| scholarly article | Q13442814 |
| P356 | DOI | 10.1007/978-3-319-60733-7_9 |
| P698 | PubMed publication ID | 28840557 |
| P50 | author | Menattallah Elserafy | Q57975478 |
| Mohamed M Ali | Q64148997 | ||
| Arwa A Abugable | Q88202260 | ||
| P2093 | author name string | Arwa A Abugable | |
| Dahlia A Awwad | |||
| Dalia Fleifel | |||
| Sherif El-Khamisy | |||
| P2860 | cites work | Linkage of ATM to cell cycle regulation by the Chk2 protein kinase | Q22008502 |
| Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome | Q22011001 | ||
| Cellular roles of dna topoisomerases: a molecular perspective | Q22121990 | ||
| TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation | Q22253885 | ||
| CHK2 kinase expression is down-regulated due to promoter methylation in non-small cell lung cancer | Q23919381 | ||
| Sequence analysis identifies TTRAP, a protein that associates with CD40 and TNF receptor-associated factors, as a member of a superfamily of divalent cation-dependent phosphodiesterases | Q24291496 | ||
| Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination | Q24294409 | ||
| Purified human BRCA2 stimulates RAD51-mediated recombination | Q24297031 | ||
| Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1 | Q24297882 | ||
| Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation? | Q24298259 | ||
| XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining | Q24302150 | ||
| Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1 | Q24311803 | ||
| Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA | Q24312076 | ||
| Isolation and characterization of the human MRE11 homologue | Q24312777 | ||
| TDP1 facilitates repair of ionizing radiation-induced DNA single-strand breaks | Q24315895 | ||
| Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair | Q24316169 | ||
| Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome | Q24316811 | ||
| Increased expression and activity of repair genes TDP1 and XPF in non-small cell lung cancer | Q24318465 | ||
| WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing | Q24318651 | ||
| A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage | Q24319904 | ||
| Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells | Q24320116 | ||
| DNA ligase IV from HeLa cell nuclei | Q24322238 | ||
| A single ataxia telangiectasia gene with a product similar to PI-3 kinase | Q24323579 | ||
| Overexpression of human RAD51 and RAD52 reduces double-strand break-induced homologous recombination in mammalian cells | Q24555124 | ||
| cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein | Q24568188 | ||
| Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes | Q24595981 | ||
| ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks | Q24596775 | ||
| Meiotic versus mitotic recombination: two different routes for double-strand break repair: the different functions of meiotic versus mitotic DSB repair are reflected in different pathway usage and different outcomes | Q24597411 | ||
| Up-regulation of WRN and DNA ligase IIIalpha in chronic myeloid leukemia: consequences for the repair of DNA double-strand breaks | Q24619366 | ||
| Human CtIP promotes DNA end resection | Q24646062 | ||
| Somatic mutations affect key pathways in lung adenocarcinoma | Q24648102 | ||
| Molecular cloning and expression of human cDNAs encoding a novel DNA ligase IV and DNA ligase III, an enzyme active in DNA repair and recombination | Q24652220 | ||
| Isoquinoline-1,3-diones as Selective Inhibitors of Tyrosyl DNA Phosphodiesterase II (TDP2). | Q50531236 | ||
| ATR inhibition induces synthetic lethality and overcomes chemoresistance in TP53- or ATM-defective chronic lymphocytic leukemia cells. | Q50913049 | ||
| CRISPR gene-editing tested in a person for the first time. | Q51047142 | ||
| Tyrosyl-DNA Phosphodiesterase 1 Inhibitors: Usnic Acid Enamines Enhance the Cytotoxic Effect of Camptothecin. | Q51277452 | ||
| Genetic abnormalities and clinical outcome in chronic lymphocytic leukemia. | Q51718865 | ||
| Manipulating the yeast genome: deletion, mutation, and tagging by PCR. | Q54192053 | ||
| Evaluation of the likelihood of a selective CHK1 inhibitor (LY2603618) to inhibit CYP2D6 with desipramine as a probe substrate in cancer patients. | Q54316808 | ||
| ATR inhibition preferentially targets homologous recombination-deficient tumor cells. | Q54326103 | ||
| Expression pattern of ATM and cyclin D1 in ductal carcinoma, normal adjacent and normal breast tissues of Iranian breast cancer patients. | Q54353413 | ||
| Direct association between the yeast Rad51 and Rad54 recombination proteins. | Q54575005 | ||
| Functionally homologous cell cycle control genes in budding and fission yeast | Q59090469 | ||
| Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells | Q39820516 | ||
| C9orf72 expansion disrupts ATM-mediated chromosomal break repair. | Q40120242 | ||
| A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription. | Q40263593 | ||
| An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae | Q40411133 | ||
| DNA end joining activity is reduced in Alzheimer's disease | Q40419228 | ||
| Rad51 siRNA delivered by HVJ envelope vector enhances the anti-cancer effect of cisplatin. | Q40448582 | ||
| A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity | Q40595505 | ||
| Saccharomyces cerevisiae cell cycle mutant cdc9 is defective in DNA ligase | Q40925838 | ||
| RAD51 haploinsufficiency causes congenital mirror movements in humans | Q40997100 | ||
| The recognition of DNA damage | Q41099842 | ||
| Discovery of 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as selective, orally bioavailable CHK1 inhibitors. | Q41761375 | ||
| A Small-Molecule Inhibitor of RAD51 Reduces Homologous Recombination and Sensitizes Multiple Myeloma Cells to Doxorubicin | Q41881917 | ||
| Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2. | Q42181420 | ||
| AP endonuclease independent repair of abasic sites in Schizosaccharomyces pombe | Q42587593 | ||
| CtIP and MRN promote non-homologous end-joining of etoposide-induced DNA double-strand breaks in G1. | Q42704196 | ||
| Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity | Q42713005 | ||
| Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents. | Q42745810 | ||
| Mutation screening of Mre11 complex genes: indication of RAD50 involvement in breast and ovarian cancer susceptibility | Q43074406 | ||
| The repair of double-strand breaks in the nuclear DNA of Saccharomyces cerevisiae and its genetic control | Q43572485 | ||
| ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones. | Q44079733 | ||
| ATM gene deletion in patients with adult acute lymphoblastic leukemia | Q44420138 | ||
| Manipulating yeast genome using plasmid vectors | Q44771988 | ||
| Visualization of altered replication dynamics after DNA damage in human cells | Q44776027 | ||
| Detection of CHK1 and CCND1 gene copy number changes in breast cancer with dual-colour fluorescence in-situ hybridization. | Q45797188 | ||
| Comparative analysis of adeno-associated viral vector serotypes 1, 2, 5, 7, and 8 in mouse brain | Q45866495 | ||
| Checkpoint kinase inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles | Q46088574 | ||
| Functional and genomic approaches reveal an ancient CHEK2 allele associated with breast cancer in the Ashkenazi Jewish population | Q47298095 | ||
| Solution structure of the C-terminal domain of Ku80 suggests important sites for protein-protein interactions | Q47638560 | ||
| Interaction between DNA and an Escherichia coli protein omega | Q47757460 | ||
| Epigenetic inactivation of checkpoint kinase 2 gene in non-small cell lung cancer and its relationship with clinicopathological features | Q48016842 | ||
| TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene | Q48070727 | ||
| Pharmacokinetics, pharmacodynamics and efficacy on pediatric tumors of the glioma radiosensitizer KU60019. | Q48621553 | ||
| Synergistic actions of Rad51 and Rad52 in recombination and DNA repair | Q50335533 | ||
| Phase I dose-escalation trial of checkpoint kinase 1 inhibitor MK-8776 as monotherapy and in combination with gemcitabine in patients with advanced solid tumors. | Q33419897 | ||
| RNAi screening of the kinome identifies modulators of cisplatin response in ovarian cancer cells | Q33664919 | ||
| Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA. | Q33668589 | ||
| In vitro and in vivo radiation sensitization of human tumor cells by a novel checkpoint kinase inhibitor, AZD7762. | Q33775399 | ||
| Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes | Q33816985 | ||
| A small molecule inhibitor of human RAD51 potentiates breast cancer cell killing by therapeutic agents in mouse xenografts | Q33817458 | ||
| The RAD51-stimulatory compound RS-1 can exploit the RAD51 overexpression that exists in cancer cells and tumors | Q33838509 | ||
| Absence of DNA ligase IV protein in XR-1 cells: evidence for stabilization by XRCC4. | Q33853314 | ||
| Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient | Q33867168 | ||
| Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair. | Q33926817 | ||
| Cellular and biochemical impact of a mutation in DNA ligase IV conferring clinical radiosensitivity | Q33946410 | ||
| In vivo genome editing using Staphylococcus aureus Cas9 | Q34043628 | ||
| Rad51 and BRCA2--New molecular targets for sensitizing glioma cells to alkylating anticancer drugs | Q34071842 | ||
| A novel Chk inhibitor, XL-844, increases human cancer cell radiosensitivity through promotion of mitotic catastrophe | Q34089160 | ||
| DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency | Q34108148 | ||
| 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer | Q34160527 | ||
| Potentiation of tumor responses to DNA damaging therapy by the selective ATR inhibitor VX-970 | Q34221860 | ||
| ATM-depletion in breast cancer cells confers sensitivity to PARP inhibition | Q34249365 | ||
| Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2. | Q34365395 | ||
| RAD50 and NBS1 are breast cancer susceptibility genes associated with genomic instability | Q34425705 | ||
| Mechanism of DNA double-strand break repair by non-homologous end joining | Q34557861 | ||
| A unified view of the DNA-damage checkpoint | Q34560932 | ||
| RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma | Q34602599 | ||
| SMRT compounds abrogate cellular phenotypes of ataxia telangiectasia in neural derivatives of patient-specific hiPSCs | Q34709237 | ||
| An activity from mammalian cells that untwists superhelical DNA--a possible swivel for DNA replication (polyoma-ethidium bromide-mouse-embryo cells-dye binding assay). | Q34767494 | ||
| Cyclin dependent kinases and cell cycle control (nobel lecture). | Q34906516 | ||
| Comparative analysis of radiosensitizers for K-RAS mutant rectal cancers | Q35070685 | ||
| DNA-PK-A candidate driver of hepatocarcinogenesis and tissue biomarker that predicts response to treatment and survival. | Q35103519 | ||
| γH2AX and Chk1 phosphorylation as predictive pharmacodynamic biomarkers of Chk1 inhibitor-chemotherapy combination treatments | Q35201518 | ||
| Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry | Q35682945 | ||
| Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors | Q35800291 | ||
| DSB repair: the yeast paradigm | Q35848414 | ||
| Scope and limitations of yeast as a model organism for studying human tissue-specific pathways | Q35880992 | ||
| The combined status of ATM and p53 link tumor development with therapeutic response | Q24652535 | ||
| Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair | Q25257863 | ||
| Replication-Associated Recombinational Repair: Lessons from Budding Yeast | Q26739929 | ||
| Trial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapy | Q26745686 | ||
| Drugging topoisomerases: lessons and challenges | Q27000099 | ||
| The crystal structure of human tyrosyl-DNA phosphodiesterase, Tdp1 | Q27637732 | ||
| Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide]. | Q27657380 | ||
| Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2⋅DNA and Top2⋅RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2) | Q27683681 | ||
| Life with 6000 genes | Q27860877 | ||
| Effects of the rad52 gene on sister chromatid recombination in Saccharomyces cerevisiae | Q27932691 | ||
| Complex formation in yeast double-strand break repair: participation of Rad51, Rad52, Rad55, and Rad57 proteins | Q27933185 | ||
| Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes | Q27933322 | ||
| Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein | Q27933995 | ||
| A DNA-dependent protease involved in DNA-protein crosslink repair | Q27934532 | ||
| PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints | Q27934828 | ||
| SPK1 is an essential S-phase-specific gene of Saccharomyces cerevisiae that encodes a nuclear serine/threonine/tyrosine kinase. | Q27935086 | ||
| Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair | Q27935229 | ||
| DNA damage checkpoints and DNA replication controls in Saccharomyces cerevisiae. | Q27937263 | ||
| Yeast Rad55 and Rad57 proteins form a heterodimer that functions with replication protein A to promote DNA strand exchange by Rad51 recombinase | Q27938070 | ||
| Identification of yeast mutants with altered telomere structure | Q27939152 | ||
| DNA ligase IV syndrome; a review | Q28080075 | ||
| TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function | Q28118952 | ||
| A versatile toolbox for PCR-based tagging of yeast genes: new fluorescent proteins, more markers and promoter substitution cassettes | Q28131622 | ||
| A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome | Q28183834 | ||
| ATM: genome stability, neuronal development, and cancer cross paths | Q28201456 | ||
| Mutation of TDP1, encoding a topoisomerase I-dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy | Q28203189 | ||
| Germline mutations in RAD51D confer susceptibility to ovarian cancer | Q28245028 | ||
| Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25 | Q28247761 | ||
| High-level expression of Rad51 is an independent prognostic marker of survival in non-small-cell lung cancer patients | Q28256642 | ||
| The response to and repair of RAG-mediated DNA double-strand breaks | Q28256889 | ||
| Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer | Q28266168 | ||
| Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene | Q28280022 | ||
| Genetic variation in a hsa-let-7 binding site in RAD52 is associated with breast cancer susceptibility | Q28280159 | ||
| Checkpoint kinase 1 inhibitors for potentiating systemic anticancer therapy | Q28280582 | ||
| DNA topoisomerases and their poisoning by anticancer and antibacterial drugs | Q28284744 | ||
| Cloning of human and mouse genes homologous to RAD52, a yeast gene involved in DNA repair and recombination | Q28287087 | ||
| Roles of Chk1 in cell biology and cancer therapy | Q28289548 | ||
| Rad52 inactivation is synthetically lethal with BRCA2 deficiency | Q28300346 | ||
| Phase I studies of CBP501, a G2 checkpoint abrogator, as monotherapy and in combination with cisplatin in patients with advanced solid tumors | Q28302900 | ||
| Rad51 overexpression contributes to chemoresistance in human soft tissue sarcoma cells: a role for p53/activator protein 2 transcriptional regulation | Q28303219 | ||
| Chk2 deficiency in Myc overexpressing lymphoma cells elicits a synergistic lethal response in combination with PARP inhibition | Q28396027 | ||
| Collaborative action of Brca1 and CtIP in elimination of covalent modifications from double-strand breaks to facilitate subsequent break repair | Q28472620 | ||
| ATM deficiency results in accumulation of DNA-topoisomerase I covalent intermediates in neural cells | Q28486683 | ||
| Identification of a Small Molecule Inhibitor of RAD52 by Structure-Based Selection | Q28552598 | ||
| Rare key functional domain missense substitutions in MRE11A, RAD50, and NBN contribute to breast cancer susceptibility: results from a Breast Cancer Family Registry case-control mutation-screening study | Q28652308 | ||
| DNA repair mechanisms and the bypass of DNA damage in Saccharomyces cerevisiae | Q28709604 | ||
| Cell cycle checkpoints: preventing an identity crisis | Q29547644 | ||
| Mechanism of eukaryotic homologous recombination | Q29547709 | ||
| ATM and related protein kinases: safeguarding genome integrity | Q29547735 | ||
| DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis | Q29614217 | ||
| Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM | Q29614843 | ||
| A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia | Q29615437 | ||
| Universal control mechanism regulating onset of M-phase | Q29616481 | ||
| Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair | Q29618204 | ||
| A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53 | Q29618277 | ||
| The DNA replication checkpoint response stabilizes stalled replication forks | Q29618306 | ||
| Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2 | Q29618838 | ||
| Function of yeast Rad52 protein as a mediator between replication protein A and the Rad51 recombinase | Q29620205 | ||
| The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast | Q29620732 | ||
| Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion | Q30434675 | ||
| Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells | Q30637438 | ||
| Nucleotide excision repair in yeast | Q30890380 | ||
| Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation | Q33369693 | ||
| Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay | Q33399360 | ||
| The mechanism of non-homologous end-joining: a synopsis of synapsis | Q35893376 | ||
| Checking on DNA damage in S phase | Q35906070 | ||
| Mutant p53 cooperates with ETS2 to promote etoposide resistance | Q35914917 | ||
| Target genes of Topoisomerase IIβ regulate neuronal survival and are defined by their chromatin state | Q35924742 | ||
| Non-homologous end-joining factors of Saccharomyces cerevisiae | Q35946165 | ||
| Homologous recombination and its regulation | Q36106937 | ||
| Recombinant adeno-associated viral vectors in the nervous system | Q36184768 | ||
| Chemosensitization of cancer cells by KU-0060648, a dual inhibitor of DNA-PK and PI-3K | Q36193197 | ||
| Radiosensitivity in ataxia-telangiectasia: a new explanation | Q36419108 | ||
| Regulation of multiple DNA repair pathways by the Fanconi anemia protein SLX4. | Q36512615 | ||
| Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation. | Q36525188 | ||
| Repair of topoisomerase I-mediated DNA damage | Q36557533 | ||
| Detection of loss of heterozygosity at RAD51, RAD52, RAD54 and BRCA1 and BRCA2 loci in breast cancer: pathological correlations. | Q36619794 | ||
| The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression | Q36878037 | ||
| The multiple roles of the Mre11 complex for meiotic recombination | Q36900911 | ||
| Cross-species genomic and functional analyses identify a combination therapy using a CHK1 inhibitor and a ribonucleotide reductase inhibitor to treat triple-negative breast cancer. | Q36924445 | ||
| Replication stress and cancer: it takes two to tango. | Q36931593 | ||
| Isoeugenol is a selective potentiator of camptothecin cytotoxicity in vertebrate cells lacking TDP1 | Q36933855 | ||
| ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation | Q36941509 | ||
| CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin? | Q37001375 | ||
| ATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase-1 inhibitors | Q37059580 | ||
| HDAC Inhibition Induces MicroRNA-182, which Targets RAD51 and Impairs HR Repair to Sensitize Cells to Sapacitabine in Acute Myelogenous Leukemia | Q37100102 | ||
| TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs | Q37148469 | ||
| Topoisomerases facilitate transcription of long genes linked to autism | Q37156727 | ||
| Structural and functional relationships of the XPF/MUS81 family of proteins | Q37179480 | ||
| Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder | Q37189141 | ||
| A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases | Q37257775 | ||
| DNA topoisomerase II and its growing repertoire of biological functions. | Q37313703 | ||
| Radioresistant cervical cancer shows upregulation of the NHEJ proteins DNA-PKcs, Ku70 and Ku86. | Q37330762 | ||
| Radiation-hypersensitive cancer patients do not manifest protein expression abnormalities in components of the nonhomologous end-joining (NHEJ) pathway | Q37355063 | ||
| Identification and validation of human DNA ligase inhibitors using computer-aided drug design | Q37459758 | ||
| Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition | Q37499042 | ||
| Epigenetic and genetic inactivation of tyrosyl-DNA-phosphodiesterase 1 (TDP1) in human lung cancer cells from the NCI-60 panel | Q37572609 | ||
| Rad54, the motor of homologous recombination | Q37678703 | ||
| PARP1-TDP1 coupling for the repair of topoisomerase I-induced DNA damage | Q37701295 | ||
| Stop pulling my strings - what telomeres taught us about the DNA damage response | Q37742751 | ||
| Unleashing Chk1 in cancer therapy. | Q37879356 | ||
| RAD51 as a potential biomarker and therapeutic target for pancreatic cancer. | Q37909573 | ||
| Surviving chromosome replication: the many roles of the S-phase checkpoint pathway | Q37956284 | ||
| Detection and repair of ionizing radiation-induced DNA double strand breaks: new developments in nonhomologous end joining | Q38083939 | ||
| The contribution of co-transcriptional RNA:DNA hybrid structures to DNA damage and genome instability | Q38205642 | ||
| TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy | Q38256796 | ||
| Synthesis and biological evaluation of novel tyrosyl-DNA phosphodiesterase 1 inhibitors with a benzopentathiepine moiety | Q38300174 | ||
| The molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinase | Q38329751 | ||
| Identification of Saccharomyces cerevisiae DNA ligase IV: involvement in DNA double-strand break repair | Q38343656 | ||
| Topoisomerase-mediated chromosomal break repair: an emerging player in many games | Q38360744 | ||
| The depletion of ATM inhibits colon cancer proliferation and migration via B56γ2-mediated Chk1/p53/CD44 cascades | Q38721055 | ||
| Depletion of tyrosyl DNA phosphodiesterase 2 activity enhances etoposide-mediated double-strand break formation and cell killing. | Q38767903 | ||
| Clinical and cellular roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecan | Q38927275 | ||
| PRKDC mutations in a SCID patient with profound neurological abnormalities | Q38955848 | ||
| The checkpoint 1 kinase inhibitor LY2603618 induces cell cycle arrest, DNA damage response and autophagy in cancer cells | Q38984960 | ||
| DNA-PKcs: A promising therapeutic target in human hepatocellular carcinoma? | Q38993009 | ||
| Catalytic and noncatalytic roles of the CtIP endonuclease in double-strand break end resection | Q38994140 | ||
| Checkpoint kinase 2 (Chk2) supports sensitivity to platinum-based treatment in high grade serous ovarian cancer | Q39012997 | ||
| An inhibitor of nonhomologous end-joining abrogates double-strand break repair and impedes cancer progression | Q39222368 | ||
| Targeted radiosensitization by the Chk1 inhibitor SAR-020106. | Q39278299 | ||
| Autoregulatory mechanisms of phosphorylation of checkpoint kinase 1. | Q39303724 | ||
| Targeting radiation-resistant hypoxic tumour cells through ATR inhibition | Q39328356 | ||
| Exploring Splicing-Switching Molecules For Seckel Syndrome Therapy | Q39378013 | ||
| Dynamic inhibition of ATM kinase provides a strategy for glioblastoma multiforme radiosensitization and growth control | Q39389281 | ||
| Radioprotection by hymenialdisine-derived checkpoint kinase 2 inhibitors. | Q39457046 | ||
| Single-agent inhibition of Chk1 is antiproliferative in human cancer cell lines in vitro and inhibits tumor xenograft growth in vivo | Q39470410 | ||
| Therapeutic implications for the induced levels of Chk1 in Myc-expressing cancer cells | Q39470889 | ||
| Functional NBS1 polymorphism is associated with occurrence and advanced disease status of nasopharyngeal carcinoma | Q39528002 | ||
| RAD51 overexpression is a negative prognostic marker for colorectal adenocarcinoma | Q39536492 | ||
| Inhibition of checkpoint kinase 1 sensitizes lung cancer brain metastases to radiotherapy | Q39598327 | ||
| Down-Regulation of Rad51 Expression Overcomes Drug Resistance to Gemcitabine in Human Non–Small-Cell Lung Cancer Cells | Q39653651 | ||
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | model organism | Q213907 |
| lessons learned | Q1673259 | ||
| P304 | page(s) | 157-178 | |
| P577 | publication date | 2017-01-01 | |
| P1433 | published in | Advances in Experimental Medicine and Biology | Q4686385 |
| P1476 | title | Personalised Medicine: Genome Maintenance Lessons Learned from Studies in Yeast as a Model Organism | |
| P478 | volume | 1007 |
| Q55322794 | A New Paradigm for Tissue Diagnostics: Tools and Techniques to Standardize Tissue Collection, Transport, and Fixation. |
| Q57072621 | Functional Interaction Between and DNA Repair in Yeast May Uncover a Role of , and Somatic Variants in Cancer Development |
| Q57753536 | Rad5, HLTF, and SHPRH: A Fresh View of an Old Story |
| Q46431649 | Tyrosyl-DNA phosphodiesterases: rescuing the genome from the risks of relaxation |
| Q97529348 | Yeast-based assays for the functional characterization of cancer-associated variants of human DNA repair genes |
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