Trypanosome RNA Editing Mediator Complex proteins have distinct functions in gRNA utilization

scientific article published on 23 May 2017

Trypanosome RNA Editing Mediator Complex proteins have distinct functions in gRNA utilization is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/NAR/GKX458
P932PMC publication ID5737529
P698PubMed publication ID28535252

P2093author name stringMichael J Buck
Andrew E Bruno
Yijun Sun
Laurie K Read
Kaylen Lott
Jonathan E Bard
Rachel M Simpson
Runpu Chen
Brianna L Tylec
P2860cites workTrypanosome REH1 is an RNA helicase involved with the 3'-5' polarity of multiple gRNA-guided uridine insertion/deletion RNA editingQ24610301
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A model for RNA editing in kinetoplastid mitochondria: "guide" RNA molecules transcribed from maxicircle DNA provide the edited informationQ28255689
A Protein Complex Map of Trypanosoma bruceiQ28550877
Alternative mRNA editing in trypanosomes is extensive and may contribute to mitochondrial protein diversityQ33319555
In vivo cleavage specificity of Trypanosoma brucei editosome endonucleases.Q33635964
A deletion site editing endonuclease in Trypanosoma brucei.Q53649384
Cycles of progressive realignment of gRNA with mRNA in RNA editingQ67702713
TbRGG2 facilitates kinetoplastid RNA editing initiation and progression past intrinsic pause sitesQ34210450
Interactions of mRNAs and gRNAs involved in trypanosome mitochondrial RNA editing: structure probing of an mRNA bound to its cognate gRNA.Q34364107
The oligonucleotide binding (OB)-fold domain of KREPA4 is essential for stable incorporation into editosomesQ34442347
RNA binding and core complexes constitute the U-insertion/deletion editosomeQ34592918
U-insertion/deletion Edited Sequence DatabaseQ34651342
Natural and induced dyskinetoplastic trypanosomatids: how to live without mitochondrial DNA.Q34738576
Endonuclease associations with three distinct editosomes in Trypanosoma bruceiQ35010902
An arginine-glycine-rich RNA binding protein impacts the abundance of specific mRNAs in the mitochondria of Trypanosoma bruceiQ35031707
A core MRB1 complex component is indispensable for RNA editing in insect and human infective stages of Trypanosoma brucei.Q35046490
Alternative editing of cytochrome c oxidase III mRNA in trypanosome mitochondria generates protein diversityQ35191171
Arginine methylation of DRBD18 differentially impacts its opposing effects on the trypanosome transcriptomeQ35770640
A tale of two TUTasesQ35977107
Complex management: RNA editing in trypanosomesQ36030102
Architecture of the trypanosome RNA editing accessory complex, MRB1.Q36061908
Analysis of the Trypanosoma brucei EATRO 164 Bloodstream Guide RNA TranscriptomeQ36072564
Functional characterization of two paralogs that are novel RNA binding proteins influencing mitochondrial transcripts of Trypanosoma bruceiQ36246623
Integrity of the core mitochondrial RNA-binding complex 1 is vital for trypanosome RNA editingQ36286474
Gene Loss and Error-Prone RNA Editing in the Mitochondrion of Perkinsela, an Endosymbiotic Kinetoplastid.Q36346028
U-Insertion/Deletion mRNA-Editing Holoenzyme: Definition in SightQ36535105
Antisense Transcripts Delimit Exonucleolytic Activity of the Mitochondrial 3' Processome to Generate Guide RNAsQ36552454
TbRGG1, an essential protein involved in kinetoplastid RNA metabolism that is associated with a novel multiprotein complex.Q36575689
REH2C Helicase and GRBC Subcomplexes May Base Pair through mRNA and Small Guide RNA in Kinetoplastid Editosomes.Q36674669
High-throughput sequencing of partially edited trypanosome mRNAs reveals barriers to editing progression and evidence for alternative editingQ36812711
Alternative RNA editing produces a novel protein involved in mitochondrial DNA maintenance in trypanosomesQ36898746
Trypanosoma brucei ATPase subunit 6 mRNA bound to gA6-14 forms a conserved three-helical structureQ36909653
Guide RNA-binding complex from mitochondria of trypanosomatidsQ37104541
Evidence for U-tail stabilization of gRNA/mRNA interactions in kinetoplastid RNA editingQ37388514
The insect-phase gRNA transcriptome in Trypanosoma bruceiQ37574200
'Gestalt,' composition and function of the Trypanosoma brucei editosomeQ38044966
Network news: the replication of kinetoplast DNA.Q38044973
RNA interference analyses suggest a transcript-specific regulatory role for mitochondrial RNA-binding proteins MRP1 and MRP2 in RNA editing and other RNA processing in Trypanosoma bruceiQ38335032
gRNA/pre-mRNA annealing and RNA chaperone activities of RBP16.Q38569122
RNA editing in Trypanosoma brucei: characterization of gRNA U-tail interactions with partially edited mRNA substratesQ38668828
The Major Protein Arginine Methyltransferase in Trypanosoma brucei Functions as an Enzyme-Prozyme Complex.Q38725177
Differential Binding of Mitochondrial Transcripts by MRB8170 and MRB4160 Regulates Distinct Editing Fates of Mitochondrial mRNA in TrypanosomesQ38988142
The two RNA ligases of the Trypanosoma brucei RNA editing complex: cloning the essential band IV gene and identifying the band V geneQ39526694
Distinct functions of two RNA ligases in active Trypanosoma brucei RNA editing complexes.Q39674967
A three-dimensional working model for a guide RNA from Trypanosoma bruceiQ39720238
Mapping contacts between gRNA and mRNA in trypanosome RNA editing.Q39726962
Identification of novel components of Trypanosoma brucei editosomesQ41827505
RNA editing in Trypanosoma brucei requires three different editosomesQ41866692
Interactions of mRNAs and gRNAs involved in trypanosome mitochondrial RNA editing: structure probing of a gRNA bound to its cognate mRNA.Q41876511
Guide RNAs in kinetoplastid mitochondria have a nonencoded 3′ oligo(U) tail involved in recognition of the preedited regionQ41941621
Compositionally and functionally distinct editosomes in Trypanosoma bruceiQ42040628
Multifunctional G-rich and RRM-containing domains of TbRGG2 perform separate yet essential functions in trypanosome RNA editingQ42326149
TbRGG2, an essential RNA editing accessory factor in two Trypanosoma brucei life cycle stagesQ42396947
Purification of a functional enzymatic editing complex from Trypanosoma brucei mitochondriaQ42623988
MRB3010 is a core component of the MRB1 complex that facilitates an early step of the kinetoplastid RNA editing processQ42718517
Trypanosoma brucei RNA editing: coupled cycles of U deletion reveal processive activity of the editing complex.Q43077446
Kinetoplastid guide RNA biogenesis is dependent on subunits of the mitochondrial RNA binding complex 1 and mitochondrial RNA polymerase.Q43155266
Targeting of a tetracycline-inducible expression system to the transcriptionally silent minichromosomes of Trypanosoma bruceiQ44239928
The polarity of editing within a multiple gRNA-mediated domain is due to formation of anchors for upstream gRNAs by downstream editingQ44303968
TbMP57 is a 3' terminal uridylyl transferase (TUTase) of the Trypanosoma brucei editosomeQ44487520
Mass spectrometric analysis of the editosome and other multiprotein complexes in Trypanosoma brucei.Q44499264
Generation of unexpected editing patterns in Leishmania tarentolae mitochondrial mRNAs: misediting produced by misguidingQ44999695
Partially edited mRNAs for cytochrome b and subunit III of cytochrome oxidase from Leishmania tarentolae mitochondria: RNA editing intermediates.Q45949285
P275copyright licenseCreative Commons Attribution-NonCommercial 4.0 InternationalQ34179348
P6216copyright statuscopyrightedQ50423863
P433issue13
P407language of work or nameEnglishQ1860
P304page(s)7965-7983
P577publication date2017-05-23
P1433published inNucleic Acids ResearchQ135122
P1476titleTrypanosome RNA Editing Mediator Complex proteins have distinct functions in gRNA utilization
P478volume45