The signal peptide plus a cluster of positive charges in prion protein dictate chaperone-mediated Sec61 channel gating

scientific article published on 05 March 2019

The signal peptide plus a cluster of positive charges in prion protein dictate chaperone-mediated Sec61 channel gating is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1242/BIO.040691
P932PMC publication ID6451349
P698PubMed publication ID30745438

P50authorAnke ZiskaQ91467808
Sarah HaßdenteufelQ91467810
Jorg TatzeltQ42754079
P2093author name stringJohanna Dudek
Richard Zimmermann
Adrienne W Paton
James C Paton
P2860cites workTransmembrane Protein Insertion Orientation in Yeast Depends on the Charge Difference across Transmembrane Segments, Their Total Hydrophobicity, and Its DistributionQ52905168
AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP.Q53595113
Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier.Q54964955
Mutations in the Sec61p Channel Affecting Signal Sequence Recognition and Membrane Protein TopologyQ56775244
A Network of Cytosolic Factors Targets SRP-Independent Proteins to the Endoplasmic ReticulumQ57821103
Prion Protein BiologyQ21972822
BiP-mediated closing of the Sec61 channel limits Ca2+ leakage from the ERQ24293288
Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cellsQ24306519
Structure of the Sec61 channel opened by a signal sequenceQ27330079
Prion diseases of humans and animals: their causes and molecular basisQ28209943
Signal sequences. The limits of variationQ29616543
Reduced translocation of nascent prion protein during ER stress contributes to neurodegenerationQ30483989
Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathwayQ33264756
The SND proteins constitute an alternative targeting route to the endoplasmic reticulumQ33364351
Evidence for the loop model of signal-sequence insertion into the endoplasmic reticulumQ33655044
Signal sequence insufficiency contributes to neurodegeneration caused by transmembrane prion proteinQ33689595
The N-terminus of the prion protein is a toxic effector regulated by the C-terminus.Q33793628
Cotranslational partitioning of nascent prion protein into multiple populations at the translocation channelQ34274103
A transmembrane form of the prion protein in neurodegenerative diseaseQ34454961
The code for directing proteins for translocation across ER membrane: SRP cotranslationally recognizes specific features of a signal sequence.Q34779006
The signal sequence influences post-translational ER translocation at distinct stagesQ35018270
Translocation channel gating kinetics balances protein translocation efficiency with signal sequence recognition fidelityQ35188535
Stepwise Insertion and Inversion of a Type II Signal Anchor Sequence in the Ribosome-Sec61 Translocon ComplexQ35235093
Cotranslational stabilization of Sec62/63 within the ER Sec61 translocon is controlled by distinct substrate-driven translocation eventsQ35470364
Folding and misfolding of the prion protein in the secretory pathwayQ35938198
Efficient secretion of small proteins in mammalian cells relies on Sec62-dependent posttranslational translocationQ36091833
Long-Timescale Dynamics and Regulation of Sec-Facilitated Protein TranslocationQ36355150
Substrate-specific regulation of the ribosome- translocon junction by N-terminal signal sequencesQ36525120
The surprising complexity of signal sequencesQ36571413
Sec61p contributes to signal sequence orientation according to the positive-inside ruleQ36782186
Targeting of the prion protein to the cytosol: mechanisms and consequencesQ37600576
The Endoplasmic Reticulum Chaperone GRP78/BiP Modulates Prion Propagation in vitro and in vivoQ37717627
Comparative Haploid Genetic Screens Reveal Divergent Pathways in the Biogenesis and Trafficking of Glycophosphatidylinositol-Anchored Proteins.Q38864129
The α-helical structure of prodomains promotes translocation of intrinsically disordered neuropeptide hormones into the endoplasmic reticulumQ39175147
Structural features within the nascent chain regulate alternative targeting of secretory proteins to mitochondriaQ39582237
alpha-Helical domains promote translocation of intrinsically disordered polypeptides into the endoplasmic reticulumQ39832083
The sequence after the signal peptide of the G protein-coupled endothelin B receptor is required for efficient translocon gating at the endoplasmic reticulum membraneQ39896666
Co-chaperone Specificity in Gating of the Polypeptide Conducting Channel in the Membrane of the Human Endoplasmic Reticulum.Q40289318
Association of Bcl-2 with misfolded prion protein is linked to the toxic potential of cytosolic PrP.Q42416416
A large presecretory protein translocates both cotranslationally, using signal recognition particle and ribosome, and post-translationally, without these ribonucleoparticles, when synthesized in the presence of mammalian microsomes.Q43665889
Regulation of protein topology by trans-acting factors at the endoplasmic reticulumQ44119458
Neurotoxicity and neurodegeneration when PrP accumulates in the cytosolQ44184139
Targeting and beyond: new roles for old signal sequencesQ44206946
An Update on Sec61 Channel Functions, Mechanisms, and Related Diseases.Q47096501
Multiple pathways facilitate the biogenesis of mammalian tail-anchored proteinsQ47108141
The Sec61/SecY complex is inherently deficient in translocating intrinsically disordered proteinsQ47586836
hSnd2 protein represents an alternative targeting factor to the endoplasmic reticulum in human cells.Q47870590
Impaired transport of intrinsically disordered proteins through the Sec61 and SecY translocon; implications for prion diseasesQ49501643
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageQuantQ112270642
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectsignal peptideQ899790
P304page(s)bio040691
P577publication date2019-03-05
P1433published inBiology OpenQ27724268
P1476titleThe signal peptide plus a cluster of positive charges in prion protein dictate chaperone-mediated Sec61 channel gating
P478volume8

Reverse relations

cites work (P2860)
Q92651089Functions and Mechanisms of the Human Ribosome-Translocon Complex
Q97541733Supporting data on prion protein translocation mechanism revealed by pulling force studies
Q90627522The signal peptide as a new target for drug design

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