NADPH oxidases-do they play a role in TRPC regulation under hypoxia?

scientific article published on October 2015

NADPH oxidases-do they play a role in TRPC regulation under hypoxia? is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1050701109
P356DOI10.1007/S00424-015-1731-3
P698PubMed publication ID26424109

P50authorNatascha SommerQ54272867
Ralph T SchermulyQ46115021
Alexander DietrichQ48892276
Norbert WeissmannQ51120582
P2093author name stringThomas Gudermann
Oleg Pak
Christine Veith
Monika Malczyk
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The NADPH oxidase inhibitors iodonium diphenyl and cadmium sulphate inhibit hypoxic pulmonary vasoconstriction in isolated rat pulmonary arteriesQ73470321
Effects of the flavoprotein inhibitor, diphenyleneiodonium sulfate, on ex vivo organic nitrate tolerance in the ratQ73693258
Bmp4 and Fgf10 play opposing roles during lung bud morphogenesisQ73815422
Voltage-independent calcium entry in hypoxic pulmonary vasoconstriction of intrapulmonary arteries of the ratQ73900885
Impairment of store-operated Ca2+ entry in TRPC4(-/-) mice interferes with increase in lung microvascular permeabilityQ74452970
Hypoxia enhances proliferation and generation of IP3 in pulmonary artery fibroblasts but not in those from the mesenteric circulationQ74805036
Hypoxia enhances cellular proliferation and inositol 1,4, 5-triphosphate generation in fibroblasts from bovine pulmonary artery but not from mesenteric arteryQ77660767
Reoxygenation-induced Ca2+ rise is mediated via Ca2+ influx and Ca2+ release from the endoplasmic reticulum in cardiac endothelial cellsQ79348164
TRPC Channel upregulation in chronically hypoxic pulmonary arteries: the HIF-1 bandwagon gathers steamQ79774926
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TRPC3-mediated Ca2+ influx contributes to Rac1-mediated production of reactive oxygen species in MLP-deficient mouse heartsQ84084185
Specific association of the gene product of PKD2 with the TRPC1 channelQ22009113
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Subunit composition of mammalian transient receptor potential channels in living cellsQ24530559
Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel componentsQ24612969
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LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell deathQ28216181
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Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatasesQ28239642
p40phox: the last NADPH oxidase subunitQ28267507
NOX2 interacts with podocyte TRPC6 channels and contributes to their activation by diacylglycerol: essential role of podocin in formation of this complexQ28296660
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An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertensionQ28576675
Extracellular calcium-sensing receptor is critical in hypoxic pulmonary vasoconstrictionQ28580462
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Pressure-induced and store-operated cation influx in vascular smooth muscle cells is independent of TRPC1Q28587996
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Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensingQ29617570
Activation of TRPC1 by STIM1 in ER-PM microdomains involves release of the channel from its scaffold caveolin-1.Q30492038
NADPH oxidase 1-mediated oxidative stress leads to dopamine neuron death in Parkinson's diseaseQ30512262
Stim, ORAI and TRPC channels in the control of calcium entry signals in smooth muscleQ37265156
BMP4 increases canonical transient receptor potential protein expression by activating p38 MAPK and ERK1/2 signaling pathways in pulmonary arterial smooth muscle cellsQ37297879
A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertensionQ37359026
Nitric oxide activates TRP channels by cysteine S-nitrosylation.Q51129304
Pulmonary artery NADPH-oxidase is activated in hypoxic pulmonary vasoconstriction.Q51558926
NO+, NO, and NO- donation by S-nitrosothiols: implications for regulation of physiological functions by S-nitrosylation and acceleration of disulfide formation.Q51605840
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Dominant negative mutation of the TGF-beta receptor blocks hypoxia-induced pulmonary vascular remodeling.Q52566550
Neutral sphingomyelinase, NADPH oxidase and reactive oxygen species. Role in acute hypoxic pulmonary vasoconstriction.Q52725132
Hypoxia-dependent regulation of nonphagocytic NADPH oxidase subunit NOX4 in the pulmonary vasculature.Q53544981
Hydrogen peroxide-induced Ca2+ mobilization in pulmonary arterial smooth muscle cells.Q53565018
Classical transient receptor potential channel 1 in hypoxia-induced pulmonary hypertension.Q54235216
NADPH oxidases and reactive oxygen species at different stages of chronic hypoxia-induced pulmonary hypertension in newborn pigletsQ37406398
Dominant-negative loss of PPARgamma function enhances smooth muscle cell proliferation, migration, and vascular remodeling.Q37411594
Ceramide mediates acute oxygen sensing in vascular tissuesQ37433922
Reactive oxygen species, vascular Noxs, and hypertension: focus on translational and clinical researchQ37433974
Lipid rafts and caveolin-1 coordinate interleukin-1beta (IL-1beta)-dependent activation of NFkappaB by controlling endocytosis of Nox2 and IL-1beta receptor 1 from the plasma membraneQ37446112
Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertensionQ37533998
The role of classical transient receptor potential channels in the regulation of hypoxic pulmonary vasoconstriction.Q37702953
NADPH oxidases in cardiovascular disease.Q37742824
Peroxynitrite-An ugly biofactor?Q37774314
Redox signaling and reactive oxygen species in hypoxic pulmonary vasoconstrictionQ37783790
Redox regulation of endothelial canonical transient receptor potential channelsQ37815207
NADPH oxidase-mediated redox signaling: roles in cellular stress response, stress tolerance, and tissue repairQ37828016
TRPC channels as effectors of cardiac hypertrophyQ37830945
NOX isoforms and reactive oxygen species in vascular healthQ37858259
Regulation of insulin secretion and reactive oxygen species production by free fatty acids in pancreatic isletsQ37900460
Redox regulation of calcium ion channels: chemical and physiological aspectsQ37935283
TRP Channels as Sensors and Signal Integrators of Redox Status ChangesQ37948046
The Nox family of NADPH oxidases: friend or foe of the vascular system?Q37954511
Relationships between vascular oxygen sensing mechanisms and hypertensive disease processesQ38019769
NADPH oxidases in redox regulation of cell adhesion and migrationQ38144099
Redox regulation of transient receptor potential channelsQ38155662
Nox NADPH oxidases and the endoplasmic reticulumQ38175423
Pros and cons of current approaches for detecting peroxynitrite and their applicationsQ38219791
The TRPCs-STIM1-Orai interaction.Q38222952
Endothelial NADPH oxidases: which NOX to target in vascular disease?Q38234422
Hypoxia-dependent reactive oxygen species signaling in the pulmonary circulation: focus on ion channelsQ38302264
Molecular analysis of a store-operated and 2-acetyl-sn-glycerol-sensitive non-selective cation channel. Heteromeric assembly of TRPC1-TRPC3.Q38327904
Nox4 mediates angiotensin II-induced activation of Akt/protein kinase B in mesangial cellsQ38352918
NOX4 mediates activation of FoxO3a and matrix metalloproteinase-2 expression by urotensin-IIQ39124068
TRPA1 underlies a sensing mechanism for O2.Q39260369
Rosiglitazone attenuates chronic hypoxia-induced pulmonary hypertension in a mouse modelQ39879690
Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators.Q39943599
Hypoxia triggers subcellular compartmental redox signaling in vascular smooth muscle cellsQ40068908
Nox1 redox signaling mediates oncogenic Ras-induced disruption of stress fibers and focal adhesions by down-regulating Rho.Q40145596
Ischemia induces nuclear NOX2 expression in cardiomyocytes and subsequently activates apoptosisQ40303320
NOX4 as an oxygen sensor to regulate TASK-1 activityQ40397773
A key role for TRPM7 channels in anoxic neuronal deathQ40603687
N-linked protein glycosylation is a major determinant for basal TRPC3 and TRPC6 channel activity.Q40635186
Selective association of TRPC channel subunits in rat brain synaptosomesQ40697831
TRPV4, TRPC1, and TRPP2 assemble to form a flow-sensitive heteromeric channelQ30593487
The expression of the NADPH oxidase subunit p22phox is regulated by a redox-sensitive pathway in endothelial cellsQ31145053
Upregulated TRP and enhanced capacitative Ca(2+) entry in human pulmonary artery myocytes during proliferationQ31833758
Inhibition of nerve growth factor signaling by peroxynitriteQ31910411
Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4-/- miceQ31929609
NADPH oxidases in vascular pathologyQ33632089
New insights on NOX enzymes in the central nervous systemQ33632673
Nox5 and the regulation of cellular functionQ33649858
Endosomal Nox2 facilitates redox-dependent induction of NF-kappaB by TNF-alphaQ33741068
A differential role for endocytosis in receptor-mediated activation of Nox1.Q33818158
Basic science of pulmonary arterial hypertension for clinicians: new concepts and experimental therapiesQ33849207
The NADPH oxidase subunit NOX4 is a new target gene of the hypoxia-inducible factor-1.Q33907086
Activation of glucose-6-phosphate dehydrogenase promotes acute hypoxic pulmonary artery contractionQ33911436
Classical transient receptor potential 1 and 6 contribute to hypoxic pulmonary hypertension through differential regulation of pulmonary vascular functionsQ33915272
Roles for Nox4 in the contractile response of bovine pulmonary arteries to hypoxiaQ33917083
NOX4 mediates BMP4-induced upregulation of TRPC1 and 6 protein expressions in distal pulmonary arterial smooth muscle cellsQ34156155
Role of reactive oxygen species (ROS) in apoptosis inductionQ34188867
PPAR{gamma} regulates hypoxia-induced Nox4 expression in human pulmonary artery smooth muscle cells through NF-{kappa}B.Q34212735
Nox4 is a protective reactive oxygen species generating vascular NADPH oxidaseQ34264162
Molecular basis of hypoxia-induced pulmonary vasoconstriction: role of voltage-gated K+ channelsQ34280464
Distinct subcellular localizations of Nox1 and Nox4 in vascular smooth muscle cellsQ34283019
The Nox4 inhibitor GKT137831 attenuates hypoxia-induced pulmonary vascular cell proliferationQ34294854
Mechanism of Ca2+ activation of the NADPH oxidase 5 (NOX5).Q34300862
Increased oxidative stress in the nucleus caused by Nox4 mediates oxidation of HDAC4 and cardiac hypertrophy.Q34319871
The role of redox changes in oxygen sensingQ34349433
Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanismsQ34569861
Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchangeQ34586634
Hypoxia. 2. Hypoxia regulates cellular metabolismQ34718056
Classical Transient Receptor Potential 1 (TRPC1): Channel or Channel Regulator?Q34774691
The E-loop is involved in hydrogen peroxide formation by the NADPH oxidase Nox4Q34787163
Regulation of hypoxic pulmonary vasoconstriction: basic mechanisms.Q34890985
TRPC1 store-operated cationic channel subunit.Q35135485
Lung ischemia-reperfusion injury: implications of oxidative stress and platelet-arteriolar wall interactionsQ35238645
Transient receptor potential channel 1 (TRPC1) reduces calcium permeability in heteromeric channel complexesQ40811040
TRPC1 and TRPC5 form a novel cation channel in mammalian brain.Q40812989
Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice.Q40859359
Trp1, a candidate protein for the store-operated Ca(2+) influx mechanism in salivary gland cellsQ40903218
Acute hypoxic pulmonary vasoconstriction: a model of oxygen sensingQ41106685
Hypoxia induces intracellular Ca2+ release by causing reactive oxygen species-mediated dissociation of FK506-binding protein 12.6 from ryanodine receptor 2 in pulmonary artery myocytesQ41121340
Superoxide-driven aconitase FE-S center cyclingQ41488893
Reactive oxygen species facilitate adipocyte differentiation by accelerating mitotic clonal expansion.Q41818769
Hypoxia does neither stimulate pulmonary artery endothelial cell proliferation in mice and rats with pulmonary hypertension and vascular remodeling nor in human pulmonary artery endothelial cellsQ41860957
Canonical transient receptor potential (TRPC) 1 acts as a negative regulator for vanilloid TRPV6-mediated Ca2+ influx.Q41897197
Nox5 forms a functional oligomer mediated by self-association of its dehydrogenase domainQ42173596
Arterial hypertension in a murine model of sleep apnea: role of NADPH oxidase 2.Q42239472
Chronic hypoxia-induced upregulation of store-operated and receptor-operated Ca2+ channels in pulmonary arterial smooth muscle cells: a novel mechanism of hypoxic pulmonary hypertensionQ42464729
Acute hypoxia increases intracellular [Ca2+] in pulmonary arterial smooth muscle by enhancing capacitative Ca2+ entryQ42473304
Hypoxia inducible factor 1 mediates hypoxia-induced TRPC expression and elevated intracellular Ca2+ in pulmonary arterial smooth muscle cellsQ42495592
Chronic oxidative stress modulates TRPC3 and TRPM2 channel expression and function in rat primary cortical neurons: relevance to the pathophysiology of bipolar disorderQ42711815
A role for receptor-operated Ca2+ entry in human pulmonary artery smooth muscle cells in response to hypoxia.Q43038174
Vascular functions of NADPH oxidasesQ43061065
Targeting mitochondrial reactive oxygen species to modulate hypoxia-induced pulmonary hypertensionQ43206778
NADPH oxidase Nox2 is required for hypoxia-induced mobilization of endothelial progenitor cellsQ43292284
Spatial and temporal analysis of NADPH oxidase-generated hydrogen peroxide signals by novel fluorescent reporter proteinsQ43478919
ET-1 stimulates pulmonary arterial smooth muscle cell proliferation via induction of reactive oxygen speciesQ43764530
Store-operated channels mediate Ca(2+) influx and contraction in rat pulmonary arteryQ43794488
Angiotensin II stimulation of NAD(P)H oxidase activity: upstream mediatorsQ44128026
Function of NADPH oxidase 1 in pulmonary arterial smooth muscle cells after monocrotaline-induced pulmonary vascular remodelingQ44214715
Role of ERK and calcium in the hypoxia-induced activation of HIF-1.Q44226840
Increased superoxide generation is associated with pulmonary hypertension in fetal lambs: a role for NADPH oxidaseQ44333254
Hypoxia enhances a cGMP-independent nitric oxide relaxing mechanism in pulmonary arteriesQ44401132
TRPC3 mediates pyrimidine receptor-induced depolarization of cerebral arteriesQ45190188
Inhibition of hypoxic pulmonary vasoconstriction by antagonists of store-operated Ca2+ and nonselective cation channelsQ45275726
Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertensionQ45869636
Transient receptor potential channels and caveolin-1: good friends in tight spacesQ46134055
Low-voltage-activated (T-type) calcium channels control proliferation of human pulmonary artery myocytesQ46387629
NOX4 regulates ROS levels under normoxic and hypoxic conditions, triggers proliferation, and inhibits apoptosis in pulmonary artery adventitial fibroblastsQ46508038
TRPC1 binds to caveolin-3 and is regulated by Src kinase - role in Duchenne muscular dystrophyQ46547351
Hypoxic pulmonary hypertension: role of superoxide and NADPH oxidase (gp91phox).Q46639326
Effect of oxidative stress on TRPM2 and TRPC3 channels in B lymphoblast cells in bipolar disorderQ46703875
IQGAP1 regulates reactive oxygen species-dependent endothelial cell migration through interacting with Nox2.Q46716879
Transforming growth factor-beta1 induces Nox4 NAD(P)H oxidase and reactive oxygen species-dependent proliferation in human pulmonary artery smooth muscle cellsQ46755210
Lipid rafts keep NADPH oxidase in the inactive state in human renal proximal tubule cellsQ46808254
Impact of mitochondria and NADPH oxidases on acute and sustained hypoxic pulmonary vasoconstrictionQ46853357
Redox activation of intracellular calcium release channels (ryanodine receptors) in the sustained phase of hypoxia-induced pulmonary vasoconstrictionQ46864939
High glucose modifies transient receptor potential canonical type 6 channels via increased oxidative stress and syndecan-4 in human podocytes.Q46877648
TRPC4 inactivation confers a survival benefit in severe pulmonary arterial hypertensionQ47094314
Gene expression profiles in peripheral blood mononuclear cells of Asian obstructive sleep apnea patients.Q48113364
The effects of oxidizing and cysteine-reactive reagents on the inward rectifier potassium channels Kir2.3 and Kir1.1.Q48904356
Oxidative stress augments pulmonary hypertension in chronically hypoxic mice overexpressing the oxidized LDL receptor.Q50981314
Mitochondrial hyperpolarization in pulmonary vascular remodeling. Mitochondrial uncoupling protein deficiency as disease model.Q51066025
CFTR and sphingolipids mediate hypoxic pulmonary vasoconstrictionQ35279508
New concepts in reactive oxygen species and cardiovascular reperfusion physiologyQ35666898
Hypoxic pulmonary vasoconstriction: redox events in oxygen sensingQ35980383
Expression and functional significance of NADPH oxidase 5 (Nox5) and its splice variants in human blood vesselsQ35994159
Vascular NADPH oxidases: molecular mechanisms of activation.Q35994483
Measurement of reactive oxygen species in cardiovascular studiesQ36012674
Hypoxia inducible factor-1-dependent up-regulation of BMP4 mediates hypoxia-induced increase of TRPC expression in PASMCsQ36027830
The NOX toolbox: validating the role of NADPH oxidases in physiology and diseaseQ36060782
Oxidant and redox signaling in vascular oxygen sensing mechanisms: basic concepts, current controversies, and potential importance of cytosolic NADPH.Q36186225
TRP channels: an overviewQ36228455
Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophagesQ36244224
NADPH oxidases: an overview from structure to innate immunity-associated pathologiesQ36302873
O2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidaseQ36411174
Hypoxia-induced endothelial CX3CL1 triggers lung smooth muscle cell phenotypic switching and proliferative expansionQ36454379
Oxygen sensors in hypoxic pulmonary vasoconstrictionQ36502612
Role of ion channels in acute and chronic responses of the pulmonary vasculature to hypoxiaQ36530890
The role of k+ channels in determining pulmonary vascular tone, oxygen sensing, cell proliferation, and apoptosis: implications in hypoxic pulmonary vasoconstriction and pulmonary arterial hypertensionQ36645325
Ca2+ channels and chronic hypoxiaQ36645336
Ca2+ signaling, TRP channels, and endothelial permeabilityQ36645346
Superoxide generated at mitochondrial complex III triggers acute responses to hypoxia in the pulmonary circulation.Q36702768
Impairment of TRPC1-STIM1 channel assembly and AQP5 translocation compromise agonist-stimulated fluid secretion in mice lacking caveolin1Q36731463
Regulation of ROS signal transduction by NADPH oxidase 4 localizationQ36741267
Reactive oxygen species and antioxidants in pulmonary hypertensionQ36747034
Redox regulation of ion channels in the pulmonary circulationQ36770811
In vivo TRPC functions in the cardiopulmonary vasculature.Q36791223
Differences in STIM1 and TRPC expression in proximal and distal pulmonary arterial smooth muscle are associated with differences in Ca2+ responses to hypoxiaQ36808053
Nuclear factor κB mediates suppression of canonical transient receptor potential 6 expression by reactive oxygen species and protein kinase C in kidney cellsQ36812431
The effects of hypoxia on the cells of the pulmonary vasculature.Q36897809
Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancerQ37033660
Chronic hypoxia selectively enhances L- and T-type voltage-dependent Ca2+ channel activity in pulmonary artery by upregulating Cav1.2 and Cav3.2.Q37054481
Mitochondrial-localized NADPH oxidase 4 is a source of superoxide in angiotensin II-stimulated neuronsQ37054954
NOX4 mediates hypoxia-induced proliferation of human pulmonary artery smooth muscle cells: the role of autocrine production of transforming growth factor-{beta}1 and insulin-like growth factor binding protein-3.Q37138896
Regulation of the phagocyte NADPH oxidase activity: phosphorylation of gp91phox/NOX2 by protein kinase C enhances its diaphorase activity and binding to Rac2, p67phox, and p47phoxQ37139780
P433issue1
P304page(s)23-41
P577publication date2015-10-01
P1433published inPfluegers ArchivQ1091689
P1476titleNADPH oxidases-do they play a role in TRPC regulation under hypoxia?
P478volume468

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Q39048721Physiological redox signalling and regulation of ion channels: implications for pulmonary hypertension.
Q38831674The role of stretch-activated ion channels in acute respiratory distress syndrome: finally a new target?

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