| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2016Sci...351...88V |
| P356 | DOI | 10.1126/SCIENCE.AAD4992 |
| P3181 | OpenCitations bibliographic resource ID | 1134686 |
| P932 | PMC publication ID | 4700591 |
| P698 | PubMed publication ID | 26721998 |
| P50 | author | Rebecca Voorhees | Q56396043 |
| Ramanujan Shankar Hegde | Q24004353 | ||
| P2860 | cites work | Decatransin, a new natural product inhibiting protein translocation at the Sec61/SecYEG translocon | Q35178294 |
| Signal Sequence Recognition in Cotranslational Translocation by Protein Components of the Endoplasmic Reticulum Membrane | Q36256284 | ||
| Substrate-specific function of the translocon-associated protein complex during translocation across the ER membrane | Q36325004 | ||
| A gating motif in the translocation channel sets the hydrophobicity threshold for signal sequence function | Q36455908 | ||
| An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate | Q37552363 | ||
| Mechanisms of Sec61/SecY-Mediated Protein Translocation Across Membranes | Q37973762 | ||
| Systematic probing of the environment of a translocating secretory protein during translocation through the ER membrane | Q40792995 | ||
| Structures of the scanning and engaged states of the mammalian SRP-ribosome complex | Q41176440 | ||
| Tools for macromolecular model building and refinement into electron cryo-microscopy reconstructions | Q41606440 | ||
| Beam-induced motion correction for sub-megadalton cryo-EM particles. | Q41607730 | ||
| Quantifying the local resolution of cryo-EM density maps | Q41609859 | ||
| Low-resolution refinement tools in REFMAC5. | Q42046452 | ||
| Preparation of microsomal membranes for cotranslational protein translocation | Q49487241 | ||
| Signal sequence recognition in posttranslational protein transport across the yeast ER membrane | Q53945518 | ||
| The protein-conducting channel in the membrane of the endoplasmic reticulum is open laterally toward the lipid bilayer | Q54011077 | ||
| Secretory proteins move through the endoplasmic reticulum membrane via an aqueous, gated pore | Q54025256 | ||
| Deregulation of the SecYEG translocation channel upon removal of the plug domain. | Q54452284 | ||
| Structure of the Yeast Mitochondrial Large Ribosomal Subunit | Q56396008 | ||
| Mutations in the Sec61p Channel Affecting Signal Sequence Recognition and Membrane Protein Topology | Q56775244 | ||
| The signal sequence moves through a ribosomal tunnel into a noncytoplasmic aqueous environment at the ER membrane early in translocation | Q70766402 | ||
| A posttargeting signal sequence recognition event in the endoplasmic reticulum membrane | Q71939462 | ||
| Site-specific photocross-linking reveals that Sec61p and TRAM contact different regions of a membrane-inserted signal sequence | Q72639603 | ||
| X-ray structure of a protein-conducting channel | Q27642744 | ||
| Structure of a complex of the ATPase SecA and the protein-translocation channel | Q27652526 | ||
| Conformational transition of Sec machinery inferred from bacterial SecYE structures | Q27652527 | ||
| Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes | Q27664605 | ||
| Structure of the SecY channel during initiation of protein translocation | Q27680440 | ||
| Structure of the Yeast Mitochondrial Large Ribosomal Subunit | Q27682617 | ||
| Structure of the Mammalian Ribosome-Sec61 Complex to 3.4 Å Resolution | Q27684332 | ||
| Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion | Q27689043 | ||
| REFMAC5 for the refinement of macromolecular crystal structures | Q27860905 | ||
| Accurate determination of local defocus and specimen tilt in electron microscopy | Q27861008 | ||
| Ribosome structures to near-atomic resolution from thirty thousand cryo-EM particles | Q28044576 | ||
| Listerin-dependent nascent protein ubiquitination relies on ribosome subunit dissociation | Q28675845 | ||
| RELION: Implementation of a Bayesian approach to cryo-EM structure determination | Q29547673 | ||
| Prevention of overfitting in cryo-EM structure determination | Q29614287 | ||
| Visualizing density maps with UCSF Chimera | Q29619793 | ||
| Structure of the native Sec61 protein-conducting channel | Q30667297 | ||
| A signal sequence is not required for protein export in prlA mutants of Escherichia coli | Q34044995 | ||
| Modeling the effects of prl mutations on the Escherichia coli SecY complex | Q34048338 | ||
| PrlA suppressor mutations cluster in regions corresponding to three distinct topological domains | Q34058568 | ||
| Reconstitution of a minimal ribosome-associated ubiquitination pathway with purified factors | Q34244144 | ||
| Cotranslational partitioning of nascent prion protein into multiple populations at the translocation channel | Q34274103 | ||
| Protein translocation into proteoliposomes reconstituted from purified components of the endoplasmic reticulum membrane | Q34344763 | ||
| In vitro dissection of protein translocation into the mammalian endoplasmic reticulum | Q35065009 | ||
| P433 | issue | 6268 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 88-91 | |
| P577 | publication date | 2016-01-01 | |
| P1433 | published in | Science | Q192864 |
| P1476 | title | Structure of the Sec61 channel opened by a signal sequence | |
| P478 | volume | 351 |
| Q47808284 | Alignment of the protein substrate hairpin along the SecA two-helix finger primes protein transport in Escherichia coli. |
| Q47096501 | An Update on Sec61 Channel Functions, Mechanisms, and Related Diseases. |
| Q54964955 | Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier. |
| Q47104994 | Chemical crosslinking and mass spectrometry to elucidate the topology of integral membrane proteins. |
| Q41600789 | Cryo-microscopy, an alternative to the X-ray crystallography? |
| Q36865827 | Crystal structure of a substrate-engaged SecY protein-translocation channel |
| Q47734450 | Driving Forces of Translocation Through Bacterial Translocon SecYEG. |
| Q90044373 | Dynamics of Co-translational Membrane Protein Integration and Translocation via the Sec Translocon |
| Q59800191 | EMC Is Required to Initiate Accurate Membrane Protein Topogenesis |
| Q64102021 | Eeyarestatin Compounds Selectively Enhance Sec61-Mediated Ca Leakage from the Endoplasmic Reticulum |
| Q61809852 | Effect of Sec61 interaction with Mpd1 on endoplasmic reticulum-associated degradation |
| Q64244254 | Folding and Misfolding of Human Membrane Proteins in Health and Disease: From Single Molecules to Cellular Proteostasis |
| Q92651089 | Functions and Mechanisms of the Human Ribosome-Translocon Complex |
| Q28118506 | Heterozygous Loss-of-Function SEC61A1 Mutations Cause Autosomal-Dominant Tubulo-Interstitial and Glomerulocystic Kidney Disease with Anemia |
| Q64284762 | Hydrophobicity, rather than secondary structure, is essential for the SRP dependent targeting of GPR35 to the ER membrane |
| Q47228430 | Inhibitors of protein translocation across membranes of the secretory pathway: novel antimicrobial and anticancer agents. |
| Q40794641 | Mechanistic insights into the inhibition of Sec61-dependent co- and post-translational translocation by mycolactone. |
| Q89601996 | MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments |
| Q64057264 | Molecular Docking and Dynamics Simulation Studies Predict Munc18b as a Target of Mycolactone: A Plausible Mechanism for Granule Exocytosis Impairment in Buruli Ulcer Pathogenesis |
| Q38951193 | Mycolactone reveals the substrate-driven complexity of Sec61-dependent transmembrane protein biogenesis. |
| Q89107222 | New Insights into Ribosome Structure and Function |
| Q93131996 | New factors for protein transport identified by a genome-wide CRISPRi screen in mammalian cells |
| Q92399576 | Partially inserted nascent chain unzips the lateral gate of the Sec translocon |
| Q39021695 | Protein export through the bacterial Sec pathway. |
| Q26747205 | Protein translocation: what's the problem? |
| Q58042832 | Proteomics Reveals Scope of Mycolactone-mediated Sec61 Blockade and Distinctive Stress Signature |
| Q58740862 | Proteomics reveals signal peptide features determining the client specificity in human TRAP-dependent ER protein import |
| Q27939146 | Quality control of nonstop membrane proteins at the ER membrane and in the cytosol |
| Q104268677 | Revealing Functional Insights into ER Proteostasis through Proteomics and Interactomics |
| Q89558910 | Sec translocon has an insertase-like function in addition to polypeptide conduction through the channel |
| Q38692382 | Sec61 blockade by mycolactone inhibits antigen cross-presentation independently of endosome-to-cytosol export |
| Q41456119 | SecY-SecA fusion protein retains the ability to mediate protein transport |
| Q52362370 | Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum. |
| Q30358357 | Structure of the Cellulose Synthase Complex of Gluconacetobacter hansenii at 23.4 Å Resolution. |
| Q91050137 | Structure of the post-translational protein translocation machinery of the ER membrane |
| Q90462140 | Structure of the posttranslational Sec protein-translocation channel complex from yeast |
| Q93116313 | Structure of the substrate-engaged SecA-SecY protein translocation machine |
| Q89513070 | TRAM1 protein may support ER protein import by modulating the phospholipid bilayer near the lateral gate of the Sec61-channel |
| Q47287563 | Targeting and translocation of proteins to the endoplasmic reticulum at a glance |
| Q64095118 | The N-terminus of Sec61p plays key roles in ER protein import and ERAD |
| Q47586836 | The Sec61/SecY complex is inherently deficient in translocating intrinsically disordered proteins |
| Q95851107 | The architecture of EMC reveals a path for membrane protein insertion |
| Q40083394 | The complex co-translational processing of glycoprotein GP5 of type 1 porcine reproductive and respiratory syndrome virus |
| Q90627522 | The signal peptide as a new target for drug design |
| Q64226641 | The signal peptide plus a cluster of positive charges in prion protein dictate chaperone-mediated Sec61 channel gating |
| Q42576947 | Two-way communication between SecY and SecA suggests a Brownian ratchet mechanism for protein translocation |
| Q39923654 | Unlocking the Bacterial SecY Translocon |
| Q60302566 | Use of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/translocation pathway |
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