Deregulated E2F5/p38/SMAD3 Circuitry Reinforces the Pro-Tumorigenic Switch of TGFβ Signaling in Prostate Cancer

scientific article published on 25 February 2016

Deregulated E2F5/p38/SMAD3 Circuitry Reinforces the Pro-Tumorigenic Switch of TGFβ Signaling in Prostate Cancer is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/JCP.25361
P698PubMed publication ID26919443

P2093author name stringAnkur Bhowal
Sanghamitra Sengupta
Sanmitra Basu
Subhadipa Majumder
Pritha Mukherjee
Urmi Chatterji
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Two faces of TGF-beta1 in breast cancerQ33661529
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Overexpression of E2F1 in human gastric carcinoma is involved in anti-cancer drug resistanceQ35481434
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Duel nature of TGF-beta signaling: tumor suppressor vs. tumor promoterQ35988691
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Smad phospho-isoforms direct context-dependent TGF-β signalingQ38122890
Prostate cancer in Asian men.Q38193300
Transforming growth factor-β stimulates human ovarian cancer cell migration by up-regulating connexin43 expression via Smad2/3 signalingQ38851786
Analysis of genetic aberrations on chromosomal region 8q21-24 identifies E2F5 as an oncogene with copy number gain in prostate cancer.Q39200185
Specific interactions between Smad proteins and AP-1 components determine TGFβ-induced breast cancer cell invasion.Q39290041
A potential oncogenic role of the commonly observed E2F5 overexpression in hepatocellular carcinomaQ39601497
Effect of verification bias on screening for prostate cancer by measurement of prostate-specific antigenQ39655731
SKI promotes Smad3 linker phosphorylations associated with the tumor-promoting trait of TGFbetaQ39726558
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EMT or apoptosis: a decision for TGF-betaQ40147080
TGF-beta and HGF transmit the signals through JNK-dependent Smad2/3 phosphorylation at the linker regionsQ40522842
TGF beta in prostate cancer: a growth inhibitor that can enhance tumorigenicityQ41435322
c-Jun N-terminal kinase 1 promotes transforming growth factor-β1-induced epithelial-to-mesenchymal transition via control of linker phosphorylation and transcriptional activity of Smad3.Q42066518
The TGF-β-Smad3 pathway inhibits CD28-dependent cell growth and proliferation of CD4 T cellsQ43686523
Profiling molecular targets of TGF-beta1 in prostate fibroblast-to-myofibroblast transdifferentiationQ44320388
Attenuation of the TGF-beta-Smad signaling pathway in pancreatic tumor cells confers resistance to TGF-beta-induced growth arrest.Q44475259
p38 MAPK mediates fibrogenic signal through Smad3 phosphorylation in rat myofibroblastsQ44598575
Smad3 and Smad3 phosphoisoforms are prognostic markers of gastric carcinoma.Q44862683
Association of clinical benign prostate hyperplasia with prostate cancer incidence and mortality revisited: a nationwide cohort study of 3,009,258 men.Q46173080
Transforming growth factor (TGF)-beta1 stimulates pulmonary fibrosis and inflammation via a Bax-dependent, bid-activated pathway that involves matrix metalloproteinase-12.Q50232161
Characterization of E2F3a function in HepG2 liver cancer cellsQ53303550
Smad2 and Smad3 phosphorylated at both linker and COOH-terminal regions transmit malignant TGF-beta signal in later stages of human colorectal cancer.Q53389037
Smad2/3 linker phosphorylation is a possible marker of cancer stem cells and correlates with carcinogenesis in a mouse model of colitis-associated colorectal cancer.Q53531646
P433issue11
P921main subjectprostate cancerQ181257
P304page(s)2482-2492
P577publication date2016-02-25
P1433published inJournal of Cellular PhysiologyQ1524270
P1476titleDeregulated E2F5/p38/SMAD3 Circuitry Reinforces the Pro-Tumorigenic Switch of TGFβ Signaling in Prostate Cancer
P478volume231

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Q58562069Deciphering genetic regulation of CD14 by SP1 through characterization of peripheral blood mononuclear transcriptome of P. faiciparum and P. vivax infected malaria patients
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Q41548014Pathway-based expression profiling of benign prostatic hyperplasia and prostate cancer delineates an immunophilin molecule associated with cancer progression
Q90150229Scientific reports concerning the impact of interleukin 4, interleukin 10 and transforming growth factor β on cancer cells

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