Structure of the posttranslational Sec protein-translocation channel complex from yeast

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Structure of the posttranslational Sec protein-translocation channel complex from yeast is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2019Sci...363...84I
P356DOI10.1126/SCIENCE.AAV6740
P932PMC publication ID6760253
P698PubMed publication ID30545845

P50authorSamuel ItskanovQ90462131
Eunyong ParkQ90462135
P2860cites workMammalian Sec61 is associated with Sec62 and Sec63Q22254037
Electrostatics of nanosystems: application to microtubules and the ribosomeQ24555224
MolProbity: all-atom structure validation for macromolecular crystallographyQ24649111
Structure of the Sec61 channel opened by a signal sequenceQ27330079
X-ray structure of a protein-conducting channelQ27642744
Structure of a complex of the ATPase SecA and the protein-translocation channelQ27652526
Structure of Monomeric Yeast and Mammalian Sec61 Complexes Interacting with the Translating RibosomeQ27658307
Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranesQ27664605
Structural Basis of Brr2-Prp8 Interactions and Implications for U5 snRNP Biogenesis and the Spliceosome Active SiteQ27678447
Structure of the Mammalian Ribosome-Sec61 Complex to 3.4 Å ResolutionQ27684332
UCSF Chimera--a visualization system for exploratory research and analysisQ27860666
Features and development of CootQ27861079
BiP acts as a molecular ratchet during posttranslational transport of prepro-alpha factor across the ER membraneQ27932673
Protein transport by purified yeast Sec complex and Kar2p without membranesQ27934892
Posttranslational protein transport in yeast reconstituted with a purified complex of Sec proteins and Kar2pQ27937164
Assembly of yeast Sec proteins involved in translocation into the endoplasmic reticulum into a membrane-bound multisubunit complexQ27937754
A Sec63p-BiP complex from yeast is required for protein translocation in a reconstituted proteoliposomeQ28257113
Automated electron microscope tomography using robust prediction of specimen movementsQ29616585
Multiple genes are required for proper insertion of secretory proteins into the endoplasmic reticulum in yeastQ29618500
cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determinationQ30398255
Two alternative binding mechanisms connect the protein translocation Sec71-Sec72 complex with heat shock proteinsQ30399829
Modeling the effects of prl mutations on the Escherichia coli SecY complexQ34048338
Homologs of the yeast Sec complex subunits Sec62p and Sec63p are abundant proteins in dog pancreas microsomesQ35155249
EMRinger: side chain-directed model and map validation for 3D cryo-electron microscopy.Q36109022
Signal sequences specify the targeting route to the endoplasmic reticulum membraneQ36236983
Identification of cytoplasmic residues of Sec61p involved in ribosome binding and cotranslational translocationQ36321273
A gating motif in the translocation channel sets the hydrophobicity threshold for signal sequence functionQ36455908
Mutants in three novel complementation groups inhibit membrane protein insertion into and soluble protein translocation across the endoplasmic reticulum membrane of Saccharomyces cerevisiaeQ36530932
Protein Translocation across the Rough Endoplasmic ReticulumQ36555178
Crystal structure of a substrate-engaged SecY protein-translocation channelQ36865827
Mechanisms of Sec61/SecY-Mediated Protein Translocation Across MembranesQ37973762
Toward a structural understanding of co-translational protein translocationQ38828338
Topology and functional domains of Sec63p, an endoplasmic reticulum membrane protein required for secretory protein translocationQ40655505
MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopyQ41598828
Translocon pores in the endoplasmic reticulum are permeable to a neutral, polar moleculeQ42502796
Preserving the membrane barrier for small molecules during bacterial protein translocationQ42733051
Molecular Mechanism of J-Domain-Triggered ATP Hydrolysis by Hsp70 ChaperonesQ47228277
CTFFIND4: Fast and accurate defocus estimation from electron micrographs.Q50866431
Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum.Q52362370
Real-space refinement in PHENIX for cryo-EM and crystallographyQ54691589
P433issue6422
P407language of work or nameEnglishQ1860
P921main subjectTranslocon subunit SEC61 YLR378CQ27550834
Sec63 complex subunit SEC66 YBR171WQ27552023
Sec63 complex subunit SEC62 YPL094CQ27552548
Translocon subunit SSS1 YDR086CQ27553197
P304page(s)84-87
P577publication date2018-12-13
P1433published inScienceQ192864
P1476titleStructure of the posttranslational Sec protein-translocation channel complex from yeast
P478volume363

Reverse relations

cites work (P2860)
Q92749458Asparagine-linked glycosylation is not directly coupled to protein translocation across the endoplasmic reticulum in Saccharomyces cerevisiae
Q92615943Degradation of integral membrane proteins modified with the photosensitive degron module requires the cytosolic endoplasmic reticulum-associated degradation pathway
Q91555669Free-energy landscapes of membrane co-translocational protein unfolding
Q92651089Functions and Mechanisms of the Human Ribosome-Translocon Complex
Q89558910Sec translocon has an insertase-like function in addition to polypeptide conduction through the channel
Q90631910Structure of the mitochondrial import gate reveals distinct preprotein paths

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