| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1085450744 |
| P356 | DOI | 10.1208/S12248-017-0099-Z |
| P698 | PubMed publication ID | 28526963 |
| P50 | author | Sibylle Neuhoff | Q73883553 |
| P2093 | author name string | David B Turner | |
| Masoud Jamei | |||
| Rachel H Rose | |||
| P2860 | cites work | Recent Advances in Development and Application of Physiologically-Based Pharmacokinetic (PBPK) Models: a Transition from Academic Curiosity to Regulatory Acceptance | Q26745824 |
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| Quantitative prediction of formulation-specific food effects and their population variability from in vitro data with the physiologically-based ADAM model: a case study using the BCS/BDDCS Class II drug nifedipine | Q30669399 | ||
| Prediction of in vivo drug clearance from in vitro data. I: impact of inter-individual variability | Q31044030 | ||
| Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach | Q31962885 | ||
| Regulation of intestinal blood flow | Q34006139 | ||
| A framework for the modeling of gut blood flow regulation and postprandial hyperaemia | Q34099269 | ||
| Intestinal phase of superior mesenteric artery blood flow in man | Q34376024 | ||
| Physiological and pharmacological variability in estimated hepatic blood flow in man. | Q34448582 | ||
| The distribution of propranolol, pindolol and atenolol between human erythrocytes and plasma | Q34449506 | ||
| Absorption of propranolol and practolol in Coeliac disease | Q34471831 | ||
| Serum alpha 1-acid glycoprotein and the binding of drugs in obesity | Q34514103 | ||
| Stereoselective ring oxidation of propranolol in man. | Q34621657 | ||
| Prediction of intestinal first-pass drug metabolism | Q34708855 | ||
| The effect of food on the pharmacokinetics of oral ibrutinib in healthy participants and patients with chronic lymphocytic leukemia | Q35567942 | ||
| Pharmacokinetics of beta-adrenoceptor blockers in obese and normal volunteers | Q36094001 | ||
| Population-based mechanistic prediction of oral drug absorption | Q37214520 | ||
| Application of physiologically based absorption modeling to formulation development of a low solubility, low permeability weak base: mechanistic investigation of food effect | Q37671837 | ||
| Mechanistic investigation of the negative food effect of modified release zolpidem | Q38912228 | ||
| Ibrutinib Dosing Strategies Based on Interaction Potential of CYP3A4 Perpetrators Using Physiologically Based Pharmacokinetic Modeling | Q39639310 | ||
| Are there differences in the catalytic activity per unit enzyme of recombinantly expressed and human liver microsomal cytochrome P450 2C9? A systematic investigation into inter-system extrapolation factors | Q39732707 | ||
| Clinical Pharmacokinetics of Propranolol | Q39798751 | ||
| Human alimentary tract model for radiological protection. ICRP Publication 100. A report of The International Commission on Radiological Protection | Q40257423 | ||
| Predicting drug clearance from recombinantly expressed CYPs: intersystem extrapolation factors | Q40529215 | ||
| The glucuronidation of opioids, other xenobiotics, and androgens by human UGT2B7Y(268) and UGT2B7H(268). | Q41060535 | ||
| Effects of food on drug absorption | Q41138408 | ||
| Food effects on propranolol systemic and oral clearance: support for a blood flow hypothesis | Q41473934 | ||
| Effect of food on hepatic blood flow: implications in the "food effect" phenomenon | Q41608956 | ||
| Stereoselective binding of propranolol in the elderly | Q41820132 | ||
| Impact of CYP2D6 poor metabolizer phenotype on propranolol pharmacokinetics and response | Q42669140 | ||
| How many and which amino acids are responsible for the large activity differences between the highly homologous UDP-glucuronosyltransferases (UGT) 1A9 and UGT1A10? | Q43188262 | ||
| Superior mesenteric artery blood flow and gastric emptying in humans and the differential effects of high fat and high carbohydrate meals. | Q43213288 | ||
| Prediction of food effects on the absorption of celecoxib based on biorelevant dissolution testing coupled with physiologically based pharmacokinetic modeling | Q44500638 | ||
| Post-prandial cardiovascular responses in man after ingestion of carbohydrate, protein or fat | Q44744192 | ||
| Mechanisms and variations in the food effect on propranolol bioavailability | Q44794049 | ||
| Stereoselective glucuronidation of propranolol in human and cynomolgus monkey liver microsomes: role of human hepatic UDP-glucuronosyltransferase isoforms, UGT1A9, UGT2B4 and UGT2B7. | Q46308203 | ||
| Tissue distribution of basic drugs: accounting for enantiomeric, compound and regional differences amongst beta-blocking drugs in rat. | Q46461608 | ||
| Duplex ultrasound measurement of postprandial intestinal blood flow: effect of meal composition | Q46947603 | ||
| The effect of meal size on the cardiovascular responses to food ingestion. | Q47374537 | ||
| Sources of interindividual variability in IVIVE of clearance: an investigation into the prediction of benzodiazepine clearance using a mechanistic population-based pharmacokinetic model | Q48276802 | ||
| Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions | Q48567088 | ||
| Meal-induced changes in splanchnic blood flow and oxygen uptake in middle-aged healthy humans. | Q50744607 | ||
| Differences in Food Effects for 2 Weak Bases With Similar BCS Drug-Related Properties: What Is Happening in the Intestinal Lumen? | Q51288073 | ||
| Insulin action in adipose tissue and muscle in hypothyroidism. | Q51488949 | ||
| MR measurements of mesenteric venous flow: prospective evaluation in healthy volunteers and patients with suspected chronic mesenteric ischemia. | Q51590244 | ||
| Cardiovascular responses to high-fat and high-carbohydrate meals in young subjects. | Q51608582 | ||
| Fasting and post-prandial splanchnic blood flow is reduced by a somatostatin analogue (octreotide) in man | Q51610080 | ||
| Effects of ingestion of carbohydrate, fat, protein, and water on the mesenteric blood flow in man. | Q51627499 | ||
| Concomitant food intake can increase the bioavailability of propranolol by transient inhibition of its presystemic primary conjugation. | Q51633368 | ||
| Measurement of mesenteric blood flow by duplex scanning. | Q51634544 | ||
| Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. | Q51975107 | ||
| Prominent but reverse stereoselectivity in propranolol glucuronidation by human UDP-glucuronosyltransferases 1A9 and 1A10. | Q53618842 | ||
| Meal induced changes in hepatic and splanchnic circulation: a noninvasive Doppler study in normal humans. | Q54219673 | ||
| Integrative physiology of human adipose tissue | Q57321418 | ||
| Food, splanchnic blood flow, and bioavailability of drugs subject to first-pass metabolism | Q67340383 | ||
| Enhancement of the bioavailability of propranolol and metoprolol by food | Q67585406 | ||
| Age and propranolol stereoselective disposition in humans | Q68126845 | ||
| Comparative pharmacokinetics of intravenous propranolol in obese and normal volunteers | Q68538815 | ||
| Quinidine reduces clearance of (+)-propranolol more than (-)-propranolol through marked reduction in 4-hydroxylation | Q68825081 | ||
| Influence of nifedipine therapy on indocyanine green and oral propranolol pharmacokinetics | Q69426460 | ||
| Plasma concentrations and bioavailability of propranolol by oral, rectal, and intravenous administration in man | Q69780911 | ||
| Portal hemodynamics after meal in normal subjects and in patients with chronic liver disease studied by echo-Doppler flowmeter | Q70039288 | ||
| pH-metric log P. II: Refinement of partition coefficients and ionization constants of multiprotic substances | Q70591025 | ||
| Reduction of first-pass hepatic clearance of propranolol by food | Q70791153 | ||
| Food-induced increase in propranolol bioavailability—Relationship to protein and effects on metabolites | Q70999671 | ||
| Influence of age on serum protein binding of propranolol | Q71352663 | ||
| Postprandial mesenteric blood flow in humans: relationship to endogenous gastrointestinal hormone secretion and energy content of food | Q71885631 | ||
| Effect of propranolol on portal vein hemodynamics: assessment by duplex sonography and indocyanine green clearance in healthy volunteers | Q72554859 | ||
| Plasma Concentrations and Beta-Blocking Effects in Normal Volunteers After Intravenous Doses of Metoprolol and Propranolol | Q72623022 | ||
| Automated definition of the enzymology of drug oxidation by the major human drug metabolizing cytochrome P450s | Q73093309 | ||
| Lack of interaction between lansoprazole and propranolol, a pharmacokinetic and safety assessment | Q73527451 | ||
| pH-metric logP 10. Determination of liposomal membrane-water partition coefficients of ionizable drugs | Q74383160 | ||
| A comparison of pharmacokinetics between humans and monkeys | Q84894982 | ||
| P433 | issue | 4 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | pharmacokinetics | Q323936 |
| P304 | page(s) | 1205-1217 | |
| P577 | publication date | 2017-05-19 | |
| P1433 | published in | The AAPS Journal | Q10695361 |
| P1476 | title | Incorporation of the Time-Varying Postprandial Increase in Splanchnic Blood Flow into a PBPK Model to Predict the Effect of Food on the Pharmacokinetics of Orally Administered High-Extraction Drugs | |
| P478 | volume | 19 |
| Q89115461 | Food Effect Projections via Physiologically Based Pharmacokinetic Modeling: Predictive Case Studies |
| Q57109389 | Model-Based Prediction of Plasma Concentration and Enterohepatic Circulation of Total Bile Acids in Humans |
| Q38605363 | Physiologically-Based Oral Absorption Modelling to Study Gut-Level Drug Interactions |
| Q49716638 | Predictive Performance of Physiologically Based Pharmacokinetic Models for the Effect of Food on Oral Drug Absorption: Current Status |
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