| scholarly article | Q13442814 |
| P50 | author | Abhishek Sharma | Q47711030 |
| P2093 | author name string | Sherif F El-Khamisy | |
| Shih-Chieh Chiang | |||
| Meryem Alagoz | |||
| P2860 | cites work | Trapping of mammalian topoisomerase I and recombinations induced by damaged DNA containing nicks or gaps. Importance of DNA end phosphorylation and camptothecin effects | Q73797210 |
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| TDP1 facilitates repair of ionizing radiation-induced DNA single-strand breaks | Q24315895 | ||
| ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks | Q24321489 | ||
| Upregulation of the E3 ligase NEDD4-1 by oxidative stress degrades IGF-1 receptor protein in neurodegeneration | Q24613053 | ||
| Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK | Q24644674 | ||
| Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks | Q24651854 | ||
| SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage | Q24682811 | ||
| The crystal structure of human tyrosyl-DNA phosphodiesterase, Tdp1 | Q27637732 | ||
| Yeast Tdp1 and Rad1-Rad10 function as redundant pathways for repairing Top1 replicative damage | Q27933291 | ||
| Repair of and checkpoint response to topoisomerase I-mediated DNA damage | Q28187875 | ||
| Mutation of TDP1, encoding a topoisomerase I-dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy | Q28203189 | ||
| Nuclear ataxia-telangiectasia mutated (ATM) mediates the cellular response to DNA double strand breaks in human neuron-like cells | Q28235590 | ||
| Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells | Q28288970 | ||
| Reactive oxygen species involved in trichosanthin-induced apoptosis of human choriocarcinoma cells | Q28363232 | ||
| Atm-deficient mice: a paradigm of ataxia telangiectasia | Q29619532 | ||
| DNA topoisomerase I inhibition by camptothecin induces escape of RNA polymerase II from promoter-proximal pause site, antisense transcription and histone acetylation at the human HIF-1alpha gene locus | Q33566415 | ||
| A novel role for ATM in regulating proteasome-mediated protein degradation through suppression of the ISG15 conjugation pathway | Q33813351 | ||
| Transcription-dependent activation of ataxia telangiectasia mutated prevents DNA-dependent protein kinase-mediated cell death in response to topoisomerase I poison | Q33832626 | ||
| ATM Activation by Oxidative Stress | Q34145092 | ||
| Effects of DNA and protein size on substrate cleavage by human tyrosyl-DNA phosphodiesterase 1. | Q35152316 | ||
| A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage | Q36119231 | ||
| To live or to die: a matter of processing damaged DNA termini in neurons | Q37830005 | ||
| Salt effects on the denaturation of DNA. V. Preferential interactions of native and denatured calf thymus DNA in Na2SO4 solutions of varying ionic strength | Q39076051 | ||
| SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair. | Q39380131 | ||
| ATM regulates proteasome-dependent subnuclear localization of TRF1, which is important for telomere maintenance. | Q39408275 | ||
| Mutations in Cullin 4B result in a human syndrome associated with increased camptothecin-induced topoisomerase I-dependent DNA breaks | Q39621855 | ||
| TDP1 serine 81 promotes interaction with DNA ligase IIIalpha and facilitates cell survival following DNA damage | Q39763393 | ||
| A ubiquitin-proteasome pathway for the repair of topoisomerase I-DNA covalent complexes. | Q39976570 | ||
| Ataxia-telangiectasia. Report of a case with Lewy bodies and vascular abnormalities within cerebral tissue | Q40246317 | ||
| Assembly of a polymeric chain of SUMO1 on human topoisomerase I in vitro | Q40326318 | ||
| Nbs1 is required for ATR-dependent phosphorylation events | Q40919759 | ||
| Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin | Q41828864 | ||
| SUMOylation and phosphorylation of GluK2 regulate kainate receptor trafficking and synaptic plasticity. | Q42323396 | ||
| Pathological neoangiogenesis depends on oxidative stress regulation by ATM. | Q47382659 | ||
| Late degeneration of nigro-striatal neurons in ATM-/- mice | Q47657597 | ||
| Measurement of chromosomal DNA single-strand breaks and replication fork progression rates. | Q51806525 | ||
| Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity | Q59066708 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 4 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | e58239 | |
| P577 | publication date | 2013-01-01 | |
| P1433 | published in | PLOS One | Q564954 |
| P1476 | title | ATM deficiency results in accumulation of DNA-topoisomerase I covalent intermediates in neural cells | |
| P478 | volume | 8 |
| Q52087842 | ATM-dependent pathways of chromatin remodelling and oxidative DNA damage responses. |
| Q38248933 | ATM: expanding roles as a chief guardian of genome stability |
| Q33816985 | Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes |
| Q47649609 | Ataxia telangiectasia syndrome: moonlighting ATM. |
| Q28079581 | Ataxia telangiectasia: a review |
| Q40120242 | C9orf72 expansion disrupts ATM-mediated chromosomal break repair. |
| Q38994140 | Catalytic and noncatalytic roles of the CtIP endonuclease in double-strand break end resection |
| Q35476632 | Cells deficient in base-excision repair reveal cancer hallmarks originating from adjustments to genetic instability |
| Q38266781 | Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability |
| Q38927275 | Clinical and cellular roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecan |
| Q61444494 | DNA damage and transcriptional regulation in iPSC-derived neurons from Ataxia Telangiectasia patients |
| Q38379038 | DNA damage foci: Meaning and significance. |
| Q48709568 | DNA damage in the oligodendrocyte lineage and its role in brain aging |
| Q58701163 | DNA protein crosslink proteolysis repair: From yeast to premature ageing and cancer in humans |
| Q36588889 | DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions. |
| Q35122653 | Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors. |
| Q42065258 | Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan |
| Q34441404 | Expression of a pathogenic mutation of SOD1 sensitizes aprataxin-deficient cells and mice to oxidative stress and triggers hallmarks of premature ageing |
| Q64101978 | FUS (fused in sarcoma) is a component of the cellular response to topoisomerase I-induced DNA breakage and transcriptional stress |
| Q42771888 | Functional and molecular defects of hiPSC-derived neurons from patients with ATM deficiency |
| Q47148140 | Genome integrity and disease prevention in the nervous system |
| Q58733026 | Increased genomic instability following treatment with direct acting anti-hepatitis C virus drugs |
| Q36933855 | Isoeugenol is a selective potentiator of camptothecin cytotoxicity in vertebrate cells lacking TDP1 |
| Q37119667 | Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors |
| Q33615689 | Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical-induced DNA damage. |
| Q58747369 | PARP-1-dependent RND1 transcription induced by topoisomerase I cleavage complexes confers cellular resistance to camptothecin |
| Q38608688 | Personalised Medicine: Genome Maintenance Lessons Learned from Studies in Yeast as a Model Organism |
| Q52627910 | Perturbed autophagy and DNA repair converge to promote neurodegeneration in amyotrophic lateral sclerosis and dementia. |
| Q46243206 | Role of Protein Linked DNA Breaks in Cancer |
| Q38256796 | TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy |
| Q41959085 | TDP1/TOP1 Ratio as a Promising Indicator for the Response of Small Cell Lung Cancer to Topotecan |
| Q90170116 | TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts |
| Q38360744 | Topoisomerase-mediated chromosomal break repair: an emerging player in many games |
| Q38261264 | Tyrosyl-DNA phosphodiesterase I resolves both naturally and chemically induced DNA adducts and its potential as a therapeutic target |
| Q55416803 | UCHL3 Regulates Topoisomerase-Induced Chromosomal Break Repair by Controlling TDP1 Proteostasis. |
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