 transactivator of transcription protein vaccine is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1517/14712598.2015.1021328
P698PubMed publication ID26096836
P5875ResearchGate publication ID279066962

P50authorBarbara EnsoliQ21255143
Fabrizio EnsoliQ55069671
Stefania BellinoQ55302859
Orietta PicconiQ38546631
Cecilia SgadariQ38546658
Paolo MoniniQ38546673
P2093author name stringAurelio Cafaro
Fausto Titti
Vittorio Francavilla
Antonella Tripiciano
Olimpia Longo
Stefano Buttò
P2860cites workDesign and pre-clinical evaluation of a universal HIV-1 vaccineQ21092234
Selective transcription and modulation of resting T cell activity by preintegrated HIV DNA.Q51964201
Long-term protection against SHIV89.6P replication in HIV-1 Tat vaccinated cynomolgus monkeys.Q51998598
Attenuated and nonproductive viral transcription in the lymphatic tissue of HIV-1-infected patients receiving potent antiretroviral therapy.Q54734214
A phase I/IIa immunotherapy trial of HIV-1-infected patients with Tat, Rev and Nef expressing dendritic cells followed by treatment interruptionQ56880126
The therapeutic phase I trial of the recombinant native HIV-1 Tat proteinQ57665211
Inhibition of CXCR4-dependent HIV-1 infection by extracellular HIV-1 TatQ22253931
Crystal structure of HIV-1 Tat complexed with human P-TEFbQ24634569
HIV-1 Tat protein mimicry of chemokinesQ24644383
The expression of the interleukin 6 gene is induced by the human immunodeficiency virus 1 TAT proteinQ24680024
Tat protein induces self-perpetuating permissivity for productive HIV-1 infectionQ24683211
A brief history of the global effort to develop a preventive HIV vaccineQ26851165
Biocompatible anionic polymeric microspheres as priming delivery system for effetive HIV/AIDS Tat-based vaccinesQ27333734
Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimersQ27683553
Quantifying the uncertainty in forecasts of anthropogenic climate changeQ28141336
HIV-1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix-associated heparan sulfate proteoglycans through its basic regionQ28252310
The site of HIV-1 integration in the human genome determines basal transcriptional activity and response to Tat transactivationQ28361880
Therapeutic immunization with HIV-1 Tat reduces immune activation and loss of regulatory T-cells and improves immune function in subjects on HAARTQ28476094
Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in ThailandQ29547531
Cell surface-associated Tat modulates HIV-1 infection and spreading through a specific interaction with gp120 viral envelope proteinQ31135334
Stochastic gene expression in a lentiviral positive-feedback loop: HIV-1 Tat fluctuations drive phenotypic diversityQ33220546
Proteomic and biochemical analysis of purified human immunodeficiency virus type 1 produced from infected monocyte-derived macrophagesQ33255758
Human immunodeficiency virus type 1, human protein interaction database at NCBI.Q33377381
Cellular levels of HIV unspliced RNA from patients on combination antiretroviral therapy with undetectable plasma viremia predict the therapy outcomeQ33521702
HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortalityQ33618542
The presence of anti-Tat antibodies in HIV-infected individuals is associated with containment of CD4+ T-cell decay and viral load, and with delay of disease progression: results of a 3-year cohort studyQ33864926
Impact of viral dose and major histocompatibility complex class IB haplotype on viral outcome in mauritian cynomolgus monkeys vaccinated with Tat upon challenge with simian/human immunodeficiency virus SHIV89.6PQ34055475
Native HIV-1 Tat protein targets monocyte-derived dendritic cells and enhances their maturation, function, and antigen-specific T cell responsesQ34105993
Challenges in HIV Vaccine Research for Treatment and PreventionQ34148683
Immune clearance of highly pathogenic SIV infectionQ34370314
The immune space: a concept and template for rationalizing vaccine developmentQ34399762
HIV-1 tat promotes integrin-mediated HIV transmission to dendritic cells by binding Env spikes and competes neutralization by anti-HIV antibodiesQ34477471
Novel biopanning strategy to identify epitopes associated with vaccine protectionQ34579037
Accelerating HIV-1 Vaccine Efficacy TrialsQ34580725
HIV-1 Tat protein induces the production of IDO in human monocyte derived-dendritic cells through a direct mechanism: effect on T cells proliferation.Q35000687
Relationship between residual plasma viremia and the size of HIV proviral DNA reservoirs in infected individuals receiving effective antiretroviral therapyQ35016645
The HIV-1 Tat protein induces the activation of CD8+ T cells and affects in vivo the magnitude and kinetics of antiviral responsesQ35040673
Broadly cross-neutralizing antibodies in HIV-1 patients with undetectable viremiaQ35077039
A replication-competent adenovirus-human immunodeficiency virus (Ad-HIV) tat and Ad-HIV env priming/Tat and envelope protein boosting regimen elicits enhanced protective efficacy against simian/human immunodeficiency virus SHIV89.6P challenge in rheQ35785031
Toxoplasmic encephalitis in AIDS.Q35810946
Mutual information analysis reveals coevolving residues in Tat that compensate for two distinct functions in HIV-1 gene expressionQ35868299
HIV-1 envelope trimer elicits more potent neutralizing antibody responses than monomeric gp120.Q36132728
HIV-1 Tat triggers TGF-beta production and NK cell apoptosis that is prevented by pertussis toxin B.Q36502262
Human macrophages support persistent transcription from unintegrated HIV-1 DNA.Q36511684
Sparse production but preferential incorporation of recently produced naive T cells in the human peripheral poolQ36579381
HIV-1 Tat B-cell epitope vaccination was ineffectual in preventing viral rebound after ART cessation: HIV rebound with current ART appears to be due to infection with new endogenous founder virus and not to resurgence of pre-existing Tat-dependent vQ36864918
Induction of IL-17 and nonclassical T-cell activation by HIV-Tat proteinQ37104090
What does the structure-function relationship of the HIV-1 Tat protein teach us about developing an AIDS vaccine?Q37220038
Parallel conduction of the phase I preventive and therapeutic trials based on the Tat vaccine candidateQ37661107
Role of HIV-1 Tat in AIDS pathogenesis: its effects on cytokine dysregulation and contributions to the pathogenesis of opportunistic infection.Q37768630
Therapeutic vaccines against HIV infectionQ38013505
HIV vaccines: a brief overview.Q38210557
The preventive phase I trial with the HIV-1 Tat-based vaccineQ38378021
Phosphatidylinositol-(4,5)-bisphosphate enables efficient secretion of HIV-1 Tat by infected T-cellsQ40508633
HIV-1 tat protein modulates the generation of cytotoxic T cell epitopes by modifying proteasome composition and enzymatic activityQ40517749
Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120.Q41335848
Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcomaQ41435232
Full-length HIV-1 immunogens induce greater magnitude and comparable breadth of T lymphocyte responses to conserved HIV-1 regions compared with conserved-region-only HIV-1 immunogens in rhesus monkeysQ41579160
Surface-bound Tat inhibits antigen-specific CD8+ T-cell activation in an integrin-dependent mannerQ41702127
Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patientsQ41734588
Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure.Q41880147
Intracellular HIV-1 Tat protein represses constitutive LMP2 transcription increasing proteasome activity by interfering with the binding of IRF-1 to STAT1.Q41925734
HIV-1 Tat affects the programming and functionality of human CD8⁺ T cells by modulating the expression of T-box transcription factors.Q42217866
HIV-1 Tat: Its Dependence on Host Factors is Crystal ClearQ42767857
The presence of anti-Tat antibodies is predictive of long-term nonprogression to AIDS or severe immunodeficiency: findings in a cohort of HIV-1 seroconvertersQ43671904
Containment of infection in tat vaccinated monkeys after rechallenge with a higher dose of SHIV89.6P(cy243).Q43967379
The trans-activator gene of the human T cell lymphotropic virus type III is required for replicationQ44579665
Evolution of CD8+ T cell immunity and viral escape following acute HIV-1 infectionQ44674538
Monitoring of HIV viral load, CD4 cell count, and clinical assessment versus clinical monitoring alone for antiretroviral therapy in low-resource settings (Stratall ANRS 12110/ESTHER): a cost-effectiveness analysisQ44843305
Vaccination with DNA containing tat coding sequences and unmethylated CpG motifs protects cynomolgus monkeys upon infection with simian/human immunodeficiency virus (SHIV89.6P).Q45012988
HIV-1 Tat addresses dendritic cells to induce a predominant Th1-type adaptive immune response that appears prevalent in the asymptomatic stage of infectionQ45341243
Antiretroviral therapy does not block the secretion of the human immunodeficiency virus tat protein.Q45360139
Sequence conservation and antibody cross-recognition of clade B human immunodeficiency virus (HIV) type 1 Tat protein in HIV-1-infected Italians, Ugandans, and South AfricansQ45710857
Acute phase cytotoxic T lymphocyte escape is a hallmark of simian immunodeficiency virus infectionQ45732713
SHIV89.6P pathogenicity in cynomolgus monkeys and control of viral replication and disease onset by human immunodeficiency virus type 1 Tat vaccine.Q45739668
Human immunodeficiency virus type 1 Rev- and Tat-specific cytotoxic T lymphocyte frequencies inversely correlate with rapid progression to AIDS.Q45761033
Immobilized HIV-1 Tat protein promotes gene transfer via a transactivation-independent mechanism which requires binding of Tat to viral particlesQ45887444
Antibodies against full-length Tat protein and some low-molecular-weight Tat-peptides correlate with low or undetectable viral load in HIV-1 seropositive patientsQ47216468
Phase I therapeutic trial of the HIV-1 Tat protein and long term follow-up.Q51828622
Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants.Q51926211
P407language of work or nameEnglishQ1860
P304page(s)S13-29
P577publication date2015-06-22
P1433published inExpert Opinion on Biological TherapyQ5421201
P1476titleDevelopment of a novel AIDS vaccine: the HIV-1 transactivator of transcription protein vaccine
P478volume15 Suppl 1

Reverse relations

cites work (P2860)
Q92906228Anti-Tat Immunity in HIV-1 Infection: Effects of Naturally Occurring and Vaccine-Induced Antibodies Against Tat on the Course of the Disease
Q26764851Approaches to preventative and therapeutic HIV vaccines
Q40040813Formulation of chitosan with the polyepitope HIV-1 protein candidate vaccine efficiently boosts cellular immune responses in mice
Q36109585HIV-1 Tat protein vaccination in mice infected with Mycobacterium tuberculosis is safe, immunogenic and reduces bacterial lung pathology
Q36986644HIV-Tat immunization induces cross-clade neutralizing antibodies and CD4(+) T cell increases in antiretroviral-treated South African volunteers: a randomized phase II clinical trial
Q33725630PKC-δ isoform plays a crucial role in Tat-TLR4 signalling pathway to activate NF-κB and CXCL8 production
Q38850174Reduced Frequency of Cells Latently Infected with Replication-Competent HIV-1 in Virally Suppressed Individuals Living in Rakai, Uganda

Search more.