Empagliflozin for Type 2 Diabetes Mellitus: An Overview of Phase 3 Clinical Trials

scientific article published on 13 June 2016

Empagliflozin for Type 2 Diabetes Mellitus: An Overview of Phase 3 Clinical Trials is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.2174/1573399812666160613113556
P932PMC publication ID5543566
P698PubMed publication ID27296042

P2093author name stringMatthew J Levine
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Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk: results of the EMPA-REG OUTCOME® trialQ27301948
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SGLT2 Inhibitors May Predispose to KetoacidosisQ28081173
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Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group.Q33864120
Role of the kidney in normal glucose homeostasis and in the hyperglycaemia of diabetes mellitus: therapeutic implicationsQ34120717
Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitorsQ34222752
Ipragliflozin: first global approvalQ34412028
Tofogliflozin: first global approvalQ34420901
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Evaluation of Bone Mineral Density and Bone Biomarkers in Patients With Type 2 Diabetes Treated With CanagliflozinQ36431654
Empagliflozin as adjunct to insulin in patients with type 1 diabetes: a 4-week, randomized, placebo-controlled trial (EASE-1)Q36555418
Sotagliflozin, a Dual SGLT1 and SGLT2 Inhibitor, as Adjunct Therapy to Insulin in Type 1 DiabetesQ36798680
Possible adverse effects of SGLT2 inhibitors on boneQ36988902
Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitusQ37141727
Empagliflozin as add-on to metformin plus sulfonylurea in patients with type 2 diabetes: a 24-week, randomized, double-blind, placebo-controlled trialQ37278239
Impact of empagliflozin added on to basal insulin in type 2 diabetes inadequately controlled on basal insulin: a 78-week randomized, double-blind, placebo-controlled trialQ37279276
Effects of empagliflozin on blood pressure and markers of arterial stiffness and vascular resistance in patients with type 2 diabetesQ37325818
Safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple rising doses of empagliflozin in patients with type 2 diabetes mellitusQ37468469
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Empagliflozin as Add-on Therapy to Pioglitazone With or Without Metformin in Patients With Type 2 Diabetes MellitusQ38408749
Renal hemodynamic effect of sodium-glucose cotransporter 2 inhibition in patients with type 1 diabetes mellitusQ38439475
POTENTIAL PLACE OF SGLT2 INHIBITORS IN TREATMENT PARADIGMS FOR TYPE 2 DIABETES MELLITUS.Q38541561
Empagliflozin (BI 10773), a Potent and Selective SGLT2 Inhibitor, Induces Dose-Dependent Glucosuria in Healthy SubjectsQ39816362
Dapagliflozin, a selective SGLT2 inhibitor, improves glucose homeostasis in normal and diabetic ratsQ39999985
Empagliflozin as add-on to metformin in patients with type 2 diabetes: a 24-week, randomized, double-blind, placebo-controlled trialQ42706050
AICAR and phlorizin reverse the hypoglycemia-specific defect in glucagon secretion in the diabetic BB rat.Q44176935
Empagliflozin improves glycaemic and weight control as add-on therapy to pioglitazone or pioglitazone plus metformin in patients with type 2 diabetes: a 24-week, randomized, placebo-controlled trialQ44251536
Safety, tolerability, pharmacokinetics and pharmacodynamics following 4 weeks' treatment with empagliflozin once daily in patients with type 2 diabetesQ45348074
Improved glucose control with weight loss, lower insulin doses, and no increased hypoglycemia with empagliflozin added to titrated multiple daily injections of insulin in obese inadequately controlled type 2 diabetesQ47581268
Pharmacokinetics, safety and tolerability of empagliflozin, a sodium glucose cotransporter 2 inhibitor, in patients with hepatic impairmentQ47998345
Pharmacokinetics, pharmacodynamics and safety of empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, in subjects with renal impairmentQ47998377
Empagliflozin reduces blood pressure in patients with type 2 diabetes and hypertensionQ50448714
Biotransformation and mass balance of the SGLT2 inhibitor empagliflozin in healthy volunteersQ50454359
AACE/ACE comprehensive diabetes management algorithm 2015.Q50931076
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Empagliflozin monotherapy with sitagliptin as an active comparator in patients with type 2 diabetes: a randomised, double-blind, placebo-controlled, phase 3 trial.Q51748822
Short-term impacts of sodium/glucose co-transporter 2 inhibitors in Japanese clinical practice: considerations for their appropriate use to avoid serious adverse events.Q53551539
Luseogliflozin: First Global ApprovalQ57485821
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Combination of empagliflozin and linagliptin as second-line therapy in subjects with type 2 diabetes inadequately controlled on metforminQ86519614
Euglycemic Diabetic Ketoacidosis in a Patient With Type 2 Diabetes After Treatment With EmpagliflozinQ86592706
Initial combination of empagliflozin and linagliptin in subjects with type 2 diabetesQ86623452
Long-term treatment with empagliflozin as add-on to oral antidiabetes therapy in Japanese patients with type 2 diabetes mellitusQ86932366
Efficacy and safety of empagliflozin added to existing antidiabetes treatment in patients with type 2 diabetes and chronic kidney disease: a randomised, double-blind, placebo-controlled trialQ87809056
Comparison of empagliflozin and glimepiride as add-on to metformin in patients with type 2 diabetes: a 104-week randomised, active-controlled, double-blind, phase 3 trialQ88117871
P275copyright licenseCreative Commons Attribution-NonCommercialQ6936496
P433issue4
P921main subjecttype 2 diabetesQ3025883
hydrocarbonQ43648
mechanism of actionQ3271540
genitourinary systemQ4712977
carbohydrateQ11358
empagliflozinQ5373824
gliflozinsQ20089925
phase III clinical trialQ42824827
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)405-423
P577publication date2016-06-13
P1433published inCurrent Diabetes ReviewsQ15761978
P1476titleEmpagliflozin for Type 2 Diabetes Mellitus: An Overview of Phase 3 Clinical Trials
P478volume13

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cites work (P2860)
Q92309828Advanced Glycation End Products: Potential Mechanism and Therapeutic Target in Cardiovascular Complications under Diabetes
Q93349329Case - Fungal urosepsis after ureteroscopy in a patient on new generation of anti-hyperglycemic medication
Q89627944Dysplastic urothelial changes accompany empagliflozin administration in urinary bladder of experimental diabetes
Q57471302Empagliflozin and Kidney Function Decline in Patients with Type 2 Diabetes: A Slope Analysis from the EMPA-REG OUTCOME Trial
Q88688841Empagliflozin as add-on to linagliptin in a fixed-dose combination in Japanese patients with type 2 diabetes: Glycaemic efficacy and safety profile in a 52-week, randomized, placebo-controlled trial
Q89273102Empagliflozin: A Review in Type 2 Diabetes
Q93032468Evidence from routine clinical practice: EMPRISE provides a new perspective on CVOTs
Q64891770Linagliptin as add-on to empagliflozin in a fixed-dose combination in Japanese patients with type 2 diabetes: Glycaemic efficacy and safety profile in a two-part, randomized, placebo-controlled trial.
Q28354224Mesenchymal Stem Cells as Therapeutic Candidates for Halting the Progression of Diabetic Nephropathy
Q91868121Renal and Glucose-Lowering Effects of Empagliflozin and Dapagliflozin in Different Chronic Kidney Disease Stages
Q42643753Translating recent results from the Cardiovascular Outcomes Trials into clinical practice: recommendations from the Central and Eastern European Diabetes Expert Group (CEEDEG).

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