Viroporins, Examples of the Two-Stage Membrane Protein Folding Model

scientific article published on 26 June 2015

Viroporins, Examples of the Two-Stage Membrane Protein Folding Model is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3390/V7072781
P932PMC publication ID4517110
P698PubMed publication ID26131957
P5875ResearchGate publication ID280030545

P50authorLuis Martinez-GilQ38545074
Ismael MingarroQ38545083
P2860cites workSignal recognition particle mediates post-translational targeting in eukaryotesQ24563135
The biology of influenza virusesQ24620598
Structure and mechanism of the M2 proton channel of influenza A virusQ24625464
Influenza virus M2 protein mediates ESCRT-independent membrane scissionQ24634367
Protein translocation across the endoplasmic reticulum. I. Detection in the microsomal membrane of a receptor for the signal recognition particleQ24680984
Different conformations of nascent polypeptides during translocation across the ER membraneQ24795321
Membrane Insertion of Marginally Hydrophobic Transmembrane Helices Depends on Sequence ContextQ57208978
Turns in transmembrane helices: determination of the minimal length of a “helical hairpin” and derivation of a fine-grained turn propensity scale 1 1Edited by F. E. CohenQ57209056
Assembly of Viral Membrane ProteinsQ57971530
Membrane protein folding and oligomerization: the two-stage modelQ67662788
A novel antimicrobial peptide from the loach, Misgurnus anguillicaudatusQ73626443
Membrane integration of the second transmembrane segment of band 3 requires a closely apposed preceding signal-anchor sequenceQ73992946
The Sec61p complex mediates the integration of a membrane protein by allowing lipid partitioning of the transmembrane domainQ74175787
Transmembrane helix-helix interactions: comparative simulations of the glycophorin a dimerQ79384860
Sec61alpha and TRAM are sequentially adjacent to a nascent viral membrane protein during its ER integrationQ79433658
Specific transmembrane segments are selectively delayed at the ER translocon during opsin biogenesisQ80628282
The elusive function of the hepatitis C virus p7 proteinQ27026459
The NS2 protein of hepatitis C virus is a transmembrane polypeptideQ27480316
Backbone Structure of the Amantadine-Blocked Trans-Membrane Domain M2 Proton Channel from Influenza A VirusQ27644223
Conformational transition of Sec machinery inferred from bacterial SecYE structuresQ27652527
Similar Energetic Contributions of Packing in the Core of Membrane and Water-Soluble ProteinsQ27656426
Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayersQ27659500
Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virusQ27663887
Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranesQ27664605
Insight into the Mechanism of the Influenza A Proton Channel from a Structure in a Lipid BilayerQ27665298
Unusual architecture of the p7 channel from hepatitis C virusQ27678504
Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysisQ27860603
SignalP 4.0: discriminating signal peptides from transmembrane regionsQ29547202
The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, AmantadineQ29620670
Experimentally determined hydrophobicity scale for proteins at membrane interfacesQ29620679
Membrane protein folding and stability: physical principlesQ29620789
Modeling the membrane environment has implications for membrane protein structure and function: influenza A M2 protein.Q30426896
Total chemical synthesis of the integral membrane protein influenza A virus M2: role of its C-terminal domain in tetramer assembly.Q30784429
Plasma membrane-porating domain in poliovirus 2B protein. A short peptide mimics viroporin activityQ33304077
The M2 Ectodomain Is Important for Its Incorporation into Influenza A VirionsQ33782503
Positive charges of translocating polypeptide chain retrieve an upstream marginal hydrophobic segment from the endoplasmic reticulum lumen to the transloconQ33907071
Specific structural alteration of the influenza haemagglutinin by amantadineQ33922433
Viroporins.Q34230206
Modification of membrane permeability by animal viruses.Q34314053
Pore-forming activity of pestivirus p7 in a minimal model system supports genus-specific viroporin function.Q35031600
How do helix-helix interactions help determine the folds of membrane proteins? Perspectives from the study of homo-oligomeric helical bundlesQ35089609
Asn- and Asp-mediated interactions between transmembrane helices during translocon-mediated membrane protein assemblyQ35191191
Unassisted translocation of large polypeptide domains across phospholipid bilayersQ36119397
Integration of a small integral membrane protein, M2, of influenza virus into the endoplasmic reticulum: analysis of the internal signal-anchor domain of a protein with an ectoplasmic NH2 terminusQ36218495
Mitochondria as functional targets of proteins coded by human tumor virusesQ36226733
Initial structural and dynamic characterization of the M2 protein transmembrane and amphipathic helices in lipid bilayersQ36631397
SRP keeps polypeptides translocation-competent by slowing translation to match limiting ER-targeting sitesQ36726739
The influenza virus M2 protein cytoplasmic tail interacts with the M1 protein and influences virus assembly at the site of virus buddingQ36933890
A precursor-specific role for Hsp40/Hsc70 during tail-anchored protein integration at the endoplasmic reticulumQ43125499
Amiloride derivatives block ion channel activity and enhancement of virus-like particle budding caused by HIV-1 protein Vpu.Q44015913
Assembling viral channel forming proteins: Vpu from HIV-1.Q44993875
Charge pair interactions in transmembrane helices and turn propensity of the connecting sequence promote helical hairpin insertion.Q45346838
Sequential triage of transmembrane segments by Sec61alpha during biogenesis of a native multispanning membrane proteinQ46722763
Molecular code for transmembrane-helix recognition by the Sec61 transloconQ46853934
Structure-based statistical analysis of transmembrane helicesQ47760302
Signal recognition particle binds to ribosome-bound signal sequences with fluorescence-detected subnanomolar affinity that does not diminish as the nascent chain lengthensQ52842432
The protein-conducting channel in the membrane of the endoplasmic reticulum is open laterally toward the lipid bilayerQ54011077
Double-spanning plant viral movement protein integration into the endoplasmic reticulum membrane is signal recognition particle-dependent, translocon-mediated, and concerted.Q54486257
Free Energy of Amide Hydrogen Bond Formation in Vacuum, in Water, and in Liquid Alkane SolutionQ57207152
Molecular code for protein insertion in the endoplasmic reticulum membrane is similar for N(in)-C(out) and N(out)-C(in) transmembrane helicesQ36949128
Influenza A virus lacking M2 protein as a live attenuated vaccineQ37191791
Insertion of short transmembrane helices by the Sec61 transloconQ37261725
Identification of the functional core of the influenza A virus A/M2 proton-selective ion channelQ37282382
The minimalist architectures of viroporins and their therapeutic implications.Q37619619
A frequent, GxxxG-mediated, transmembrane association motif is optimized for the formation of interhelical Cα-H hydrogen bonds.Q37640954
Protein folding in membranes.Q37681352
Influenza virus A M2 protein generates negative Gaussian membrane curvature necessary for budding and scission.Q37724175
Inserting membrane proteins: The YidC/Oxa1/Alb3 machinery in bacteria, mitochondria, and chloroplastsQ37783709
Membrane protein folding: how important are hydrogen bonds?Q37809384
Structural and dynamic mechanisms for the function and inhibition of the M2 proton channel from influenza A virus.Q37830140
Membrane protein integration into the endoplasmic reticulumQ37876968
Hepatitis C virus and host cell lipids: an intimate connectionQ37877090
Biogenesis of Mitochondrial ProteinsQ38021397
Viroporins: structure and biological functions.Q38023155
The YidC/Oxa1/Alb3 protein family: common principles and distinct featuresQ38056629
Incorporation of hepatitis C virus E1 and E2 glycoproteins: the keystones on a peculiar virionQ38195180
Toward understanding driving forces in membrane protein foldingQ38238311
Stitching proteins into membranes, not sew simple.Q38242873
Antivirals--current trends in fighting influenza.Q38245448
Viral M2 ion channel protein: a promising target for anti-influenza drug discovery.Q38262431
Membrane pore formation at protein-lipid interfacesQ38273877
Hepatitis C virus p7-a viroporin crucial for virus assembly and an emerging target for antiviral therapyQ38615924
Membrane integration of poliovirus 2B viroporin.Q38725275
Transcending the impenetrable: how proteins come to terms with membranesQ39641550
The multifaceted poliovirus 2A protease: regulation of gene expression by picornavirus proteases.Q39754200
Cooperation of transmembrane segments during the integration of a double-spanning protein into the ER membraneQ39790858
Viroporins from RNA viruses induce caspase-dependent apoptosisQ40062300
Membrane leakiness after viral infection and a new approach to the development of antiviral agentsQ40141845
Subcellular localization and membrane association of SARS-CoV 3a protein.Q40447673
Recognition of transmembrane helices by the endoplasmic reticulum translocon.Q40464906
The transmembrane domain of influenza A M2 protein forms amantadine-sensitive proton channels in planar lipid bilayersQ41093991
The structure of melittin in membranesQ41158738
Polar/Ionizable residues in transmembrane segments: effects on helix-helix packing.Q41872052
Haemolytic activity of stonustoxin from stonefish (Synanceja horrida) venom: pore formation and the role of cationic amino acid residuesQ42159675
A dimer is the minimal proton-conducting unit of the influenza a virus M2 channel.Q42219487
The surfactant peptide KL4 sequence is inserted with a transmembrane orientation into the endoplasmic reticulum membraneQ42423801
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectvirusQ808
viral proteinQ952587
viral infectious diseaseQ1928978
membrane proteinQ423042
protein foldingQ847556
plasma membraneQ29548
influenza virus matrix protein 2Q17119463
viroporinQ26789532
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)3462-3482
P577publication date2015-06-26
P13046publication type of scholarly workreview articleQ7318358
P1433published inVirusesQ7935305
P1476titleViroporins, Examples of the Two-Stage Membrane Protein Folding Model
P478volume7

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cites work (P2860)
Q92543291Biological Function and Application of Picornaviral 2B Protein: A New Target for Antiviral Drug Development
Q38618537Disentangling the Frames, the State of Research on the Alphavirus 6K and TF Proteins.
Q45330627Hydrophobic domains of mouse polyomavirus minor capsid proteins promote membrane association and virus exit from the ER.
Q40135359Ion channel activity of the CSFV p7 viroporin in surrogates of the ER lipid bilayer.
Q59352342Molecular Characterization of the Viroporin Function of Foot-and-Mouth Disease Virus Nonstructural Protein 2B
Q63547227The role of hydrophobic matching on transmembrane helix packing in cells
Q47149209The soluble loop BC region guides, but not dictates, the assembly of the transmembrane cytochrome b6.
Q103027729Viral Bcl2s' transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis

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