| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1003623063 |
| P356 | DOI | 10.1038/NRN4020 |
| P8608 | Fatcat ID | release_zjxmlgezivep5chkqtmgs2juqy |
| P698 | PubMed publication ID | 26462757 |
| P50 | author | Hei-Man Chow | Q90860074 |
| P2093 | author name string | Karl Herrup | |
| P2860 | cites work | Identification of miRNA Changes in Alzheimer's Disease Brain and CSF Yields Putative Biomarkers and Insights into Disease Pathways | Q57982495 |
| Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease | Q58006825 | ||
| Alterations in mitochondrial membrane fluidity by lipid peroxidation products | Q72461830 | ||
| The logic linking protein acetylation and metabolism | Q84625102 | ||
| TLK1B promotes repair of UV-damaged DNA through chromatin remodeling by Asf1 | Q21263009 | ||
| DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development | Q22010765 | ||
| Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene | Q22011158 | ||
| Cell cycle regulation in the postmitotic neuron: oxymoron or new biology? | Q22337222 | ||
| Role of SIRT1 in homologous recombination | Q24297067 | ||
| SIRT1 promotes DNA repair activity and deacetylation of Ku70 | Q24298814 | ||
| Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo | Q24300037 | ||
| Tudor, MBT and chromo domains gauge the degree of lysine methylation | Q24301294 | ||
| Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression | Q24309909 | ||
| SIRT1 regulates the function of the Nijmegen breakage syndrome protein | Q24317230 | ||
| Aneuploid neurons are functionally active and integrated into brain circuitry | Q24523693 | ||
| Chromosomal variation in neurons of the developing and adult mammalian nervous system | Q24555100 | ||
| miRNA response to DNA damage | Q24594312 | ||
| SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging | Q24595900 | ||
| Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice | Q24598687 | ||
| HDAC2 negatively regulates memory formation and synaptic plasticity. | Q24611806 | ||
| An epigenetic blockade of cognitive functions in the neurodegenerating brain | Q24611928 | ||
| Targeted DNA methylation by homology-directed repair in mammalian cells. Transcription reshapes methylation on the repaired gene. | Q24613629 | ||
| miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor | Q24628906 | ||
| Repression of the miR-17-92 cluster by p53 has an important function in hypoxia-induced apoptosis | Q24648286 | ||
| miR-34a repression of SIRT1 regulates apoptosis | Q24652720 | ||
| The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo | Q24657924 | ||
| Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain. | Q48487273 | ||
| Hyperphosphorylation of the retinoblastoma gene product and altered subcellular distribution of E2F-1 during Alzheimer's disease and amyotrophic lateral sclerosis. | Q48492301 | ||
| An inhibitor of DNA recombination blocks memory consolidation, but not reconsolidation, in context fear conditioning. | Q48535007 | ||
| Synaptic proteome changes in a DNA repair deficient ercc1 mouse model of accelerated aging | Q48685070 | ||
| Pictures in molecular medicine: contemplating Alzheimer's disease as cancer: a loss of cell-cycle control | Q48722906 | ||
| Accelerated age-related cognitive decline and neurodegeneration, caused by deficient DNA repair. | Q48924423 | ||
| The variation of aneuploidy frequency in the developing and adult human brain revealed by an interphase FISH study. | Q51932470 | ||
| The induction of multiple cell cycle events precedes target-related neuronal death | Q52206831 | ||
| Enhanced DNA repair synthesis in hyperacetylated nucleosomes. | Q52868121 | ||
| Deficiency of the Mre11 DNA repair complex in Alzheimer's disease brains. | Q53263839 | ||
| In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs. | Q53314394 | ||
| Distinct patterns of sirtuin expression during progression of Alzheimer's disease. | Q53348494 | ||
| Chromosome 17 and 21 aneuploidy in buccal cells is increased with ageing and in Alzheimer's disease. | Q53390217 | ||
| Tumor suppressor miR-145 reverses drug resistance by directly targeting DNA damage-related gene RAD18 in colorectal cancer. | Q53529113 | ||
| Changes in nuclear protein acetylation in u.v.-damaged human cells. | Q53535802 | ||
| Cell cycle activation in postmitotic neurons is essential for DNA repair. | Q53571469 | ||
| Tau protein binds single-stranded DNA sequence specifically--the proof obtained in vitro with non-equilibrium capillary electrophoresis of equilibrium mixtures. | Q54490742 | ||
| miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42. | Q54780999 | ||
| The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease | Q35652312 | ||
| Alterations in G(1) to S phase cell-cycle regulators during amyotrophic lateral sclerosis | Q35791339 | ||
| Initiating cellular stress responses | Q35830545 | ||
| Functional links between telomeres and proteins of the DNA-damage response | Q35853775 | ||
| Divide and die: cell cycle events as triggers of nerve cell death. | Q35924071 | ||
| Tet family proteins and 5-hydroxymethylcytosine in development and disease | Q35944741 | ||
| To die or grow: Parkinson's disease and cancer | Q36137649 | ||
| Dynamics of DNA methylation in aging and Alzheimer's disease | Q36290480 | ||
| Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease | Q36360616 | ||
| Molecular mechanisms of mammalian global genome nucleotide excision repair. | Q36389623 | ||
| Chromosome-specific accumulation of aneuploidy in the aging mouse brain | Q36435859 | ||
| Cell division in the CNS: protective response or lethal event in post-mitotic neurons? | Q36678493 | ||
| Epigenetic mechanisms in neurological disease | Q36682567 | ||
| miR-128 exerts pro-apoptotic effect in a p53 transcription-dependent and -independent manner via PUMA-Bak axis | Q36733176 | ||
| DNA damage checkpoints: from initiation to recovery or adaptation | Q36736655 | ||
| Oxidative damage in mild cognitive impairment and early Alzheimer's disease | Q36825753 | ||
| Controlling DNA-end resection: a new task for CDKs | Q36893881 | ||
| Cell cycle proteins exhibit altered expression patterns in lentiviral-associated encephalitis | Q36897534 | ||
| DNA-dependent protein kinase and DNA repair: relevance to Alzheimer's disease | Q36998015 | ||
| Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice | Q37097951 | ||
| Living on a break: cellular senescence as a DNA-damage response | Q37198572 | ||
| MiR-26b, upregulated in Alzheimer's disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons | Q37261417 | ||
| DNA repair deficiency and neurological disease | Q37368873 | ||
| DNA damage and repair in Alzheimer's disease | Q37387273 | ||
| DNA base excision repair activities in mouse models of Alzheimer's disease | Q37392155 | ||
| Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients. | Q37638856 | ||
| Neural mechanisms of ageing and cognitive decline | Q37718609 | ||
| Changes of telomere length with aging. | Q37768853 | ||
| Franklin H. Epstein Lecture: Sirtuins, aging, and medicine | Q37886170 | ||
| Potential of chromatin modifying compounds for the treatment of Alzheimer's disease | Q38041123 | ||
| MicroRNAs and neurodegeneration: role and impact | Q38048423 | ||
| The sirtuins, oxidative stress and aging: an emerging link | Q38087848 | ||
| Dual control of mitochondrial biogenesis by sirtuin 1 and sirtuin 3. | Q38098825 | ||
| Sirtuin deacetylases in neurodegenerative diseases of aging | Q38108128 | ||
| Exceptional stories of microRNAs | Q38113930 | ||
| Meiotic recombination in mammals: localization and regulation | Q38153644 | ||
| MicroRNA-193b is a regulator of amyloid precursor protein in the blood and cerebrospinal fluid derived exosomal microRNA-193b is a biomarker of Alzheimer's disease | Q38305012 | ||
| MicroRNA-124 (miR-124) regulates Ku70 expression and is correlated with neuronal death induced by ischemia/reperfusion | Q38311591 | ||
| Characterization of ATM gene mutations in 66 ataxia telangiectasia families. | Q38329510 | ||
| Alteration of gene expression by chromosome loss in the postnatal mouse brain. | Q38352877 | ||
| SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons | Q38543012 | ||
| Increased acetyl and total histone levels in post-mortem Alzheimer's disease brain | Q38931123 | ||
| Hyperphosphorylation results in tau dysfunction in DNA folding and protection | Q39092274 | ||
| The DNA-damage response to γ-radiation is affected by miR-27a in A549 cells. | Q39100694 | ||
| miR-381, a novel intrinsic WEE1 inhibitor, sensitizes renal cancer cells to 5-FU by up-regulation of Cdc2 activities in 786-O. | Q39132348 | ||
| Oxidative stress induces DNA demethylation and histone acetylation in SH-SY5Y cells: potential epigenetic mechanisms in gene transcription in Aβ production | Q39247131 | ||
| miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation | Q39812163 | ||
| miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells | Q39859199 | ||
| MicroRNA-125b is a novel negative regulator of p53. | Q39871732 | ||
| Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways | Q39975165 | ||
| Characterisation of the sites of DNA damage-induced 53BP1 phosphorylation catalysed by ATM and ATR. | Q40123020 | ||
| DNA end joining activity is reduced in Alzheimer's disease | Q40419228 | ||
| Toward an early diagnosis and treatment of Alzheimer's disease | Q40533774 | ||
| Sublethal doses of β-amyloid peptide abrogate DNA-dependent protein kinase activity | Q40733321 | ||
| Chromatin structure and DNA damage repair | Q41189289 | ||
| The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system | Q41699861 | ||
| The role of ATM and DNA damage in neurons: upstream and downstream connections. | Q42021833 | ||
| Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks. | Q42150641 | ||
| The Effects of SIRT1 on Alzheimer's Disease Models | Q42401543 | ||
| Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease. | Q42439458 | ||
| DNA replication precedes neuronal cell death in Alzheimer's disease. | Q42502934 | ||
| Xeroderma pigmentosum. Defective DNA repair causes skin cancer and neurodegeneration | Q42518877 | ||
| MicroRNA regulation of DNA repair gene expression in 4-aminobiphenyl-treated HepG2 cells | Q42705538 | ||
| Aberrant microRNA expression in the brains of neurodegenerative diseases: miR-29a decreased in Alzheimer disease brains targets neurone navigator 3. | Q43143033 | ||
| Aneuploidy in the normal, Alzheimer's disease and ataxia-telangiectasia brain: differential expression and pathological meaning | Q43598274 | ||
| Mild cerebral ischemia induces loss of cyclin-dependent kinase inhibitors and activation of cell cycle machinery before delayed neuronal cell death. | Q43662812 | ||
| Sirtuin 1 activation enhances the PGC-1α/mitochondrial antioxidant system pathway in status epilepticus | Q43884070 | ||
| Ectopic localization of phosphorylated histone H3 in Alzheimer's disease: a mitotic catastrophe? | Q44391611 | ||
| Telomere Dysfunction of Lymphocytes in Patients With Alzheimer Disease | Q44591292 | ||
| Cell cycle activation linked to neuronal cell death initiated by DNA damage | Q44774050 | ||
| Targeted proteomics for quantification of histone acetylation in Alzheimer's disease. | Q44787901 | ||
| Lithium, a common drug for bipolar disorder treatment, regulates amyloid-beta precursor protein processing | Q44915813 | ||
| MiR-26a enhances the radiosensitivity of glioblastoma multiforme cells through targeting of ataxia-telangiectasia mutated | Q45012413 | ||
| Failed clearance of aneuploid embryonic neural progenitor cells leads to excess aneuploidy in the Atm-deficient but not the Trp53-deficient adult cerebral cortex. | Q46228941 | ||
| Increased oxidative damage in nuclear and mitochondrial DNA in mild cognitive impairment | Q46888735 | ||
| Aneuploidy and DNA replication in the normal human brain and Alzheimer's disease | Q48124201 | ||
| Neuronal expression of cell cycle-related proteins after brain ischaemia in man. | Q48132342 | ||
| Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus | Q48266570 | ||
| Nestin-CreER mice reveal DNA synthesis by nonapoptotic neurons following cerebral ischemia hypoxia. | Q48295231 | ||
| On somatic recombination in the central nervous system of transgenic mice | Q48454771 | ||
| Shorter telomeres are associated with mortality in those with APOE epsilon4 and dementia | Q48483738 | ||
| Telomerase deficiency affects normal brain functions in mice | Q48483814 | ||
| Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair | Q24669691 | ||
| MicroRNA profiling: approaches and considerations | Q26861675 | ||
| Oxidative stress, DNA damage, and the telomeric complex as therapeutic targets in acute neurodegeneration | Q26995219 | ||
| DNA methylation and healthy human aging | Q27012262 | ||
| Mammalian microRNAs predominantly act to decrease target mRNA levels | Q27860535 | ||
| DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139 | Q28131715 | ||
| Genome maintenance mechanisms for preventing cancer | Q28131737 | ||
| DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1 | Q28215916 | ||
| Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells | Q28249223 | ||
| The DNA damage response: ten years after | Q28261230 | ||
| MicroRNA-16 targets amyloid precursor protein to potentially modulate Alzheimer's-associated pathogenesis in SAMP8 mice | Q28287534 | ||
| Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks | Q28291639 | ||
| A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis | Q28292871 | ||
| The role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint control | Q28296356 | ||
| Systematic screen identifies miRNAs that target RAD51 and RAD51D to enhance chemosensitivity | Q28299698 | ||
| A microRNA component of the p53 tumour suppressor network | Q28305330 | ||
| Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice | Q28504593 | ||
| DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway | Q28506076 | ||
| Genomic instability and aging-like phenotype in the absence of mammalian SIRT6 | Q28509079 | ||
| Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis | Q28510836 | ||
| Effect of ionizing radiation in sensory ganglion neurons: organization and dynamics of nuclear compartments of DNA damage/repair and their relationship with transcription and cell cycle | Q28569081 | ||
| ATM and related protein kinases: safeguarding genome integrity | Q29547735 | ||
| Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage | Q29614218 | ||
| Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage | Q29614528 | ||
| Understanding the odd science of aging | Q29617341 | ||
| Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks | Q29617463 | ||
| Recovery of learning and memory is associated with chromatin remodelling | Q29619784 | ||
| microRNA-34a promotes DNA damage and mitotic catastrophe. | Q30409530 | ||
| Mosaic copy number variation in human neurons | Q30409886 | ||
| Impaired social recognition memory in recombination activating gene 1-deficient mice | Q30463825 | ||
| Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia | Q30516583 | ||
| Neurobehavioral changes resulting from recombinase activation gene 1 deletion | Q30531755 | ||
| Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β | Q30539255 | ||
| EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia | Q30574640 | ||
| Binding to the minor groove of the double-strand, tau protein prevents DNA from damage by peroxidation | Q33348647 | ||
| SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling | Q34890876 | ||
| Increased chromosome instability dramatically disrupts neural genome integrity and mediates cerebellar degeneration in the ataxia-telangiectasia brain | Q34979102 | ||
| The ATM kinase induces microRNA biogenesis in the DNA damage response. | Q35043572 | ||
| DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes | Q35098038 | ||
| Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction. | Q35165995 | ||
| Review and hypothesis: Alzheimer disease and Down syndrome--chromosome 21 nondisjunction may underlie both disorders | Q35196704 | ||
| Yeast telomeres exert a position effect on recombination between internal tracts of yeast telomeric DNA | Q35210267 | ||
| Dyskeratosis congenita as a disorder of telomere maintenance | Q35529338 | ||
| Ionizing radiation-induced oxidative stress alters miRNA expression | Q33487162 | ||
| ATM is down-regulated by N-Myc-regulated microRNA-421. | Q33667539 | ||
| Neuronal DNA content variation (DCV) with regional and individual differences in the human brain | Q33671904 | ||
| Human interphase chromosomes: a review of available molecular cytogenetic technologies. | Q33698277 | ||
| Nijmegen breakage syndrome: consequences of defective DNA double strand break repair | Q33707289 | ||
| p53-Responsive micrornas 192 and 215 are capable of inducing cell cycle arrest | Q33719450 | ||
| The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1. | Q33722837 | ||
| SIRT6 promotes DNA repair under stress by activating PARP1 | Q33803766 | ||
| Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes | Q33816985 | ||
| Cyclin-C-dependent cell-cycle entry is required for activation of non-homologous end joining DNA repair in postmitotic neurons | Q33912831 | ||
| Selective cell death of hyperploid neurons in Alzheimer's disease | Q33947138 | ||
| Maintaining genome stability in the nervous system | Q33957193 | ||
| Terminally differentiated human neurons repair transcribed genes but display attenuated global DNA repair and modulation of repair gene expression | Q33962255 | ||
| miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors | Q34157084 | ||
| ATM and ataxia telangiectasia | Q34166198 | ||
| Down-regulation of BRCA1 expression by miR-146a and miR-146b-5p in triple negative sporadic breast cancers. | Q34176503 | ||
| Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process. | Q34200511 | ||
| The role of miRNAs in human papilloma virus (HPV)-associated cancers: bridging between HPV-related head and neck cancer and cervical cancer | Q34219266 | ||
| miR-26b promotes granulosa cell apoptosis by targeting ATM during follicular atresia in porcine ovary | Q34318355 | ||
| miR-9 regulation of BRCA1 and ovarian cancer sensitivity to cisplatin and PARP inhibition | Q34380980 | ||
| Constitutional aneuploidy in the normal human brain. | Q34399858 | ||
| Loss of neuronal cell cycle control in ataxia-telangiectasia: a unified disease mechanism. | Q34401594 | ||
| CNS SIRT3 expression is altered by reactive oxygen species and in Alzheimer's disease | Q34471903 | ||
| DNA damage and base excision repair in mitochondria and their role in aging. | Q34479569 | ||
| Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances. | Q34518938 | ||
| Transcriptional silencing at Saccharomyces telomeres: implications for other organisms | Q34535610 | ||
| ATM function and telomere stability | Q34535665 | ||
| Senescence and apoptosis: dueling or complementary cell fates? | Q34619554 | ||
| Regulation of the DNA damage response by cyclin-dependent kinases. | Q34679077 | ||
| Context-Dependent Bidirectional Regulation of the MutS Homolog 2 by Transforming Growth Factor β Contributes to Chemoresistance in Breast Cancer Cells | Q34688096 | ||
| TOM40 mediates mitochondrial dysfunction induced by α-synuclein accumulation in Parkinson's disease | Q34692945 | ||
| DNA hypomethylation leads to elevated mutation rates | Q34752442 | ||
| SIRT6 minor allele genotype is associated with >5-year decrease in lifespan in an aged cohort. | Q34776699 | ||
| P433 | issue | 11 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 672-684 | |
| P577 | publication date | 2015-10-14 | |
| P1433 | published in | Nature Reviews Neuroscience | Q2108225 |
| P1476 | title | Genomic integrity and the ageing brain | |
| P478 | volume | 16 |
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