SKI promotes Smad3 linker phosphorylations associated with the tumor-promoting trait of TGFbeta

scientific article published on 21 May 2010

SKI promotes Smad3 linker phosphorylations associated with the tumor-promoting trait of TGFbeta is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4161/CC.9.9.11292
P932PMC publication ID3235508
P698PubMed publication ID20404506
P5875ResearchGate publication ID43201872

P2093author name stringDahu Chen
Estela E Medrano
Nikolai A Timchenko
Qiushi Lin
P2860cites workSmad2 and Smad3 phosphorylated at both linker and COOH-terminal regions transmit malignant TGF-beta signal in later stages of human colorectal cancer.Q53389037
TGF-beta repressors SnoN and Ski are implicated in human colorectal carcinogenesis.Q54855795
Decreased expression of retinoid receptors in melanoma: entailment in tumorigenesis and prognosisQ80798262
SKI knockdown inhibits human melanoma tumor growth in vivoQ84759300
Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptorQ22008813
SKI activates Wnt/beta-catenin signaling in human melanomaQ24298640
Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signalingQ24306193
SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cellsQ24320328
Rewired ERK-JNK signaling pathways in melanomaQ24683737
Repression of TGF-beta signaling by the oncogenic protein SKI in human melanomas: consequences for proliferation, survival, and metastasisQ28177586
Cytoplasmic localization of the oncogenic protein Ski in human cutaneous melanomas in vivo: functional implications for transforming growth factor beta signalingQ28207048
SKI pathways inducing progression of human melanomaQ28258871
Involvement of Smad3 phosphoisoform-mediated signaling in the development of colonic cancer in IL-10-deficient miceQ28281032
Smad3 phosphoisoform-mediated signaling during sporadic human colorectal carcinogenesisQ28301271
A functional screen to identify novel effectors of hematopoietic stem cell activityQ28513837
Reversible Smad-dependent signaling between tumor suppression and oncogenesisQ28564212
Increased susceptibility to tumorigenesis of ski-deficient heterozygous miceQ28592881
In vivo switching of human melanoma cells between proliferative and invasive statesQ34745037
Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signalingQ35013177
Ski acts as a co-repressor with Smad2 and Smad3 to regulate the response to type beta transforming growth factorQ35754725
Transformation-defective v-ski induces MyoD and myogenin expression but not myotube formationQ36685768
Regulation of the anaphase-promoting complex-separase cascade by transforming growth factor-beta modulates mitotic progression in bone marrow stromal cellsQ36992934
To (TGF)beta or not to (TGF)beta: fine-tuning of Smad signaling via post-translational modificationsQ37128066
The Ski protein can inhibit ligand induced RARalpha and HDAC3 degradation in the retinoic acid signaling pathwayQ37225648
A negative feedback control of transforming growth factor-beta signaling by glycogen synthase kinase 3-mediated Smad3 linker phosphorylation at Ser-204.Q37338950
Vitamin D and melanomaQ37413793
c-Ski overexpression promotes tumor growth and angiogenesis through inhibition of transforming growth factor-beta signaling in diffuse-type gastric carcinoma.Q39826243
Dual role of Ski in pancreatic cancer cells: tumor-promoting versus metastasis-suppressive functionQ39834774
Transforming growth factor-{beta}-inducible phosphorylation of Smad3Q39883712
The Ski oncoprotein is upregulated and localized at the centrosomes and mitotic spindle during mitosisQ40439605
Signal-dependent N-CoR Requirement for Repression by the Ski OncoproteinQ40652029
Distinct oligomeric states of SMAD proteins in the transforming growth factor-beta pathwayQ42494147
Inhibition of retinoic acid receptor signaling by Ski in acute myeloid leukemiaQ46902755
Clinical significance of the expression of c-Ski and SnoN, possible mediators in TGF-beta resistance, in primary cutaneous melanomaQ49157540
Aging reduces proliferative capacities of liver by switching pathways of C/EBPalpha growth arrest.Q52105236
Transforming growth factor-beta suppresses the ability of Ski to inhibit tumor metastasis by inducing its degradation.Q53321709
P433issue9
P1104number of pages6
P304page(s)1684-1689
P577publication date2010-05-21
P1433published inCell CycleQ1254166
P1476titleSKI promotes Smad3 linker phosphorylations associated with the tumor-promoting trait of TGFbeta
P478volume9

Reverse relations

cites work (P2860)
Q38790780Deregulated E2F5/p38/SMAD3 Circuitry Reinforces the Pro-Tumorigenic Switch of TGFβ Signaling in Prostate Cancer
Q37602977Next generation sequencing analysis of miRNAs: MiR-127-3p inhibits glioblastoma proliferation and activates TGF-β signaling by targeting SKI.
Q36116217Phospho-specific Smad3 signaling: impact on breast oncogenesis
Q39167481Rice cyclophilin OsCYP18-2 is translocated to the nucleus by an interaction with SKIP and enhances drought tolerance in rice and Arabidopsis
Q42049845SERPINE1 expression discriminates site-specific metastasis in human melanoma
Q35478946Smad phosphoisoform signaling specificity: the right place at the right time
Q35649316Smad phosphoisoform signals in acute and chronic liver injury: similarities and differences between epithelial and mesenchymal cells

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