Counteracting effects of cellular Notch and Epstein-Barr virus EBNA2: implications for stromal effects on virus-host interactions

scientific article published on 13 August 2014

Counteracting effects of cellular Notch and Epstein-Barr virus EBNA2: implications for stromal effects on virus-host interactions is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.01431-14
P932PMC publication ID4178707
P698PubMed publication ID25122803

P50authorMartin RoweQ37376494
Claire Shannon LoweQ95607355
P2093author name stringSweta Raithatha
P2860cites workA novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACEQ28139998
Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H)Q28286560
ZEB1 regulates the latent-lytic switch in infection by Epstein-Barr virusQ28471803
The B-cell specific transcription factor, Oct-2, promotes Epstein-Barr virus latency by inhibiting the viral immediate-early protein, BZLF1Q28480586
Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivoQ28509550
Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cellsQ28594415
Nuclear access and action of notch in vivoQ28646384
The canonical Notch signaling pathway: unfolding the activation mechanismQ29547725
IL-21 imposes a type II EBV gene expression on type III and type I B cells by the repression of C- and activation of LMP-1-promoterQ33640213
Activated Notch1 modulates gene expression in B cells similarly to Epstein-Barr viral nuclear antigen 2.Q33797347
Activated Notch1 can transiently substitute for EBNA2 in the maintenance of proliferation of LMP1-expressing immortalized B cellsQ33850400
Either ZEB1 or ZEB2/SIP1 can play a central role in regulating the Epstein-Barr virus latent-lytic switch in a cell-type-specific mannerQ33877497
Cellular MicroRNAs 200b and 429 Regulate the Epstein-Barr Virus Switch between Latency and Lytic ReplicationQ34120915
Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage developmentQ34197865
The Epstein-Barr virus nuclear antigen 2 interacts with an EBNA2 responsive cis-element of the terminal protein 1 gene promoterQ34355226
ZEB negatively regulates the lytic-switch BZLF1 gene promoter of Epstein-Barr virusQ34461528
Role of CCAAT/enhancer-binding protein alpha (C/EBPalpha) in activation of the Kaposi's sarcoma-associated herpesvirus (KSHV) lytic-cycle replication-associated protein (RAP) promoter in cooperation with the KSHV replication and transcription activaQ34461819
Resting B cells as a transfer vehicle for Epstein-Barr virus infection of epithelial cellsQ34598541
Cellular transcription factor Oct-1 interacts with the Epstein-Barr virus BRLF1 protein to promote disruption of viral latencyQ35192797
The Epstein-Barr virus nuclear antigen 2 transactivator is directed to response elements by the J kappa recombination signal binding proteinQ35648541
Soluble factors produced by activated CD4+ T cells modulate EBV latencyQ35749824
Regulation of lymphoid development, differentiation, and function by the Notch pathway.Q36072476
Propagation and recovery of intact, infectious Epstein-Barr virus from prokaryotic to human cellsQ36173276
Monoclonal antibody against a 250,000-dalton glycoprotein of Epstein-Barr virus identifies a membrane antigen and a neutralizing antigenQ36390855
An auto-regulatory loop for EBV LMP2A involves activation of NotchQ36528115
Epstein-Barr virus latency in blood mononuclear cells: analysis of viral gene transcription during primary infection and in the carrier state.Q36637195
EBNA-2 transactivates a lymphoid-specific enhancer in the BamHI C promoter of Epstein-Barr virusQ36688330
cis-acting regulatory elements near the Epstein-Barr virus latent-infection membrane protein transcriptional start siteQ36804472
Epstein-Barr virus latent membrane protein 2A exploits Notch1 to alter B-cell identity in vivoQ37039112
Early activation of the Kaposi's sarcoma-associated herpesvirus RTA, RAP, and MTA promoters by the tetradecanoyl phorbol acetate-induced AP1 pathway.Q37093134
Role for the Epstein-Barr virus nuclear antigen 2 in viral promoter switching during initial stages of infectionQ37504372
Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.Q37724159
The pathogenesis of Epstein-Barr virus persistent infection.Q38107595
Role of Notch signal transduction in Kaposi's sarcoma-associated herpesvirus gene expressionQ38319392
Genome-wide analyses of Zta binding to the Epstein-Barr virus genome reveals interactions in both early and late lytic cycles and an epigenetic switch leading to an altered binding profileQ38321333
Epstein-Barr virus and Hodgkin's disease: transcriptional analysis of virus latency in the malignant cellsQ38322174
Wide-scale use of Notch signaling factor CSL/RBP-Jkappa in RTA-mediated activation of Kaposi's sarcoma-associated herpesvirus lytic genesQ38348963
Activated mouse Notch1 transactivates Epstein-Barr virus nuclear antigen 2-regulated viral promotersQ39549769
Functional replacement of the intracellular region of the Notch1 receptor by Epstein-Barr virus nuclear antigen 2.Q39582561
Octamer-binding sequence is a key element for the autoregulation of Kaposi's sarcoma-associated herpesvirus ORF50/Lyta gene expressionQ39603733
STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr virus–encoded protein LMP-1 in absence of EBNA-2: implications for the type II EBV latent gene expression in Hodgkin lymphomaQ39650776
Features distinguishing Epstein-Barr virus infections of epithelial cells and B cells: viral genome expression, genome maintenance, and genome amplificationQ39852028
The lytic switch protein of KSHV activates gene expression via functional interaction with RBP-Jkappa (CSL), the target of the Notch signaling pathway.Q39860135
Clonal propagation of Epstein-Barr virus (EBV) recombinants in EBV-negative Akata cellsQ39876626
In vitro human T cell development directed by notch-ligand interactionsQ39997849
Epstein-Barr virus nuclear antigen 2 activates transcription of the terminal protein geneQ40062679
Differentiation-associated expression of the Epstein-Barr virus BZLF1 transactivator protein in oral hairy leukoplakiaQ40064626
IL-10 can induce the expression of EBV-encoded latent membrane protein-1 (LMP-1) in the absence of EBNA-2 in B lymphocytes and in Burkitt lymphoma- and NK lymphoma-derived cell linesQ40342745
Epstein-Barr virus nuclear antigen 2 exerts its transactivating function through interaction with recombination signal binding protein RBP-J kappa, the homologue of Drosophila Suppressor of Hairless.Q40793575
Monoclonal antibodies to the latent membrane protein of Epstein-Barr virus reveal heterogeneity of the protein and inducible expression in virus-transformed cellsQ42010316
ZEB1 and c-Jun levels contribute to the establishment of highly lytic Epstein-Barr virus infection in gastric AGS cellsQ42638304
Expression of Epstein-Barr virus transformation-associated genes in tissues of patients with EBV lymphoproliferative diseaseQ43936463
Notch1, Notch2, and Epstein-Barr virus-encoded nuclear antigen 2 signaling differentially affects proliferation and survival of Epstein-Barr virus-infected B cellsQ45385554
Analysis of Epstein-Barr virus latent gene expression in endemic Burkitt's lymphoma and nasopharyngeal carcinoma tumour cells by using quantitative real-time PCR assaysQ45412384
Epstein-Barr Virus (EBV) LMP2A induces alterations in gene transcription similar to those observed in Reed-Sternberg cells of Hodgkin lymphomaQ45722302
Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein J kappaQ45781476
Monoclonal antibodies raised against denatured HLA-B locus heavy chains permit biochemical characterization of certain HLA-C locus productsQ69621634
Genetic and biochemical evidence that EBNA 2 interaction with a 63-kDa cellular GTG-binding protein is essential for B lymphocyte growth transformation by EBVQ72756611
CCAAT/enhancer-binding protein-alpha is induced during the early stages of Kaposi's sarcoma-associated herpesvirus (KSHV) lytic cycle reactivation and together with the KSHV replication and transcription activator (RTA) cooperatively stimulates theQ73802773
A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1Q73958442
Notch activity synergizes with B-cell-receptor and CD40 signaling to enhance B-cell activationQ79441801
P433issue20
P407language of work or nameEnglishQ1860
P921main subjectEpstein–Barr virusQ6900
P304page(s)12065-12076
P577publication date2014-08-13
P1433published inJournal of VirologyQ1251128
P1476titleCounteracting effects of cellular Notch and Epstein-Barr virus EBNA2: implications for stromal effects on virus-host interactions
P478volume88

Reverse relations

cites work (P2860)
Q27321686Computational discovery of Epstein-Barr virus targeted human genes and signalling pathways
Q38596350Contribution of the Epstein-Barr Virus to the Pathogenesis of Hodgkin Lymphoma
Q36346985Cross talk between EBV and telomerase: the role of TERT and NOTCH2 in the switch of latent/lytic cycle of the virus
Q28552335EBNA2 Drives Formation of New Chromosome Binding Sites and Target Genes for B-Cell Master Regulatory Transcription Factors RBP-jκ and EBF1
Q36736629Epstein-Barr Virus Nuclear Antigen 3 (EBNA3) Proteins Regulate EBNA2 Binding to Distinct RBPJ Genomic Sites
Q26998999Epstein-Barr virus and the origin of Hodgkin lymphoma
Q56888557Investigating genetic-and-epigenetic networks, and the cellular mechanisms occurring in Epstein-Barr virus-infected human B lymphocytes via big data mining and genome-wide two-sided NGS data identification
Q59353945Molecular mechanisms of viral oncogenesis in humans
Q37342493Notch Signaling Contributes to Liver Inflammation by Regulation of Interleukin-22-Producing Cells in Hepatitis B Virus Infection
Q64086953Opportunities to Target the Life Cycle of Epstein-Barr Virus (EBV) in EBV-Associated Lymphoproliferative Disorders
Q38258049The Epstein-Barr virus and the pathogenesis of lymphoma.
Q91754323Whole-Exome Sequencing of Nasopharyngeal Carcinoma Families Reveals Novel Variants Potentially Involved in Nasopharyngeal Carcinoma

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