Differential phosphorylation-based regulation of αB-crystallin chaperone activity for multipass transmembrane proteins

scientific article published on 15 September 2016

Differential phosphorylation-based regulation of αB-crystallin chaperone activity for multipass transmembrane proteins is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BBRC.2016.09.071
P932PMC publication ID5053547
P698PubMed publication ID27641668

P2093author name stringStefano Bonatti
Lucrezia Della Volpe
Maria Camilla Ciardulli
Massimo D'Agostino
Michela Ciano
Simona Allocca
P2860cites workMutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerizationQ24302520
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Alpha-crystallin can function as a molecular chaperoneQ29618672
A disorder-to-order structural transition in the COOH-tail of Fz4 determines misfolding of the L501fsX533-Fz4 mutantQ30544835
Phosphorylation-induced change of the oligomerization state of alpha B-crystallinQ31629257
alpha-crystallin: a review of its structure and functionQ33983488
alpha-Crystallin polymers and polymerization: the view from down underQ34066883
Serine 59 phosphorylation of {alpha}B-crystallin down-regulates its anti-apoptotic function by binding and sequestering Bcl-2 in breast cancer cells.Q34333585
Alpha B-crystallin correlates with poor survival in colorectal cancerQ34371573
Cardioprotective role of P38 MAPK during myocardial infarction via parallel activation of α-crystallin B and Nrf2.Q34400162
A Mechanism of Subunit Recruitment in Human Small Heat Shock Protein OligomersQ34481801
Chaperone-like activity of alpha-crystallin and other small heat shock proteinsQ34947004
Difference in stability of the N-domain underlies distinct intracellular properties of the E1064A and H1069Q mutants of copper-transporting ATPase ATP7B.Q34963655
p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasisQ35419603
Identification of the posttranslational modifications of bovine lens αB‐crystallins by mass spectrometryQ36277606
ERK1/2 MAP kinases in cell survival and apoptosisQ36645288
The MEK/ERK cascade: from signaling specificity to diverse functionsQ36656631
Hsp27 (HspB1) and alphaB-crystallin (HspB5) as therapeutic targets.Q36805868
Chaperone peptides of α-crystallin inhibit epithelial cell apoptosis, protein insolubilization, and opacification in experimental cataractsQ36812475
Canonical and alternative MAPK signaling.Q36980271
Regulated structural transitions unleash the chaperone activity of αB-crystallinQ37218406
The role of MAPK signalling pathways in the response to endoplasmic reticulum stressQ38179717
Role of α-crystallin B in regulation of stress induced cardiomyocyte apoptosisQ38328978
Ligand of Numb proteins LNX1p80 and LNX2 interact with the human glycoprotein CD8α and promote its ubiquitylation and endocytosis.Q39449307
Mimicking phosphorylation of alphaB-crystallin affects its chaperone activityQ41084011
Lens alpha-crystallin: function and structureQ41632199
alpha B-crystallin gene induction and phosphorylation by MKK6-activated p38. A potential role for alpha B-crystallin as a target of the p38 branch of the cardiac stress responseQ41736665
Quantification of anti-aggregation activity of UV-irradiated α-crystallinQ41760301
alpha-Crystallin quaternary structure: molecular basis for its chaperone activityQ42676284
alpha-Crystallin: molecular chaperone and heat shock proteinQ42818535
α-Crystallin B prevents apoptosis after H2O2 exposure in mouse neonatal cardiomyocytes.Q43100002
The small heat-shock protein Hsp27 undergoes ERK-dependent phosphorylation and redistribution to the cytoskeleton in response to dual leucine zipper-bearing kinase expressionQ43292767
The cytosolic chaperone α-crystallin B rescues folding and compartmentalization of misfolded multispan transmembrane proteinsQ44720530
Phosphorylation of alphaB-crystallin alters chaperone function through loss of dimeric substructureQ44875494
Cellular distribution of alpha B-crystallin in non-lenticular tissues.Q46033579
Extracellular α-crystallin protects astrocytes from cell death through activation of MAPK, PI3K/Akt signaling pathway and blockade of ROS release from mitochondriaQ46725625
Effect of phosphorylation on alpha B-crystallin: differences in stability, subunit exchange and chaperone activity of homo and mixed oligomers of alpha B-crystallin and its phosphorylation-mimicking mutantQ46864451
The chaperone αB-crystallin uses different interfaces to capture an amorphous and an amyloid clientQ48121254
αA- and αB-crystallins interact with caspase-3 and Bax to guard mouse lens development.Q51821016
Phosphorylation of alphaB-crystallin in mitotic cells and identification of enzymatic activities responsible for phosphorylation.Q52183272
Association of Alpha B-Crystallin (CRYAB) genotypes with breast cancer susceptibility in Taiwan.Q54344880
Expression and prognostic significance of the alpha B-crystallin gene in human hepatocellular carcinoma.Q54508476
ER Reorganization is Remarkably Induced in COS-7 Cells Accumulating Transmembrane Protein Receptors Not Competent for Export from the Endoplasmic ReticulumQ59171169
Induction of the synthesis of hsp27 and alpha B crystallin in tissues of heat-stressed rats and its suppression by ethanol or an alpha 1-adrenergic antagonistQ71565624
R120G alphaB-crystallin promotes the unfolding of reduced alpha-lactalbumin and is inherently unstableQ81318355
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectmolecular chaperonesQ422496
transmembrane proteinQ424204
P1104number of pages6
P304page(s)325-330
P577publication date2016-09-15
P1433published inBiochemical and Biophysical Research CommunicationsQ864228
P1476titleDifferential phosphorylation-based regulation of αB-crystallin chaperone activity for multipass transmembrane proteins
P478volume479

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cites work (P2860)
Q90207068Broccoli sprouts juice prevents lens protein aggregation in streptozotocin-induced diabetic rat
Q92376669Effects of Long-Term Citrate Treatment in the PC3 Prostate Cancer Cell Line
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Q64105433Structural and functional consequences of age-related isomerization in α-crystallins
Q91292054Unconventional secretion of α-Crystallin B requires the Autophagic pathway and is controlled by phosphorylation of its serine 59 residue

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