Phenethyl isothiocyanate suppresses the metastasis of ovarian cancer associated with the inhibition of CRM1-mediated nuclear export and mTOR-STAT3 pathway

scientific article published on 16 December 2016

Phenethyl isothiocyanate suppresses the metastasis of ovarian cancer associated with the inhibition of CRM1-mediated nuclear export and mTOR-STAT3 pathway is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1080/15384047.2016.1264540
P932PMC publication ID5323014
P698PubMed publication ID27981892

P2093author name stringShu Zhang
Qian Huang
Huan Yan
Yong Liang Yang
Kai Jiang Liu
Wen Yu Shao
P2860cites workThe Survivin-Crm1 interaction is essential for chromosomal passenger complex localization and functionQ24314715
mTOR signaling in growth control and diseaseQ24634174
Phenethyl isothiocyanate inhibits angiogenesis in vitro and ex vivoQ79856335
Prognostic value of CRM1 in pancreas cancerQ82214423
Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved regionQ24685870
The coiled coil region (amino acids 129-250) of the tumor suppressor protein adenomatous polyposis coli (APC). Its structure and its interaction with chromosome maintenance region 1 (Crm-1)Q27639186
Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylationQ28288257
Phenethyl isothiocyanate exhibits antileukemic activity in vitro and in vivo by inactivation of Akt and activation of JNK pathwaysQ28308253
Cancer statistics, 2016Q29547383
Identification of a signal for rapid export of proteins from the nucleusQ29547742
NM23 as a prognostic biomarker in ovarian serous carcinomaQ33327971
Phenethyl isothiocyanate sensitizes androgen-independent human prostate cancer cells to docetaxel-induced apoptosis in vitro and in vivoQ33724512
Antitumor activity of phenethyl isothiocyanate in HER2-positive breast cancer modelsQ34348403
Inhibition of EGFR-AKT axis results in the suppression of ovarian tumors in vitro and in preclinical mouse modelQ34405324
Expression of the nuclear export protein chromosomal region maintenance/exportin 1/Xpo1 is a prognostic factor in human ovarian cancerQ34756429
MiR-373 targeting of the Rab22a oncogene suppresses tumor invasion and metastasis in ovarian cancerQ35068063
Characterization of BRCA1 protein targeting, dynamics, and function at the centrosome: a role for the nuclear export signal, CRM1, and Aurora A kinaseQ35801868
Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiationQ35842286
Phenethyl isothiocyanate suppresses inhibitor of apoptosis family protein expression in prostate cancer cells in culture and in vivoQ35846374
Snail promotes epithelial-mesenchymal transition and invasiveness in human ovarian cancer cells.Q35870779
ROS Accumulation by PEITC Selectively Kills Ovarian Cancer Cells via UPR-Mediated ApoptosisQ35896411
Investigation of PI3K/PKB/mTOR/S6K1 signaling pathway in relationship of type 2 diabetes and Alzheimer's diseaseQ36411921
Covalent binding to tubulin by isothiocyanates. A mechanism of cell growth arrest and apoptosisQ36808478
Inflammation and ovarian cancer--current views.Q38108779
The Kiss-1/Kiss-1R complex as a negative regulator of cell motility and cancer metastasis (Review).Q38130843
beta-Catenin/TCF pathway upregulates STAT3 expression in human esophageal squamous cell carcinoma.Q38289538
B7‑H3 promotes cell migration and invasion through the Jak2/Stat3/MMP9 signaling pathway in colorectal cancerQ38855860
Cancer treatment and survivorship statistics, 2016.Q38859236
TRAP1 shows clinical significance and promotes cellular migration and invasion through STAT3/MMP2 pathway in human esophageal squamous cell cancerQ38936450
CRM1 is a cellular target of curcumin: new insights for the myriad of biological effects of an ancient spiceQ39129924
The nuclear exporter, Crm1, is regulated by NFY and Sp1 in cancer cells and repressed by p53 in response to DNA damageQ39522372
Tumor suppressor KAI1 affects integrin alphavbeta3-mediated ovarian cancer cell adhesion, motility, and proliferationQ39860223
A nuclear transport signal in mammalian target of rapamycin is critical for its cytoplasmic signaling to S6 kinase 1.Q40331048
TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2.Q43166689
Determination of phenethyl isothiocyanate in human plasma and urine by ammonia derivatization and liquid chromatography–tandem mass spectrometryQ44658811
The expression of CRM1 is associated with prognosis in human osteosarcomaQ46198414
The Karyopherin proteins, Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation.Q46668855
Pharmacokinetics of dietary phenethyl isothiocyanate in ratsQ46717292
Nobel Prize for artemisinin brings phytotherapy into the spotlight.Q47912472
Circulating tumor cells and brain metastasis outcome in patients with HER2-positive breast cancer: the LANDSCAPE trial.Q49061268
mTOR/P70S6K promotes spermatogonia proliferation and spermatogenesis in Sprague Dawley rats.Q50542508
Influence of p-hydroxy-propiophenone on liver tumorigenesis in rats ingesting ethionine and N-2-fluorenylacetamide.Q53613299
P433issue1
P921main subjectovarian cancerQ172341
P304page(s)26-35
P577publication date2016-12-16
P1433published inCancer Biology and TherapyQ2544651
P1476titlePhenethyl isothiocyanate suppresses the metastasis of ovarian cancer associated with the inhibition of CRM1-mediated nuclear export and mTOR-STAT3 pathway
P478volume18

Reverse relations

cites work (P2860)
Q47233186Allyl Isothiocyanate Exhibits No Anticancer Activity in MDA-MB-231 Breast Cancer Cells.
Q59803350Anti-Carcinogenic Glucosinolates in Cruciferous Vegetables and Their Antagonistic Effects on Prevention of Cancers
Q64967545Crm1 knockdown by specific small interfering RNA reduces cell proliferation and induces apoptosis in head and neck cancer cell lines.
Q92714758Expression of exportin-1 in diffuse large B-cell lymphoma: immunohistochemistry and TCGA analyses
Q48347918Inhibition of autophagy potentiates the anti-metastasis effect of phenethyl isothiocyanate through JAK2/STAT3 pathway in lung cancer cells.
Q54984581PIM Kinases and Their Relevance to the PI3K/AKT/mTOR Pathway in the Regulation of Ovarian Cancer.

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