Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes

scientific article

Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2010PNAS..10717182E
P356DOI10.1073/PNAS.1012556107
P932PMC publication ID2951439
P698PubMed publication ID20855604
P5875ResearchGate publication ID46381122

P50authorPascal F. EgeaQ64682851
P2093author name stringRobert M Stroud
P2860cites workThe bacterial SecY/E translocation complex forms channel-like structures similar to those of the eukaryotic Sec61p complexQ77901565
Determining the conductance of the SecY protein translocation channel for small moleculesQ80390141
Structures of the signal recognition particle receptor from the archaeon Pyrococcus furiosus: implications for the targeting step at the membraneQ27438158
X-ray structure of a protein-conducting channelQ27642744
Ribosome binding of a single copy of the SecY complex: implications for protein translocationQ27649425
Structure of a complex of the ATPase SecA and the protein-translocation channelQ27652526
Conformational transition of Sec machinery inferred from bacterial SecYE structuresQ27652527
Structures of SRP54 and SRP19, the Two Proteins that Organize the Ribonucleic Core of the Signal Recognition Particle from Pyrococcus furiosusQ27652680
Regulation of the Protein-Conducting Channel by a Bound RibosomeQ27658163
Structure of Monomeric Yeast and Mammalian Sec61 Complexes Interacting with the Translating RibosomeQ27658307
Control of translocation through the Sec61 translocon by nascent polypeptide structure within the ribosomeQ33334739
Dynamics of SecY translocons with translocation-defective mutationsQ34017810
Molecular dynamics studies of the archaeal transloconQ34452349
The plug domain of yeast Sec61p is important for efficient protein translocation, but is not essential for cell viabilityQ35010304
Molecular mechanism of signal sequence orientation in the endoplasmic reticulumQ35160351
The machinery of membrane protein assemblyQ35863877
Topogenesis of membrane proteins at the endoplasmic reticulumQ35906853
Targeting proteins to membranes: structure of the signal recognition particle.Q36101119
Identification of cytoplasmic residues of Sec61p involved in ribosome binding and cotranslational translocationQ36321273
Sec61p contributes to signal sequence orientation according to the positive-inside ruleQ36782186
Interactions that drive Sec-dependent bacterial protein transportQ36901775
The roles of pore ring and plug in the SecY protein-conducting channelQ36980008
The lateral gate of SecYEG opens during protein translocationQ37257359
Recognition of transmembrane helices by the endoplasmic reticulum translocon.Q40464906
Protein insertion into the membrane of the endoplasmic reticulum: the architecture of the translocation siteQ41124912
alpha-Helical nascent polypeptide chains visualized within distinct regions of the ribosomal exit tunnelQ41619420
The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane sealQ42621979
A role for the two-helix finger of the SecA ATPase in protein translocation.Q43181763
Probing the environment of signal-anchor sequences during topogenesis in the endoplasmic reticulumQ45255069
The purified E. coli integral membrane protein SecY/E is sufficient for reconstitution of SecA-dependent precursor protein translocation.Q46008320
Sequential triage of transmembrane segments by Sec61alpha during biogenesis of a native multispanning membrane proteinQ46722763
Molecular code for transmembrane-helix recognition by the Sec61 transloconQ46853934
SecYEG proteoliposomes catalyze the Deltaphi-dependent membrane insertion of FtsQ.Q47423880
Nascent membrane and secretory proteins differ in FRET-detected folding far inside the ribosome and in their exposure to ribosomal proteins.Q47987631
Sec61beta--a component of the archaeal protein secretory systemQ48309376
Signal sequence recognition in posttranslational protein transport across the yeast ER membraneQ53945518
The protein-conducting channel in the membrane of the endoplasmic reticulum is open laterally toward the lipid bilayerQ54011077
Protein translocation is mediated by oligomers of the SecY complex with one SecY copy forming the channelQ54443529
Mutations in the Sec61p Channel Affecting Signal Sequence Recognition and Membrane Protein TopologyQ56775244
Structural determinants of lateral gate opening in the protein transloconQ57117535
P433issue40
P407language of work or nameEnglishQ1860
P304page(s)17182-17187
P577publication date2010-09-20
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleLateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes
P478volume107

Reverse relations

cites work (P2860)
Q42944586A biphasic pulling force acts on transmembrane helices during translocon-mediated membrane integration
Q36455908A gating motif in the translocation channel sets the hydrophobicity threshold for signal sequence function
Q47808284Alignment of the protein substrate hairpin along the SecA two-helix finger primes protein transport in Escherichia coli.
Q37552363An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate
Q35895551Anomalous behavior of water inside the SecY translocon
Q35149690Apolar surface area determines the efficiency of translocon-mediated membrane-protein integration into the endoplasmic reticulum
Q64448582Archaeal cell surface biogenesis
Q36205340Bacterial protein translocation requires only one copy of the SecY complex in vivo
Q38065265Breaking on through to the other side: protein export through the bacterial Sec system.
Q39935945Conformational dynamics of the plug domain of the SecYEG protein-conducting channel.
Q35796082Conserved SMP domains of the ERMES complex bind phospholipids and mediate tether assembly
Q89479706Conserved motifs on the cytoplasmic face of the protein translocation channel are critical for the transition between resting and active conformations
Q37157341Cotranslational folding of membrane proteins probed by arrest-peptide-mediated force measurements
Q27667539Cryo-EM structure of the ribosome–SecYE complex in the membrane environment
Q38799711Crystal structure of Mdm12 and combinatorial reconstitution of Mdm12/Mmm1 ERMES complexes for structural studies.
Q36865827Crystal structure of a substrate-engaged SecY protein-translocation channel
Q27701598Crystal structures of a polypeptide processing and secretion transporter
Q36674746Determination of the Oligomeric State of SecYEG Protein Secretion Channel Complex Using in Vivo Photo- and Disulfide Cross-linking
Q36200511Direct simulation of early-stage Sec-facilitated protein translocation
Q47734450Driving Forces of Translocation Through Bacterial Translocon SecYEG.
Q36206572Emerging themes in SecA2-mediated protein export
Q64244254Folding and Misfolding of Human Membrane Proteins in Health and Disease: From Single Molecules to Cellular Proteostasis
Q58123006Forces on Nascent Polypeptides during Membrane Insertion and Translocation via the Sec Translocon
Q34999575Free Energy of Nascent-Chain Folding in the Translocon
Q37340628Functional asymmetry within the Sec61p translocon
Q92651089Functions and Mechanisms of the Human Ribosome-Translocon Complex
Q26863353Hydrogen bond dynamics in membrane protein function
Q35551833Hydrophobic blocks facilitate lipid compatibility and translocon recognition of transmembrane protein sequences
Q43190054Influence of Pathogenic Mutations on the Energetics of Translocon-Mediated Bilayer Integration of Transmembrane Helices
Q24561993Internal lipid architecture of the hetero-oligomeric cytochrome b6f complex
Q51165696Introduction to Theme “Membrane Protein Folding and Insertion”
Q42973854Lateral opening of the bacterial translocon on ribosome binding and signal peptide insertion
Q36355150Long-Timescale Dynamics and Regulation of Sec-Facilitated Protein Translocation
Q34916095Mapping of the SecA Signal Peptide Binding Site and Dimeric Interface by Using the Substituted Cysteine Accessibility Method
Q35846068Marginally hydrophobic transmembrane α-helices shaping membrane protein folding
Q37973762Mechanisms of Sec61/SecY-Mediated Protein Translocation Across Membranes
Q35118815Mechanisms of integral membrane protein insertion and folding
Q30375519Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory.
Q37876968Membrane protein integration into the endoplasmic reticulum
Q36455887Mobility of the SecA 2-helix-finger is not essential for polypeptide translocation via the SecYEG complex
Q92857391Mycobacteria and their sweet proteins: An overview of protein glycosylation and lipoglycosylation in M. tuberculosis
Q92399576Partially inserted nascent chain unzips the lateral gate of the Sec translocon
Q36555178Protein Translocation across the Rough Endoplasmic Reticulum
Q37976983Protein conducting channels—mechanisms, structures and applications
Q38220635Protein transport into the human ER and related diseases, Sec61-channelopathies
Q36613612Reconciling the Roles of Kinetic and Thermodynamic Factors in Membrane–Protein Insertion
Q36255160Regulation of multispanning membrane protein topology via post-translational annealing
Q89558910Sec translocon has an insertase-like function in addition to polypeptide conduction through the channel
Q24631210SecA, a remarkable nanomachine
Q41456119SecY-SecA fusion protein retains the ability to mediate protein transport
Q38990342Stability and flexibility of marginally hydrophobic-segment stalling at the endoplasmic reticulum translocon
Q37031742Stoichiometry of SecYEG in the active translocase of Escherichia coli varies with precursor species
Q90634563Structural Relaxation Processes and Collective Dynamics of Water in Biomolecular Environments
Q34076055Structural and functional profiling of the lateral gate of the Sec61 translocon
Q36318227Structurally detailed coarse-grained model for Sec-facilitated co-translational protein translocation and membrane integration
Q27684332Structure of the Mammalian Ribosome-Sec61 Complex to 3.4 Å Resolution
Q27330079Structure of the Sec61 channel opened by a signal sequence
Q27680440Structure of the SecY channel during initiation of protein translocation
Q42000002Structure of the SecY complex unlocked by a preprotein mimic.
Q30667297Structure of the native Sec61 protein-conducting channel
Q91050137Structure of the post-translational protein translocation machinery of the ER membrane
Q90462140Structure of the posttranslational Sec protein-translocation channel complex from yeast
Q30854427Structure of the quaternary complex between SRP, SR, and translocon bound to the translating ribosome
Q93116313Structure of the substrate-engaged SecA-SecY protein translocation machine
Q55282553Structure-based working model of SecDF, a proton-driven bacterial protein translocation factor.
Q27334605Structures of the E. coli translating ribosome with SRP and its receptor and with the translocon
Q27689043Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion
Q38789175The Archaeal Signal Recognition Particle: Present Understanding and Future Perspective
Q47374398The Sec System: Protein Export in Escherichia coli
Q38206834The Sec translocon mediated protein transport in prokaryotes and eukaryotes.
Q47684820The SecA protein deeply penetrates into the SecYEG channel during insertion, contacting most channel transmembrane helices and periplasmic regions
Q37883694The SecY complex: conducting the orchestra of protein translocation
Q35814696The bacterial Sec-translocase: structure and mechanism.
Q37970858The ins and outs of Mycobacterium tuberculosis protein export
Q38270911The safety dance: biophysics of membrane protein folding and misfolding in a cellular context
Q37412726Transmembrane segments form tertiary hairpins in the folding vestibule of the ribosome
Q54203381Understanding GPCR Recognition and Folding from NMR Studies of Fragments.
Q38541409Viroporins, Examples of the Two-Stage Membrane Protein Folding Model
Q27690670Visualization of a polytopic membrane protein during SecY-mediated membrane insertion
Q42087433YfgM is an ancillary subunit of the SecYEG translocon in Escherichia coli
Q42144026YidC occupies the lateral gate of the SecYEG translocon and is sequentially displaced by a nascent membrane protein.

Search more.